Incidental Mutation 'R6682:Cox6c'
ID 527555
Institutional Source Beutler Lab
Gene Symbol Cox6c
Ensembl Gene ENSMUSG00000014313
Gene Name cytochrome c oxidase subunit 6C
Synonyms
MMRRC Submission 044801-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R6682 (G1)
Quality Score 92.0077
Status Not validated
Chromosome 15
Chromosomal Location 35932122-35938392 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 35938319 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014457] [ENSMUST00000153512] [ENSMUST00000156915]
AlphaFold Q9CPQ1
Predicted Effect probably null
Transcript: ENSMUST00000014457
SMART Domains Protein: ENSMUSP00000014457
Gene: ENSMUSG00000014313

DomainStartEndE-ValueType
Pfam:COX6C 6 75 3e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127999
Predicted Effect probably null
Transcript: ENSMUST00000153512
SMART Domains Protein: ENSMUSP00000123609
Gene: ENSMUSG00000014313

DomainStartEndE-ValueType
Pfam:COX6C 4 76 1.5e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155638
Predicted Effect probably null
Transcript: ENSMUST00000156915
SMART Domains Protein: ENSMUSP00000122391
Gene: ENSMUSG00000014313

DomainStartEndE-ValueType
Pfam:COX6C 6 75 3e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227231
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aspm T C 1: 139,385,460 (GRCm39) V368A possibly damaging Het
Bcl9l A G 9: 44,412,400 (GRCm39) T92A possibly damaging Het
Celsr2 A T 3: 108,307,817 (GRCm39) probably null Het
Cndp2 T C 18: 84,695,455 (GRCm39) K149E probably benign Het
Cnpy4 T C 5: 138,185,984 (GRCm39) probably null Het
Cpt2 G T 4: 107,761,627 (GRCm39) S158R probably damaging Het
Dlgap1 A G 17: 71,094,118 (GRCm39) K813R probably damaging Het
Dock10 A C 1: 80,490,338 (GRCm39) L1927R probably damaging Het
Gak T A 5: 108,746,742 (GRCm39) K430I probably damaging Het
Grik3 T A 4: 125,544,259 (GRCm39) Y327N probably damaging Het
Ldb3 T A 14: 34,274,221 (GRCm39) T334S possibly damaging Het
Ldlr A G 9: 21,643,671 (GRCm39) D85G probably benign Het
Med26 T A 8: 73,249,927 (GRCm39) T391S probably benign Het
Mmp27 A G 9: 7,573,606 (GRCm39) T233A probably benign Het
Mob1a A G 6: 83,311,132 (GRCm39) Y117C possibly damaging Het
Mrps35 A T 6: 146,949,777 (GRCm39) E97V possibly damaging Het
Msln A T 17: 25,971,993 (GRCm39) S75T probably damaging Het
Myoz1 C T 14: 20,703,687 (GRCm39) probably null Het
Nim1k A G 13: 120,173,724 (GRCm39) I390T probably benign Het
Or10k2 A G 8: 84,268,187 (GRCm39) H138R probably benign Het
Or4k51 C T 2: 111,584,980 (GRCm39) P129S probably damaging Het
Pclo A C 5: 14,589,893 (GRCm39) Q731P unknown Het
Prl3d3 G A 13: 27,345,023 (GRCm39) E132K probably benign Het
Pth1r C T 9: 110,556,319 (GRCm39) probably null Het
Ptpru T C 4: 131,548,093 (GRCm39) M135V probably benign Het
Slc12a9 A T 5: 137,325,663 (GRCm39) L316Q probably damaging Het
Slc35f6 G A 5: 30,814,764 (GRCm39) M177I possibly damaging Het
Smc4 T A 3: 68,914,574 (GRCm39) S62R probably damaging Het
Tmem179 C T 12: 112,469,714 (GRCm39) D29N probably benign Het
Togaram2 A T 17: 72,011,749 (GRCm39) D476V probably benign Het
Trpc4ap C T 2: 155,479,687 (GRCm39) probably null Het
Trpm8 C A 1: 88,254,224 (GRCm39) T149K probably damaging Het
Uhmk1 C T 1: 170,039,804 (GRCm39) probably null Het
Vmn2r79 C A 7: 86,653,370 (GRCm39) T545K possibly damaging Het
Vmn2r95 C A 17: 18,660,489 (GRCm39) N300K probably damaging Het
Wdr41 G A 13: 95,149,639 (GRCm39) G419D probably damaging Het
Zc3hav1 A T 6: 38,302,130 (GRCm39) H597Q probably benign Het
Zfp704 T C 3: 9,630,253 (GRCm39) E36G probably benign Het
Zfp9 A G 6: 118,444,202 (GRCm39) V47A possibly damaging Het
Other mutations in Cox6c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2135:Cox6c UTSW 15 35,937,429 (GRCm39) splice site probably benign
Predicted Primers PCR Primer
(F):5'- TGAAGCTGTGGGACTAGAGC -3'
(R):5'- AGGACTCGTTTTCAAGGTCC -3'

Sequencing Primer
(F):5'- TGGCCGCGGCAAAATAC -3'
(R):5'- AATTTCAGCTGTGACCGG -3'
Posted On 2018-07-23