Incidental Mutation 'IGL01112:Zfp263'
| ID |
52937 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp263
|
| Ensembl Gene |
ENSMUSG00000022529 |
| Gene Name |
zinc finger protein 263 |
| Synonyms |
mFPM315, NT2, 1200014J04Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
IGL01112
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
16 |
| Chromosomal Location |
3561957-3568654 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 3566776 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 76
(C76S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124433
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023176]
[ENSMUST00000161630]
[ENSMUST00000162207]
|
| AlphaFold |
Q8CF60 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023176
AA Change: C364S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: C364S
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
39 |
151 |
5.15e-71 |
SMART |
|
KRAB
|
219 |
279 |
1.86e-9 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
6.52e-5 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
600 |
622 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
628 |
650 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
656 |
678 |
1.72e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159060
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159425
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159469
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160923
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161630
|
| SMART Domains |
Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
39 |
143 |
1.61e-63 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162207
AA Change: C76S
PolyPhen 2
Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529
AA Change: C76S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
90 |
112 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
146 |
168 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
174 |
196 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
202 |
224 |
6.52e-5 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
284 |
306 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
312 |
334 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
340 |
362 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
368 |
390 |
1.72e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano1 |
T |
C |
7: 144,190,882 (GRCm39) |
I401V |
possibly damaging |
Het |
| Ap2a2 |
A |
T |
7: 141,184,932 (GRCm39) |
|
probably benign |
Het |
| Apol7c |
T |
A |
15: 77,410,637 (GRCm39) |
D103V |
probably damaging |
Het |
| Arid4a |
T |
C |
12: 71,119,507 (GRCm39) |
|
probably null |
Het |
| Atp2a1 |
A |
G |
7: 126,049,479 (GRCm39) |
V521A |
probably benign |
Het |
| Ccdc88c |
G |
T |
12: 100,883,062 (GRCm39) |
D1603E |
probably benign |
Het |
| Clec4f |
T |
C |
6: 83,630,182 (GRCm39) |
I125M |
probably benign |
Het |
| Dsc1 |
T |
C |
18: 20,227,679 (GRCm39) |
I520V |
probably benign |
Het |
| Eomes |
G |
A |
9: 118,311,334 (GRCm39) |
A386T |
probably damaging |
Het |
| Gldc |
C |
T |
19: 30,135,913 (GRCm39) |
|
probably null |
Het |
| Hectd4 |
G |
T |
5: 121,445,013 (GRCm39) |
M1420I |
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,508,303 (GRCm39) |
|
probably benign |
Het |
| Ighv6-3 |
G |
A |
12: 114,355,335 (GRCm39) |
T118I |
possibly damaging |
Het |
| Krt82 |
A |
G |
15: 101,453,958 (GRCm39) |
F250S |
probably damaging |
Het |
| Ltb |
A |
G |
17: 35,413,576 (GRCm39) |
T27A |
probably benign |
Het |
| Mex3b |
T |
A |
7: 82,518,911 (GRCm39) |
S409T |
probably benign |
Het |
| Mki67 |
A |
T |
7: 135,315,745 (GRCm39) |
I39N |
probably damaging |
Het |
| Or51a7 |
A |
G |
7: 102,615,235 (GRCm39) |
|
probably benign |
Het |
| Palmd |
A |
G |
3: 116,717,922 (GRCm39) |
S192P |
probably damaging |
Het |
| Pcdh20 |
A |
T |
14: 88,704,636 (GRCm39) |
M888K |
probably benign |
Het |
| Pclo |
A |
T |
5: 14,731,083 (GRCm39) |
H3195L |
unknown |
Het |
| Pgm2 |
A |
T |
5: 64,260,225 (GRCm39) |
I137F |
possibly damaging |
Het |
| Polq |
T |
A |
16: 36,837,671 (GRCm39) |
N194K |
probably damaging |
Het |
| Rmnd1 |
T |
C |
10: 4,360,793 (GRCm39) |
|
probably null |
Het |
| Rnf114 |
T |
C |
2: 167,354,459 (GRCm39) |
M180T |
probably damaging |
Het |
| Sap30 |
A |
G |
8: 57,938,123 (GRCm39) |
F165L |
possibly damaging |
Het |
| Scgb3a2 |
T |
A |
18: 43,900,059 (GRCm39) |
|
probably benign |
Het |
| Sftpa1 |
A |
T |
14: 40,854,527 (GRCm39) |
N38I |
probably benign |
Het |
| Sumf1 |
A |
G |
6: 108,152,977 (GRCm39) |
F137S |
probably damaging |
Het |
| Tln2 |
C |
A |
9: 67,219,093 (GRCm39) |
R284L |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,570,703 (GRCm39) |
R26730Q |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,540,808 (GRCm39) |
R25732S |
probably damaging |
Het |
| Tubgcp4 |
T |
C |
2: 121,004,082 (GRCm39) |
V41A |
probably benign |
Het |
| Usp53 |
T |
A |
3: 122,751,367 (GRCm39) |
Q230L |
probably damaging |
Het |
| Vmn2r57 |
T |
C |
7: 41,074,467 (GRCm39) |
E532G |
probably damaging |
Het |
| Vps9d1 |
G |
T |
8: 123,972,769 (GRCm39) |
N454K |
probably damaging |
Het |
| Wdr55 |
T |
C |
18: 36,895,132 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zfp263 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00489:Zfp263
|
APN |
16 |
3,563,710 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02049:Zfp263
|
APN |
16 |
3,562,482 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02534:Zfp263
|
APN |
16 |
3,564,279 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02674:Zfp263
|
APN |
16 |
3,564,629 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03065:Zfp263
|
APN |
16 |
3,564,344 (GRCm39) |
missense |
probably benign |
|
|
IGL03105:Zfp263
|
APN |
16 |
3,566,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03153:Zfp263
|
APN |
16 |
3,564,744 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02796:Zfp263
|
UTSW |
16 |
3,564,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1201:Zfp263
|
UTSW |
16 |
3,567,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1414:Zfp263
|
UTSW |
16 |
3,567,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1448:Zfp263
|
UTSW |
16 |
3,564,323 (GRCm39) |
missense |
probably benign |
0.18 |
|
R3085:Zfp263
|
UTSW |
16 |
3,567,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Zfp263
|
UTSW |
16 |
3,562,770 (GRCm39) |
unclassified |
probably benign |
|
|
R4989:Zfp263
|
UTSW |
16 |
3,566,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5072:Zfp263
|
UTSW |
16 |
3,564,704 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5073:Zfp263
|
UTSW |
16 |
3,564,704 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5074:Zfp263
|
UTSW |
16 |
3,564,704 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5122:Zfp263
|
UTSW |
16 |
3,567,719 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5705:Zfp263
|
UTSW |
16 |
3,564,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Zfp263
|
UTSW |
16 |
3,566,081 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6879:Zfp263
|
UTSW |
16 |
3,567,719 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7133:Zfp263
|
UTSW |
16 |
3,567,255 (GRCm39) |
nonsense |
probably null |
|
|
R7216:Zfp263
|
UTSW |
16 |
3,562,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8517:Zfp263
|
UTSW |
16 |
3,564,760 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8822:Zfp263
|
UTSW |
16 |
3,562,004 (GRCm39) |
unclassified |
probably benign |
|
|
R9130:Zfp263
|
UTSW |
16 |
3,567,701 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9172:Zfp263
|
UTSW |
16 |
3,567,323 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9512:Zfp263
|
UTSW |
16 |
3,564,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9616:Zfp263
|
UTSW |
16 |
3,567,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation