Incidental Mutation 'R6651:Rerg'
ID 527784
Institutional Source Beutler Lab
Gene Symbol Rerg
Ensembl Gene ENSMUSG00000030222
Gene Name RAS-like, estrogen-regulated, growth-inhibitor
Synonyms
MMRRC Submission 044772-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R6651 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 137031822-137147494 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 137033384 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 97 (V97A)
Ref Sequence ENSEMBL: ENSMUSP00000113702 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032347] [ENSMUST00000117919] [ENSMUST00000119610] [ENSMUST00000203003]
AlphaFold Q8R367
Predicted Effect probably damaging
Transcript: ENSMUST00000032347
AA Change: V116A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000032347
Gene: ENSMUSG00000030222
AA Change: V116A

DomainStartEndE-ValueType
RAS 4 170 7.2e-71 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000117919
AA Change: V116A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000113105
Gene: ENSMUSG00000030222
AA Change: V116A

DomainStartEndE-ValueType
RAS 4 170 7.2e-71 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119610
AA Change: V97A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113702
Gene: ENSMUSG00000030222
AA Change: V97A

DomainStartEndE-ValueType
RAS 4 151 8.5e-50 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000203003
SMART Domains Protein: ENSMUSP00000144823
Gene: ENSMUSG00000030222

DomainStartEndE-ValueType
Pfam:Ras 1 59 3.4e-9 PFAM
Meta Mutation Damage Score 0.5940 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.7%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik A C 7: 43,147,496 (GRCm39) S198A possibly damaging Het
Adamts15 A T 9: 30,833,448 (GRCm39) I29N probably damaging Het
Ankrd61 A T 5: 143,830,438 (GRCm39) I33N probably damaging Het
Arl6ip1 C T 7: 117,728,708 (GRCm39) R7H probably benign Het
Atp8a2 A T 14: 60,011,470 (GRCm39) D946E probably benign Het
Cc2d2b A T 19: 40,766,573 (GRCm39) Q114L probably damaging Het
Ccdc163 T A 4: 116,566,261 (GRCm39) S16R possibly damaging Het
Chil6 C T 3: 106,311,576 (GRCm39) C68Y probably damaging Het
Cngb3 G T 4: 19,375,231 (GRCm39) R287L probably benign Het
Crem C T 18: 3,325,428 (GRCm39) R16H probably benign Het
Cyp4f16 C T 17: 32,763,118 (GRCm39) R188C probably benign Het
Dap A G 15: 31,273,353 (GRCm39) D46G probably damaging Het
Dnah7c C A 1: 46,688,500 (GRCm39) T1890K probably benign Het
Dnah7c A G 1: 46,688,511 (GRCm39) S1894G probably benign Het
Enam T C 5: 88,650,776 (GRCm39) Y687H probably damaging Het
Fzd4 A T 7: 89,054,010 (GRCm39) D39V possibly damaging Het
Ggta1 G T 2: 35,292,306 (GRCm39) H334N probably benign Het
Golga3 C T 5: 110,365,996 (GRCm39) R1254* probably null Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Helz2 C T 2: 180,881,350 (GRCm39) W377* probably null Het
Hfm1 T C 5: 106,995,553 (GRCm39) D1286G probably benign Het
Hhatl T C 9: 121,613,768 (GRCm39) R425G probably damaging Het
Hivep3 G A 4: 119,980,146 (GRCm39) R1728H probably damaging Het
Hyal1 A G 9: 107,456,570 (GRCm39) Y419C probably damaging Het
Ighv8-12 A T 12: 115,611,644 (GRCm39) D84E possibly damaging Het
Itln1 A G 1: 171,345,940 (GRCm39) F271L possibly damaging Het
Klra7 C A 6: 130,206,908 (GRCm39) L64F probably benign Het
Kmt2a A T 9: 44,740,108 (GRCm39) C1878* probably null Het
Mia2 C A 12: 59,201,148 (GRCm39) Q825K possibly damaging Het
Mmp12 C A 9: 7,355,345 (GRCm39) P294Q possibly damaging Het
Nedd4 A G 9: 72,638,553 (GRCm39) N480S possibly damaging Het
Or4c12b A T 2: 89,647,240 (GRCm39) E190V probably benign Het
Or4e5 C T 14: 52,728,250 (GRCm39) R57Q probably benign Het
Pax6 T A 2: 105,516,175 (GRCm39) M151K probably benign Het
Pgm2 A G 5: 64,269,437 (GRCm39) Y508C probably benign Het
Ptpn20 T C 14: 33,354,897 (GRCm39) F324S probably damaging Het
Recql A G 6: 142,310,160 (GRCm39) probably null Het
Rffl C A 11: 82,703,605 (GRCm39) C106F probably damaging Het
Scaper T G 9: 55,765,788 (GRCm39) N499T probably benign Het
Sfxn3 G A 19: 45,038,354 (GRCm39) probably null Het
Slc36a4 A G 9: 15,634,874 (GRCm39) S139G probably benign Het
Slco2b1 T A 7: 99,316,376 (GRCm39) M385L probably benign Het
Smg8 T C 11: 86,977,372 (GRCm39) T70A probably benign Het
Spats2l A T 1: 57,985,336 (GRCm39) K463M probably damaging Het
Thbs4 T C 13: 92,893,044 (GRCm39) I715V probably benign Het
Tmem234 T A 4: 129,501,264 (GRCm39) M113K possibly damaging Het
Vmn2r10 T C 5: 109,143,488 (GRCm39) I821V probably null Het
Vmn2r116 A T 17: 23,607,805 (GRCm39) K458* probably null Het
Vmn2r76 T A 7: 85,878,059 (GRCm39) N446I possibly damaging Het
Vmn2r95 T A 17: 18,660,622 (GRCm39) Y345N probably damaging Het
Other mutations in Rerg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01799:Rerg APN 6 137,033,376 (GRCm39) nonsense probably null
R0502:Rerg UTSW 6 137,033,305 (GRCm39) nonsense probably null
R1370:Rerg UTSW 6 137,034,799 (GRCm39) splice site probably benign
R2056:Rerg UTSW 6 137,034,878 (GRCm39) missense probably benign 0.00
R4919:Rerg UTSW 6 137,033,142 (GRCm39) missense probably damaging 0.99
R7089:Rerg UTSW 6 137,044,033 (GRCm39) missense possibly damaging 0.84
R8167:Rerg UTSW 6 137,034,869 (GRCm39) missense possibly damaging 0.92
R8477:Rerg UTSW 6 137,033,184 (GRCm39) missense probably benign 0.02
R9683:Rerg UTSW 6 137,033,252 (GRCm39) missense probably damaging 1.00
R9721:Rerg UTSW 6 137,033,415 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCATCTTGTTAATCGCTTGCTTG -3'
(R):5'- CTTTGCCCACAGGAAGACAC -3'

Sequencing Primer
(F):5'- AATCGCTTGCTTGACGTGTG -3'
(R):5'- CAGGAAGACACCATCCAGAGG -3'
Posted On 2018-07-23