Incidental Mutation 'R6676:Mup12'
ID 527280
Institutional Source Beutler Lab
Gene Symbol Mup12
Ensembl Gene ENSMUSG00000094793
Gene Name major urinary protein 12
Synonyms Gm2024
MMRRC Submission 044795-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R6676 (G1)
Quality Score 152.008
Status Not validated
Chromosome 4
Chromosomal Location 60693382-60697325 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 60696642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112787 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117932] [ENSMUST00000117932]
AlphaFold P11588
PDB Structure Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein [X-RAY DIFFRACTION]
Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein [X-RAY DIFFRACTION]
Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein [X-RAY DIFFRACTION]
Van der Waals Interactions Dominate Hydrophobic Association in a Protein Binding Site Occluded From Solvent Water [X-RAY DIFFRACTION]
Van der Waals Interactions Dominate Hydrophobic Association in a Protein Binding Site Occluded From Solvent Water [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000117932
SMART Domains Protein: ENSMUSP00000112787
Gene: ENSMUSG00000094793

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
Pfam:Lipocalin 34 173 6e-34 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000117932
SMART Domains Protein: ENSMUSP00000112787
Gene: ENSMUSG00000094793

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
Pfam:Lipocalin 34 173 6e-34 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra2 A T 8: 27,601,268 (GRCm39) I303F possibly damaging Het
Cldn9 A G 17: 23,902,023 (GRCm39) S201P probably benign Het
Clstn2 G T 9: 97,343,584 (GRCm39) P621Q probably damaging Het
Ctdspl2 A G 2: 121,837,445 (GRCm39) N403S probably damaging Het
Cyp2j5 T C 4: 96,524,045 (GRCm39) Y329C possibly damaging Het
Elapor1 A G 3: 108,377,231 (GRCm39) L461P probably damaging Het
Elovl1 A G 4: 118,287,700 (GRCm39) probably benign Het
Fam83a A G 15: 57,856,439 (GRCm39) D206G possibly damaging Het
Fancd2 C T 6: 113,514,626 (GRCm39) Q144* probably null Het
Fhl2 T C 1: 43,170,970 (GRCm39) M115V possibly damaging Het
Fry T A 5: 150,304,387 (GRCm39) D592E probably benign Het
Lrp1 G A 10: 127,396,005 (GRCm39) H2422Y probably damaging Het
Mamdc2 T A 19: 23,280,997 (GRCm39) I684F probably damaging Het
Mia2 T C 12: 59,155,156 (GRCm39) Y290H probably damaging Het
Olr1 T A 6: 129,477,040 (GRCm39) probably null Het
Or51a24 T C 7: 103,733,661 (GRCm39) T209A probably benign Het
Pcdhb15 T C 18: 37,607,860 (GRCm39) V364A possibly damaging Het
Pfkp A G 13: 6,636,575 (GRCm39) S654P possibly damaging Het
Rab3gap2 T G 1: 185,015,607 (GRCm39) V1275G probably damaging Het
Rbbp4 A G 4: 129,222,414 (GRCm39) F93L probably benign Het
Ripk1 T C 13: 34,194,587 (GRCm39) V75A probably damaging Het
Scg2 T A 1: 79,413,499 (GRCm39) Q368L possibly damaging Het
Tmprss9 A G 10: 80,734,145 (GRCm39) probably benign Het
Other mutations in Mup12
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6366:Mup12 UTSW 4 60,696,657 (GRCm39) missense probably damaging 0.98
R6687:Mup12 UTSW 4 60,697,308 (GRCm39) start gained probably benign
R7194:Mup12 UTSW 4 60,696,734 (GRCm39) missense probably benign 0.33
R9057:Mup12 UTSW 4 60,696,779 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGAATTAATTCCTGTCACCAACC -3'
(R):5'- TGTGCATGTGGTATCCCTGC -3'

Sequencing Primer
(F):5'- GTCTCTGACTTTTGAAAAATCCCTGG -3'
(R):5'- GCATGTGGTATCCCTGCTTCTTC -3'
Posted On 2018-07-23