Incidental Mutation 'R6735:Nts'
ID 530191
Institutional Source Beutler Lab
Gene Symbol Nts
Ensembl Gene ENSMUSG00000019890
Gene Name neurotensin
Synonyms 5033428E16Rik, NT/N, NTS1, NMN-125, neuromedin N
MMRRC Submission 044853-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6735 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 102317617-102326294 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102320859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 77 (M77L)
Ref Sequence ENSEMBL: ENSMUSP00000020040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020040]
AlphaFold Q9D3P9
Predicted Effect probably benign
Transcript: ENSMUST00000020040
AA Change: M77L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000020040
Gene: ENSMUSG00000019890
AA Change: M77L

DomainStartEndE-ValueType
Pfam:Pro-NT_NN 3 169 2.4e-77 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.5%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation are viable, fertile, and grossly normal, but display altered responses to antipsychotic drugs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik A G 4: 148,026,274 (GRCm39) T265A probably benign Het
Adap1 A T 5: 139,278,900 (GRCm39) Y127N probably damaging Het
Alg8 T C 7: 97,032,189 (GRCm39) F246S probably benign Het
Alpk1 A G 3: 127,518,098 (GRCm39) Y68H probably damaging Het
Arhgef5 T C 6: 43,251,966 (GRCm39) S906P probably benign Het
C9 A T 15: 6,519,387 (GRCm39) D408V probably benign Het
Cnot2 G A 10: 116,334,058 (GRCm39) P371S possibly damaging Het
Cpeb4 T A 11: 31,874,700 (GRCm39) Y174N probably benign Het
Enpp3 A G 10: 24,683,351 (GRCm39) Y289H probably damaging Het
Erbin A T 13: 104,020,718 (GRCm39) D80E probably damaging Het
Fgd6 A T 10: 93,910,182 (GRCm39) E829V possibly damaging Het
Foxn2 T G 17: 88,794,223 (GRCm39) S387A probably benign Het
Hapstr1 T A 16: 8,673,764 (GRCm39) H230Q probably benign Het
Irag2 T C 6: 145,106,619 (GRCm39) L201S probably damaging Het
Kif13a A G 13: 46,906,222 (GRCm39) S574P possibly damaging Het
Lhx6 T G 2: 35,981,390 (GRCm39) D67A probably damaging Het
Lmbr1l A T 15: 98,807,121 (GRCm39) M220K probably damaging Het
Macroh2a2 A G 10: 61,577,046 (GRCm39) I274T probably damaging Het
Naa35 T C 13: 59,773,378 (GRCm39) L111P probably damaging Het
Notch2 T A 3: 98,041,902 (GRCm39) V1307E probably damaging Het
Or5m11b A C 2: 85,805,778 (GRCm39) S64R possibly damaging Het
Pigz A G 16: 31,764,361 (GRCm39) N473S probably benign Het
Pkd2 A G 5: 104,628,195 (GRCm39) D423G probably damaging Het
Plac8 A G 5: 100,710,485 (GRCm39) probably null Het
Ppp2r2b T C 18: 42,821,653 (GRCm39) probably null Het
Proc T C 18: 32,256,701 (GRCm39) N322S probably benign Het
Prpf40b C T 15: 99,212,784 (GRCm39) R627W probably damaging Het
Psd3 A G 8: 68,573,398 (GRCm39) probably null Het
Safb A G 17: 56,892,169 (GRCm39) probably benign Het
Scnn1g A G 7: 121,341,486 (GRCm39) D216G probably benign Het
Septin7 A G 9: 25,215,048 (GRCm39) E345G possibly damaging Het
Sult2a5 A T 7: 13,398,983 (GRCm39) K197* probably null Het
Suv39h1 C A X: 7,929,138 (GRCm39) R397L probably damaging Homo
Thbs4 T A 13: 92,891,674 (GRCm39) M814L possibly damaging Het
Tmem14a T A 1: 21,299,805 (GRCm39) probably benign Het
Tmprss11d C A 5: 86,457,159 (GRCm39) A167S probably damaging Het
Ttn C A 2: 76,629,252 (GRCm39) C14362F probably damaging Het
Usp15 T C 10: 123,004,272 (GRCm39) I161V possibly damaging Het
Vmn1r67 T C 7: 10,181,138 (GRCm39) L134P probably damaging Het
Wdr74 A G 19: 8,713,586 (GRCm39) E73G possibly damaging Het
Zbtb49 A T 5: 38,358,402 (GRCm39) M617K possibly damaging Het
Zc3h3 G A 15: 75,628,483 (GRCm39) T937I probably benign Het
Zeb2 C T 2: 45,000,028 (GRCm39) V25M probably null Het
Zfp108 T C 7: 23,961,197 (GRCm39) F596S probably damaging Het
Zfyve1 T A 12: 83,641,618 (GRCm39) N13Y possibly damaging Het
Zswim2 T C 2: 83,754,105 (GRCm39) D185G probably benign Het
Other mutations in Nts
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02475:Nts APN 10 102,326,108 (GRCm39) splice site probably benign
IGL02585:Nts APN 10 102,318,329 (GRCm39) missense probably benign 0.01
IGL02838:Nts APN 10 102,318,290 (GRCm39) missense probably damaging 0.98
R1962:Nts UTSW 10 102,320,918 (GRCm39) missense probably damaging 1.00
R4433:Nts UTSW 10 102,320,888 (GRCm39) missense probably benign 0.00
R6063:Nts UTSW 10 102,320,856 (GRCm39) missense probably benign 0.25
R7640:Nts UTSW 10 102,326,165 (GRCm39) missense possibly damaging 0.74
R7723:Nts UTSW 10 102,320,784 (GRCm39) missense probably damaging 1.00
R8458:Nts UTSW 10 102,320,921 (GRCm39) missense probably damaging 0.98
R8886:Nts UTSW 10 102,320,868 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTAAGTCTCCCTGCTATGATCG -3'
(R):5'- TTCACACAGTCCAAGCATGTTCC -3'

Sequencing Primer
(F):5'- TCTAGGTTGCATACAAGTGACAGCC -3'
(R):5'- AGTCCTCCGTCTTGGAAA -3'
Posted On 2018-08-01