Incidental Mutation 'R6694:Zfp976'
ID 528496
Institutional Source Beutler Lab
Gene Symbol Zfp976
Ensembl Gene ENSMUSG00000074158
Gene Name zinc finger protein 976
Synonyms 9830147E19Rik
MMRRC Submission 044812-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R6694 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 42258950-42292012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42263610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 76 (Y76N)
Ref Sequence ENSEMBL: ENSMUSP00000141023 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098503] [ENSMUST00000187616]
AlphaFold E9Q981
Predicted Effect probably damaging
Transcript: ENSMUST00000098503
AA Change: Y77N

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000096105
Gene: ENSMUSG00000074158
AA Change: Y77N

DomainStartEndE-ValueType
KRAB 4 66 1.73e-18 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 1.67e-2 SMART
ZnF_C2H2 187 209 5.9e-3 SMART
ZnF_C2H2 215 237 1.38e-3 SMART
ZnF_C2H2 243 265 8.94e-3 SMART
ZnF_C2H2 271 293 2.24e-3 SMART
ZnF_C2H2 299 321 1.03e-2 SMART
ZnF_C2H2 327 349 1.58e-3 SMART
ZnF_C2H2 355 377 7.9e-4 SMART
ZnF_C2H2 383 405 5.9e-3 SMART
ZnF_C2H2 411 433 2.57e-3 SMART
ZnF_C2H2 439 461 3.16e-3 SMART
ZnF_C2H2 467 489 1.26e-2 SMART
ZnF_C2H2 495 517 8.34e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 4.79e-3 SMART
ZnF_C2H2 579 601 9.73e-4 SMART
ZnF_C2H2 607 629 3.63e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107994
Predicted Effect probably damaging
Transcript: ENSMUST00000187616
AA Change: Y76N

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000141023
Gene: ENSMUSG00000074158
AA Change: Y76N

DomainStartEndE-ValueType
KRAB 3 65 7.4e-21 SMART
ZnF_C2H2 130 152 3.2e-5 SMART
ZnF_C2H2 158 180 7.1e-5 SMART
ZnF_C2H2 186 208 2.4e-5 SMART
ZnF_C2H2 214 236 5.7e-6 SMART
ZnF_C2H2 242 264 3.8e-5 SMART
ZnF_C2H2 270 292 9.7e-6 SMART
ZnF_C2H2 298 320 4.2e-5 SMART
ZnF_C2H2 326 348 6.6e-6 SMART
ZnF_C2H2 354 376 3.3e-6 SMART
ZnF_C2H2 382 404 2.5e-5 SMART
ZnF_C2H2 410 432 1e-5 SMART
ZnF_C2H2 438 460 1.3e-5 SMART
ZnF_C2H2 466 488 5.2e-5 SMART
ZnF_C2H2 494 516 3.6e-5 SMART
ZnF_C2H2 522 544 1.6e-5 SMART
ZnF_C2H2 550 572 2e-5 SMART
ZnF_C2H2 578 600 4e-6 SMART
ZnF_C2H2 606 628 1.5e-5 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.7%
Validation Efficiency 95% (41/43)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1l2 G A 6: 48,907,480 (GRCm39) S160N probably benign Het
Arap3 A C 18: 38,124,590 (GRCm39) probably null Het
Arhgap10 A G 8: 78,137,692 (GRCm39) F300L probably benign Het
Ccdc116 T C 16: 16,960,655 (GRCm39) E54G probably benign Het
Cd53 T A 3: 106,674,702 (GRCm39) I122F probably benign Het
Ctnnd1 T C 2: 84,454,849 (GRCm39) probably benign Het
Ddx60 A G 8: 62,490,104 (GRCm39) D1691G probably damaging Het
Dnah11 T C 12: 118,150,617 (GRCm39) probably null Het
Exoc1 T A 5: 76,697,399 (GRCm39) M392K probably damaging Het
Exoc3l G C 8: 106,017,122 (GRCm39) R622G probably benign Het
Grid2 C G 6: 63,908,031 (GRCm39) R224G possibly damaging Het
Kif20a A G 18: 34,758,579 (GRCm39) E16G probably damaging Het
Kit T C 5: 75,801,417 (GRCm39) V568A possibly damaging Het
Lhx4 T C 1: 155,580,456 (GRCm39) S257G probably benign Het
Med18 C T 4: 132,187,293 (GRCm39) V114I probably benign Het
Mrps30 C T 13: 118,523,497 (GRCm39) V92M possibly damaging Het
Mtrr C T 13: 68,712,452 (GRCm39) V645I probably benign Het
Nuak2 T G 1: 132,260,048 (GRCm39) S609A probably damaging Het
Or2y1g A T 11: 49,171,379 (GRCm39) I135F probably benign Het
Plk4 T C 3: 40,756,263 (GRCm39) V58A probably damaging Het
Polq T A 16: 36,835,535 (GRCm39) F145L probably null Het
Rab11fip2 T C 19: 59,925,707 (GRCm39) K170R probably damaging Het
Rapgef3 A G 15: 97,657,865 (GRCm39) V246A probably benign Het
Rc3h2 A G 2: 37,290,555 (GRCm39) S316P probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Homo
Rsf1 GCGGCGGC GCGGCGGCGACGGCGGC 7: 97,229,135 (GRCm39) probably benign Het
Sae1 G T 7: 16,102,461 (GRCm39) A171E probably damaging Het
Semp2l2b T C 10: 21,943,620 (GRCm39) E120G probably damaging Het
Setd5 T A 6: 113,120,669 (GRCm39) N959K probably benign Het
Siae T A 9: 37,528,119 (GRCm39) Y31N probably damaging Het
Sit1 C T 4: 43,483,311 (GRCm39) G51D probably damaging Het
Slc5a11 A G 7: 122,867,012 (GRCm39) I436V possibly damaging Het
Tcfl5 A G 2: 180,264,447 (GRCm39) S470P probably damaging Het
Timd2 A T 11: 46,561,779 (GRCm39) C288* probably null Het
Timeless T G 10: 128,075,868 (GRCm39) probably null Het
Ubxn8 G T 8: 34,111,572 (GRCm39) Q274K possibly damaging Het
Usp29 A G 7: 6,965,276 (GRCm39) E373G probably benign Het
Zap70 A G 1: 36,821,598 (GRCm39) Y597C probably damaging Het
Zfp523 T G 17: 28,419,446 (GRCm39) Y195D probably damaging Het
Zfp74 G A 7: 29,634,559 (GRCm39) A383V probably damaging Het
Zfp93 A T 7: 23,975,338 (GRCm39) Q441L probably damaging Het
Other mutations in Zfp976
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Zfp976 APN 7 42,263,109 (GRCm39) missense unknown
IGL01102:Zfp976 APN 7 42,263,333 (GRCm39) nonsense probably null
IGL01111:Zfp976 APN 7 42,265,711 (GRCm39) missense probably damaging 0.99
IGL01628:Zfp976 APN 7 42,261,935 (GRCm39) missense unknown
IGL02008:Zfp976 APN 7 42,263,656 (GRCm39) splice site probably benign
IGL02548:Zfp976 APN 7 42,261,953 (GRCm39) missense unknown
R0190:Zfp976 UTSW 7 42,291,948 (GRCm39) start gained probably benign
R0685:Zfp976 UTSW 7 42,263,141 (GRCm39) missense probably damaging 0.98
R1310:Zfp976 UTSW 7 42,262,610 (GRCm39) missense probably damaging 1.00
R1353:Zfp976 UTSW 7 42,265,442 (GRCm39) missense probably damaging 0.99
R1447:Zfp976 UTSW 7 42,262,023 (GRCm39) missense possibly damaging 0.79
R1569:Zfp976 UTSW 7 42,262,806 (GRCm39) missense probably damaging 1.00
R1702:Zfp976 UTSW 7 42,265,424 (GRCm39) missense possibly damaging 0.86
R1829:Zfp976 UTSW 7 42,265,735 (GRCm39) missense probably damaging 1.00
R1939:Zfp976 UTSW 7 42,263,105 (GRCm39) missense unknown
R1978:Zfp976 UTSW 7 42,263,265 (GRCm39) missense probably damaging 1.00
R1981:Zfp976 UTSW 7 42,263,046 (GRCm39) missense probably damaging 0.99
R2160:Zfp976 UTSW 7 42,263,354 (GRCm39) missense probably benign
R2192:Zfp976 UTSW 7 42,262,695 (GRCm39) missense probably damaging 1.00
R3121:Zfp976 UTSW 7 42,262,938 (GRCm39) missense probably damaging 1.00
R4210:Zfp976 UTSW 7 42,265,749 (GRCm39) missense probably damaging 0.99
R4724:Zfp976 UTSW 7 42,262,457 (GRCm39) missense possibly damaging 0.91
R4943:Zfp976 UTSW 7 42,261,846 (GRCm39) unclassified probably benign
R5047:Zfp976 UTSW 7 42,262,843 (GRCm39) nonsense probably null
R5071:Zfp976 UTSW 7 42,262,354 (GRCm39) nonsense probably null
R5125:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5178:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5305:Zfp976 UTSW 7 42,262,902 (GRCm39) missense probably benign 0.00
R5777:Zfp976 UTSW 7 42,263,504 (GRCm39) missense probably benign 0.00
R6153:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R7226:Zfp976 UTSW 7 42,262,684 (GRCm39) nonsense probably null
R7479:Zfp976 UTSW 7 42,262,603 (GRCm39) missense probably benign 0.01
R7561:Zfp976 UTSW 7 42,265,701 (GRCm39) missense probably damaging 1.00
R8178:Zfp976 UTSW 7 42,262,959 (GRCm39) missense probably benign 0.03
R8261:Zfp976 UTSW 7 42,262,125 (GRCm39) missense unknown
R8715:Zfp976 UTSW 7 42,262,869 (GRCm39) missense possibly damaging 0.89
R8921:Zfp976 UTSW 7 42,262,575 (GRCm39) missense possibly damaging 0.57
R9168:Zfp976 UTSW 7 42,263,011 (GRCm39) nonsense probably null
R9575:Zfp976 UTSW 7 42,262,041 (GRCm39) missense unknown
Z1088:Zfp976 UTSW 7 42,262,184 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TTACATATGTAGGGTCTCACTCCA -3'
(R):5'- TCTAGTCCCGTGATAAAGCCC -3'

Sequencing Primer
(F):5'- CATGTGCTCGAAGATACTTGAGC -3'
(R):5'- TAGTCCCGTGATAAAGCCCTAAGATC -3'
Posted On 2018-07-24