Mutagenetix > Incidental Mutation

Incidental Mutation 'R6710:Dcpp3'

529107

Institutional Source

Beutler Lab

Gene Symbol

Dcpp3

Ensembl Gene

ENSMUSG00000057417

Gene Name

demilune cell and parotid protein 3

Synonyms

EG620253

MMRRC Submission

044828-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

R6710 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

24136432-24138415 bp(+) (GRCm39)

Type of Mutation

small deletion (3 aa in frame mutation)

DNA Base Change (assembly)

AGGCCATGCTGGCC to AGGCC at 24136572 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000111088 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115428]

AlphaFold

L7N259

Predicted Effect

probably benign
Transcript: ENSMUST00000115428

SMART Domains

Protein: ENSMUSP00000111088
Gene: ENSMUSG00000057417

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Jacalin	32	158	5.04e-2	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.9%
20x: 93.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	G	T	10: 87,061,923 (GRCm39)	E124D	probably benign	Het
Aph1c	T	C	9: 66,741,802 (GRCm39)	T27A	probably benign	Het
Ash2l	T	C	8: 26,309,740 (GRCm39)	I507V	possibly damaging	Het
Cela2a	C	A	4: 141,549,554 (GRCm39)	A74S	probably damaging	Het
Drc1	A	G	5: 30,520,429 (GRCm39)	D590G	possibly damaging	Het
Epn1	A	G	7: 5,100,303 (GRCm39)	E472G	probably damaging	Het
Erfe	A	G	1: 91,300,128 (GRCm39)	D318G	probably damaging	Het
Ifnar2	T	C	16: 91,190,771 (GRCm39)	C227R	probably damaging	Het
Marchf11	A	G	15: 26,387,949 (GRCm39)	Y268C	probably damaging	Het
Muc16	A	T	9: 18,553,366 (GRCm39)	I4309N	possibly damaging	Het
Nit2	A	G	16: 56,980,493 (GRCm39)	V95A	possibly damaging	Het
Nup205	T	G	6: 35,224,308 (GRCm39)	I2049S	probably benign	Het
Or2h1	T	G	17: 37,404,638 (GRCm39)	I43L	probably damaging	Het
Or7e175	C	T	9: 20,049,378 (GRCm39)	A322V	probably benign	Het
Pcdhb17	T	C	18: 37,618,452 (GRCm39)	S81P	probably damaging	Het
Plcg2	A	G	8: 118,284,086 (GRCm39)	I128V	probably benign	Het
Sem1	C	A	6: 6,578,497 (GRCm39)	E20*	probably null	Het
Tap1	C	T	17: 34,407,083 (GRCm39)	A77V	possibly damaging	Het
Tmem26	T	C	10: 68,559,884 (GRCm39)	L52P	probably damaging	Het
Utp3	T	C	5: 88,703,823 (GRCm39)	Y451H	probably damaging	Het
Vmn2r103	T	A	17: 20,032,239 (GRCm39)	I671N	probably damaging	Het
Zbtb39	T	A	10: 127,579,505 (GRCm39)	I693N	probably damaging	Het
Zfp174	A	G	16: 3,665,921 (GRCm39)	E62G	probably damaging	Het

Other mutations in Dcpp3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0393:Dcpp3	UTSW	17	24,136,925 (GRCm39)	splice site	probably benign
R6562:Dcpp3	UTSW	17	24,136,572 (GRCm39)	small deletion	probably benign
R6709:Dcpp3	UTSW	17	24,136,572 (GRCm39)	small deletion	probably benign
R6711:Dcpp3	UTSW	17	24,136,572 (GRCm39)	small deletion	probably benign
R8685:Dcpp3	UTSW	17	24,138,096 (GRCm39)	missense	probably benign	0.16
R8852:Dcpp3	UTSW	17	24,138,123 (GRCm39)	nonsense	probably null
R9646:Dcpp3	UTSW	17	24,138,156 (GRCm39)	missense	possibly damaging	0.51
X0021:Dcpp3	UTSW	17	24,137,027 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GGCCCCAGAAGCATATAAGG -3'
(R):5'- TTGTGAGAGACGAGGTGGCTAC -3'

Sequencing Primer
(F):5'- CCCCAGAAGCATATAAGGGGAGG -3'
(R):5'- AGACGAGGTGGCTACTAGAG -3'

Posted On

2018-07-24