Mutagenetix > Incidental Mutation

Incidental Mutation 'R6678:Vmn1r113'

527346

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r113

Ensembl Gene

ENSMUSG00000091638

Gene Name

vomeronasal 1 receptor 113

Synonyms

Gm5748

MMRRC Submission

044797-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R6678 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20521210-20522133 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20521903 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Serine at position 232 (G232S)

Ref Sequence

ENSEMBL: ENSMUSP00000133307 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168794] [ENSMUST00000173723]

AlphaFold

G3UWI8

Predicted Effect

probably benign
Transcript: ENSMUST00000168794
AA Change: G222S

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000126041
Gene: ENSMUSG00000091638
AA Change: G222S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	288	4.2e-8	PFAM
Pfam:V1R	41	288	2.8e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173723
AA Change: G232S

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000133307
Gene: ENSMUSG00000091638
AA Change: G232S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	4e-16	PFAM
Pfam:7tm_1	31	290	9.3e-7	PFAM
Pfam:V1R	41	298	5e-17	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.5%
20x: 96.1%

Validation Efficiency

97% (37/38)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb3	T	C	1: 25,499,891 (GRCm39)	N644S	possibly damaging	Het
Agl	C	A	3: 116,546,969 (GRCm39)	V1294F	probably damaging	Het
Ash2l	A	C	8: 26,323,805 (GRCm39)	W125G	probably damaging	Het
Dap	C	T	15: 31,273,396 (GRCm39)	T51M	probably benign	Het
Dnah12	G	A	14: 26,456,847 (GRCm39)	R871H	probably damaging	Het
Filip1l	T	C	16: 57,390,333 (GRCm39)	I307T	probably benign	Het
Gdap1l1	T	A	2: 163,280,574 (GRCm39)	S37T	probably benign	Het
Gm43302	G	T	5: 105,438,820 (GRCm39)	Q23K	probably benign	Het
Golga2	T	C	2: 32,189,072 (GRCm39)	V227A	probably damaging	Het
Gramd4	A	T	15: 85,975,704 (GRCm39)	S74C	probably damaging	Het
Gramd4	G	C	15: 85,975,705 (GRCm39)	S74T	possibly damaging	Het
Hsph1	A	C	5: 149,541,962 (GRCm39)	S755A	probably benign	Het
Inppl1	A	G	7: 101,481,477 (GRCm39)	V235A	probably damaging	Het
Kcnc1	A	G	7: 46,047,229 (GRCm39)	H43R	probably benign	Het
Klhl41	T	G	2: 69,501,188 (GRCm39)	S216R	probably benign	Het
Kmt2e	A	G	5: 23,704,293 (GRCm39)	E1162G	possibly damaging	Het
Lrp1	G	A	10: 127,396,005 (GRCm39)	H2422Y	probably damaging	Het
Ms4a13	T	C	19: 11,161,222 (GRCm39)	I106V	probably benign	Het
Myo1f	G	A	17: 33,794,819 (GRCm39)	D20N	probably damaging	Het
Ndel1	T	C	11: 68,724,239 (GRCm39)	T245A	possibly damaging	Het
Or5al1	A	T	2: 85,990,529 (GRCm39)	F62I	probably damaging	Het
P2rx6	C	A	16: 17,388,820 (GRCm39)	N360K	probably benign	Het
Pcdhgb5	C	T	18: 37,864,255 (GRCm39)	L17F	probably damaging	Het
Plcl1	A	G	1: 55,734,935 (GRCm39)	K92R	probably benign	Het
Prelp	C	T	1: 133,842,513 (GRCm39)	D211N	probably benign	Het
Rgl1	T	C	1: 152,400,475 (GRCm39)	Y677C	probably damaging	Het
Rnd2	C	T	11: 101,359,825 (GRCm39)	L57F	probably damaging	Het
Rreb1	G	T	13: 38,083,675 (GRCm39)	D113Y	probably damaging	Het
Sf1	T	A	19: 6,424,543 (GRCm39)		probably null	Het
Sh3bp1	T	C	15: 78,792,714 (GRCm39)		probably null	Het
Shprh	T	A	10: 11,042,289 (GRCm39)	D757E	probably benign	Het
Slc6a1	A	G	6: 114,284,737 (GRCm39)	K81R	probably benign	Het
Spata31e4	A	G	13: 50,855,946 (GRCm39)	K528R	probably benign	Het
Ttc22	T	A	4: 106,480,242 (GRCm39)	S165R	probably benign	Het
Vwa7	C	A	17: 35,238,776 (GRCm39)	A288D	probably damaging	Het
Wdpcp	A	G	11: 21,671,105 (GRCm39)	I449V	probably benign	Het
Wdsub1	G	A	2: 59,692,975 (GRCm39)	T313I	probably benign	Het
Zyg11a	A	G	4: 108,046,878 (GRCm39)	V532A	probably benign	Het

Other mutations in Vmn1r113

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01908:Vmn1r113	APN	7	20,521,943 (GRCm39)	missense	probably damaging	1.00
IGL02082:Vmn1r113	APN	7	20,521,672 (GRCm39)	missense	probably benign
IGL02148:Vmn1r113	APN	7	20,521,747 (GRCm39)	missense	probably benign	0.14
IGL03169:Vmn1r113	APN	7	20,522,012 (GRCm39)	missense	probably benign	0.11
R0593:Vmn1r113	UTSW	7	20,521,388 (GRCm39)	missense	probably damaging	0.99
R0669:Vmn1r113	UTSW	7	20,521,345 (GRCm39)	missense	probably benign	0.00
R1212:Vmn1r113	UTSW	7	20,521,356 (GRCm39)	missense	probably benign	0.19
R1693:Vmn1r113	UTSW	7	20,521,532 (GRCm39)	missense	probably damaging	0.98
R2228:Vmn1r113	UTSW	7	20,521,832 (GRCm39)	missense	probably damaging	1.00
R3945:Vmn1r113	UTSW	7	20,521,637 (GRCm39)	missense	probably benign	0.00
R4209:Vmn1r113	UTSW	7	20,521,535 (GRCm39)	missense	probably benign	0.44
R5038:Vmn1r113	UTSW	7	20,521,419 (GRCm39)	missense	possibly damaging	0.70
R6306:Vmn1r113	UTSW	7	20,521,792 (GRCm39)	missense	probably damaging	1.00
R6623:Vmn1r113	UTSW	7	20,521,991 (GRCm39)	missense	probably benign	0.01
R6675:Vmn1r113	UTSW	7	20,521,903 (GRCm39)	missense	probably benign	0.02
R6677:Vmn1r113	UTSW	7	20,521,903 (GRCm39)	missense	probably benign	0.02
R6968:Vmn1r113	UTSW	7	20,521,876 (GRCm39)	missense	probably damaging	1.00
R7054:Vmn1r113	UTSW	7	20,521,427 (GRCm39)	missense	probably benign	0.14
R7256:Vmn1r113	UTSW	7	20,521,370 (GRCm39)	missense	probably damaging	1.00
R8926:Vmn1r113	UTSW	7	20,521,874 (GRCm39)	missense	possibly damaging	0.82
R9131:Vmn1r113	UTSW	7	20,521,342 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAAGTTGTTCTGTTCCACTTCTGG -3'
(R):5'- GCCACTCTGATTTTCAACAGTTG -3'

Sequencing Primer
(F):5'- TCCACTTCTGGATTCAGTGTG -3'
(R):5'- TCTCTGAAGATCAACAGTAAAGGAG -3'

Posted On

2018-07-23