Incidental Mutation 'IGL01077:Zfp945'
ID |
53020 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp945
|
Ensembl Gene |
ENSMUSG00000059142 |
Gene Name |
zinc finger protein 945 |
Synonyms |
C730040L01Rik, A630033E08Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.063)
|
Stock # |
IGL01077
|
Quality Score |
|
Status
|
|
Chromosome |
17 |
Chromosomal Location |
23065671-23086108 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 23071359 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 180
(K180R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000086074
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088696]
[ENSMUST00000150092]
[ENSMUST00000160457]
|
AlphaFold |
F6WAU7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000088696
AA Change: K180R
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000086074 Gene: ENSMUSG00000059142 AA Change: K180R
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
68 |
9.12e-18 |
SMART |
ZnF_C2H2
|
210 |
232 |
1.45e-2 |
SMART |
ZnF_C2H2
|
238 |
260 |
1.03e-2 |
SMART |
ZnF_C2H2
|
266 |
288 |
1.76e-1 |
SMART |
ZnF_C2H2
|
322 |
344 |
7.37e-4 |
SMART |
ZnF_C2H2
|
350 |
372 |
1.5e-4 |
SMART |
ZnF_C2H2
|
378 |
400 |
5.14e-3 |
SMART |
ZnF_C2H2
|
406 |
428 |
9.73e-4 |
SMART |
ZnF_C2H2
|
434 |
456 |
2.99e-4 |
SMART |
ZnF_C2H2
|
462 |
484 |
4.54e-4 |
SMART |
ZnF_C2H2
|
490 |
512 |
2.4e-3 |
SMART |
ZnF_C2H2
|
518 |
540 |
1.38e-3 |
SMART |
ZnF_C2H2
|
546 |
568 |
1.13e-4 |
SMART |
ZnF_C2H2
|
574 |
596 |
5.59e-4 |
SMART |
ZnF_C2H2
|
602 |
624 |
9.31e1 |
SMART |
ZnF_C2H2
|
630 |
652 |
7.9e-4 |
SMART |
ZnF_C2H2
|
658 |
680 |
3.69e-4 |
SMART |
ZnF_C2H2
|
686 |
708 |
3.16e-3 |
SMART |
ZnF_C2H2
|
714 |
736 |
2.95e-3 |
SMART |
ZnF_C2H2
|
742 |
764 |
1.98e-4 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000095615
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000150092
|
SMART Domains |
Protein: ENSMUSP00000117978 Gene: ENSMUSG00000059142
Domain | Start | End | E-Value | Type |
KRAB
|
34 |
89 |
9.12e-18 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000160457
AA Change: K201R
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000124123 Gene: ENSMUSG00000059142 AA Change: K201R
Domain | Start | End | E-Value | Type |
KRAB
|
34 |
89 |
9.12e-18 |
SMART |
ZnF_C2H2
|
231 |
253 |
1.45e-2 |
SMART |
ZnF_C2H2
|
259 |
281 |
1.03e-2 |
SMART |
ZnF_C2H2
|
287 |
309 |
1.76e-1 |
SMART |
ZnF_C2H2
|
343 |
365 |
7.37e-4 |
SMART |
ZnF_C2H2
|
371 |
393 |
1.5e-4 |
SMART |
ZnF_C2H2
|
399 |
421 |
5.14e-3 |
SMART |
ZnF_C2H2
|
427 |
449 |
9.73e-4 |
SMART |
ZnF_C2H2
|
455 |
477 |
2.99e-4 |
SMART |
ZnF_C2H2
|
483 |
505 |
4.54e-4 |
SMART |
ZnF_C2H2
|
511 |
533 |
2.4e-3 |
SMART |
ZnF_C2H2
|
539 |
561 |
1.38e-3 |
SMART |
ZnF_C2H2
|
567 |
589 |
1.13e-4 |
SMART |
ZnF_C2H2
|
595 |
617 |
5.59e-4 |
SMART |
ZnF_C2H2
|
623 |
645 |
9.31e1 |
SMART |
ZnF_C2H2
|
651 |
673 |
7.9e-4 |
SMART |
ZnF_C2H2
|
679 |
701 |
3.69e-4 |
SMART |
ZnF_C2H2
|
707 |
729 |
3.16e-3 |
SMART |
ZnF_C2H2
|
735 |
757 |
2.95e-3 |
SMART |
ZnF_C2H2
|
763 |
785 |
1.98e-4 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 28 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aox1 |
A |
T |
1: 58,096,569 (GRCm39) |
|
probably benign |
Het |
Arhgap4 |
A |
G |
X: 72,943,699 (GRCm39) |
|
probably benign |
Het |
Ascc3 |
T |
G |
10: 50,525,413 (GRCm39) |
|
probably benign |
Het |
Cacng5 |
C |
T |
11: 107,772,531 (GRCm39) |
V106I |
probably benign |
Het |
Car10 |
T |
C |
11: 93,487,969 (GRCm39) |
I222T |
possibly damaging |
Het |
Cep250 |
G |
A |
2: 155,804,054 (GRCm39) |
V55M |
probably damaging |
Het |
Chst4 |
T |
A |
8: 110,756,597 (GRCm39) |
Y422F |
probably benign |
Het |
Dnajc13 |
T |
C |
9: 104,108,220 (GRCm39) |
E185G |
probably benign |
Het |
Dtx2 |
T |
A |
5: 136,058,057 (GRCm39) |
M454K |
possibly damaging |
Het |
Flg2 |
T |
A |
3: 93,127,513 (GRCm39) |
S2142T |
unknown |
Het |
Ganc |
C |
T |
2: 120,276,996 (GRCm39) |
T686M |
possibly damaging |
Het |
Gm53 |
C |
T |
11: 96,142,594 (GRCm39) |
|
noncoding transcript |
Het |
Gria3 |
T |
C |
X: 40,677,369 (GRCm39) |
V254A |
possibly damaging |
Het |
H2-DMb2 |
G |
T |
17: 34,367,587 (GRCm39) |
A3S |
probably damaging |
Het |
H2-DMb2 |
A |
G |
17: 34,366,694 (GRCm39) |
Y42C |
probably damaging |
Het |
Mtrex |
A |
T |
13: 113,051,023 (GRCm39) |
I184K |
probably damaging |
Het |
Myzap |
T |
C |
9: 71,454,042 (GRCm39) |
E343G |
probably damaging |
Het |
Nap1l2 |
T |
C |
X: 102,228,922 (GRCm39) |
D332G |
probably benign |
Het |
Npr1 |
T |
G |
3: 90,365,669 (GRCm39) |
D628A |
probably damaging |
Het |
Raet1e |
T |
C |
10: 22,057,219 (GRCm39) |
L181S |
probably damaging |
Het |
Rnf43 |
G |
T |
11: 87,622,718 (GRCm39) |
M606I |
probably benign |
Het |
Serpinb6b |
G |
A |
13: 33,162,049 (GRCm39) |
D283N |
possibly damaging |
Het |
Slit2 |
A |
G |
5: 48,374,785 (GRCm39) |
|
probably null |
Het |
Supt5 |
C |
T |
7: 28,023,213 (GRCm39) |
W323* |
probably null |
Het |
Svep1 |
T |
A |
4: 58,068,760 (GRCm39) |
I3009F |
possibly damaging |
Het |
Tedc1 |
C |
T |
12: 113,126,808 (GRCm39) |
R357* |
probably null |
Het |
Tll1 |
T |
C |
8: 64,523,266 (GRCm39) |
Y482C |
probably benign |
Het |
Trappc8 |
G |
A |
18: 20,970,035 (GRCm39) |
T985I |
probably benign |
Het |
|
Other mutations in Zfp945 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00754:Zfp945
|
APN |
17 |
23,070,931 (GRCm39) |
unclassified |
probably benign |
|
IGL02706:Zfp945
|
APN |
17 |
23,076,256 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03408:Zfp945
|
APN |
17 |
23,071,511 (GRCm39) |
nonsense |
probably null |
|
Small-scale
|
UTSW |
17 |
23,069,955 (GRCm39) |
missense |
probably damaging |
1.00 |
R0427:Zfp945
|
UTSW |
17 |
23,084,226 (GRCm39) |
missense |
probably benign |
0.10 |
R0718:Zfp945
|
UTSW |
17 |
23,070,004 (GRCm39) |
missense |
probably damaging |
1.00 |
R1305:Zfp945
|
UTSW |
17 |
23,071,360 (GRCm39) |
missense |
probably damaging |
0.97 |
R1801:Zfp945
|
UTSW |
17 |
23,070,736 (GRCm39) |
missense |
probably damaging |
0.97 |
R1837:Zfp945
|
UTSW |
17 |
23,070,247 (GRCm39) |
missense |
probably damaging |
1.00 |
R2001:Zfp945
|
UTSW |
17 |
23,076,223 (GRCm39) |
critical splice donor site |
probably null |
|
R4193:Zfp945
|
UTSW |
17 |
23,070,144 (GRCm39) |
unclassified |
probably benign |
|
R4247:Zfp945
|
UTSW |
17 |
23,069,583 (GRCm39) |
missense |
probably damaging |
0.98 |
R5026:Zfp945
|
UTSW |
17 |
23,069,859 (GRCm39) |
missense |
probably damaging |
1.00 |
R5918:Zfp945
|
UTSW |
17 |
23,069,955 (GRCm39) |
missense |
probably damaging |
1.00 |
R6076:Zfp945
|
UTSW |
17 |
23,070,432 (GRCm39) |
missense |
probably damaging |
1.00 |
R6664:Zfp945
|
UTSW |
17 |
23,071,339 (GRCm39) |
missense |
probably damaging |
0.99 |
R6997:Zfp945
|
UTSW |
17 |
23,071,543 (GRCm39) |
nonsense |
probably null |
|
R7040:Zfp945
|
UTSW |
17 |
23,071,264 (GRCm39) |
missense |
probably damaging |
0.98 |
R7479:Zfp945
|
UTSW |
17 |
23,070,340 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7566:Zfp945
|
UTSW |
17 |
23,070,727 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7948:Zfp945
|
UTSW |
17 |
23,071,096 (GRCm39) |
missense |
unknown |
|
R8383:Zfp945
|
UTSW |
17 |
23,070,798 (GRCm39) |
missense |
probably benign |
0.05 |
R9776:Zfp945
|
UTSW |
17 |
23,070,582 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9790:Zfp945
|
UTSW |
17 |
23,071,228 (GRCm39) |
missense |
probably benign |
0.33 |
R9791:Zfp945
|
UTSW |
17 |
23,071,228 (GRCm39) |
missense |
probably benign |
0.33 |
X0063:Zfp945
|
UTSW |
17 |
23,071,202 (GRCm39) |
unclassified |
probably benign |
|
|
Posted On |
2013-06-21 |