Incidental Mutation 'R6717:Fry'
ID 529429
Institutional Source Beutler Lab
Gene Symbol Fry
Ensembl Gene ENSMUSG00000056602
Gene Name FRY microtubule binding protein
Synonyms cg003, 9330186A19Rik
MMRRC Submission 044835-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.460) question?
Stock # R6717 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 150042110-150421218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 150419777 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 980 (T980A)
Ref Sequence ENSEMBL: ENSMUSP00000144657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087204] [ENSMUST00000202566]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000087204
AA Change: T2984A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000084454
Gene: ENSMUSG00000056602
AA Change: T2984A

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_N 165 697 5.3e-170 PFAM
low complexity region 1014 1040 N/A INTRINSIC
Pfam:MOR2-PAG1_mid 1188 1380 1.2e-15 PFAM
Pfam:MOR2-PAG1_mid 1398 1534 1.5e-5 PFAM
Pfam:MOR2-PAG1_mid 1632 1704 1.8e-7 PFAM
Pfam:MOR2-PAG1_mid 1772 1906 4.9e-10 PFAM
low complexity region 1936 1956 N/A INTRINSIC
low complexity region 1962 1980 N/A INTRINSIC
Pfam:MOR2-PAG1_C 2050 2303 1.9e-74 PFAM
low complexity region 2369 2385 N/A INTRINSIC
low complexity region 2463 2482 N/A INTRINSIC
low complexity region 2525 2534 N/A INTRINSIC
low complexity region 2836 2852 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000200863
AA Change: T616A
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201196
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201628
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202066
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202386
Predicted Effect probably benign
Transcript: ENSMUST00000202566
AA Change: T980A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000144657
Gene: ENSMUSG00000056602
AA Change: T980A

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_C 37 290 1.5e-71 PFAM
low complexity region 356 372 N/A INTRINSIC
low complexity region 447 472 N/A INTRINSIC
low complexity region 515 524 N/A INTRINSIC
low complexity region 832 848 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202571
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 C T 5: 4,114,086 (GRCm39) L3122F probably damaging Het
Atp6v1b1 A T 6: 83,730,632 (GRCm39) probably null Het
Ccdc178 A T 18: 22,153,946 (GRCm39) V621E probably damaging Het
Cfap126 T C 1: 170,941,671 (GRCm39) probably null Het
Cog2 T C 8: 125,252,488 (GRCm39) I64T probably damaging Het
Dhx9 A C 1: 153,349,210 (GRCm39) probably null Het
Efcab7 A G 4: 99,761,931 (GRCm39) D407G possibly damaging Het
Eif2b5 G T 16: 20,324,033 (GRCm39) G459C probably damaging Het
Eml5 T C 12: 98,793,765 (GRCm39) E1168G probably damaging Het
Flnc AGCTGTCAAGTATGCTG AGCTG 6: 29,450,901 (GRCm39) probably benign Het
Gabbr2 A G 4: 46,787,574 (GRCm39) V363A possibly damaging Het
Ggt6 T A 11: 72,328,346 (GRCm39) L244* probably null Het
Gprc6a T A 10: 51,491,233 (GRCm39) I768F probably damaging Het
Grk1 G A 8: 13,466,237 (GRCm39) M560I probably benign Het
Hapln4 G A 8: 70,537,740 (GRCm39) E145K probably damaging Het
Hoxd9 C T 2: 74,528,733 (GRCm39) P112S probably benign Het
Ly6g6f T A 17: 35,304,550 (GRCm39) M1L probably benign Het
Mast1 T C 8: 85,644,383 (GRCm39) T849A probably benign Het
Mob4 A T 1: 55,175,872 (GRCm39) M39L possibly damaging Het
Mrgpre A T 7: 143,335,260 (GRCm39) L81Q probably damaging Het
Mst1 T C 9: 107,957,774 (GRCm39) probably null Het
Muc5b A T 7: 141,411,559 (GRCm39) R1502* probably null Het
Or4b13 T A 2: 90,082,868 (GRCm39) I155L probably benign Het
Or5ap2 T A 2: 85,680,567 (GRCm39) I257N probably damaging Het
Or9e1 T C 11: 58,732,113 (GRCm39) Y58H probably damaging Het
Pdc A G 1: 150,208,769 (GRCm39) D84G probably damaging Het
Peak1 T C 9: 56,114,523 (GRCm39) N443D probably benign Het
Pkd1l3 T A 8: 110,341,401 (GRCm39) W85R unknown Het
Pramel31 G T 4: 144,089,227 (GRCm39) V182L probably benign Het
Rfc1 G A 5: 65,459,347 (GRCm39) Q190* probably null Het
Rfc1 A G 5: 65,470,304 (GRCm39) S68P probably damaging Het
Rnf145 T C 11: 44,452,317 (GRCm39) V432A probably benign Het
Ror2 A G 13: 53,273,018 (GRCm39) S204P probably damaging Het
Scn1a T C 2: 66,162,631 (GRCm39) E205G probably damaging Het
Slc2a8 A C 2: 32,866,189 (GRCm39) M277R probably damaging Het
Slc4a1 T C 11: 102,245,249 (GRCm39) Y566C probably damaging Het
Slc6a12 A G 6: 121,331,262 (GRCm39) N185S probably benign Het
Srcap GCTCCTCCTCCTCCTCCT GCTCCTCCTCCTCCT 7: 127,157,482 (GRCm39) probably benign Het
Stk33 T A 7: 108,926,823 (GRCm39) T279S possibly damaging Het
Taok3 A G 5: 117,379,015 (GRCm39) probably benign Het
Tlr11 A G 14: 50,599,561 (GRCm39) T516A probably benign Het
Tmem132c T A 5: 127,641,093 (GRCm39) L1088Q possibly damaging Het
Tmem132d T A 5: 127,861,485 (GRCm39) M879L probably benign Het
Tnk2 A G 16: 32,489,687 (GRCm39) E322G probably damaging Het
Ttc28 T C 5: 111,433,302 (GRCm39) V2081A probably benign Het
Ttn C T 2: 76,624,753 (GRCm39) probably null Het
Zfp105 T C 9: 122,759,373 (GRCm39) V348A possibly damaging Het
Zswim2 T C 2: 83,745,753 (GRCm39) R562G probably benign Het
Other mutations in Fry
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Fry APN 5 150,263,869 (GRCm39) nonsense probably null
IGL00328:Fry APN 5 150,263,869 (GRCm39) nonsense probably null
IGL00841:Fry APN 5 150,346,189 (GRCm39) missense probably benign
IGL00938:Fry APN 5 150,293,645 (GRCm39) missense probably damaging 1.00
IGL01015:Fry APN 5 150,346,252 (GRCm39) missense probably benign 0.18
IGL01401:Fry APN 5 150,362,253 (GRCm39) missense probably benign
IGL01616:Fry APN 5 150,323,064 (GRCm39) missense probably damaging 1.00
IGL01616:Fry APN 5 150,362,276 (GRCm39) splice site probably null
IGL01748:Fry APN 5 150,269,116 (GRCm39) splice site probably benign
IGL01965:Fry APN 5 150,305,086 (GRCm39) missense probably damaging 1.00
IGL02030:Fry APN 5 150,395,083 (GRCm39) splice site probably benign
IGL02079:Fry APN 5 150,323,089 (GRCm39) missense probably damaging 0.97
IGL02087:Fry APN 5 150,327,059 (GRCm39) missense probably benign 0.23
IGL02113:Fry APN 5 150,323,070 (GRCm39) missense probably benign
IGL02209:Fry APN 5 150,360,491 (GRCm39) missense probably benign 0.00
IGL02250:Fry APN 5 150,326,899 (GRCm39) splice site probably benign
IGL02265:Fry APN 5 150,360,618 (GRCm39) missense probably damaging 1.00
IGL02486:Fry APN 5 150,414,642 (GRCm39) missense probably damaging 0.99
IGL02552:Fry APN 5 150,304,375 (GRCm39) missense probably damaging 1.00
IGL02881:Fry APN 5 150,282,516 (GRCm39) missense probably damaging 0.99
IGL03008:Fry APN 5 150,269,021 (GRCm39) missense possibly damaging 0.82
IGL03140:Fry APN 5 150,419,166 (GRCm39) missense probably damaging 0.98
IGL03171:Fry APN 5 150,304,274 (GRCm39) missense probably damaging 1.00
IGL03389:Fry APN 5 150,317,696 (GRCm39) missense probably damaging 1.00
IGL03404:Fry APN 5 150,249,633 (GRCm39) missense probably damaging 1.00
Brook UTSW 5 150,249,597 (GRCm39) missense probably damaging 1.00
haydn UTSW 5 150,341,929 (GRCm39) missense possibly damaging 0.94
miracle UTSW 5 150,360,624 (GRCm39) missense probably damaging 0.99
quickening UTSW 5 150,358,241 (GRCm39) missense probably damaging 1.00
seasons UTSW 5 150,389,902 (GRCm39) missense probably benign 0.06
Vivaldi UTSW 5 150,317,603 (GRCm39) missense possibly damaging 0.80
R0023:Fry UTSW 5 150,374,563 (GRCm39) missense possibly damaging 0.78
R0024:Fry UTSW 5 150,304,268 (GRCm39) missense probably benign 0.03
R0030:Fry UTSW 5 150,296,034 (GRCm39) nonsense probably null
R0053:Fry UTSW 5 150,384,842 (GRCm39) splice site probably benign
R0089:Fry UTSW 5 150,263,892 (GRCm39) missense possibly damaging 0.91
R0212:Fry UTSW 5 150,419,862 (GRCm39) missense probably damaging 0.99
R0241:Fry UTSW 5 150,183,811 (GRCm39) intron probably benign
R0265:Fry UTSW 5 150,358,241 (GRCm39) missense probably damaging 1.00
R0317:Fry UTSW 5 150,394,933 (GRCm39) missense probably damaging 1.00
R0532:Fry UTSW 5 150,402,226 (GRCm39) splice site probably benign
R0532:Fry UTSW 5 150,357,172 (GRCm39) unclassified probably benign
R0599:Fry UTSW 5 150,360,624 (GRCm39) missense probably damaging 0.99
R0631:Fry UTSW 5 150,419,817 (GRCm39) missense possibly damaging 0.82
R0723:Fry UTSW 5 150,419,825 (GRCm39) missense probably damaging 1.00
R0766:Fry UTSW 5 150,326,897 (GRCm39) splice site probably benign
R0790:Fry UTSW 5 150,389,902 (GRCm39) missense probably benign 0.06
R0928:Fry UTSW 5 150,360,549 (GRCm39) missense probably damaging 1.00
R1104:Fry UTSW 5 150,419,754 (GRCm39) missense probably damaging 1.00
R1144:Fry UTSW 5 150,341,929 (GRCm39) missense possibly damaging 0.94
R1172:Fry UTSW 5 150,404,959 (GRCm39) nonsense probably null
R1312:Fry UTSW 5 150,326,897 (GRCm39) splice site probably benign
R1347:Fry UTSW 5 150,419,283 (GRCm39) missense probably damaging 1.00
R1347:Fry UTSW 5 150,419,283 (GRCm39) missense probably damaging 1.00
R1437:Fry UTSW 5 150,233,890 (GRCm39) missense possibly damaging 0.92
R1458:Fry UTSW 5 150,304,324 (GRCm39) missense probably damaging 1.00
R1542:Fry UTSW 5 150,328,431 (GRCm39) missense probably benign 0.13
R1692:Fry UTSW 5 150,293,692 (GRCm39) missense probably damaging 1.00
R1826:Fry UTSW 5 150,360,174 (GRCm39) missense possibly damaging 0.82
R1874:Fry UTSW 5 150,269,386 (GRCm39) missense probably damaging 1.00
R1875:Fry UTSW 5 150,249,597 (GRCm39) missense probably damaging 1.00
R1881:Fry UTSW 5 150,401,511 (GRCm39) missense probably damaging 0.97
R1884:Fry UTSW 5 150,326,985 (GRCm39) missense probably benign 0.00
R1929:Fry UTSW 5 150,324,389 (GRCm39) missense probably null 0.02
R2066:Fry UTSW 5 150,293,584 (GRCm39) splice site probably benign
R2270:Fry UTSW 5 150,324,389 (GRCm39) missense probably null 0.02
R2356:Fry UTSW 5 150,394,897 (GRCm39) missense probably benign
R3720:Fry UTSW 5 150,378,037 (GRCm39) missense probably damaging 1.00
R3773:Fry UTSW 5 150,321,663 (GRCm39) missense probably damaging 0.96
R3824:Fry UTSW 5 150,419,884 (GRCm39) missense possibly damaging 0.94
R3902:Fry UTSW 5 150,269,392 (GRCm39) missense probably damaging 1.00
R3923:Fry UTSW 5 150,336,814 (GRCm39) missense probably benign
R4250:Fry UTSW 5 150,233,825 (GRCm39) missense probably damaging 0.99
R4332:Fry UTSW 5 150,305,128 (GRCm39) missense probably damaging 1.00
R4495:Fry UTSW 5 150,233,928 (GRCm39) missense probably damaging 1.00
R4610:Fry UTSW 5 150,309,569 (GRCm39) missense probably damaging 1.00
R4682:Fry UTSW 5 150,346,219 (GRCm39) missense probably damaging 1.00
R4732:Fry UTSW 5 150,309,472 (GRCm39) missense
R4733:Fry UTSW 5 150,309,472 (GRCm39) missense
R4755:Fry UTSW 5 150,321,719 (GRCm39) missense probably damaging 0.99
R4788:Fry UTSW 5 150,323,101 (GRCm39) missense probably benign 0.00
R4803:Fry UTSW 5 150,322,998 (GRCm39) missense probably benign 0.31
R4858:Fry UTSW 5 150,325,108 (GRCm39) missense possibly damaging 0.78
R4872:Fry UTSW 5 150,317,704 (GRCm39) critical splice donor site probably null
R4902:Fry UTSW 5 150,419,168 (GRCm39) missense probably benign 0.43
R4915:Fry UTSW 5 150,402,328 (GRCm39) missense probably benign 0.30
R4938:Fry UTSW 5 150,401,454 (GRCm39) missense probably damaging 1.00
R4983:Fry UTSW 5 150,321,719 (GRCm39) missense probably damaging 1.00
R5004:Fry UTSW 5 150,357,069 (GRCm39) missense probably benign 0.16
R5040:Fry UTSW 5 150,312,319 (GRCm39) missense probably damaging 0.99
R5145:Fry UTSW 5 150,293,689 (GRCm39) missense probably damaging 0.98
R5170:Fry UTSW 5 150,353,319 (GRCm39) missense probably benign 0.03
R5233:Fry UTSW 5 150,393,185 (GRCm39) missense possibly damaging 0.71
R5428:Fry UTSW 5 150,328,824 (GRCm39) missense possibly damaging 0.89
R5468:Fry UTSW 5 150,323,053 (GRCm39) missense probably benign 0.44
R5481:Fry UTSW 5 150,183,784 (GRCm39) missense probably benign 0.01
R5494:Fry UTSW 5 150,314,132 (GRCm39) missense probably damaging 1.00
R5538:Fry UTSW 5 150,419,313 (GRCm39) missense probably damaging 1.00
R5638:Fry UTSW 5 150,282,546 (GRCm39) missense possibly damaging 0.46
R5645:Fry UTSW 5 150,304,332 (GRCm39) missense probably damaging 1.00
R5716:Fry UTSW 5 150,293,686 (GRCm39) nonsense probably null
R5812:Fry UTSW 5 150,323,136 (GRCm39) missense probably damaging 0.99
R5813:Fry UTSW 5 150,323,136 (GRCm39) missense probably damaging 0.99
R5873:Fry UTSW 5 150,302,350 (GRCm39) missense probably damaging 1.00
R5933:Fry UTSW 5 150,314,265 (GRCm39) intron probably benign
R6037:Fry UTSW 5 150,351,644 (GRCm39) missense probably benign 0.03
R6037:Fry UTSW 5 150,351,644 (GRCm39) missense probably benign 0.03
R6158:Fry UTSW 5 150,378,037 (GRCm39) missense probably damaging 1.00
R6178:Fry UTSW 5 150,377,987 (GRCm39) missense probably damaging 1.00
R6481:Fry UTSW 5 150,309,479 (GRCm39) missense probably damaging 1.00
R6562:Fry UTSW 5 150,249,614 (GRCm39) missense probably damaging 1.00
R6676:Fry UTSW 5 150,304,387 (GRCm39) missense probably benign 0.22
R6828:Fry UTSW 5 150,389,911 (GRCm39) splice site probably null
R6874:Fry UTSW 5 150,360,768 (GRCm39) missense probably benign 0.00
R6930:Fry UTSW 5 150,351,695 (GRCm39) missense probably benign 0.00
R6963:Fry UTSW 5 150,381,309 (GRCm39) missense probably benign 0.17
R6965:Fry UTSW 5 150,339,685 (GRCm39) missense possibly damaging 0.79
R7051:Fry UTSW 5 150,318,634 (GRCm39) missense possibly damaging 0.93
R7085:Fry UTSW 5 150,362,214 (GRCm39) missense probably benign 0.02
R7108:Fry UTSW 5 150,414,555 (GRCm39) missense
R7108:Fry UTSW 5 150,319,251 (GRCm39) missense probably damaging 1.00
R7115:Fry UTSW 5 150,309,532 (GRCm39) missense probably damaging 1.00
R7116:Fry UTSW 5 150,319,334 (GRCm39) critical splice donor site probably null
R7197:Fry UTSW 5 150,393,232 (GRCm39) missense
R7256:Fry UTSW 5 150,390,251 (GRCm39) missense
R7318:Fry UTSW 5 150,360,458 (GRCm39) missense probably damaging 0.98
R7323:Fry UTSW 5 150,419,814 (GRCm39) missense
R7358:Fry UTSW 5 150,339,788 (GRCm39) missense probably benign
R7361:Fry UTSW 5 150,360,312 (GRCm39) missense possibly damaging 0.92
R7395:Fry UTSW 5 150,304,348 (GRCm39) missense possibly damaging 0.82
R7487:Fry UTSW 5 150,338,039 (GRCm39) missense possibly damaging 0.79
R7491:Fry UTSW 5 150,389,791 (GRCm39) missense
R7574:Fry UTSW 5 150,304,359 (GRCm39) missense probably benign 0.00
R7582:Fry UTSW 5 150,419,847 (GRCm39) missense
R7586:Fry UTSW 5 150,349,683 (GRCm39) missense probably damaging 1.00
R7650:Fry UTSW 5 150,336,883 (GRCm39) missense probably damaging 1.00
R7699:Fry UTSW 5 150,328,792 (GRCm39) missense probably damaging 0.98
R7700:Fry UTSW 5 150,328,792 (GRCm39) missense probably damaging 0.98
R7972:Fry UTSW 5 150,233,861 (GRCm39) missense probably benign 0.05
R8058:Fry UTSW 5 150,419,232 (GRCm39) missense
R8070:Fry UTSW 5 150,401,472 (GRCm39) missense
R8159:Fry UTSW 5 150,322,998 (GRCm39) missense probably benign 0.31
R8202:Fry UTSW 5 150,355,202 (GRCm39) missense probably damaging 1.00
R8261:Fry UTSW 5 150,369,372 (GRCm39) missense probably damaging 1.00
R8279:Fry UTSW 5 150,419,726 (GRCm39) missense
R8338:Fry UTSW 5 150,282,516 (GRCm39) missense probably damaging 0.99
R8370:Fry UTSW 5 150,319,284 (GRCm39) missense probably damaging 1.00
R8673:Fry UTSW 5 150,318,576 (GRCm39) missense possibly damaging 0.91
R8786:Fry UTSW 5 150,317,501 (GRCm39) missense probably benign 0.00
R8815:Fry UTSW 5 150,317,603 (GRCm39) missense possibly damaging 0.80
R8847:Fry UTSW 5 150,309,472 (GRCm39) missense
R9023:Fry UTSW 5 150,360,768 (GRCm39) missense probably benign 0.00
R9025:Fry UTSW 5 150,219,273 (GRCm39) intron probably benign
R9125:Fry UTSW 5 150,269,525 (GRCm39) missense probably damaging 0.97
R9172:Fry UTSW 5 150,336,793 (GRCm39) missense probably benign
R9262:Fry UTSW 5 150,305,109 (GRCm39) missense probably damaging 1.00
R9263:Fry UTSW 5 150,322,728 (GRCm39) missense probably damaging 1.00
R9293:Fry UTSW 5 150,419,297 (GRCm39) missense
R9368:Fry UTSW 5 150,401,403 (GRCm39) missense
R9401:Fry UTSW 5 150,302,403 (GRCm39) missense probably damaging 1.00
R9402:Fry UTSW 5 150,360,318 (GRCm39) missense probably damaging 1.00
R9402:Fry UTSW 5 150,357,161 (GRCm39) missense possibly damaging 0.91
R9420:Fry UTSW 5 150,356,994 (GRCm39) missense possibly damaging 0.72
R9557:Fry UTSW 5 150,389,781 (GRCm39) missense
R9647:Fry UTSW 5 150,292,984 (GRCm39) missense probably damaging 1.00
R9650:Fry UTSW 5 150,369,375 (GRCm39) missense probably damaging 1.00
R9655:Fry UTSW 5 150,362,251 (GRCm39) missense possibly damaging 0.90
R9664:Fry UTSW 5 150,282,488 (GRCm39) missense probably damaging 0.98
R9668:Fry UTSW 5 150,282,318 (GRCm39) missense probably damaging 1.00
R9732:Fry UTSW 5 150,328,758 (GRCm39) missense probably benign 0.00
R9773:Fry UTSW 5 150,322,728 (GRCm39) missense probably damaging 1.00
Z1177:Fry UTSW 5 150,233,902 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GACTCATACTTCCCAACTCCATG -3'
(R):5'- CGAAGGCCGAGAAGACACT -3'

Sequencing Primer
(F):5'- AACTCCATGCCTCTAAATCTTTGTTG -3'
(R):5'- ACACTGAAGGAGGTCGCC -3'
Posted On 2018-08-01