Incidental Mutation 'R6737:Tnik'
| ID |
530221 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
044855-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6737 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 28650235 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 449
(K449N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124681
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162777]
|
| AlphaFold |
P83510 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159236
AA Change: K449N
PolyPhen 2
Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: K449N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159308
AA Change: K449N
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: K449N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159680
AA Change: K478N
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: K478N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160307
AA Change: K478N
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: K478N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160518
AA Change: K449N
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: K449N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161423
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000161964
AA Change: K449N
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: K449N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162485
AA Change: K478N
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: K478N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162777
AA Change: K478N
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: K478N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.6%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310061N02Rik |
T |
C |
16: 88,504,456 (GRCm39) |
R114G |
probably damaging |
Het |
| Atm |
A |
T |
9: 53,397,351 (GRCm39) |
S1661T |
probably benign |
Het |
| Castor1 |
A |
G |
11: 4,171,685 (GRCm39) |
D303G |
probably damaging |
Het |
| Cd69 |
C |
T |
6: 129,245,262 (GRCm39) |
A188T |
probably benign |
Het |
| Cecr2 |
G |
T |
6: 120,714,084 (GRCm39) |
L225F |
possibly damaging |
Het |
| Cep295 |
A |
G |
9: 15,243,647 (GRCm39) |
V1603A |
possibly damaging |
Het |
| Clec4g |
T |
C |
8: 3,757,716 (GRCm39) |
|
probably benign |
Het |
| Clptm1 |
A |
T |
7: 19,371,001 (GRCm39) |
|
probably null |
Het |
| Crybg2 |
G |
T |
4: 133,800,001 (GRCm39) |
G387V |
probably damaging |
Het |
| Ctcf |
T |
A |
8: 106,391,140 (GRCm39) |
M249K |
probably benign |
Het |
| Ctnnd2 |
C |
A |
15: 30,966,980 (GRCm39) |
S952* |
probably null |
Het |
| Cxcr2 |
T |
C |
1: 74,197,790 (GRCm39) |
F95L |
probably benign |
Het |
| Ddx55 |
C |
A |
5: 124,691,008 (GRCm39) |
T5K |
probably damaging |
Het |
| Depp1 |
G |
T |
6: 116,629,058 (GRCm39) |
V134L |
possibly damaging |
Het |
| Eif2ak2 |
T |
C |
17: 79,171,377 (GRCm39) |
N342S |
probably benign |
Het |
| Eif2ak4 |
TGG |
TG |
2: 118,292,749 (GRCm39) |
|
probably null |
Het |
| Epb41l2 |
C |
G |
10: 25,364,916 (GRCm39) |
|
probably null |
Het |
| Fam234b |
A |
G |
6: 135,205,513 (GRCm39) |
K493E |
probably damaging |
Het |
| Fndc7 |
C |
A |
3: 108,779,594 (GRCm39) |
V317L |
probably damaging |
Het |
| Fpr-rs6 |
T |
C |
17: 20,403,339 (GRCm39) |
I7M |
probably benign |
Het |
| Gal3st1 |
T |
A |
11: 3,948,903 (GRCm39) |
I370N |
probably benign |
Het |
| Glo1 |
C |
T |
17: 30,816,814 (GRCm39) |
S114N |
probably benign |
Het |
| Grik1 |
T |
C |
16: 87,848,279 (GRCm39) |
D163G |
probably damaging |
Het |
| Grxcr1 |
T |
C |
5: 68,267,835 (GRCm39) |
C195R |
probably damaging |
Het |
| Hdac9 |
T |
C |
12: 34,265,451 (GRCm39) |
N806S |
probably damaging |
Het |
| Igfn1 |
T |
C |
1: 135,897,605 (GRCm39) |
N987S |
probably benign |
Het |
| Klhl29 |
G |
T |
12: 5,260,124 (GRCm39) |
S31R |
possibly damaging |
Het |
| Lama4 |
C |
T |
10: 38,970,907 (GRCm39) |
R1491C |
probably damaging |
Het |
| Lmtk3 |
T |
C |
7: 45,443,051 (GRCm39) |
L578P |
probably damaging |
Het |
| Lrrk2 |
A |
C |
15: 91,607,421 (GRCm39) |
M595L |
possibly damaging |
Het |
| Mmp27 |
A |
T |
9: 7,571,955 (GRCm39) |
N52Y |
possibly damaging |
Het |
| Mrc1 |
C |
T |
2: 14,276,088 (GRCm39) |
A474V |
possibly damaging |
Het |
| Msl1 |
A |
G |
11: 98,694,908 (GRCm39) |
H134R |
probably damaging |
Het |
| Muc5b |
T |
C |
7: 141,411,236 (GRCm39) |
M1394T |
unknown |
Het |
| Myof |
G |
A |
19: 37,931,962 (GRCm39) |
T968I |
probably benign |
Het |
| Nat8f2 |
A |
T |
6: 85,845,194 (GRCm39) |
M56K |
probably benign |
Het |
| Ncoa5 |
C |
T |
2: 164,844,055 (GRCm39) |
G116D |
probably damaging |
Het |
| Ndst2 |
A |
G |
14: 20,777,562 (GRCm39) |
L494P |
probably damaging |
Het |
| Nfatc3 |
T |
A |
8: 106,810,601 (GRCm39) |
V459E |
probably damaging |
Het |
| Nup133 |
A |
T |
8: 124,633,030 (GRCm39) |
Y1034N |
probably damaging |
Het |
| Nup153 |
A |
T |
13: 46,842,682 (GRCm39) |
S829T |
probably benign |
Het |
| Or3a1b |
A |
G |
11: 74,012,732 (GRCm39) |
S206G |
probably benign |
Het |
| Or4f47 |
T |
C |
2: 111,972,548 (GRCm39) |
F86S |
probably damaging |
Het |
| Or52a24 |
C |
T |
7: 103,381,357 (GRCm39) |
L75F |
probably damaging |
Het |
| Or5ac19 |
A |
G |
16: 59,089,175 (GRCm39) |
L285P |
possibly damaging |
Het |
| Pcdh18 |
C |
A |
3: 49,710,344 (GRCm39) |
V324F |
probably damaging |
Het |
| Pcdhb5 |
T |
A |
18: 37,455,723 (GRCm39) |
L701H |
probably damaging |
Het |
| Plau |
T |
G |
14: 20,887,884 (GRCm39) |
Y43D |
probably damaging |
Het |
| Pld5 |
T |
A |
1: 175,917,588 (GRCm39) |
N53I |
probably damaging |
Het |
| Pon2 |
T |
A |
6: 5,266,183 (GRCm39) |
I279F |
probably benign |
Het |
| Prep |
A |
T |
10: 44,973,591 (GRCm39) |
K233I |
possibly damaging |
Het |
| Rap1b |
T |
C |
10: 117,658,713 (GRCm39) |
Y40C |
probably damaging |
Het |
| Ric8a |
T |
C |
7: 140,438,789 (GRCm39) |
|
probably null |
Het |
| Rnf19b |
T |
C |
4: 128,979,344 (GRCm39) |
|
probably benign |
Het |
| Rpl9-ps6 |
A |
C |
19: 32,443,727 (GRCm39) |
S75R |
probably damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,719,818 (GRCm39) |
Y609C |
probably damaging |
Het |
| Skint5 |
T |
C |
4: 113,392,936 (GRCm39) |
N1232S |
unknown |
Het |
| Slc28a1 |
T |
G |
7: 80,818,996 (GRCm39) |
V615G |
probably benign |
Het |
| Smc1b |
C |
T |
15: 84,976,232 (GRCm39) |
R825Q |
probably benign |
Het |
| Snx13 |
T |
G |
12: 35,190,185 (GRCm39) |
N845K |
probably damaging |
Het |
| Srms |
T |
C |
2: 180,851,253 (GRCm39) |
Y171C |
probably damaging |
Het |
| Supt6 |
A |
G |
11: 78,122,644 (GRCm39) |
L193P |
probably damaging |
Het |
| Syt7 |
G |
A |
19: 10,421,408 (GRCm39) |
V531M |
probably damaging |
Het |
| Tmem255b |
T |
C |
8: 13,507,096 (GRCm39) |
|
probably null |
Het |
| Trim29 |
A |
T |
9: 43,230,681 (GRCm39) |
D288V |
probably benign |
Het |
| Ttc13 |
T |
A |
8: 125,408,900 (GRCm39) |
|
probably null |
Het |
| Uchl3 |
A |
T |
14: 101,928,033 (GRCm39) |
D167V |
probably damaging |
Het |
| Ugt3a1 |
T |
C |
15: 9,311,895 (GRCm39) |
V379A |
probably benign |
Het |
| Vps13b |
A |
G |
15: 35,910,757 (GRCm39) |
D3507G |
probably damaging |
Het |
| Wfdc2 |
A |
T |
2: 164,405,362 (GRCm39) |
K88* |
probably null |
Het |
| Ylpm1 |
C |
A |
12: 85,077,620 (GRCm39) |
H1448Q |
probably damaging |
Het |
| Zc3h14 |
A |
G |
12: 98,751,305 (GRCm39) |
K667E |
probably damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTACAGTTCTCCAAGGACATG -3'
(R):5'- ACACAGCAAGTCTTCTGTCC -3'
Sequencing Primer
(F):5'- AAGTAATGTTCTGTAGGGAATGCC -3'
(R):5'- ACACAGCAAGTCTTCTGTCCTTACC -3'
|
| Posted On |
2018-08-01 |
Incidental Mutation