Incidental Mutation 'R6676:Tmprss9'
ID 527290
Institutional Source Beutler Lab
Gene Symbol Tmprss9
Ensembl Gene ENSMUSG00000059406
Gene Name transmembrane protease, serine 9
Synonyms Serase-1B
MMRRC Submission 044795-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6676 (G1)
Quality Score 212.009
Status Not validated
Chromosome 10
Chromosomal Location 80707682-80735326 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 80734145 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151696 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020440] [ENSMUST00000057623] [ENSMUST00000105332] [ENSMUST00000105333] [ENSMUST00000179022] [ENSMUST00000219817] [ENSMUST00000219896] [ENSMUST00000218481]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000020440
SMART Domains Protein: ENSMUSP00000020440
Gene: ENSMUSG00000020219

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
Pfam:zf-Tim10_DDP 23 87 4.6e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000057623
SMART Domains Protein: ENSMUSP00000057291
Gene: ENSMUSG00000062075

DomainStartEndE-ValueType
Filament 42 398 1.97e-47 SMART
low complexity region 402 422 N/A INTRINSIC
internal_repeat_1 427 442 1.72e-5 PROSPERO
low complexity region 444 458 N/A INTRINSIC
Pfam:LTD 462 575 9.3e-16 PFAM
low complexity region 579 596 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105332
SMART Domains Protein: ENSMUSP00000100969
Gene: ENSMUSG00000062075

DomainStartEndE-ValueType
Pfam:Filament 77 257 1.2e-49 PFAM
low complexity region 261 281 N/A INTRINSIC
Pfam:LTD 317 435 6.7e-23 PFAM
low complexity region 438 455 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000105333
AA Change: D1043G
SMART Domains Protein: ENSMUSP00000100970
Gene: ENSMUSG00000059406
AA Change: D1043G

DomainStartEndE-ValueType
Pfam:SEA 62 155 1.7e-10 PFAM
LDLa 189 227 1.15e-4 SMART
Tryp_SPc 238 467 2.43e-96 SMART
low complexity region 477 502 N/A INTRINSIC
Tryp_SPc 539 767 7.28e-86 SMART
Tryp_SPc 867 1093 1.62e-92 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179022
SMART Domains Protein: ENSMUSP00000136524
Gene: ENSMUSG00000062075

DomainStartEndE-ValueType
Pfam:Filament 23 379 8.9e-96 PFAM
low complexity region 383 403 N/A INTRINSIC
internal_repeat_1 408 423 1.1e-5 PROSPERO
Pfam:LTD 439 557 1.3e-23 PFAM
low complexity region 560 577 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218149
Predicted Effect unknown
Transcript: ENSMUST00000219817
AA Change: D1043G
Predicted Effect probably benign
Transcript: ENSMUST00000219896
Predicted Effect probably benign
Transcript: ENSMUST00000218481
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra2 A T 8: 27,601,268 (GRCm39) I303F possibly damaging Het
Cldn9 A G 17: 23,902,023 (GRCm39) S201P probably benign Het
Clstn2 G T 9: 97,343,584 (GRCm39) P621Q probably damaging Het
Ctdspl2 A G 2: 121,837,445 (GRCm39) N403S probably damaging Het
Cyp2j5 T C 4: 96,524,045 (GRCm39) Y329C possibly damaging Het
Elapor1 A G 3: 108,377,231 (GRCm39) L461P probably damaging Het
Elovl1 A G 4: 118,287,700 (GRCm39) probably benign Het
Fam83a A G 15: 57,856,439 (GRCm39) D206G possibly damaging Het
Fancd2 C T 6: 113,514,626 (GRCm39) Q144* probably null Het
Fhl2 T C 1: 43,170,970 (GRCm39) M115V possibly damaging Het
Fry T A 5: 150,304,387 (GRCm39) D592E probably benign Het
Lrp1 G A 10: 127,396,005 (GRCm39) H2422Y probably damaging Het
Mamdc2 T A 19: 23,280,997 (GRCm39) I684F probably damaging Het
Mia2 T C 12: 59,155,156 (GRCm39) Y290H probably damaging Het
Mup12 C T 4: 60,696,642 (GRCm39) probably null Het
Olr1 T A 6: 129,477,040 (GRCm39) probably null Het
Or51a24 T C 7: 103,733,661 (GRCm39) T209A probably benign Het
Pcdhb15 T C 18: 37,607,860 (GRCm39) V364A possibly damaging Het
Pfkp A G 13: 6,636,575 (GRCm39) S654P possibly damaging Het
Rab3gap2 T G 1: 185,015,607 (GRCm39) V1275G probably damaging Het
Rbbp4 A G 4: 129,222,414 (GRCm39) F93L probably benign Het
Ripk1 T C 13: 34,194,587 (GRCm39) V75A probably damaging Het
Scg2 T A 1: 79,413,499 (GRCm39) Q368L possibly damaging Het
Other mutations in Tmprss9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00482:Tmprss9 APN 10 80,730,262 (GRCm39) critical splice donor site probably null
IGL00990:Tmprss9 APN 10 80,728,126 (GRCm39) missense possibly damaging 0.92
IGL01710:Tmprss9 APN 10 80,733,793 (GRCm39) unclassified probably benign
IGL03075:Tmprss9 APN 10 80,719,863 (GRCm39) missense possibly damaging 0.77
IGL03132:Tmprss9 APN 10 80,730,699 (GRCm39) missense probably damaging 0.98
R0142:Tmprss9 UTSW 10 80,730,212 (GRCm39) missense possibly damaging 0.92
R0546:Tmprss9 UTSW 10 80,735,157 (GRCm39) missense probably benign 0.00
R1171:Tmprss9 UTSW 10 80,715,692 (GRCm39) missense possibly damaging 0.92
R1296:Tmprss9 UTSW 10 80,726,279 (GRCm39) missense probably benign 0.02
R1302:Tmprss9 UTSW 10 80,730,963 (GRCm39) missense probably benign 0.00
R1498:Tmprss9 UTSW 10 80,730,934 (GRCm39) missense probably benign 0.01
R1706:Tmprss9 UTSW 10 80,734,021 (GRCm39) unclassified probably benign
R1851:Tmprss9 UTSW 10 80,728,119 (GRCm39) missense probably damaging 0.98
R2096:Tmprss9 UTSW 10 80,725,268 (GRCm39) missense probably damaging 1.00
R2198:Tmprss9 UTSW 10 80,723,293 (GRCm39) missense probably damaging 1.00
R3783:Tmprss9 UTSW 10 80,723,301 (GRCm39) missense probably damaging 1.00
R5682:Tmprss9 UTSW 10 80,733,207 (GRCm39) splice site probably null
R5868:Tmprss9 UTSW 10 80,718,580 (GRCm39) missense probably benign 0.03
R6006:Tmprss9 UTSW 10 80,719,555 (GRCm39) missense possibly damaging 0.92
R6542:Tmprss9 UTSW 10 80,724,389 (GRCm39) missense probably damaging 1.00
R6718:Tmprss9 UTSW 10 80,726,198 (GRCm39) missense probably benign
R7062:Tmprss9 UTSW 10 80,730,883 (GRCm39) missense probably benign 0.00
R7316:Tmprss9 UTSW 10 80,730,813 (GRCm39) missense probably benign 0.00
R7337:Tmprss9 UTSW 10 80,718,504 (GRCm39) missense probably benign 0.00
R7624:Tmprss9 UTSW 10 80,728,053 (GRCm39) missense possibly damaging 0.77
R7659:Tmprss9 UTSW 10 80,728,843 (GRCm39) missense probably damaging 0.97
R7770:Tmprss9 UTSW 10 80,733,903 (GRCm39) splice site probably null
R7810:Tmprss9 UTSW 10 80,733,145 (GRCm39) missense unknown
R8177:Tmprss9 UTSW 10 80,730,882 (GRCm39) missense probably benign 0.00
R8324:Tmprss9 UTSW 10 80,733,205 (GRCm39) critical splice donor site probably null
R8354:Tmprss9 UTSW 10 80,723,320 (GRCm39) missense probably benign 0.04
R8454:Tmprss9 UTSW 10 80,723,320 (GRCm39) missense probably benign 0.04
R8456:Tmprss9 UTSW 10 80,730,251 (GRCm39) missense possibly damaging 0.92
R8729:Tmprss9 UTSW 10 80,726,177 (GRCm39) missense probably benign 0.01
R8968:Tmprss9 UTSW 10 80,730,163 (GRCm39) missense possibly damaging 0.71
R9010:Tmprss9 UTSW 10 80,733,701 (GRCm39) missense unknown
R9336:Tmprss9 UTSW 10 80,730,787 (GRCm39) missense probably benign 0.02
R9529:Tmprss9 UTSW 10 80,730,640 (GRCm39) missense probably damaging 0.99
R9786:Tmprss9 UTSW 10 80,734,042 (GRCm39) missense unknown
R9789:Tmprss9 UTSW 10 80,730,993 (GRCm39) missense probably benign 0.00
X0062:Tmprss9 UTSW 10 80,719,772 (GRCm39) splice site probably null
X0066:Tmprss9 UTSW 10 80,729,064 (GRCm39) missense probably damaging 0.99
Z1176:Tmprss9 UTSW 10 80,724,256 (GRCm39) missense probably damaging 0.98
Z1177:Tmprss9 UTSW 10 80,723,356 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGGAGGTATACACGCATGC -3'
(R):5'- GAAATGTGATGTCCCCAGAGTC -3'

Sequencing Primer
(F):5'- CGCAGTAAGGGTCCTCA -3'
(R):5'- CTCAGTAAGAAGATGGCTTGTCACAC -3'
Posted On 2018-07-23