Incidental Mutation 'IGL01077:Zfp945'
ID 53020
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp945
Ensembl Gene ENSMUSG00000059142
Gene Name zinc finger protein 945
Synonyms C730040L01Rik, A630033E08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL01077
Quality Score
Status
Chromosome 17
Chromosomal Location 23065671-23086108 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23071359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 180 (K180R)
Ref Sequence ENSEMBL: ENSMUSP00000086074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088696] [ENSMUST00000150092] [ENSMUST00000160457]
AlphaFold F6WAU7
Predicted Effect probably damaging
Transcript: ENSMUST00000088696
AA Change: K180R

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000086074
Gene: ENSMUSG00000059142
AA Change: K180R

DomainStartEndE-ValueType
KRAB 13 68 9.12e-18 SMART
ZnF_C2H2 210 232 1.45e-2 SMART
ZnF_C2H2 238 260 1.03e-2 SMART
ZnF_C2H2 266 288 1.76e-1 SMART
ZnF_C2H2 322 344 7.37e-4 SMART
ZnF_C2H2 350 372 1.5e-4 SMART
ZnF_C2H2 378 400 5.14e-3 SMART
ZnF_C2H2 406 428 9.73e-4 SMART
ZnF_C2H2 434 456 2.99e-4 SMART
ZnF_C2H2 462 484 4.54e-4 SMART
ZnF_C2H2 490 512 2.4e-3 SMART
ZnF_C2H2 518 540 1.38e-3 SMART
ZnF_C2H2 546 568 1.13e-4 SMART
ZnF_C2H2 574 596 5.59e-4 SMART
ZnF_C2H2 602 624 9.31e1 SMART
ZnF_C2H2 630 652 7.9e-4 SMART
ZnF_C2H2 658 680 3.69e-4 SMART
ZnF_C2H2 686 708 3.16e-3 SMART
ZnF_C2H2 714 736 2.95e-3 SMART
ZnF_C2H2 742 764 1.98e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000095615
Predicted Effect probably benign
Transcript: ENSMUST00000150092
SMART Domains Protein: ENSMUSP00000117978
Gene: ENSMUSG00000059142

DomainStartEndE-ValueType
KRAB 34 89 9.12e-18 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000160457
AA Change: K201R

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000124123
Gene: ENSMUSG00000059142
AA Change: K201R

DomainStartEndE-ValueType
KRAB 34 89 9.12e-18 SMART
ZnF_C2H2 231 253 1.45e-2 SMART
ZnF_C2H2 259 281 1.03e-2 SMART
ZnF_C2H2 287 309 1.76e-1 SMART
ZnF_C2H2 343 365 7.37e-4 SMART
ZnF_C2H2 371 393 1.5e-4 SMART
ZnF_C2H2 399 421 5.14e-3 SMART
ZnF_C2H2 427 449 9.73e-4 SMART
ZnF_C2H2 455 477 2.99e-4 SMART
ZnF_C2H2 483 505 4.54e-4 SMART
ZnF_C2H2 511 533 2.4e-3 SMART
ZnF_C2H2 539 561 1.38e-3 SMART
ZnF_C2H2 567 589 1.13e-4 SMART
ZnF_C2H2 595 617 5.59e-4 SMART
ZnF_C2H2 623 645 9.31e1 SMART
ZnF_C2H2 651 673 7.9e-4 SMART
ZnF_C2H2 679 701 3.69e-4 SMART
ZnF_C2H2 707 729 3.16e-3 SMART
ZnF_C2H2 735 757 2.95e-3 SMART
ZnF_C2H2 763 785 1.98e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 A T 1: 58,096,569 (GRCm39) probably benign Het
Arhgap4 A G X: 72,943,699 (GRCm39) probably benign Het
Ascc3 T G 10: 50,525,413 (GRCm39) probably benign Het
Cacng5 C T 11: 107,772,531 (GRCm39) V106I probably benign Het
Car10 T C 11: 93,487,969 (GRCm39) I222T possibly damaging Het
Cep250 G A 2: 155,804,054 (GRCm39) V55M probably damaging Het
Chst4 T A 8: 110,756,597 (GRCm39) Y422F probably benign Het
Dnajc13 T C 9: 104,108,220 (GRCm39) E185G probably benign Het
Dtx2 T A 5: 136,058,057 (GRCm39) M454K possibly damaging Het
Flg2 T A 3: 93,127,513 (GRCm39) S2142T unknown Het
Ganc C T 2: 120,276,996 (GRCm39) T686M possibly damaging Het
Gm53 C T 11: 96,142,594 (GRCm39) noncoding transcript Het
Gria3 T C X: 40,677,369 (GRCm39) V254A possibly damaging Het
H2-DMb2 G T 17: 34,367,587 (GRCm39) A3S probably damaging Het
H2-DMb2 A G 17: 34,366,694 (GRCm39) Y42C probably damaging Het
Mtrex A T 13: 113,051,023 (GRCm39) I184K probably damaging Het
Myzap T C 9: 71,454,042 (GRCm39) E343G probably damaging Het
Nap1l2 T C X: 102,228,922 (GRCm39) D332G probably benign Het
Npr1 T G 3: 90,365,669 (GRCm39) D628A probably damaging Het
Raet1e T C 10: 22,057,219 (GRCm39) L181S probably damaging Het
Rnf43 G T 11: 87,622,718 (GRCm39) M606I probably benign Het
Serpinb6b G A 13: 33,162,049 (GRCm39) D283N possibly damaging Het
Slit2 A G 5: 48,374,785 (GRCm39) probably null Het
Supt5 C T 7: 28,023,213 (GRCm39) W323* probably null Het
Svep1 T A 4: 58,068,760 (GRCm39) I3009F possibly damaging Het
Tedc1 C T 12: 113,126,808 (GRCm39) R357* probably null Het
Tll1 T C 8: 64,523,266 (GRCm39) Y482C probably benign Het
Trappc8 G A 18: 20,970,035 (GRCm39) T985I probably benign Het
Other mutations in Zfp945
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00754:Zfp945 APN 17 23,070,931 (GRCm39) unclassified probably benign
IGL02706:Zfp945 APN 17 23,076,256 (GRCm39) missense probably damaging 1.00
IGL03408:Zfp945 APN 17 23,071,511 (GRCm39) nonsense probably null
Small-scale UTSW 17 23,069,955 (GRCm39) missense probably damaging 1.00
R0427:Zfp945 UTSW 17 23,084,226 (GRCm39) missense probably benign 0.10
R0718:Zfp945 UTSW 17 23,070,004 (GRCm39) missense probably damaging 1.00
R1305:Zfp945 UTSW 17 23,071,360 (GRCm39) missense probably damaging 0.97
R1801:Zfp945 UTSW 17 23,070,736 (GRCm39) missense probably damaging 0.97
R1837:Zfp945 UTSW 17 23,070,247 (GRCm39) missense probably damaging 1.00
R2001:Zfp945 UTSW 17 23,076,223 (GRCm39) critical splice donor site probably null
R4193:Zfp945 UTSW 17 23,070,144 (GRCm39) unclassified probably benign
R4247:Zfp945 UTSW 17 23,069,583 (GRCm39) missense probably damaging 0.98
R5026:Zfp945 UTSW 17 23,069,859 (GRCm39) missense probably damaging 1.00
R5918:Zfp945 UTSW 17 23,069,955 (GRCm39) missense probably damaging 1.00
R6076:Zfp945 UTSW 17 23,070,432 (GRCm39) missense probably damaging 1.00
R6664:Zfp945 UTSW 17 23,071,339 (GRCm39) missense probably damaging 0.99
R6997:Zfp945 UTSW 17 23,071,543 (GRCm39) nonsense probably null
R7040:Zfp945 UTSW 17 23,071,264 (GRCm39) missense probably damaging 0.98
R7479:Zfp945 UTSW 17 23,070,340 (GRCm39) missense possibly damaging 0.93
R7566:Zfp945 UTSW 17 23,070,727 (GRCm39) missense possibly damaging 0.71
R7948:Zfp945 UTSW 17 23,071,096 (GRCm39) missense unknown
R8383:Zfp945 UTSW 17 23,070,798 (GRCm39) missense probably benign 0.05
R9776:Zfp945 UTSW 17 23,070,582 (GRCm39) missense possibly damaging 0.93
R9790:Zfp945 UTSW 17 23,071,228 (GRCm39) missense probably benign 0.33
R9791:Zfp945 UTSW 17 23,071,228 (GRCm39) missense probably benign 0.33
X0063:Zfp945 UTSW 17 23,071,202 (GRCm39) unclassified probably benign
Posted On 2013-06-21