Incidental Mutation 'R6703:Or2m13'
ID 528312
Institutional Source Beutler Lab
Gene Symbol Or2m13
Ensembl Gene ENSMUSG00000050158
Gene Name olfactory receptor family 2 subfamily M member 13
Synonyms Olfr165, MOR279-1, GA_x54KRFPKG5P-15855164-15854223
MMRRC Submission 044821-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R6703 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 19224994-19241884 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19226122 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 215 (I215V)
Ref Sequence ENSEMBL: ENSMUSP00000145668 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052516] [ENSMUST00000206110] [ENSMUST00000206410]
AlphaFold Q8VFA2
Predicted Effect probably benign
Transcript: ENSMUST00000052516
AA Change: I215V

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000062079
Gene: ENSMUSG00000050158
AA Change: I215V

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 5.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 36 306 6e-10 PFAM
Pfam:7tm_1 42 291 4e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103984
Predicted Effect probably benign
Transcript: ENSMUST00000206110
AA Change: I215V

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000206410
AA Change: I216V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Meta Mutation Damage Score 0.0726 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.0%
Validation Efficiency 99% (73/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020N01Rik T A 10: 21,497,558 (GRCm39) Y66* probably null Het
Akap13 T C 7: 75,252,646 (GRCm39) S259P probably damaging Het
Aoc1 A C 6: 48,882,648 (GRCm39) T197P probably damaging Het
Blnk A T 19: 40,950,950 (GRCm39) probably null Het
Ccser1 A T 6: 61,615,495 (GRCm39) K94* probably null Het
Cfap54 T A 10: 92,704,596 (GRCm39) D2828V unknown Het
Clec4n A G 6: 123,212,553 (GRCm39) Q89R probably null Het
Col6a3 T C 1: 90,707,161 (GRCm39) D1984G unknown Het
Col6a3 C T 1: 90,720,184 (GRCm39) R1552Q probably benign Het
Csnk2a1 A G 2: 152,100,608 (GRCm39) T93A probably benign Het
Dna2 T A 10: 62,809,073 (GRCm39) I1055N possibly damaging Het
Dnm3 A G 1: 162,146,256 (GRCm39) F296L probably benign Het
Dock7 T C 4: 98,834,909 (GRCm39) E1822G probably damaging Het
Dpyd A T 3: 118,690,849 (GRCm39) probably null Het
Dyrk4 A T 6: 126,867,045 (GRCm39) I329N probably damaging Het
E4f1 C A 17: 24,666,105 (GRCm39) R231L probably damaging Het
Fat1 A G 8: 45,406,083 (GRCm39) T945A probably benign Het
Fkbp7 A T 2: 76,502,106 (GRCm39) M99K probably damaging Het
Flad1 T C 3: 89,315,897 (GRCm39) S222G probably benign Het
H1f7 C A 15: 98,155,153 (GRCm39) probably benign Het
Ighg2b T C 12: 113,268,653 (GRCm39) probably benign Het
Iqub T A 6: 24,449,744 (GRCm39) N707I probably damaging Het
Itln1 C T 1: 171,358,151 (GRCm39) C199Y probably damaging Het
Kctd3 G A 1: 188,728,726 (GRCm39) R137C probably damaging Het
Lamp5 C G 2: 135,901,483 (GRCm39) N102K possibly damaging Het
Larp7 C T 3: 127,337,873 (GRCm39) M395I probably damaging Het
Lpcat3 C T 6: 124,640,185 (GRCm39) A5V probably benign Het
Lrrc43 C T 5: 123,637,532 (GRCm39) T233M possibly damaging Het
Map4k1 T G 7: 28,701,821 (GRCm39) S803A possibly damaging Het
Mef2c T A 13: 83,773,525 (GRCm39) C134S possibly damaging Het
Mgst2 T C 3: 51,572,033 (GRCm39) probably null Het
Mug2 T G 6: 122,055,653 (GRCm39) I1112R probably benign Het
Myo15a A G 11: 60,383,818 (GRCm39) I1622V probably benign Het
Ndor1 A G 2: 25,139,902 (GRCm39) F142S possibly damaging Het
Nectin3 A G 16: 46,284,205 (GRCm39) S160P probably damaging Het
Nudt16l2 T C 9: 105,021,758 (GRCm39) Y96C possibly damaging Het
Nynrin A G 14: 56,101,935 (GRCm39) T535A possibly damaging Het
Or4k15 A G 14: 50,364,688 (GRCm39) Y218C probably damaging Het
Or4k42 T A 2: 111,320,454 (GRCm39) probably null Het
Or8b51 A T 9: 38,569,073 (GRCm39) I205N possibly damaging Het
Pcdh10 G A 3: 45,335,734 (GRCm39) V683M possibly damaging Het
Per2 C T 1: 91,355,671 (GRCm39) E696K probably damaging Het
Pif1 T C 9: 65,500,545 (GRCm39) V490A probably damaging Het
Plekhn1 A T 4: 156,309,250 (GRCm39) Y219N probably benign Het
Ppl T G 16: 4,907,328 (GRCm39) E989A probably damaging Het
Prkdc T G 16: 15,488,392 (GRCm39) S505A probably benign Het
Psg16 T C 7: 16,824,321 (GRCm39) L35P probably damaging Het
Ptges A G 2: 30,793,133 (GRCm39) V33A possibly damaging Het
Qser1 G A 2: 104,607,670 (GRCm39) T1416I possibly damaging Het
Rab3a A G 8: 71,209,095 (GRCm39) D77G probably damaging Het
Rtn3 A T 19: 7,412,410 (GRCm39) V788D probably damaging Het
Rtn4r T C 16: 17,969,055 (GRCm39) L161P probably damaging Het
Rtn4rl1 G A 11: 75,156,354 (GRCm39) R262Q probably benign Het
S1pr3 A T 13: 51,573,475 (GRCm39) I219F probably damaging Het
Sec23b A T 2: 144,401,109 (GRCm39) probably null Het
Senp6 A G 9: 80,029,203 (GRCm39) E522G probably damaging Het
Slc27a6 A G 18: 58,742,911 (GRCm39) N533S probably benign Het
Slc39a5 T A 10: 128,233,651 (GRCm39) D282V probably damaging Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Snx14 A G 9: 88,304,967 (GRCm39) I109T probably damaging Het
Sorl1 A T 9: 41,982,497 (GRCm39) V361E probably damaging Het
Sox5 G T 6: 143,779,191 (GRCm39) S648R probably damaging Het
Sptbn2 G A 19: 4,799,842 (GRCm39) S2161N probably benign Het
Sptbn2 C A 19: 4,799,843 (GRCm39) S2161R probably benign Het
St6galnac2 A G 11: 116,575,213 (GRCm39) S209P probably benign Het
Tmub1 T C 5: 24,651,944 (GRCm39) S7G probably benign Het
Trarg1 A T 11: 76,584,988 (GRCm39) probably null Het
Trpm5 C A 7: 142,623,055 (GRCm39) probably benign Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp438 A G 18: 5,214,044 (GRCm39) S305P probably benign Het
Zfp780b T C 7: 27,671,066 (GRCm39) T81A possibly damaging Het
Other mutations in Or2m13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Or2m13 APN 16 19,226,333 (GRCm39) missense probably benign 0.03
IGL01355:Or2m13 APN 16 19,226,333 (GRCm39) missense probably benign 0.03
IGL01363:Or2m13 APN 16 19,226,333 (GRCm39) missense probably benign 0.03
IGL01467:Or2m13 APN 16 19,226,539 (GRCm39) missense probably benign 0.24
IGL02267:Or2m13 APN 16 19,225,914 (GRCm39) missense possibly damaging 0.80
R1194:Or2m13 UTSW 16 19,225,930 (GRCm39) missense possibly damaging 0.75
R1624:Or2m13 UTSW 16 19,226,454 (GRCm39) missense probably benign 0.06
R2248:Or2m13 UTSW 16 19,225,944 (GRCm39) missense probably damaging 0.98
R4865:Or2m13 UTSW 16 19,226,051 (GRCm39) missense probably damaging 0.98
R4988:Or2m13 UTSW 16 19,225,860 (GRCm39) missense probably benign 0.00
R5384:Or2m13 UTSW 16 19,226,547 (GRCm39) missense probably damaging 1.00
R5858:Or2m13 UTSW 16 19,225,975 (GRCm39) missense possibly damaging 0.91
R5997:Or2m13 UTSW 16 19,226,694 (GRCm39) missense probably benign 0.10
R6301:Or2m13 UTSW 16 19,226,167 (GRCm39) missense possibly damaging 0.96
R6570:Or2m13 UTSW 16 19,226,068 (GRCm39) missense probably benign 0.00
R6953:Or2m13 UTSW 16 19,226,278 (GRCm39) missense probably benign 0.04
R7424:Or2m13 UTSW 16 19,225,944 (GRCm39) missense probably damaging 0.98
R7975:Or2m13 UTSW 16 19,226,301 (GRCm39) missense probably damaging 1.00
R8312:Or2m13 UTSW 16 19,225,987 (GRCm39) missense probably benign 0.11
R8880:Or2m13 UTSW 16 19,226,396 (GRCm39) nonsense probably null
R9008:Or2m13 UTSW 16 19,226,173 (GRCm39) missense probably benign 0.00
R9394:Or2m13 UTSW 16 19,226,019 (GRCm39) missense probably benign
R9698:Or2m13 UTSW 16 19,226,342 (GRCm39) nonsense probably null
Z1176:Or2m13 UTSW 16 19,226,485 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCGGAGGCTGTAAATTAGG -3'
(R):5'- TCGATGTTGCAGCTGTACTATC -3'

Sequencing Primer
(F):5'- GTGTAGAAAGCTGACACTAGTTTGTC -3'
(R):5'- TCTTTTTCATATTGTGGTACCAGAG -3'
Posted On 2018-07-24