Incidental Mutation 'R6713:Lekr1'
ID 529199
Institutional Source Beutler Lab
Gene Symbol Lekr1
Ensembl Gene ENSMUSG00000074579
Gene Name leucine, glutamate and lysine rich 1
Synonyms Gm6534, EG546798
MMRRC Submission 044831-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.385) question?
Stock # R6713 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 65573649-65738776 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 65591380 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Aspartic acid at position 39 (A39D)
Ref Sequence ENSEMBL: ENSMUSP00000096674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099075]
AlphaFold A0A571BF98
Predicted Effect probably benign
Transcript: ENSMUST00000099075
AA Change: A39D

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000096674
Gene: ENSMUSG00000074579
AA Change: A39D

DomainStartEndE-ValueType
coiled coil region 32 88 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107848
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161534
SMART Domains Protein: ENSMUSP00000124130
Gene: ENSMUSG00000074579

DomainStartEndE-ValueType
coiled coil region 32 123 N/A INTRINSIC
coiled coil region 191 275 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161794
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161851
SMART Domains Protein: ENSMUSP00000124508
Gene: ENSMUSG00000074579

DomainStartEndE-ValueType
coiled coil region 32 123 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177434
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193471
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.9%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol10a C T 15: 77,373,051 (GRCm39) T229M possibly damaging Het
Cdh16 G A 8: 105,346,617 (GRCm39) Q226* probably null Het
Cemip A T 7: 83,592,845 (GRCm39) N1227K probably benign Het
Dusp13b A G 14: 21,798,541 (GRCm39) V41A probably damaging Het
F3 C T 3: 121,525,323 (GRCm39) T53I possibly damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fyb2 T A 4: 104,847,432 (GRCm39) M484K probably benign Het
Glb1l A T 1: 75,179,061 (GRCm39) H253Q probably benign Het
Grm8 T C 6: 27,363,190 (GRCm39) E775G probably damaging Het
Hipk3 C T 2: 104,276,916 (GRCm39) V388M probably damaging Het
Ighe T C 12: 113,232,908 (GRCm39) probably benign Het
Kif14 A G 1: 136,453,544 (GRCm39) T1491A probably benign Het
Klre1 A G 6: 129,559,229 (GRCm39) probably null Het
Kpna6 A T 4: 129,547,777 (GRCm39) L257M probably damaging Het
Ldhc G A 7: 46,515,955 (GRCm39) probably null Het
Lins1 A G 7: 66,358,230 (GRCm39) T122A probably benign Het
Lrrc40 G A 3: 157,769,350 (GRCm39) R516Q probably benign Het
Meis3 G T 7: 15,916,255 (GRCm39) G72* probably null Het
Mpo A G 11: 87,686,194 (GRCm39) T115A probably damaging Het
Mrgprb5 A G 7: 47,818,537 (GRCm39) V66A probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Nags C A 11: 102,037,347 (GRCm39) A146E probably benign Het
Nkain4 C T 2: 180,585,970 (GRCm39) G31D probably damaging Het
Or2y1 T G 11: 49,385,784 (GRCm39) C141W probably damaging Het
Or4k1 T A 14: 50,377,181 (GRCm39) H305L probably benign Het
Or5ak24 A C 2: 85,260,883 (GRCm39) C97G probably damaging Het
Or8a1 A G 9: 37,641,560 (GRCm39) C240R probably damaging Het
Otud6b C T 4: 14,822,739 (GRCm39) V122I probably benign Het
Ovca2 C T 11: 75,069,569 (GRCm39) S18N possibly damaging Het
Pax2 A G 19: 44,823,916 (GRCm39) S370G unknown Het
Pias2 G A 18: 77,153,416 (GRCm39) probably null Het
Slc2a10 T C 2: 165,357,128 (GRCm39) F263L probably damaging Het
Slc6a17 T G 3: 107,378,703 (GRCm39) M660L probably benign Het
Smarcc2 A G 10: 128,323,638 (GRCm39) probably null Het
Srcap A G 7: 127,134,089 (GRCm39) T937A probably benign Het
Ssh2 C A 11: 77,340,259 (GRCm39) D470E possibly damaging Het
St8sia1 A T 6: 142,775,008 (GRCm39) probably null Het
Supt20 T A 3: 54,606,022 (GRCm39) I36K possibly damaging Het
Tor1aip2 T A 1: 155,941,155 (GRCm39) L487Q probably damaging Het
Zfp619 G T 7: 39,187,322 (GRCm39) K1117N probably damaging Het
Other mutations in Lekr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01701:Lekr1 APN 3 65,591,425 (GRCm39) missense probably damaging 1.00
R1652:Lekr1 UTSW 3 65,591,508 (GRCm39) missense probably benign 0.02
R2061:Lekr1 UTSW 3 65,632,860 (GRCm39) splice site noncoding transcript
R3086:Lekr1 UTSW 3 65,634,581 (GRCm39) exon noncoding transcript
R4572:Lekr1 UTSW 3 65,691,336 (GRCm39) exon noncoding transcript
R5073:Lekr1 UTSW 3 65,727,215 (GRCm39) splice site noncoding transcript
R5398:Lekr1 UTSW 3 65,688,807 (GRCm39) exon noncoding transcript
R5547:Lekr1 UTSW 3 65,576,601 (GRCm39) critical splice donor site probably null
R5947:Lekr1 UTSW 3 65,680,498 (GRCm39) splice site noncoding transcript
R8387:Lekr1 UTSW 3 65,591,520 (GRCm39) missense possibly damaging 0.50
R9129:Lekr1 UTSW 3 65,591,426 (GRCm39) nonsense probably null
R9528:Lekr1 UTSW 3 65,591,608 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ATAGTGACTATCCCAGCGGC -3'
(R):5'- CCAAATCTACTGTTTGCCTTGAAAC -3'

Sequencing Primer
(F):5'- GGCTAGCCGACTGTGTATTCC -3'
(R):5'- TGCCTTGAAACTAAATAAGAGACAG -3'
Posted On 2018-07-24