Mutagenetix > Incidental Mutation

Incidental Mutation 'R6667:Vmn1r1'

527003

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r1

Ensembl Gene

ENSMUSG00000091013

Gene Name

vomeronasal 1 receptor 1

Synonyms

Gm6628

MMRRC Submission

044787-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

R6667 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

181984743-181985663 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 181985342 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 108 (V108I)

Ref Sequence

ENSEMBL: ENSMUSP00000153940 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169123] [ENSMUST00000227586] [ENSMUST00000227629]

AlphaFold

E9PVR6

Predicted Effect

probably benign
Transcript: ENSMUST00000169123
AA Change: V108I

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000133035
Gene: ENSMUSG00000091013
AA Change: V108I

Domain	Start	End	E-Value	Type
Pfam:V1R	38	301	8e-79	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227586
AA Change: V108I

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000227629
AA Change: V108I

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.6%

Validation Efficiency

98% (41/42)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3100002H09Rik	G	T	4: 124,504,435 (GRCm39)	A39E	probably damaging	Het
Agtr1b	T	A	3: 20,369,913 (GRCm39)	N231I	possibly damaging	Het
Alpk2	T	C	18: 65,440,811 (GRCm39)	E661G	probably damaging	Het
Ankrd26	C	T	6: 118,484,749 (GRCm39)	S1496N	probably benign	Het
Asah2	T	C	19: 31,972,758 (GRCm39)	N659S	probably benign	Het
Atp12a	T	C	14: 56,621,645 (GRCm39)	V760A	possibly damaging	Het
Casp2	T	C	6: 42,256,770 (GRCm39)	C343R	probably damaging	Het
Cblb	T	A	16: 51,973,007 (GRCm39)	M446K	possibly damaging	Het
Cipc	T	C	12: 87,008,864 (GRCm39)	V241A	probably benign	Het
Ddit4l	A	G	3: 137,331,882 (GRCm39)	K83E	probably benign	Het
Eif1ad10	A	T	12: 88,216,475 (GRCm39)	D132E	unknown	Het
Epc2	A	G	2: 49,412,681 (GRCm39)	T220A	probably damaging	Het
Epha5	T	C	5: 84,219,050 (GRCm39)	D741G	probably damaging	Het
Flg2	A	T	3: 93,109,068 (GRCm39)	R365S	possibly damaging	Het
Ggn	A	T	7: 28,872,093 (GRCm39)	H491L	possibly damaging	Het
Gpat2	G	C	2: 127,273,838 (GRCm39)	G294R	possibly damaging	Het
Ighv6-4	A	G	12: 114,370,152 (GRCm39)	V100A	probably benign	Het
Invs	A	T	4: 48,402,870 (GRCm39)	Y501F	possibly damaging	Het
Iqcm	G	T	8: 76,479,980 (GRCm39)	G313W	probably damaging	Het
Jph2	A	G	2: 163,218,206 (GRCm39)	S157P	probably damaging	Het
Mast4	T	C	13: 102,874,004 (GRCm39)	E1596G	probably damaging	Het
Mllt6	T	A	11: 97,567,760 (GRCm39)	L759Q	probably damaging	Het
Nalcn	A	G	14: 123,558,735 (GRCm39)	L837P	probably damaging	Het
Neb	G	A	2: 52,037,201 (GRCm39)	T6836I	probably damaging	Het
Nol12	T	A	15: 78,824,280 (GRCm39)	D133E	probably benign	Het
Or5w13	A	G	2: 87,523,914 (GRCm39)	V104A	probably benign	Het
Oxtr	C	A	6: 112,454,060 (GRCm39)		probably benign	Het
Pcmt1	A	G	10: 7,538,913 (GRCm39)	L38P	probably damaging	Het
Pik3r2	T	C	8: 71,221,817 (GRCm39)	Y617C	probably damaging	Het
Potefam3b	T	C	8: 21,161,955 (GRCm39)	S267P	probably benign	Het
Prl7a2	T	C	13: 27,845,024 (GRCm39)	N121D	probably benign	Het
Pvr	G	T	7: 19,639,727 (GRCm39)	Q380K	probably benign	Het
Rtn2	A	G	7: 19,021,184 (GRCm39)	E188G	probably benign	Het
Setd4	C	A	16: 93,386,918 (GRCm39)	R260L	probably benign	Het
Six5	A	G	7: 18,830,494 (GRCm39)	N374D	probably benign	Het
Slc9b1	T	C	3: 135,077,726 (GRCm39)	I140T	probably damaging	Het
Supt16	A	G	14: 52,409,520 (GRCm39)	F797L	probably damaging	Het
Tbata	T	C	10: 61,021,142 (GRCm39)	L262P	probably damaging	Het
Tti1	A	T	2: 157,850,347 (GRCm39)	C297*	probably null	Het
Ush1c	C	A	7: 45,875,048 (GRCm39)	G139C	probably damaging	Het
Vmn2r116	C	T	17: 23,620,066 (GRCm39)	T600I	probably damaging	Het
Zfp764l1	A	G	7: 126,992,595 (GRCm39)	M5T	probably benign	Het
Zfp873	A	G	10: 81,896,423 (GRCm39)	T422A	probably benign	Het
Zfp943	G	A	17: 22,211,889 (GRCm39)	C325Y	probably damaging	Het

Other mutations in Vmn1r1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0535:Vmn1r1	UTSW	1	181,985,516 (GRCm39)	missense	probably benign	0.00
R1330:Vmn1r1	UTSW	1	181,985,572 (GRCm39)	missense	probably damaging	1.00
R1696:Vmn1r1	UTSW	1	181,985,624 (GRCm39)	missense	probably benign	0.26
R1809:Vmn1r1	UTSW	1	181,985,371 (GRCm39)	missense	possibly damaging	0.82
R4661:Vmn1r1	UTSW	1	181,984,789 (GRCm39)	missense	possibly damaging	0.90
R4717:Vmn1r1	UTSW	1	181,984,774 (GRCm39)	missense	possibly damaging	0.66
R4765:Vmn1r1	UTSW	1	181,985,471 (GRCm39)	missense	probably benign	0.00
R4772:Vmn1r1	UTSW	1	181,985,111 (GRCm39)	missense	probably benign	0.41
R4864:Vmn1r1	UTSW	1	181,985,332 (GRCm39)	missense	probably benign
R5369:Vmn1r1	UTSW	1	181,985,341 (GRCm39)	missense	possibly damaging	0.87
R5594:Vmn1r1	UTSW	1	181,984,972 (GRCm39)	missense	probably damaging	1.00
R6240:Vmn1r1	UTSW	1	181,985,186 (GRCm39)	missense	probably damaging	1.00
R7075:Vmn1r1	UTSW	1	181,985,597 (GRCm39)	missense	probably benign	0.00
R7686:Vmn1r1	UTSW	1	181,985,590 (GRCm39)	missense	probably damaging	1.00
R7908:Vmn1r1	UTSW	1	181,984,915 (GRCm39)	missense	probably benign	0.45
R8514:Vmn1r1	UTSW	1	181,985,138 (GRCm39)	missense	probably benign	0.04
R8951:Vmn1r1	UTSW	1	181,985,309 (GRCm39)	missense	probably damaging	1.00
R9332:Vmn1r1	UTSW	1	181,985,002 (GRCm39)	missense	probably damaging	1.00
R9450:Vmn1r1	UTSW	1	181,984,770 (GRCm39)	nonsense	probably null
R9459:Vmn1r1	UTSW	1	181,985,503 (GRCm39)	missense	probably benign	0.08

Predicted Primers

Posted On

2018-07-23