Incidental Mutation 'R6745:Cyp2g1'
ID |
530528 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cyp2g1
|
Ensembl Gene |
ENSMUSG00000049685 |
Gene Name |
cytochrome P450, family 2, subfamily g, polypeptide 1 |
Synonyms |
|
MMRRC Submission |
044862-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6745 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
26508352-26520622 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 26513604 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glycine
at position 181
(V181G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000047150
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040944]
|
AlphaFold |
Q9WV19 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000040944
AA Change: V181G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000047150 Gene: ENSMUSG00000049685 AA Change: V181G
Domain | Start | End | E-Value | Type |
low complexity region
|
12 |
23 |
N/A |
INTRINSIC |
Pfam:p450
|
34 |
491 |
4e-150 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205273
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.5%
|
Validation Efficiency |
100% (43/43) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 42 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adgb |
G |
T |
10: 10,265,941 (GRCm39) |
T1040K |
probably damaging |
Het |
Adgrf3 |
A |
G |
5: 30,408,601 (GRCm39) |
V59A |
probably benign |
Het |
Ankk1 |
G |
T |
9: 49,327,480 (GRCm39) |
H566Q |
probably benign |
Het |
Avil |
A |
C |
10: 126,849,988 (GRCm39) |
D613A |
probably benign |
Het |
Bbs9 |
A |
G |
9: 22,582,132 (GRCm39) |
N613S |
probably benign |
Het |
Chd1 |
A |
G |
17: 17,607,429 (GRCm39) |
T326A |
probably benign |
Het |
Clasp2 |
A |
T |
9: 113,704,338 (GRCm39) |
R558* |
probably null |
Het |
Cmbl |
A |
G |
15: 31,589,933 (GRCm39) |
D221G |
possibly damaging |
Het |
Col3a1 |
G |
T |
1: 45,377,782 (GRCm39) |
|
probably benign |
Het |
Creb5 |
A |
T |
6: 53,581,517 (GRCm39) |
M172L |
probably benign |
Het |
Crybg3 |
A |
G |
16: 59,372,607 (GRCm39) |
V2291A |
possibly damaging |
Het |
Dclk1 |
T |
A |
3: 55,385,229 (GRCm39) |
S40T |
probably damaging |
Het |
Dnah10 |
G |
T |
5: 124,885,876 (GRCm39) |
M3053I |
probably damaging |
Het |
Dnah12 |
T |
A |
14: 26,428,383 (GRCm39) |
I268K |
probably damaging |
Het |
Dock2 |
C |
G |
11: 34,596,669 (GRCm39) |
D396H |
probably damaging |
Het |
Dock2 |
T |
A |
11: 34,596,670 (GRCm39) |
K395N |
probably damaging |
Het |
Gpbp1 |
G |
A |
13: 111,589,919 (GRCm39) |
R59C |
probably benign |
Het |
Ifi47 |
T |
G |
11: 48,986,329 (GRCm39) |
I32S |
probably benign |
Het |
Ighg3 |
A |
G |
12: 113,323,890 (GRCm39) |
V166A |
unknown |
Het |
Katnip |
T |
C |
7: 125,369,822 (GRCm39) |
S137P |
probably benign |
Het |
Kdm5d |
T |
A |
Y: 927,112 (GRCm39) |
C617S |
probably benign |
Homo |
Kif20b |
T |
G |
19: 34,906,276 (GRCm39) |
S55A |
possibly damaging |
Het |
Klhl1 |
C |
T |
14: 96,517,438 (GRCm39) |
|
probably null |
Het |
Kndc1 |
C |
T |
7: 139,500,892 (GRCm39) |
T727I |
probably benign |
Het |
Lrrk1 |
A |
T |
7: 65,922,749 (GRCm39) |
I298N |
probably damaging |
Het |
Ly75 |
C |
A |
2: 60,138,523 (GRCm39) |
R1448L |
probably damaging |
Het |
Mup4 |
C |
T |
4: 59,960,091 (GRCm39) |
V58M |
possibly damaging |
Het |
Nr2c1 |
T |
C |
10: 94,026,526 (GRCm39) |
F467S |
probably damaging |
Het |
Or14j9 |
T |
A |
17: 37,874,470 (GRCm39) |
H244L |
probably damaging |
Het |
Pla2g4a |
G |
T |
1: 149,761,981 (GRCm39) |
Q151K |
probably benign |
Het |
Pom121l2 |
A |
T |
13: 22,167,868 (GRCm39) |
Q713L |
probably benign |
Het |
Pomgnt1 |
T |
A |
4: 116,011,080 (GRCm39) |
S210T |
probably damaging |
Het |
Prb1a |
T |
C |
6: 132,186,383 (GRCm39) |
|
probably null |
Het |
Pyroxd2 |
T |
C |
19: 42,735,799 (GRCm39) |
D101G |
probably damaging |
Het |
Ranbp3 |
A |
G |
17: 57,016,308 (GRCm39) |
D359G |
probably benign |
Het |
Rgsl1 |
T |
A |
1: 153,698,063 (GRCm39) |
I531F |
probably benign |
Het |
Serpina1b |
T |
C |
12: 103,696,614 (GRCm39) |
N265S |
possibly damaging |
Het |
Slc51b |
T |
C |
9: 65,320,212 (GRCm39) |
E85G |
possibly damaging |
Het |
Stk32c |
T |
A |
7: 138,702,809 (GRCm39) |
R195W |
probably damaging |
Het |
Uggt2 |
T |
C |
14: 119,280,022 (GRCm39) |
T819A |
possibly damaging |
Het |
Ugt1a9 |
A |
T |
1: 87,998,898 (GRCm39) |
E116V |
probably benign |
Het |
Zswim5 |
C |
G |
4: 116,832,401 (GRCm39) |
P543A |
probably damaging |
Het |
|
Other mutations in Cyp2g1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01134:Cyp2g1
|
APN |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
IGL01137:Cyp2g1
|
APN |
7 |
26,513,684 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL02052:Cyp2g1
|
APN |
7 |
26,513,719 (GRCm39) |
splice site |
probably benign |
|
IGL02338:Cyp2g1
|
APN |
7 |
26,514,229 (GRCm39) |
splice site |
probably benign |
|
IGL02452:Cyp2g1
|
APN |
7 |
26,510,871 (GRCm39) |
missense |
probably benign |
0.28 |
IGL02523:Cyp2g1
|
APN |
7 |
26,518,612 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03165:Cyp2g1
|
APN |
7 |
26,509,201 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL03230:Cyp2g1
|
APN |
7 |
26,518,828 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4472001:Cyp2g1
|
UTSW |
7 |
26,513,619 (GRCm39) |
missense |
probably benign |
0.28 |
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
R0106:Cyp2g1
|
UTSW |
7 |
26,513,607 (GRCm39) |
missense |
probably damaging |
1.00 |
R0380:Cyp2g1
|
UTSW |
7 |
26,513,720 (GRCm39) |
splice site |
probably benign |
|
R0697:Cyp2g1
|
UTSW |
7 |
26,514,152 (GRCm39) |
nonsense |
probably null |
|
R0830:Cyp2g1
|
UTSW |
7 |
26,514,216 (GRCm39) |
missense |
probably benign |
0.00 |
R1660:Cyp2g1
|
UTSW |
7 |
26,509,107 (GRCm39) |
critical splice acceptor site |
probably null |
|
R2093:Cyp2g1
|
UTSW |
7 |
26,518,858 (GRCm39) |
missense |
probably benign |
0.35 |
R2131:Cyp2g1
|
UTSW |
7 |
26,520,135 (GRCm39) |
missense |
probably damaging |
0.99 |
R4606:Cyp2g1
|
UTSW |
7 |
26,513,579 (GRCm39) |
missense |
possibly damaging |
0.80 |
R5030:Cyp2g1
|
UTSW |
7 |
26,520,226 (GRCm39) |
missense |
probably benign |
0.06 |
R5574:Cyp2g1
|
UTSW |
7 |
26,520,165 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5877:Cyp2g1
|
UTSW |
7 |
26,516,065 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7040:Cyp2g1
|
UTSW |
7 |
26,520,184 (GRCm39) |
missense |
probably damaging |
0.99 |
R7223:Cyp2g1
|
UTSW |
7 |
26,514,057 (GRCm39) |
missense |
probably damaging |
0.98 |
R7934:Cyp2g1
|
UTSW |
7 |
26,518,618 (GRCm39) |
missense |
probably damaging |
1.00 |
R8112:Cyp2g1
|
UTSW |
7 |
26,518,886 (GRCm39) |
missense |
probably benign |
|
R8177:Cyp2g1
|
UTSW |
7 |
26,518,578 (GRCm39) |
missense |
probably damaging |
1.00 |
R8194:Cyp2g1
|
UTSW |
7 |
26,514,159 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9043:Cyp2g1
|
UTSW |
7 |
26,509,256 (GRCm39) |
missense |
probably benign |
0.05 |
R9406:Cyp2g1
|
UTSW |
7 |
26,518,910 (GRCm39) |
critical splice donor site |
probably null |
|
R9441:Cyp2g1
|
UTSW |
7 |
26,514,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
X0067:Cyp2g1
|
UTSW |
7 |
26,520,187 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCAGTTTGGAAAACCTAGACTC -3'
(R):5'- TTAAGGGCCTCCAAGGGATG -3'
Sequencing Primer
(F):5'- CCTAGACTCAGATATGATAATGAGGC -3'
(R):5'- AAAGTACAGGAATGTGCTTGCTTTG -3'
|
Posted On |
2018-08-01 |