Incidental Mutation 'R6690:Vmn2r59'
ID 530380
Institutional Source Beutler Lab
Gene Symbol Vmn2r59
Ensembl Gene ENSMUSG00000092032
Gene Name vomeronasal 2, receptor 59
Synonyms EG628444
MMRRC Submission 044808-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6690 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 41661216-41708405 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41695890 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 174 (D174G)
Ref Sequence ENSEMBL: ENSMUSP00000131856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168489]
AlphaFold E9PUT5
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121359
Predicted Effect probably damaging
Transcript: ENSMUST00000168489
AA Change: D174G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: D174G

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-44 PFAM
Pfam:NCD3G 514 567 4.3e-23 PFAM
Pfam:7tm_3 600 835 5.4e-53 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C T 2: 69,115,062 (GRCm39) G628D probably damaging Het
Ahnak G T 19: 8,986,945 (GRCm39) G2743V probably benign Het
Akr1c14 A T 13: 4,113,713 (GRCm39) T82S possibly damaging Het
Ccdc7b A G 8: 129,904,700 (GRCm39) T113A probably benign Het
Cep152 A T 2: 125,406,290 (GRCm39) L1414Q probably damaging Het
Chd8 T C 14: 52,464,694 (GRCm39) E658G possibly damaging Het
Clca3a1 G C 3: 144,719,644 (GRCm39) A442G probably damaging Het
Coro6 A G 11: 77,356,606 (GRCm39) T105A probably benign Het
Cux1 A G 5: 136,368,971 (GRCm39) I232T probably damaging Het
Dmrt1 A G 19: 25,523,449 (GRCm39) T267A probably benign Het
Fam149a G T 8: 45,802,071 (GRCm39) A387E probably damaging Het
Fat4 G A 3: 39,037,688 (GRCm39) G3780D probably damaging Het
Igf2r A T 17: 12,910,824 (GRCm39) L1998* probably null Het
Iqcf6 C T 9: 106,504,501 (GRCm39) T55I possibly damaging Het
Mterf3 G A 13: 67,065,110 (GRCm39) L264F probably damaging Het
Or10k2 G T 8: 84,267,904 (GRCm39) V44L probably benign Het
Or8g32 A G 9: 39,305,845 (GRCm39) I253V probably benign Het
Pcdhgb7 A T 18: 37,886,050 (GRCm39) I407F probably benign Het
Pip4k2b T C 11: 97,620,393 (GRCm39) D114G probably damaging Het
Plbd1 G T 6: 136,612,598 (GRCm39) N198K probably damaging Het
Prkcb T C 7: 121,888,737 (GRCm39) I57T probably damaging Het
Ralgapa1 C T 12: 55,769,558 (GRCm39) probably null Het
Slc26a8 A G 17: 28,863,629 (GRCm39) I710T possibly damaging Het
Smc2 A T 4: 52,449,375 (GRCm39) I179L probably benign Het
Tmub2 C T 11: 102,178,345 (GRCm39) H83Y probably damaging Het
Trip11 C A 12: 101,851,710 (GRCm39) D785Y possibly damaging Het
Vill A G 9: 118,890,975 (GRCm39) T194A probably benign Het
Other mutations in Vmn2r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Vmn2r59 APN 7 41,661,488 (GRCm39) missense possibly damaging 0.91
IGL01432:Vmn2r59 APN 7 41,661,983 (GRCm39) missense possibly damaging 0.82
IGL02119:Vmn2r59 APN 7 41,695,593 (GRCm39) missense probably benign 0.36
IGL02216:Vmn2r59 APN 7 41,661,817 (GRCm39) missense probably damaging 1.00
IGL02327:Vmn2r59 APN 7 41,661,655 (GRCm39) missense probably benign
IGL03346:Vmn2r59 APN 7 41,693,253 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r59 APN 7 41,708,340 (GRCm39) missense probably benign 0.43
IGL03412:Vmn2r59 APN 7 41,661,862 (GRCm39) missense probably benign
PIT4366001:Vmn2r59 UTSW 7 41,695,205 (GRCm39) missense possibly damaging 0.91
R0068:Vmn2r59 UTSW 7 41,695,725 (GRCm39) missense probably damaging 0.99
R0094:Vmn2r59 UTSW 7 41,661,722 (GRCm39) missense probably benign 0.07
R0179:Vmn2r59 UTSW 7 41,696,432 (GRCm39) nonsense probably null
R0370:Vmn2r59 UTSW 7 41,662,150 (GRCm39) missense probably benign 0.23
R0412:Vmn2r59 UTSW 7 41,695,916 (GRCm39) splice site probably benign
R0465:Vmn2r59 UTSW 7 41,696,332 (GRCm39) missense probably benign
R0487:Vmn2r59 UTSW 7 41,696,528 (GRCm39) nonsense probably null
R0576:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R0632:Vmn2r59 UTSW 7 41,708,308 (GRCm39) missense probably damaging 1.00
R1356:Vmn2r59 UTSW 7 41,661,218 (GRCm39) makesense probably null
R1387:Vmn2r59 UTSW 7 41,695,521 (GRCm39) missense probably damaging 1.00
R1388:Vmn2r59 UTSW 7 41,695,133 (GRCm39) missense probably benign 0.01
R1435:Vmn2r59 UTSW 7 41,695,629 (GRCm39) missense possibly damaging 0.50
R1750:Vmn2r59 UTSW 7 41,695,251 (GRCm39) missense possibly damaging 0.50
R2020:Vmn2r59 UTSW 7 41,693,203 (GRCm39) missense probably damaging 1.00
R2249:Vmn2r59 UTSW 7 41,708,326 (GRCm39) missense probably benign 0.00
R2256:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2257:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2441:Vmn2r59 UTSW 7 41,695,570 (GRCm39) missense probably benign 0.00
R2511:Vmn2r59 UTSW 7 41,693,190 (GRCm39) missense probably damaging 1.00
R2860:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R2861:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R3690:Vmn2r59 UTSW 7 41,661,370 (GRCm39) missense possibly damaging 0.77
R3912:Vmn2r59 UTSW 7 41,695,744 (GRCm39) missense probably benign 0.00
R4167:Vmn2r59 UTSW 7 41,670,732 (GRCm39) intron probably benign
R4357:Vmn2r59 UTSW 7 41,661,644 (GRCm39) missense probably damaging 1.00
R4445:Vmn2r59 UTSW 7 41,691,874 (GRCm39) missense probably damaging 1.00
R4542:Vmn2r59 UTSW 7 41,695,497 (GRCm39) missense possibly damaging 0.93
R4587:Vmn2r59 UTSW 7 41,695,648 (GRCm39) missense probably benign 0.00
R4616:Vmn2r59 UTSW 7 41,661,862 (GRCm39) missense probably benign
R4653:Vmn2r59 UTSW 7 41,693,228 (GRCm39) missense probably benign 0.19
R4703:Vmn2r59 UTSW 7 41,661,686 (GRCm39) missense probably benign 0.01
R4895:Vmn2r59 UTSW 7 41,695,218 (GRCm39) missense probably damaging 0.98
R4910:Vmn2r59 UTSW 7 41,693,077 (GRCm39) missense probably benign
R5045:Vmn2r59 UTSW 7 41,695,496 (GRCm39) missense possibly damaging 0.93
R5105:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R5153:Vmn2r59 UTSW 7 41,691,834 (GRCm39) critical splice donor site probably null
R5566:Vmn2r59 UTSW 7 41,696,247 (GRCm39) missense possibly damaging 0.92
R5586:Vmn2r59 UTSW 7 41,695,105 (GRCm39) missense probably benign 0.12
R5606:Vmn2r59 UTSW 7 41,695,318 (GRCm39) missense probably benign 0.27
R5616:Vmn2r59 UTSW 7 41,708,191 (GRCm39) splice site probably null
R5625:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R5696:Vmn2r59 UTSW 7 41,695,468 (GRCm39) missense probably benign 0.00
R5982:Vmn2r59 UTSW 7 41,695,491 (GRCm39) missense probably benign 0.00
R6106:Vmn2r59 UTSW 7 41,661,749 (GRCm39) nonsense probably null
R6196:Vmn2r59 UTSW 7 41,661,679 (GRCm39) missense probably benign 0.36
R6228:Vmn2r59 UTSW 7 41,691,835 (GRCm39) critical splice donor site probably null
R6590:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6625:Vmn2r59 UTSW 7 41,693,177 (GRCm39) missense probably benign 0.02
R6768:Vmn2r59 UTSW 7 41,661,392 (GRCm39) missense probably benign 0.17
R6830:Vmn2r59 UTSW 7 41,693,171 (GRCm39) missense probably benign 0.10
R6859:Vmn2r59 UTSW 7 41,693,277 (GRCm39) missense probably damaging 1.00
R7034:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7036:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7145:Vmn2r59 UTSW 7 41,695,188 (GRCm39) missense probably damaging 1.00
R7556:Vmn2r59 UTSW 7 41,695,233 (GRCm39) missense probably damaging 1.00
R7733:Vmn2r59 UTSW 7 41,661,443 (GRCm39) missense probably benign 0.17
R7770:Vmn2r59 UTSW 7 41,708,336 (GRCm39) missense probably damaging 1.00
R7812:Vmn2r59 UTSW 7 41,695,196 (GRCm39) nonsense probably null
R7867:Vmn2r59 UTSW 7 41,661,707 (GRCm39) missense probably damaging 1.00
R7975:Vmn2r59 UTSW 7 41,693,199 (GRCm39) missense probably damaging 1.00
R7999:Vmn2r59 UTSW 7 41,696,256 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r59 UTSW 7 41,661,521 (GRCm39) missense probably damaging 0.97
R8367:Vmn2r59 UTSW 7 41,661,247 (GRCm39) missense probably benign 0.44
R9106:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R9135:Vmn2r59 UTSW 7 41,693,127 (GRCm39) missense
R9135:Vmn2r59 UTSW 7 41,693,125 (GRCm39) missense probably benign 0.33
R9234:Vmn2r59 UTSW 7 41,661,907 (GRCm39) missense possibly damaging 0.67
R9273:Vmn2r59 UTSW 7 41,695,286 (GRCm39) nonsense probably null
R9432:Vmn2r59 UTSW 7 41,696,254 (GRCm39) missense probably damaging 1.00
R9433:Vmn2r59 UTSW 7 41,695,590 (GRCm39) missense probably damaging 0.99
R9616:Vmn2r59 UTSW 7 41,661,299 (GRCm39) missense probably damaging 1.00
R9654:Vmn2r59 UTSW 7 41,693,217 (GRCm39) missense probably benign 0.10
R9741:Vmn2r59 UTSW 7 41,708,209 (GRCm39) missense probably damaging 0.99
X0025:Vmn2r59 UTSW 7 41,695,365 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r59 UTSW 7 41,661,838 (GRCm39) missense possibly damaging 0.85
Z1176:Vmn2r59 UTSW 7 41,691,941 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATTCCATGTGCCAGAGATC -3'
(R):5'- GTGGGTAAGACCAGCTATGTAATTG -3'

Sequencing Primer
(F):5'- AGGCTATGCAGATGCCATGATTC -3'
(R):5'- GACCAGCTATGTAATTGTAATTGGAG -3'
Posted On 2018-08-01