Incidental Mutation 'R6728:Platr25'
ID 529952
Institutional Source Beutler Lab
Gene Symbol Platr25
Ensembl Gene ENSMUSG00000074863
Gene Name pluripotency associated transcript 25
Synonyms Gm5665, 6720490N10Rik
MMRRC Submission 044846-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R6728 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 62819598-62908523 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 62848197 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 222 (H222Y)
Ref Sequence ENSEMBL: ENSMUSP00000152625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143260] [ENSMUST00000220733] [ENSMUST00000222303] [ENSMUST00000222477] [ENSMUST00000222602] [ENSMUST00000223219] [ENSMUST00000223528]
AlphaFold A0A1Y7VIZ1
Predicted Effect probably benign
Transcript: ENSMUST00000143260
Predicted Effect probably benign
Transcript: ENSMUST00000220733
Predicted Effect probably benign
Transcript: ENSMUST00000222303
Predicted Effect probably benign
Transcript: ENSMUST00000222477
Predicted Effect probably damaging
Transcript: ENSMUST00000222602
AA Change: H222Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000223219
Predicted Effect probably benign
Transcript: ENSMUST00000223528
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,384,645 (GRCm39) Y440C possibly damaging Het
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Adcy5 T A 16: 34,977,535 (GRCm39) V356E possibly damaging Het
Agmat G T 4: 141,476,897 (GRCm39) C101F probably benign Het
Aoc1l3 T C 6: 48,965,779 (GRCm39) S596P possibly damaging Het
Atl1 T C 12: 69,994,324 (GRCm39) V276A possibly damaging Het
Barhl1 G A 2: 28,805,495 (GRCm39) P66L probably benign Het
Camk4 A T 18: 33,317,992 (GRCm39) E383V probably benign Het
Cap2 G A 13: 46,793,335 (GRCm39) E234K possibly damaging Het
Col24a1 A T 3: 145,020,957 (GRCm39) M443L probably benign Het
Cyp17a1 A G 19: 46,657,673 (GRCm39) V293A probably benign Het
Epha6 C A 16: 60,245,198 (GRCm39) A334S possibly damaging Het
Frmpd1 T C 4: 45,284,664 (GRCm39) S1162P probably benign Het
Hspbp1 T A 7: 4,663,781 (GRCm39) M355L possibly damaging Het
Insrr C T 3: 87,720,873 (GRCm39) R1044C probably damaging Het
Kin G A 2: 10,094,959 (GRCm39) R82Q possibly damaging Het
Ninl G T 2: 150,817,777 (GRCm39) S129* probably null Het
Or11h4 T C 14: 50,974,296 (GRCm39) T108A possibly damaging Het
Or4k35 A T 2: 111,100,018 (GRCm39) D231E probably benign Het
Paqr5 C T 9: 61,871,065 (GRCm39) R171Q probably damaging Het
Plcb2 G T 2: 118,554,171 (GRCm39) S94Y probably damaging Het
Rock2 T C 12: 17,011,737 (GRCm39) Y722H probably benign Het
Sh3kbp1 A T X: 158,624,176 (GRCm39) E39D probably benign Homo
Thsd4 T C 9: 59,904,480 (GRCm39) D572G probably benign Het
Tnrc6b T A 15: 80,802,727 (GRCm39) L1510H probably damaging Het
Tsc2 A G 17: 24,840,098 (GRCm39) S433P probably damaging Het
Vegfc T C 8: 54,639,057 (GRCm39) V401A probably damaging Het
Vwa3b A G 1: 37,196,453 (GRCm39) M27V probably damaging Het
Other mutations in Platr25
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6272:Platr25 UTSW 13 62,820,811 (GRCm39) missense possibly damaging 0.82
R6379:Platr25 UTSW 13 62,854,051 (GRCm39) missense probably damaging 1.00
R6548:Platr25 UTSW 13 62,821,623 (GRCm39) missense possibly damaging 0.93
R6951:Platr25 UTSW 13 62,853,562 (GRCm39) missense probably benign 0.00
R7365:Platr25 UTSW 13 62,848,719 (GRCm39) missense probably benign
R7885:Platr25 UTSW 13 62,848,676 (GRCm39) missense possibly damaging 0.91
R8114:Platr25 UTSW 13 62,821,738 (GRCm39) missense possibly damaging 0.66
R8331:Platr25 UTSW 13 62,848,717 (GRCm39) missense probably benign 0.01
R8514:Platr25 UTSW 13 62,848,586 (GRCm39) missense probably damaging 1.00
R8754:Platr25 UTSW 13 62,847,924 (GRCm39) makesense probably null
R8822:Platr25 UTSW 13 62,848,658 (GRCm39) missense probably benign 0.45
R9011:Platr25 UTSW 13 62,848,280 (GRCm39) missense probably damaging 1.00
R9038:Platr25 UTSW 13 62,848,007 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGAGGGTTTCTTGCCAAT -3'
(R):5'- TCTCCAAAAGCATAGAAGGACAC -3'

Sequencing Primer
(F):5'- GCTTTTGAAGATGCCTGTGACATAC -3'
(R):5'- GCATAGAAGGACACACACAGG -3'
Posted On 2018-08-01