Incidental Mutation 'R6748:Slc35f3'
ID 530645
Institutional Source Beutler Lab
Gene Symbol Slc35f3
Ensembl Gene ENSMUSG00000057060
Gene Name solute carrier family 35, member F3
Synonyms B230375D17Rik
MMRRC Submission 044865-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.160) question?
Stock # R6748 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 126865734-127122717 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 127121377 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 413 (R413*)
Ref Sequence ENSEMBL: ENSMUSP00000104390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108759]
AlphaFold Q1LZI2
Predicted Effect probably null
Transcript: ENSMUST00000108759
AA Change: R413*
SMART Domains Protein: ENSMUSP00000104390
Gene: ENSMUSG00000057060
AA Change: R413*

DomainStartEndE-ValueType
low complexity region 25 49 N/A INTRINSIC
Pfam:EamA 67 223 3.2e-7 PFAM
Pfam:SLC35F 145 374 3.2e-6 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 C A 1: 38,574,327 (GRCm39) R178I probably damaging Het
Agr3 A G 12: 35,997,594 (GRCm39) probably null Het
Aoc1 C T 6: 48,883,228 (GRCm39) T368I possibly damaging Het
Aph1c A G 9: 66,740,577 (GRCm39) S50P probably damaging Het
Arhgap30 A G 1: 171,232,378 (GRCm39) E341G possibly damaging Het
Atp8b3 A T 10: 80,361,058 (GRCm39) M926K possibly damaging Het
C1qtnf9 A G 14: 61,017,276 (GRCm39) N269D probably damaging Het
Cdc42bpb T C 12: 111,261,273 (GRCm39) probably benign Het
Clec4a1 T C 6: 122,910,856 (GRCm39) I237T possibly damaging Het
Clpx A G 9: 65,217,441 (GRCm39) N3S probably benign Het
Col19a1 A G 1: 24,573,151 (GRCm39) I207T unknown Het
Cyp2j8 T A 4: 96,363,782 (GRCm39) T294S probably benign Het
Dnah1 A G 14: 31,021,945 (GRCm39) I1186T probably damaging Het
Dnhd1 T G 7: 105,369,844 (GRCm39) V4423G probably benign Het
Dock4 A T 12: 40,754,465 (GRCm39) I485F probably benign Het
Drd2 T A 9: 49,314,502 (GRCm39) C244* probably null Het
Frmpd1 T A 4: 45,274,397 (GRCm39) I435K probably benign Het
Fzd5 A G 1: 64,774,723 (GRCm39) M346T possibly damaging Het
Gc T C 5: 89,583,431 (GRCm39) T371A probably benign Het
Gm12185 T A 11: 48,807,123 (GRCm39) T23S possibly damaging Het
Hbq1a A G 11: 32,250,169 (GRCm39) probably null Het
Herc1 TCCC TCC 9: 66,408,470 (GRCm39) probably null Het
Il1rap A T 16: 26,541,106 (GRCm39) N449I probably benign Het
Itgb5 T A 16: 33,719,667 (GRCm39) D279E probably damaging Het
Mat2b T A 11: 40,571,021 (GRCm39) I268F probably benign Het
Mtor T C 4: 148,634,641 (GRCm39) F2421L probably damaging Het
Myo5b G A 18: 74,834,574 (GRCm39) R878Q possibly damaging Het
Nkx2-6 A G 14: 69,412,555 (GRCm39) D241G probably benign Het
Or4f14 T A 2: 111,742,702 (GRCm39) N191I possibly damaging Het
Or5h23 T A 16: 58,906,253 (GRCm39) M198L probably benign Het
Pcdhb22 A C 18: 37,651,799 (GRCm39) D89A probably damaging Het
Pcnx2 C T 8: 126,577,074 (GRCm39) R986Q probably damaging Het
Plxna2 A G 1: 194,476,490 (GRCm39) probably null Het
Ppwd1 A T 13: 104,344,538 (GRCm39) Y527* probably null Het
Pramel35 T C 5: 94,000,072 (GRCm39) W38R probably benign Het
Rnf126 A G 10: 79,597,970 (GRCm39) L131P probably benign Het
Rsl1 T A 13: 67,330,688 (GRCm39) C379S probably benign Het
Sec23b A G 2: 144,408,714 (GRCm39) Y133C probably damaging Het
Slc25a24 T A 3: 109,056,823 (GRCm39) V112D possibly damaging Het
Tas1r2 T C 4: 139,396,922 (GRCm39) F754L probably damaging Het
Tbc1d14 A G 5: 36,652,598 (GRCm39) S615P probably damaging Het
Ttc17 T C 2: 94,216,447 (GRCm39) K80R probably benign Het
Ttn T C 2: 76,576,428 (GRCm39) T24822A possibly damaging Het
Vmn1r222 C A 13: 23,417,117 (GRCm39) R32L probably benign Het
Zfp354b G A 11: 50,813,659 (GRCm39) T422M probably damaging Het
Zfp407 G A 18: 84,226,955 (GRCm39) T2218M probably damaging Het
Other mutations in Slc35f3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00687:Slc35f3 APN 8 127,108,903 (GRCm39) missense probably benign 0.02
IGL00956:Slc35f3 APN 8 127,108,963 (GRCm39) missense probably damaging 1.00
IGL01105:Slc35f3 APN 8 127,025,553 (GRCm39) missense probably damaging 1.00
IGL01710:Slc35f3 APN 8 127,115,900 (GRCm39) missense probably benign 0.00
IGL01771:Slc35f3 APN 8 127,115,951 (GRCm39) missense probably benign 0.00
IGL02254:Slc35f3 APN 8 127,115,862 (GRCm39) missense probably damaging 1.00
IGL02610:Slc35f3 APN 8 127,047,956 (GRCm39) missense probably damaging 1.00
R1666:Slc35f3 UTSW 8 127,115,960 (GRCm39) missense probably damaging 0.98
R2510:Slc35f3 UTSW 8 127,025,445 (GRCm39) start gained probably benign
R2520:Slc35f3 UTSW 8 127,121,312 (GRCm39) missense possibly damaging 0.81
R3807:Slc35f3 UTSW 8 127,115,978 (GRCm39) missense probably damaging 1.00
R4644:Slc35f3 UTSW 8 127,047,809 (GRCm39) missense possibly damaging 0.87
R4675:Slc35f3 UTSW 8 127,047,935 (GRCm39) nonsense probably null
R4976:Slc35f3 UTSW 8 127,116,020 (GRCm39) splice site probably null
R5037:Slc35f3 UTSW 8 127,116,011 (GRCm39) missense probably damaging 0.99
R5225:Slc35f3 UTSW 8 127,117,846 (GRCm39) missense probably damaging 0.98
R5259:Slc35f3 UTSW 8 127,115,872 (GRCm39) missense probably damaging 1.00
R5856:Slc35f3 UTSW 8 127,047,819 (GRCm39) missense probably benign 0.07
R5925:Slc35f3 UTSW 8 127,115,946 (GRCm39) missense probably benign 0.24
R6254:Slc35f3 UTSW 8 127,047,833 (GRCm39) missense possibly damaging 0.96
R6785:Slc35f3 UTSW 8 127,121,198 (GRCm39) missense probably benign 0.02
R7002:Slc35f3 UTSW 8 127,115,773 (GRCm39) critical splice acceptor site unknown
R7291:Slc35f3 UTSW 8 127,121,297 (GRCm39) missense probably benign 0.02
R7411:Slc35f3 UTSW 8 127,115,777 (GRCm39) critical splice acceptor site probably benign
R7456:Slc35f3 UTSW 8 127,115,779 (GRCm39) critical splice acceptor site unknown
R7790:Slc35f3 UTSW 8 127,115,777 (GRCm39) critical splice acceptor site probably benign
R7852:Slc35f3 UTSW 8 127,121,219 (GRCm39) missense probably damaging 1.00
R8000:Slc35f3 UTSW 8 127,047,812 (GRCm39) missense probably benign
R8277:Slc35f3 UTSW 8 127,115,925 (GRCm39) missense possibly damaging 0.88
R8827:Slc35f3 UTSW 8 127,115,780 (GRCm39) critical splice acceptor site probably benign
R8983:Slc35f3 UTSW 8 127,115,775 (GRCm39) critical splice acceptor site probably benign
R9205:Slc35f3 UTSW 8 127,115,928 (GRCm39) missense probably damaging 0.96
R9355:Slc35f3 UTSW 8 127,108,967 (GRCm39) missense probably damaging 0.97
R9475:Slc35f3 UTSW 8 127,108,993 (GRCm39) missense probably damaging 1.00
R9492:Slc35f3 UTSW 8 127,048,026 (GRCm39) missense probably damaging 1.00
R9714:Slc35f3 UTSW 8 127,115,781 (GRCm39) critical splice acceptor site probably benign
R9729:Slc35f3 UTSW 8 127,115,777 (GRCm39) critical splice acceptor site probably benign
R9769:Slc35f3 UTSW 8 127,121,336 (GRCm39) missense probably damaging 0.99
X0067:Slc35f3 UTSW 8 127,109,062 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGGTCGATCACTACACCAGTCAG -3'
(R):5'- GGTCTGACGTGGAAAAGTGC -3'

Sequencing Primer
(F):5'- CAGTCAGATAGTCTTCAACGGGGTC -3'
(R):5'- TGCAAGCAAATTGGACATGCC -3'
Posted On 2018-08-01