Incidental Mutation 'R6712:Fcmr'
ID 529162
Institutional Source Beutler Lab
Gene Symbol Fcmr
Ensembl Gene ENSMUSG00000042474
Gene Name Fc fragment of IgM receptor
Synonyms 1810037B05Rik, FcmuR, Faim3
MMRRC Submission 044830-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6712 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 130793514-130808528 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130805588 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 274 (L274P)
Ref Sequence ENSEMBL: ENSMUSP00000048303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038829] [ENSMUST00000121040] [ENSMUST00000187650] [ENSMUST00000191279]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000038829
AA Change: L274P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000048303
Gene: ENSMUSG00000042474
AA Change: L274P

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:V-set 21 122 1.3e-10 PFAM
low complexity region 212 223 N/A INTRINSIC
transmembrane domain 264 283 N/A INTRINSIC
low complexity region 285 311 N/A INTRINSIC
low complexity region 344 363 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121040
SMART Domains Protein: ENSMUSP00000113064
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
IL10 76 219 1.14e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126821
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145446
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149355
Predicted Effect probably benign
Transcript: ENSMUST00000187650
SMART Domains Protein: ENSMUSP00000140149
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IL10 37 180 5.4e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191279
SMART Domains Protein: ENSMUSP00000140821
Gene: ENSMUSG00000026420

DomainStartEndE-ValueType
low complexity region 44 56 N/A INTRINSIC
Blast:IL10 76 118 2e-21 BLAST
SCOP:d2ilk__ 80 119 2e-9 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap8l G A 17: 32,551,862 (GRCm39) T443M probably damaging Het
Ankmy1 A T 1: 92,798,644 (GRCm39) V950D probably damaging Het
Cep350 T C 1: 155,733,852 (GRCm39) K3014E possibly damaging Het
Col5a3 C T 9: 20,690,329 (GRCm39) G1162R probably damaging Het
Dmxl2 A G 9: 54,318,908 (GRCm39) Y1586H probably damaging Het
Dnah11 A T 12: 118,014,457 (GRCm39) I2010N probably damaging Het
Dock10 T A 1: 80,514,583 (GRCm39) M1446L probably benign Het
Foxn1 T G 11: 78,252,085 (GRCm39) D382A probably damaging Het
Gpr179 T C 11: 97,226,993 (GRCm39) R1721G possibly damaging Het
H2aj A G 6: 136,785,524 (GRCm39) I63V probably benign Het
Mfsd9 T C 1: 40,825,601 (GRCm39) probably null Het
Mis18a T C 16: 90,524,045 (GRCm39) E39G possibly damaging Het
Mmp27 A T 9: 7,572,177 (GRCm39) T126S probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Myo5a A C 9: 75,120,182 (GRCm39) D1635A probably benign Het
Ngdn T C 14: 55,253,645 (GRCm39) V11A probably benign Het
Nlrc4 A T 17: 74,753,831 (GRCm39) M184K probably damaging Het
Or10h28 T G 17: 33,488,242 (GRCm39) H181Q possibly damaging Het
Or52e15 A T 7: 104,645,625 (GRCm39) I162K possibly damaging Het
Peli2 C A 14: 48,488,051 (GRCm39) Q81K probably benign Het
Pfdn2 T A 1: 171,185,419 (GRCm39) I97K probably damaging Het
Pknox1 C A 17: 31,814,290 (GRCm39) T205K probably benign Het
Polh T C 17: 46,501,655 (GRCm39) S179G probably benign Het
Ppp4r4 G A 12: 103,562,702 (GRCm39) R557Q probably damaging Het
Sipa1 A T 19: 5,710,847 (GRCm39) D54E possibly damaging Het
Tmc8 C A 11: 117,675,639 (GRCm39) N185K probably benign Het
Tns1 C A 1: 74,118,460 (GRCm39) E57* probably null Het
Tyro3 G A 2: 119,635,335 (GRCm39) A209T probably null Het
Ube2f T A 1: 91,204,171 (GRCm39) C116S possibly damaging Het
Vmn1r231 T C 17: 21,109,992 (GRCm39) T308A possibly damaging Het
Wwc2 T A 8: 48,353,838 (GRCm39) M99L probably benign Het
Zfp516 C T 18: 82,975,433 (GRCm39) R544C probably damaging Het
Zfp764l1 A T 7: 126,991,482 (GRCm39) H168Q probably damaging Het
Other mutations in Fcmr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01638:Fcmr APN 1 130,802,859 (GRCm39) missense probably benign 0.06
IGL01652:Fcmr APN 1 130,806,244 (GRCm39) missense probably benign 0.25
IGL02106:Fcmr APN 1 130,802,872 (GRCm39) missense probably benign
IGL03270:Fcmr APN 1 130,803,779 (GRCm39) missense possibly damaging 0.63
R1635:Fcmr UTSW 1 130,803,922 (GRCm39) splice site probably null
R1651:Fcmr UTSW 1 130,805,988 (GRCm39) missense probably benign
R1728:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1728:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1729:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1729:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1730:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1730:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1739:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1739:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1762:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1762:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1783:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1783:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1784:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1784:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1785:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1785:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R2037:Fcmr UTSW 1 130,806,070 (GRCm39) missense possibly damaging 0.61
R6111:Fcmr UTSW 1 130,805,566 (GRCm39) missense probably damaging 0.96
R6217:Fcmr UTSW 1 130,806,060 (GRCm39) missense probably damaging 0.96
R6538:Fcmr UTSW 1 130,802,762 (GRCm39) missense possibly damaging 0.72
R6965:Fcmr UTSW 1 130,803,724 (GRCm39) missense possibly damaging 0.65
R7765:Fcmr UTSW 1 130,802,025 (GRCm39) missense probably damaging 1.00
R8770:Fcmr UTSW 1 130,803,799 (GRCm39) missense probably benign
R9343:Fcmr UTSW 1 130,802,072 (GRCm39) missense
R9468:Fcmr UTSW 1 130,801,951 (GRCm39) missense possibly damaging 0.65
X0025:Fcmr UTSW 1 130,802,004 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCACTGAAGGGTGAGTCTTTAAG -3'
(R):5'- GGCAATGTTGTAGCCTGGAC -3'

Sequencing Primer
(F):5'- ACTGAAGGGTGAGTCTTTAAGTTTCC -3'
(R):5'- CAATGTTGTAGCCTGGACTTAGAC -3'
Posted On 2018-07-24