Incidental Mutation 'R6668:Or8b38'
ID 527069
Institutional Source Beutler Lab
Gene Symbol Or8b38
Ensembl Gene ENSMUSG00000096424
Gene Name olfactory receptor family 8 subfamily B member 38
Synonyms MOR162-12, GA_x6K02T2PVTD-31740639-31741568, Olfr885
MMRRC Submission 044788-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R6668 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 37972618-37973547 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37973066 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 150 (M150K)
Ref Sequence ENSEMBL: ENSMUSP00000080646 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081985]
AlphaFold Q7TRE0
Predicted Effect possibly damaging
Transcript: ENSMUST00000081985
AA Change: M150K

PolyPhen 2 Score 0.833 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000080646
Gene: ENSMUSG00000096424
AA Change: M150K

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 224 1.1e-5 PFAM
Pfam:7tm_1 41 288 7.5e-24 PFAM
Meta Mutation Damage Score 0.7695 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat G T 11: 116,486,868 (GRCm39) probably benign Het
Adam26b A T 8: 43,973,727 (GRCm39) V425D possibly damaging Het
Ahctf1 A G 1: 179,579,972 (GRCm39) S2077P probably benign Het
Amacr A G 15: 10,983,468 (GRCm39) T93A probably benign Het
Arsb T A 13: 93,930,728 (GRCm39) probably null Het
Bcas3 G A 11: 85,692,677 (GRCm39) R354Q probably damaging Het
Chia1 C T 3: 106,038,264 (GRCm39) L387F probably damaging Het
Cyp24a1 A T 2: 170,327,805 (GRCm39) probably null Het
Dennd4a G A 9: 64,794,247 (GRCm39) G689S probably damaging Het
Elovl4 G A 9: 83,688,039 (GRCm39) A18V probably benign Het
Fam135a A T 1: 24,067,929 (GRCm39) V80E probably damaging Het
Fmo2 T A 1: 162,704,617 (GRCm39) T430S probably benign Het
Fpgs T C 2: 32,577,618 (GRCm39) I213V probably benign Het
Gm10134 A T 2: 28,396,263 (GRCm39) R53* probably null Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Ift172 T C 5: 31,412,683 (GRCm39) N1524S probably benign Het
Kif1b G A 4: 149,297,864 (GRCm39) S1104F probably benign Het
Map3k21 T C 8: 126,652,852 (GRCm39) V326A possibly damaging Het
Mlst8 A G 17: 24,696,453 (GRCm39) probably null Het
Muc16 A T 9: 18,551,681 (GRCm39) S4871T probably benign Het
Myo1d A G 11: 80,474,701 (GRCm39) probably benign Het
Ndufa3 A G 7: 3,622,465 (GRCm39) Y41C probably damaging Het
Nfkbid T A 7: 30,123,866 (GRCm39) L142Q probably benign Het
Peg10 T A 6: 4,754,502 (GRCm39) D94E probably benign Het
Phactr3 A T 2: 177,974,657 (GRCm39) I492F probably damaging Het
Plxna2 T C 1: 194,492,396 (GRCm39) V1751A possibly damaging Het
Prss16 T C 13: 22,190,918 (GRCm39) E238G probably null Het
Rad51ap2 T C 12: 11,507,647 (GRCm39) V523A probably benign Het
Rbm33 T A 5: 28,547,498 (GRCm39) S223T probably benign Het
Ryk T A 9: 102,746,475 (GRCm39) F137I possibly damaging Het
Sars2 G A 7: 28,446,429 (GRCm39) E194K probably benign Het
Spata2l T C 8: 123,960,167 (GRCm39) D374G probably damaging Het
Tenm2 A G 11: 35,937,592 (GRCm39) probably null Het
Ubr4 A G 4: 139,192,652 (GRCm39) K1097E probably damaging Het
Ulk4 A T 9: 121,017,408 (GRCm39) V690E probably damaging Het
Usp34 A G 11: 23,410,659 (GRCm39) N2703S probably damaging Het
Zfp273 C G 13: 67,973,243 (GRCm39) L124V probably damaging Het
Zfp608 A G 18: 55,031,091 (GRCm39) S950P probably damaging Het
Zfp994 A T 17: 22,420,081 (GRCm39) H289Q probably damaging Het
Other mutations in Or8b38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01470:Or8b38 APN 9 37,973,300 (GRCm39) missense possibly damaging 0.58
IGL02441:Or8b38 APN 9 37,973,233 (GRCm39) missense probably benign 0.02
IGL03263:Or8b38 APN 9 37,973,009 (GRCm39) missense probably damaging 0.98
R1748:Or8b38 UTSW 9 37,972,796 (GRCm39) missense probably damaging 1.00
R1870:Or8b38 UTSW 9 37,972,646 (GRCm39) missense probably benign 0.24
R1920:Or8b38 UTSW 9 37,972,981 (GRCm39) missense probably damaging 1.00
R1921:Or8b38 UTSW 9 37,972,981 (GRCm39) missense probably damaging 1.00
R1922:Or8b38 UTSW 9 37,972,981 (GRCm39) missense probably damaging 1.00
R4073:Or8b38 UTSW 9 37,973,165 (GRCm39) missense probably damaging 1.00
R4727:Or8b38 UTSW 9 37,973,389 (GRCm39) missense probably damaging 1.00
R4945:Or8b38 UTSW 9 37,973,068 (GRCm39) missense probably damaging 1.00
R4950:Or8b38 UTSW 9 37,973,297 (GRCm39) missense probably damaging 1.00
R5116:Or8b38 UTSW 9 37,972,634 (GRCm39) missense probably benign
R5233:Or8b38 UTSW 9 37,973,446 (GRCm39) missense probably damaging 0.96
R5923:Or8b38 UTSW 9 37,973,154 (GRCm39) missense probably benign 0.08
R8035:Or8b38 UTSW 9 37,972,961 (GRCm39) missense probably damaging 0.99
R9392:Or8b38 UTSW 9 37,973,195 (GRCm39) missense probably benign 0.01
R9481:Or8b38 UTSW 9 37,972,707 (GRCm39) missense probably benign 0.01
RF020:Or8b38 UTSW 9 37,972,620 (GRCm39) start codon destroyed probably null 0.01
Predicted Primers PCR Primer
(F):5'- AGCAGAATATCATCTCTCATGCAG -3'
(R):5'- ACCTTCCCCAGAATGGATGC -3'

Sequencing Primer
(F):5'- GTGCTTGACTCAGCTCTT -3'
(R):5'- GCTGGGCACTGTTATATTGACACC -3'
Posted On 2018-07-23