Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01141:Vpreb1a'

52971

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vpreb1a

Ensembl Gene

ENSMUSG00000059305

Gene Name

V-set pre-B cell surrogate light chain 1A

Synonyms

Vpreb1, Vpreb-1, CD179a

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL01141

Quality Score

Status

Chromosome

Chromosomal Location

16686265-16687119 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 16686951 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 9 (M9V)

Ref Sequence

ENSEMBL: ENSMUSP00000074537 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023465] [ENSMUST00000075017] [ENSMUST00000232080] [ENSMUST00000232547] [ENSMUST00000232231] [ENSMUST00000232017] [ENSMUST00000232200] [ENSMUST00000232581] [ENSMUST00000231812]

AlphaFold

P13372

Predicted Effect

probably benign
Transcript: ENSMUST00000023465

SMART Domains

Protein: ENSMUSP00000023465
Gene: ENSMUSG00000022779

Domain	Start	End	E-Value	Type
TOPRIM	3	138	2.64e-27	SMART
TOP1Bc	146	242	3.84e-38	SMART
TOP1Ac	289	545	2.28e-104	SMART
low complexity region	824	850	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000075017
AA Change: M9V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000074537
Gene: ENSMUSG00000059305
AA Change: M9V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
IGv	36	117	3.96e-25	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118424

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125202

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132272

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135276

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135597

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138618

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232531

Predicted Effect

probably benign
Transcript: ENSMUST00000232080

Predicted Effect

probably benign
Transcript: ENSMUST00000232547

Predicted Effect

probably benign
Transcript: ENSMUST00000232231

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231278

Predicted Effect

probably benign
Transcript: ENSMUST00000232017

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231704

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231345

Predicted Effect

probably benign
Transcript: ENSMUST00000232200

Predicted Effect

probably benign
Transcript: ENSMUST00000232581

Predicted Effect

probably benign
Transcript: ENSMUST00000231812

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231576

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232380

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232670

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mutants have fewer cells with functional pre-B cell receptors. Double knockouts homozygous for null mutations at Vpreb1 and Vpreb2 show impaired B-cell development. Fewer B-cells are found in bone marrow, spleen and peritoneum. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	A	T	11: 109,828,556 (GRCm39)	D1447E	probably damaging	Het
Atp2a3	T	C	11: 72,873,491 (GRCm39)	I788T	probably damaging	Het
Axin1	G	A	17: 26,409,015 (GRCm39)	E672K	probably damaging	Het
Ccno	A	G	13: 113,125,561 (GRCm39)	D175G	probably damaging	Het
Cep83	C	A	10: 94,624,619 (GRCm39)	T632K	probably benign	Het
Ckmt1	A	T	2: 121,193,474 (GRCm39)	I345F	probably benign	Het
Cntnap1	G	A	11: 101,069,633 (GRCm39)		probably benign	Het
Cstdc3	A	G	16: 36,128,426 (GRCm39)	E7G	probably benign	Het
Edem2	A	G	2: 155,550,948 (GRCm39)	Y340H	probably benign	Het
Erich3	A	G	3: 154,419,653 (GRCm39)	K249R	probably benign	Het
Fndc9	T	C	11: 46,128,526 (GRCm39)	I15T	probably benign	Het
Grip2	G	T	6: 91,759,878 (GRCm39)	Q300K	probably benign	Het
Herc2	T	C	7: 55,862,589 (GRCm39)	V4050A	possibly damaging	Het
Jup	A	T	11: 100,277,075 (GRCm39)	D44E	probably benign	Het
Lingo3	G	T	10: 80,671,147 (GRCm39)	P261Q	probably damaging	Het
Lrrfip2	C	T	9: 111,048,783 (GRCm39)	R311W	probably damaging	Het
Mansc1	C	A	6: 134,598,748 (GRCm39)	L56F	probably benign	Het
Map1b	A	G	13: 99,571,269 (GRCm39)	I484T	probably damaging	Het
Mpeg1	T	A	19: 12,440,149 (GRCm39)	F536I	probably damaging	Het
Mrgprb1	T	G	7: 48,097,775 (GRCm39)	T46P	probably benign	Het
Mug1	A	G	6: 121,847,458 (GRCm39)	N612S	probably benign	Het
Or5p56	T	C	7: 107,589,758 (GRCm39)	F62S	probably damaging	Het
Or6c212	T	A	10: 129,558,814 (GRCm39)	I200L	probably benign	Het
Pax8	A	G	2: 24,331,162 (GRCm39)	S178P	probably damaging	Het
Peak1	A	G	9: 56,165,811 (GRCm39)	F706L	probably benign	Het
Prkdc	A	G	16: 15,544,568 (GRCm39)	T1853A	probably damaging	Het
Reln	A	C	5: 22,174,031 (GRCm39)	F2024C	probably damaging	Het
Reln	G	T	5: 22,124,067 (GRCm39)	P2813Q	probably damaging	Het
Riox1	A	G	12: 83,998,568 (GRCm39)	Q368R	probably damaging	Het
Rspry1	T	C	8: 95,376,483 (GRCm39)	V335A	probably benign	Het
Scn3a	T	C	2: 65,325,457 (GRCm39)	N1020S	possibly damaging	Het
Scyl2	A	G	10: 89,476,497 (GRCm39)	V876A	probably benign	Het
Sdhaf3	T	A	6: 6,956,141 (GRCm39)	F39I	probably damaging	Het
Sfxn4	T	C	19: 60,839,452 (GRCm39)	E202G	possibly damaging	Het
Slc1a4	A	T	11: 20,258,644 (GRCm39)		probably benign	Het
Sln	A	G	9: 53,760,784 (GRCm39)	I10V	probably benign	Het
Ssh2	A	G	11: 77,340,552 (GRCm39)	E568G	probably damaging	Het
Supt7l	G	A	5: 31,675,779 (GRCm39)	P270S	probably benign	Het
Tanc2	A	G	11: 105,777,300 (GRCm39)		probably benign	Het
Tatdn1	A	T	15: 58,781,416 (GRCm39)		probably benign	Het
Tfip11	C	T	5: 112,477,369 (GRCm39)	P117L	possibly damaging	Het

Other mutations in Vpreb1a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02232:Vpreb1a	APN	16	16,686,603 (GRCm39)	missense	possibly damaging	0.95
R1824:Vpreb1a	UTSW	16	16,686,935 (GRCm39)	splice site	probably null
R1836:Vpreb1a	UTSW	16	16,686,933 (GRCm39)	missense	probably benign	0.17
R3625:Vpreb1a	UTSW	16	16,686,668 (GRCm39)	missense	probably benign	0.01
R5239:Vpreb1a	UTSW	16	16,686,592 (GRCm39)	nonsense	probably null
R5446:Vpreb1a	UTSW	16	16,686,554 (GRCm39)	missense	probably damaging	0.99
R6692:Vpreb1a	UTSW	16	16,686,666 (GRCm39)	missense	probably damaging	1.00
R6996:Vpreb1a	UTSW	16	16,686,678 (GRCm39)	missense	probably damaging	1.00
R7388:Vpreb1a	UTSW	16	16,686,516 (GRCm39)	missense	probably benign

Posted On

2013-06-21