Incidental Mutation 'R6741:Il17rb'
ID 530464
Institutional Source Beutler Lab
Gene Symbol Il17rb
Ensembl Gene ENSMUSG00000015966
Gene Name interleukin 17 receptor B
Synonyms IL-17Rh1, Il17br, IL17RH1, IL-17ER, Evi27
MMRRC Submission 044858-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R6741 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 29718125-29730853 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 29722293 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 246 (Q246L)
Ref Sequence ENSEMBL: ENSMUSP00000113686 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016110] [ENSMUST00000122205] [ENSMUST00000135888] [ENSMUST00000136726] [ENSMUST00000224797]
AlphaFold Q9JIP3
Predicted Effect possibly damaging
Transcript: ENSMUST00000016110
AA Change: Q246L

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000016110
Gene: ENSMUSG00000015966
AA Change: Q246L

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:IL17R_fnIII_D1 22 175 4.3e-26 PFAM
Pfam:IL17R_fnIII_D2 176 268 1.3e-11 PFAM
transmembrane domain 287 309 N/A INTRINSIC
Pfam:SEFIR 329 476 3.5e-49 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000122205
AA Change: Q246L

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000113686
Gene: ENSMUSG00000015966
AA Change: Q246L

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PDB:4HSA|F 34 276 2e-23 PDB
transmembrane domain 287 309 N/A INTRINSIC
Pfam:SEFIR 329 476 1.7e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135888
SMART Domains Protein: ENSMUSP00000121407
Gene: ENSMUSG00000015966

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:IL17R_fnIII_D1 22 123 1.1e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000136726
SMART Domains Protein: ENSMUSP00000117802
Gene: ENSMUSG00000015966

DomainStartEndE-ValueType
PDB:3JVF|C 13 171 5e-12 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223643
Predicted Effect probably benign
Transcript: ENSMUST00000224797
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225746
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225368
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency 97% (34/35)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice that are homozygous for a null allele have defects in their response to IL17A or IL17F. In addition this locus is a common site of retoviral integration in BXH2 murine myeloid leukemias and occurred at a CpG island 6 kb upstream of the Il17rb gene. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt3 A C 3: 30,652,663 (GRCm39) F144V possibly damaging Het
Arhgef12 A G 9: 42,883,503 (GRCm39) I1342T probably benign Het
Dbn1 A G 13: 55,629,350 (GRCm39) probably null Het
Defb12 T C 8: 19,164,757 (GRCm39) E27G probably benign Het
Dennd2b A G 7: 109,144,304 (GRCm39) Y534H possibly damaging Het
Dthd1 A T 5: 63,000,289 (GRCm39) H537L probably damaging Het
Ep400 A T 5: 110,824,761 (GRCm39) S2359T unknown Het
Epha5 T C 5: 84,254,557 (GRCm39) I572V possibly damaging Het
Grb10 C A 11: 11,886,717 (GRCm39) probably null Het
Hectd2 T C 19: 36,589,759 (GRCm39) I628T probably damaging Het
Knop1 C T 7: 118,445,061 (GRCm39) R301Q possibly damaging Het
Lrp1b T C 2: 41,136,001 (GRCm39) I1770M possibly damaging Het
Mgst1 A C 6: 138,127,836 (GRCm39) D66A probably damaging Het
Nags A G 11: 102,037,718 (GRCm39) D237G possibly damaging Het
Nfatc2ip T A 7: 125,995,182 (GRCm39) Q122L possibly damaging Het
Nod2 T C 8: 89,379,694 (GRCm39) V72A probably damaging Het
Notch3 G T 17: 32,362,458 (GRCm39) P1389Q probably benign Het
Or5ac25 A G 16: 59,181,918 (GRCm39) L221P probably damaging Het
Plekhn1 A T 4: 156,306,249 (GRCm39) I607N probably damaging Het
Plekho2 C A 9: 65,471,197 (GRCm39) R84L probably damaging Het
Prag1 A T 8: 36,614,434 (GRCm39) M1329L probably benign Het
Prpsap2 C T 11: 61,631,771 (GRCm39) probably null Het
Ptprf A G 4: 118,080,565 (GRCm39) S1230P probably benign Het
Rigi A G 4: 40,211,624 (GRCm39) I648T probably damaging Het
Rptor T G 11: 119,786,803 (GRCm39) L1256R possibly damaging Het
Sesn3 T C 9: 14,231,636 (GRCm39) I189T possibly damaging Het
Skic2 G A 17: 35,064,166 (GRCm39) R507* probably null Het
Slc39a4 C T 15: 76,498,283 (GRCm39) D385N probably damaging Het
Tnfsf13b T C 8: 10,057,314 (GRCm39) F128S possibly damaging Het
Vmn1r49 A G 6: 90,049,195 (GRCm39) V269A probably benign Het
Vmn2r69 T A 7: 85,061,724 (GRCm39) E83D probably benign Het
Vmn2r76 T C 7: 85,879,560 (GRCm39) N247D probably benign Het
Zmym4 A G 4: 126,808,878 (GRCm39) S390P possibly damaging Het
Other mutations in Il17rb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01584:Il17rb APN 14 29,725,637 (GRCm39) missense probably damaging 1.00
IGL03151:Il17rb APN 14 29,728,810 (GRCm39) missense probably benign 0.05
R0276:Il17rb UTSW 14 29,726,337 (GRCm39) missense probably damaging 1.00
R0391:Il17rb UTSW 14 29,728,112 (GRCm39) splice site probably null
R0391:Il17rb UTSW 14 29,726,304 (GRCm39) missense probably benign 0.00
R0408:Il17rb UTSW 14 29,718,637 (GRCm39) missense probably benign 0.02
R2011:Il17rb UTSW 14 29,718,797 (GRCm39) nonsense probably null
R2012:Il17rb UTSW 14 29,718,797 (GRCm39) nonsense probably null
R2057:Il17rb UTSW 14 29,719,111 (GRCm39) missense probably benign 0.01
R2227:Il17rb UTSW 14 29,728,038 (GRCm39) missense probably benign 0.02
R3548:Il17rb UTSW 14 29,730,729 (GRCm39) splice site probably null
R4199:Il17rb UTSW 14 29,718,601 (GRCm39) missense probably benign
R4578:Il17rb UTSW 14 29,724,356 (GRCm39) missense probably damaging 0.97
R5092:Il17rb UTSW 14 29,724,333 (GRCm39) missense probably benign 0.00
R5928:Il17rb UTSW 14 29,726,232 (GRCm39) critical splice donor site probably null
R6280:Il17rb UTSW 14 29,724,928 (GRCm39) missense probably benign 0.00
R6378:Il17rb UTSW 14 29,722,320 (GRCm39) missense probably damaging 0.97
R6470:Il17rb UTSW 14 29,724,866 (GRCm39) missense probably benign 0.10
R6919:Il17rb UTSW 14 29,726,228 (GRCm39) splice site probably null
R7133:Il17rb UTSW 14 29,718,828 (GRCm39) missense probably damaging 1.00
R7423:Il17rb UTSW 14 29,719,072 (GRCm39) missense probably damaging 0.97
R7470:Il17rb UTSW 14 29,719,990 (GRCm39) missense probably damaging 1.00
R7559:Il17rb UTSW 14 29,719,000 (GRCm39) missense probably damaging 1.00
R7847:Il17rb UTSW 14 29,718,763 (GRCm39) missense probably damaging 1.00
R8685:Il17rb UTSW 14 29,726,297 (GRCm39) missense probably benign 0.32
R8835:Il17rb UTSW 14 29,722,308 (GRCm39) missense possibly damaging 0.95
R9025:Il17rb UTSW 14 29,724,857 (GRCm39) intron probably benign
R9434:Il17rb UTSW 14 29,728,054 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AACACTGCTTGACTGGGGAG -3'
(R):5'- GAAGTTCTAGGCTTCTCGAGTGAG -3'

Sequencing Primer
(F):5'- ACTGGGGAGAGACTTGCCATC -3'
(R):5'- CTCGAGTGAGTCATTCAGAGTTCAC -3'
Posted On 2018-08-01