Incidental Mutation 'R6659:Ppp1r37'
ID 526761
Institutional Source Beutler Lab
Gene Symbol Ppp1r37
Ensembl Gene ENSMUSG00000051403
Gene Name protein phosphatase 1, regulatory subunit 37
Synonyms Lrrc68
MMRRC Submission 044779-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.246) question?
Stock # R6659 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 19264725-19297001 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19266048 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 573 (S573P)
Ref Sequence ENSEMBL: ENSMUSP00000060233 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058444]
AlphaFold Q8BKR5
Predicted Effect probably benign
Transcript: ENSMUST00000058444
AA Change: S573P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000060233
Gene: ENSMUSG00000051403
AA Change: S573P

DomainStartEndE-ValueType
low complexity region 7 38 N/A INTRINSIC
Blast:LRR 139 166 1e-9 BLAST
LRR 224 251 1.77e2 SMART
LRR 252 280 3.52e-1 SMART
LRR 281 308 8.27e-7 SMART
LRR 310 337 3.05e1 SMART
LRR 338 365 1.4e-4 SMART
LRR 366 393 1.56e-2 SMART
LRR 394 421 2.36e-2 SMART
low complexity region 504 540 N/A INTRINSIC
low complexity region 566 574 N/A INTRINSIC
low complexity region 596 628 N/A INTRINSIC
low complexity region 660 679 N/A INTRINSIC
low complexity region 696 702 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208678
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209190
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap2 T C 16: 30,950,133 (GRCm39) D212G probably damaging Het
Add1 C T 5: 34,770,639 (GRCm39) A250V possibly damaging Het
Atxn2 A G 5: 121,916,027 (GRCm39) N411S probably benign Het
AW551984 T C 9: 39,500,395 (GRCm39) T788A probably benign Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Ddx46 A G 13: 55,817,537 (GRCm39) T721A probably damaging Het
Eif2b1 G A 5: 124,717,171 (GRCm39) probably benign Het
Eif4g3 A G 4: 137,905,243 (GRCm39) K1241E probably damaging Het
Engase T A 11: 118,372,142 (GRCm39) Y145N probably benign Het
Fbrs C A 7: 127,087,091 (GRCm39) A674D probably damaging Het
Gm4884 G A 7: 40,694,046 (GRCm39) G672R probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Iars2 T A 1: 185,020,273 (GRCm39) I954F possibly damaging Het
Itgad A T 7: 127,785,120 (GRCm39) I310F probably damaging Het
Kcnmb3 A G 3: 32,526,594 (GRCm39) V199A possibly damaging Het
Kctd12 G T 14: 103,219,622 (GRCm39) D85E probably damaging Het
Lama1 G A 17: 68,125,630 (GRCm39) R2929H probably damaging Het
Lgmn T A 12: 102,368,951 (GRCm39) Y176F probably benign Het
Lipo3 A G 19: 33,533,828 (GRCm39) F335L possibly damaging Het
Map2k3 T C 11: 60,833,150 (GRCm39) S46P probably benign Het
Megf8 C A 7: 25,058,159 (GRCm39) H2144Q probably benign Het
Neb A T 2: 52,124,365 (GRCm39) W3694R probably damaging Het
Nek10 A G 14: 14,861,684 (GRCm38) E580G probably benign Het
Obscn G A 11: 58,929,835 (GRCm39) P5930S probably damaging Het
Palld A G 8: 61,986,477 (GRCm39) F621L probably benign Het
Pkn2 A T 3: 142,509,348 (GRCm39) I732N probably damaging Het
Plpbp T A 8: 27,542,307 (GRCm39) I214N possibly damaging Het
Prg4 C A 1: 150,336,432 (GRCm39) C97F probably damaging Het
Prmt2 T C 10: 76,053,208 (GRCm39) D269G possibly damaging Het
Ptbp3 T A 4: 59,517,640 (GRCm39) L80F probably damaging Het
Reep1 T A 6: 71,750,179 (GRCm39) F64I probably damaging Het
Srcap C A 7: 127,141,563 (GRCm39) P1720Q probably damaging Het
Ssr1 A T 13: 38,171,666 (GRCm39) F124I probably damaging Het
Tbx18 A G 9: 87,589,864 (GRCm39) L358P probably damaging Het
Tfpt T C 7: 3,623,835 (GRCm39) K71E probably benign Het
Tmem132a C A 19: 10,837,685 (GRCm39) G542C probably damaging Het
Tmem135 C A 7: 88,956,371 (GRCm39) L81F probably benign Het
Tmem135 A T 7: 88,956,372 (GRCm39) L81* probably null Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Washc5 A G 15: 59,212,739 (GRCm39) probably null Het
Zfp24 T C 18: 24,150,391 (GRCm39) E173G possibly damaging Het
Zgrf1 T C 3: 127,410,155 (GRCm39) I1814T probably damaging Het
Other mutations in Ppp1r37
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0313:Ppp1r37 UTSW 7 19,267,923 (GRCm39) missense probably damaging 1.00
R0718:Ppp1r37 UTSW 7 19,266,179 (GRCm39) missense probably benign
R0883:Ppp1r37 UTSW 7 19,266,102 (GRCm39) missense probably benign 0.01
R1606:Ppp1r37 UTSW 7 19,268,924 (GRCm39) missense probably damaging 0.97
R2220:Ppp1r37 UTSW 7 19,266,371 (GRCm39) missense probably null 0.43
R2256:Ppp1r37 UTSW 7 19,295,943 (GRCm39) unclassified probably benign
R2257:Ppp1r37 UTSW 7 19,295,943 (GRCm39) unclassified probably benign
R2325:Ppp1r37 UTSW 7 19,266,609 (GRCm39) missense probably damaging 1.00
R2510:Ppp1r37 UTSW 7 19,266,357 (GRCm39) missense possibly damaging 0.79
R3401:Ppp1r37 UTSW 7 19,266,712 (GRCm39) missense probably damaging 0.99
R3402:Ppp1r37 UTSW 7 19,266,712 (GRCm39) missense probably damaging 0.99
R4006:Ppp1r37 UTSW 7 19,268,994 (GRCm39) missense probably damaging 1.00
R4750:Ppp1r37 UTSW 7 19,265,445 (GRCm39) missense probably benign
R4956:Ppp1r37 UTSW 7 19,266,636 (GRCm39) nonsense probably null
R5156:Ppp1r37 UTSW 7 19,295,900 (GRCm39) unclassified probably benign
R5582:Ppp1r37 UTSW 7 19,266,219 (GRCm39) missense probably damaging 1.00
R5659:Ppp1r37 UTSW 7 19,269,448 (GRCm39) missense probably damaging 1.00
R5918:Ppp1r37 UTSW 7 19,266,036 (GRCm39) missense probably benign 0.02
R6172:Ppp1r37 UTSW 7 19,266,329 (GRCm39) missense possibly damaging 0.93
R7626:Ppp1r37 UTSW 7 19,295,778 (GRCm39) missense probably damaging 0.99
R7779:Ppp1r37 UTSW 7 19,266,712 (GRCm39) missense possibly damaging 0.81
R7785:Ppp1r37 UTSW 7 19,265,996 (GRCm39) missense probably damaging 1.00
R7819:Ppp1r37 UTSW 7 19,267,989 (GRCm39) missense probably damaging 1.00
R7965:Ppp1r37 UTSW 7 19,265,868 (GRCm39) missense probably damaging 0.99
R8185:Ppp1r37 UTSW 7 19,266,873 (GRCm39) missense probably damaging 1.00
R9125:Ppp1r37 UTSW 7 19,269,014 (GRCm39) missense probably benign 0.12
R9224:Ppp1r37 UTSW 7 19,265,729 (GRCm39) missense probably damaging 0.98
R9417:Ppp1r37 UTSW 7 19,269,658 (GRCm39) missense probably damaging 0.98
R9453:Ppp1r37 UTSW 7 19,295,796 (GRCm39) missense probably damaging 0.99
R9777:Ppp1r37 UTSW 7 19,295,783 (GRCm39) missense probably benign 0.23
Z1177:Ppp1r37 UTSW 7 19,268,997 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGGGCAAACTCAGGCTTCAG -3'
(R):5'- TGAGATCACCATCACTGCAC -3'

Sequencing Primer
(F):5'- CAGATGACTCTGGGTCCTGG -3'
(R):5'- TGACTCAGACTCAGACTCAGACTCTG -3'
Posted On 2018-07-23