Incidental Mutation 'R6733:Zfp942'
| ID |
530162 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp942
|
| Ensembl Gene |
ENSMUSG00000071267 |
| Gene Name |
zinc finger protein 942 |
| Synonyms |
3110048L19Rik |
| MMRRC Submission |
044851-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
R6733 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
22145941-22181445 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 22147733 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Stop codon
at position 299
(E299*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000089494
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074295]
[ENSMUST00000091879]
|
| AlphaFold |
B8JJA7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000074295
AA Change: E299*
|
| SMART Domains |
Protein: ENSMUSP00000073907
Gene: ENSMUSG00000071267
AA Change: E299*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
69 |
6.55e-19 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.99e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000091879
AA Change: E299*
|
| SMART Domains |
Protein: ENSMUSP00000089494
Gene: ENSMUSG00000071267
AA Change: E299*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
69 |
6.55e-19 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.99e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afdn |
C |
T |
17: 14,043,615 (GRCm39) |
H358Y |
probably benign |
Het |
| Aoc1l2 |
T |
C |
6: 48,907,464 (GRCm39) |
S155P |
probably damaging |
Het |
| Ccdc125 |
T |
A |
13: 100,830,995 (GRCm39) |
M394K |
probably benign |
Het |
| Cfd |
C |
A |
10: 79,727,636 (GRCm39) |
H103Q |
probably damaging |
Het |
| Cnot2 |
G |
A |
10: 116,334,058 (GRCm39) |
P371S |
possibly damaging |
Het |
| Dedd2 |
T |
C |
7: 24,903,332 (GRCm39) |
E209G |
probably benign |
Het |
| Dnah3 |
A |
G |
7: 119,522,197 (GRCm39) |
S3999P |
probably benign |
Het |
| Fer1l5 |
T |
C |
1: 36,447,753 (GRCm39) |
|
probably null |
Het |
| H6pd |
A |
T |
4: 150,069,578 (GRCm39) |
|
probably null |
Het |
| Il25 |
T |
C |
14: 55,170,490 (GRCm39) |
I21T |
probably benign |
Het |
| Kmt2c |
C |
T |
5: 25,614,291 (GRCm39) |
S143N |
probably damaging |
Het |
| Marveld3 |
T |
C |
8: 110,688,681 (GRCm39) |
D20G |
possibly damaging |
Het |
| Msl1 |
A |
G |
11: 98,690,882 (GRCm39) |
E122G |
probably damaging |
Het |
| Obscn |
A |
T |
11: 58,919,421 (GRCm39) |
V6861E |
probably damaging |
Het |
| Or5b97 |
A |
T |
19: 12,878,605 (GRCm39) |
C180S |
probably damaging |
Het |
| Phc1 |
A |
T |
6: 122,313,845 (GRCm39) |
M29K |
possibly damaging |
Het |
| Pkd1l3 |
T |
A |
8: 110,375,126 (GRCm39) |
|
probably null |
Het |
| Prl5a1 |
G |
T |
13: 28,333,919 (GRCm39) |
V141F |
possibly damaging |
Het |
| Psg20 |
A |
T |
7: 18,408,547 (GRCm39) |
V391D |
probably damaging |
Het |
| Ptprh |
T |
C |
7: 4,606,043 (GRCm39) |
|
probably null |
Het |
| Rasa3 |
T |
C |
8: 13,630,037 (GRCm39) |
E580G |
possibly damaging |
Het |
| Ror1 |
T |
C |
4: 100,283,252 (GRCm39) |
V439A |
probably benign |
Het |
| Rsl1 |
A |
G |
13: 67,325,206 (GRCm39) |
T81A |
probably benign |
Het |
| Sgpp1 |
G |
C |
12: 75,782,243 (GRCm39) |
P32R |
probably benign |
Het |
| Slc22a8 |
T |
C |
19: 8,586,656 (GRCm39) |
L389P |
probably benign |
Het |
| Slc6a11 |
A |
G |
6: 114,111,859 (GRCm39) |
Y142C |
probably damaging |
Het |
| Syt9 |
C |
T |
7: 107,024,503 (GRCm39) |
T132I |
probably damaging |
Het |
| Thop1 |
T |
A |
10: 80,917,246 (GRCm39) |
I583N |
probably damaging |
Het |
| Tom1l1 |
A |
G |
11: 90,575,886 (GRCm39) |
|
probably null |
Het |
| Unk |
A |
G |
11: 115,941,581 (GRCm39) |
D276G |
probably damaging |
Het |
| Zkscan6 |
A |
G |
11: 65,719,461 (GRCm39) |
T494A |
probably damaging |
Het |
| Zscan25 |
T |
A |
5: 145,227,723 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zfp942 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Zfp942
|
APN |
17 |
22,148,042 (GRCm39) |
missense |
probably benign |
|
|
IGL00586:Zfp942
|
APN |
17 |
22,147,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02973:Zfp942
|
APN |
17 |
22,151,972 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03212:Zfp942
|
APN |
17 |
22,148,445 (GRCm39) |
nonsense |
probably null |
|
|
IGL03382:Zfp942
|
APN |
17 |
22,148,083 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0008:Zfp942
|
UTSW |
17 |
22,147,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Zfp942
|
UTSW |
17 |
22,148,066 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0244:Zfp942
|
UTSW |
17 |
22,147,553 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0369:Zfp942
|
UTSW |
17 |
22,148,017 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1664:Zfp942
|
UTSW |
17 |
22,147,420 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1824:Zfp942
|
UTSW |
17 |
22,147,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4545:Zfp942
|
UTSW |
17 |
22,147,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4785:Zfp942
|
UTSW |
17 |
22,148,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5493:Zfp942
|
UTSW |
17 |
22,151,985 (GRCm39) |
missense |
probably null |
0.66 |
|
R6568:Zfp942
|
UTSW |
17 |
22,148,043 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7650:Zfp942
|
UTSW |
17 |
22,147,818 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7935:Zfp942
|
UTSW |
17 |
22,148,208 (GRCm39) |
nonsense |
probably null |
|
|
R8065:Zfp942
|
UTSW |
17 |
22,149,391 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8067:Zfp942
|
UTSW |
17 |
22,149,391 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8237:Zfp942
|
UTSW |
17 |
22,147,226 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8513:Zfp942
|
UTSW |
17 |
22,147,282 (GRCm39) |
missense |
probably benign |
|
|
R9468:Zfp942
|
UTSW |
17 |
22,148,422 (GRCm39) |
missense |
probably benign |
0.24 |
|
R9539:Zfp942
|
UTSW |
17 |
22,148,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Zfp942
|
UTSW |
17 |
22,147,463 (GRCm39) |
missense |
probably benign |
0.05 |
|
X0025:Zfp942
|
UTSW |
17 |
22,148,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTCGTAGGTAAAGCATTTGTCAC -3'
(R):5'- CTTGGGCTGAAACAAACCAATAG -3'
Sequencing Primer
(F):5'- GGTAAAGCATTTGTCACATTCACTAC -3'
(R):5'- GTGAATGTTCCAGATGCTTCACCAAG -3'
|
| Posted On |
2018-08-01 |
Incidental Mutation