Incidental Mutation 'R6667:Agtr1b'
ID |
527009 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Agtr1b
|
Ensembl Gene |
ENSMUSG00000054988 |
Gene Name |
angiotensin II receptor, type 1b |
Synonyms |
AT1B, Angtr-1b, Agtr-1b |
MMRRC Submission |
044787-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6667 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
20368637-20421341 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 20369913 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Isoleucine
at position 231
(N231I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000128724
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068316]
[ENSMUST00000163776]
|
AlphaFold |
P29755 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000068316
AA Change: N231I
PolyPhen 2
Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000068298 Gene: ENSMUSG00000054988 AA Change: N231I
Domain | Start | End | E-Value | Type |
Pfam:7TM_GPCR_Srsx
|
39 |
310 |
5.4e-10 |
PFAM |
Pfam:7tm_1
|
45 |
302 |
3e-52 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163776
AA Change: N231I
PolyPhen 2
Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000128724 Gene: ENSMUSG00000054988 AA Change: N231I
Domain | Start | End | E-Value | Type |
Pfam:7TM_GPCR_Srsx
|
39 |
310 |
5.4e-10 |
PFAM |
Pfam:7tm_1
|
45 |
302 |
1.1e-65 |
PFAM |
|
Meta Mutation Damage Score |
0.1468 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.6%
|
Validation Efficiency |
98% (41/42) |
MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations are phenotypically normal, but homozygotes for the Agtr1b/Agtr1a double knockout exhibit reductions in growth, survival, blood pressure, and kidney size not found in either single knockout. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 44 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
3100002H09Rik |
G |
T |
4: 124,504,435 (GRCm39) |
A39E |
probably damaging |
Het |
Alpk2 |
T |
C |
18: 65,440,811 (GRCm39) |
E661G |
probably damaging |
Het |
Ankrd26 |
C |
T |
6: 118,484,749 (GRCm39) |
S1496N |
probably benign |
Het |
Asah2 |
T |
C |
19: 31,972,758 (GRCm39) |
N659S |
probably benign |
Het |
Atp12a |
T |
C |
14: 56,621,645 (GRCm39) |
V760A |
possibly damaging |
Het |
Casp2 |
T |
C |
6: 42,256,770 (GRCm39) |
C343R |
probably damaging |
Het |
Cblb |
T |
A |
16: 51,973,007 (GRCm39) |
M446K |
possibly damaging |
Het |
Cipc |
T |
C |
12: 87,008,864 (GRCm39) |
V241A |
probably benign |
Het |
Ddit4l |
A |
G |
3: 137,331,882 (GRCm39) |
K83E |
probably benign |
Het |
Eif1ad10 |
A |
T |
12: 88,216,475 (GRCm39) |
D132E |
unknown |
Het |
Epc2 |
A |
G |
2: 49,412,681 (GRCm39) |
T220A |
probably damaging |
Het |
Epha5 |
T |
C |
5: 84,219,050 (GRCm39) |
D741G |
probably damaging |
Het |
Flg2 |
A |
T |
3: 93,109,068 (GRCm39) |
R365S |
possibly damaging |
Het |
Ggn |
A |
T |
7: 28,872,093 (GRCm39) |
H491L |
possibly damaging |
Het |
Gpat2 |
G |
C |
2: 127,273,838 (GRCm39) |
G294R |
possibly damaging |
Het |
Ighv6-4 |
A |
G |
12: 114,370,152 (GRCm39) |
V100A |
probably benign |
Het |
Invs |
A |
T |
4: 48,402,870 (GRCm39) |
Y501F |
possibly damaging |
Het |
Iqcm |
G |
T |
8: 76,479,980 (GRCm39) |
G313W |
probably damaging |
Het |
Jph2 |
A |
G |
2: 163,218,206 (GRCm39) |
S157P |
probably damaging |
Het |
Mast4 |
T |
C |
13: 102,874,004 (GRCm39) |
E1596G |
probably damaging |
Het |
Mllt6 |
T |
A |
11: 97,567,760 (GRCm39) |
L759Q |
probably damaging |
Het |
Nalcn |
A |
G |
14: 123,558,735 (GRCm39) |
L837P |
probably damaging |
Het |
Neb |
G |
A |
2: 52,037,201 (GRCm39) |
T6836I |
probably damaging |
Het |
Nol12 |
T |
A |
15: 78,824,280 (GRCm39) |
D133E |
probably benign |
Het |
Or5w13 |
A |
G |
2: 87,523,914 (GRCm39) |
V104A |
probably benign |
Het |
Oxtr |
C |
A |
6: 112,454,060 (GRCm39) |
|
probably benign |
Het |
Pcmt1 |
A |
G |
10: 7,538,913 (GRCm39) |
L38P |
probably damaging |
Het |
Pik3r2 |
T |
C |
8: 71,221,817 (GRCm39) |
Y617C |
probably damaging |
Het |
Potefam3b |
T |
C |
8: 21,161,955 (GRCm39) |
S267P |
probably benign |
Het |
Prl7a2 |
T |
C |
13: 27,845,024 (GRCm39) |
N121D |
probably benign |
Het |
Pvr |
G |
T |
7: 19,639,727 (GRCm39) |
Q380K |
probably benign |
Het |
Rtn2 |
A |
G |
7: 19,021,184 (GRCm39) |
E188G |
probably benign |
Het |
Setd4 |
C |
A |
16: 93,386,918 (GRCm39) |
R260L |
probably benign |
Het |
Six5 |
A |
G |
7: 18,830,494 (GRCm39) |
N374D |
probably benign |
Het |
Slc9b1 |
T |
C |
3: 135,077,726 (GRCm39) |
I140T |
probably damaging |
Het |
Supt16 |
A |
G |
14: 52,409,520 (GRCm39) |
F797L |
probably damaging |
Het |
Tbata |
T |
C |
10: 61,021,142 (GRCm39) |
L262P |
probably damaging |
Het |
Tti1 |
A |
T |
2: 157,850,347 (GRCm39) |
C297* |
probably null |
Het |
Ush1c |
C |
A |
7: 45,875,048 (GRCm39) |
G139C |
probably damaging |
Het |
Vmn1r1 |
C |
T |
1: 181,985,342 (GRCm39) |
V108I |
probably benign |
Het |
Vmn2r116 |
C |
T |
17: 23,620,066 (GRCm39) |
T600I |
probably damaging |
Het |
Zfp764l1 |
A |
G |
7: 126,992,595 (GRCm39) |
M5T |
probably benign |
Het |
Zfp873 |
A |
G |
10: 81,896,423 (GRCm39) |
T422A |
probably benign |
Het |
Zfp943 |
G |
A |
17: 22,211,889 (GRCm39) |
C325Y |
probably damaging |
Het |
|
Other mutations in Agtr1b |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01558:Agtr1b
|
APN |
3 |
20,370,424 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02706:Agtr1b
|
APN |
3 |
20,370,027 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02958:Agtr1b
|
APN |
3 |
20,370,258 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL03243:Agtr1b
|
APN |
3 |
20,369,959 (GRCm39) |
missense |
probably benign |
0.13 |
R0125:Agtr1b
|
UTSW |
3 |
20,369,704 (GRCm39) |
missense |
probably benign |
0.00 |
R0565:Agtr1b
|
UTSW |
3 |
20,369,838 (GRCm39) |
missense |
probably damaging |
0.99 |
R0661:Agtr1b
|
UTSW |
3 |
20,370,163 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1070:Agtr1b
|
UTSW |
3 |
20,369,912 (GRCm39) |
missense |
probably benign |
0.34 |
R1469:Agtr1b
|
UTSW |
3 |
20,369,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R1469:Agtr1b
|
UTSW |
3 |
20,369,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R1713:Agtr1b
|
UTSW |
3 |
20,370,473 (GRCm39) |
missense |
probably benign |
0.00 |
R4502:Agtr1b
|
UTSW |
3 |
20,369,962 (GRCm39) |
missense |
probably damaging |
1.00 |
R5613:Agtr1b
|
UTSW |
3 |
20,370,424 (GRCm39) |
missense |
probably damaging |
0.99 |
R6142:Agtr1b
|
UTSW |
3 |
20,370,558 (GRCm39) |
missense |
probably benign |
0.06 |
R6320:Agtr1b
|
UTSW |
3 |
20,369,943 (GRCm39) |
missense |
probably benign |
0.22 |
R6987:Agtr1b
|
UTSW |
3 |
20,370,585 (GRCm39) |
missense |
probably benign |
0.00 |
R7407:Agtr1b
|
UTSW |
3 |
20,369,895 (GRCm39) |
missense |
possibly damaging |
0.79 |
R7598:Agtr1b
|
UTSW |
3 |
20,370,077 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8701:Agtr1b
|
UTSW |
3 |
20,370,256 (GRCm39) |
missense |
probably damaging |
0.99 |
R8791:Agtr1b
|
UTSW |
3 |
20,370,280 (GRCm39) |
missense |
probably damaging |
1.00 |
R9005:Agtr1b
|
UTSW |
3 |
20,370,343 (GRCm39) |
missense |
possibly damaging |
0.66 |
X0037:Agtr1b
|
UTSW |
3 |
20,370,552 (GRCm39) |
missense |
probably damaging |
1.00 |
X0060:Agtr1b
|
UTSW |
3 |
20,370,552 (GRCm39) |
missense |
probably damaging |
1.00 |
X0063:Agtr1b
|
UTSW |
3 |
20,370,552 (GRCm39) |
missense |
probably damaging |
1.00 |
X0063:Agtr1b
|
UTSW |
3 |
20,369,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGATGGGCATAGCAGTGTC -3'
(R):5'- CCTGCATCATCATCTGGCTG -3'
Sequencing Primer
(F):5'- GCATAGCAGTGTCCACTACGTC -3'
(R):5'- GCCGTCATCCACCGAAATGTG -3'
|
Posted On |
2018-07-23 |