Incidental Mutation 'R6750:Naa25'
ID 530688
Institutional Source Beutler Lab
Gene Symbol Naa25
Ensembl Gene ENSMUSG00000042719
Gene Name N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms C330023M02Rik, 4833422K13Rik
MMRRC Submission 044867-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6750 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 121535977-121580612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 121546372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 86 (T86M)
Ref Sequence ENSEMBL: ENSMUSP00000038977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042163] [ENSMUST00000151458] [ENSMUST00000173895]
AlphaFold Q8BWZ3
Predicted Effect probably damaging
Transcript: ENSMUST00000042163
AA Change: T86M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038977
Gene: ENSMUSG00000042719
AA Change: T86M

DomainStartEndE-ValueType
low complexity region 35 45 N/A INTRINSIC
Pfam:NatB_MDM20 263 658 1.6e-121 PFAM
low complexity region 672 683 N/A INTRINSIC
low complexity region 687 700 N/A INTRINSIC
low complexity region 721 734 N/A INTRINSIC
low complexity region 915 935 N/A INTRINSIC
low complexity region 958 971 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131598
Predicted Effect probably damaging
Transcript: ENSMUST00000151458
AA Change: T86M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000120970
Gene: ENSMUSG00000042719
AA Change: T86M

DomainStartEndE-ValueType
SCOP:d1a17__ 21 94 1e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173895
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198012
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.7%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adal A T 2: 120,973,130 (GRCm39) L62F probably damaging Het
Akap13 C T 7: 75,389,206 (GRCm39) P2375S probably benign Het
Apob T A 12: 8,047,853 (GRCm39) L931Q probably damaging Het
Arcn1 A G 9: 44,661,691 (GRCm39) V391A possibly damaging Het
Ccdc162 A T 10: 41,437,222 (GRCm39) I1729N possibly damaging Het
Cd24a T C 10: 43,458,721 (GRCm39) L86P unknown Het
Cdcp3 T A 7: 130,889,974 (GRCm39) probably benign Het
Churc1 C A 12: 76,822,405 (GRCm39) H71Q probably damaging Het
Clcn3 A G 8: 61,367,809 (GRCm39) L780P possibly damaging Het
Cldn17 C T 16: 88,303,195 (GRCm39) G178E possibly damaging Het
Cmah A G 13: 24,648,235 (GRCm39) Y345C probably damaging Het
Cntnap5b C T 1: 100,202,224 (GRCm39) S357L probably damaging Het
Col6a6 A G 9: 105,660,879 (GRCm39) I410T probably damaging Het
Crmp1 T C 5: 37,422,666 (GRCm39) probably null Het
Csmd2 A C 4: 128,091,018 (GRCm39) N186H possibly damaging Het
Cyp1a1 A T 9: 57,607,539 (GRCm39) M56L probably benign Het
D2hgdh G C 1: 93,754,129 (GRCm39) R56P probably benign Het
Dapk2 A G 9: 66,128,034 (GRCm39) E104G probably damaging Het
Dld T C 12: 31,382,213 (GRCm39) N498S probably benign Het
Dyrk4 G T 6: 126,875,918 (GRCm39) Q106K probably benign Het
Eif2b4 T C 5: 31,347,304 (GRCm39) I333V probably damaging Het
F5 A G 1: 164,021,076 (GRCm39) T1184A possibly damaging Het
Fbxl6 C T 15: 76,422,612 (GRCm39) G102D probably damaging Het
Foxa1 C T 12: 57,589,396 (GRCm39) G275R probably benign Het
Fryl A G 5: 73,179,575 (GRCm39) I2944T probably damaging Het
Gna15 T C 10: 81,350,117 (GRCm39) D95G probably benign Het
Greb1 T A 12: 16,738,584 (GRCm39) M1460L probably benign Het
Herc1 TCCC TCC 9: 66,408,470 (GRCm39) probably null Het
Herc2 T C 7: 55,747,195 (GRCm39) I444T probably damaging Het
Ifngr1 T A 10: 19,485,099 (GRCm39) M366K probably benign Het
Krt27 C T 11: 99,239,806 (GRCm39) E253K probably damaging Het
Mical2 C T 7: 111,981,046 (GRCm39) T406I probably damaging Het
Mocs2 T G 13: 114,962,784 (GRCm39) D156E probably damaging Het
Mprip A T 11: 59,586,957 (GRCm39) K43N probably damaging Het
Myo5b A T 18: 74,750,106 (GRCm39) T190S possibly damaging Het
Ncam1 T C 9: 49,478,639 (GRCm39) D163G probably damaging Het
Nlrp4f A T 13: 65,329,468 (GRCm39) Y908* probably null Het
Nlrp9b T A 7: 19,757,159 (GRCm39) L132* probably null Het
Nrg1 A C 8: 32,308,124 (GRCm39) S679A probably damaging Het
Or1j1 C A 2: 36,702,954 (GRCm39) R50M possibly damaging Het
Or52p1 C T 7: 104,267,320 (GRCm39) R145C probably damaging Het
Paqr9 A T 9: 95,443,050 (GRCm39) T347S probably damaging Het
Pcdhb21 T C 18: 37,647,501 (GRCm39) L210P probably damaging Het
Pdzd7 T G 19: 45,016,187 (GRCm39) D978A probably benign Het
Phf8-ps A T 17: 33,285,372 (GRCm39) S477T possibly damaging Het
Pkd1l1 A T 11: 8,923,217 (GRCm39) S17T unknown Het
Plcz1 T C 6: 139,974,164 (GRCm39) K93E possibly damaging Het
Pom121l2 G C 13: 22,166,107 (GRCm39) R126P probably damaging Het
Prkg1 C T 19: 31,741,961 (GRCm39) E88K probably benign Het
Psme4 A T 11: 30,803,203 (GRCm39) D15V probably damaging Het
Ptprf A G 4: 118,088,928 (GRCm39) V625A probably benign Het
Rab27a G A 9: 72,992,290 (GRCm39) S106N probably damaging Het
Rasa4 A G 5: 136,129,802 (GRCm39) T261A probably benign Het
Sardh T C 2: 27,118,269 (GRCm39) D487G probably benign Het
Sec16a A G 2: 26,330,030 (GRCm39) Y662H probably benign Het
Sema3d T A 5: 12,635,067 (GRCm39) L711* probably null Het
Septin14 T A 5: 129,773,181 (GRCm39) Y152F probably damaging Het
Smc5 A G 19: 23,220,004 (GRCm39) L411P probably damaging Het
Spata31e5 C A 1: 28,816,495 (GRCm39) E512D probably damaging Het
Spg7 T A 8: 123,800,650 (GRCm39) V39E probably damaging Het
Tas2r117 A G 6: 132,779,817 (GRCm39) probably benign Het
Tle1 A T 4: 72,040,687 (GRCm39) I631N probably damaging Het
Tmed3 T A 9: 89,581,843 (GRCm39) S207C probably damaging Het
Tmem59l G A 8: 70,939,022 (GRCm39) P51S probably benign Het
Trpc3 A G 3: 36,678,542 (GRCm39) Y848H probably damaging Het
Tsen2 T C 6: 115,526,881 (GRCm39) F66S probably damaging Het
Ttll5 T A 12: 86,003,384 (GRCm39) S216R probably damaging Het
Usp22 A T 11: 61,048,042 (GRCm39) V426E probably damaging Het
Vmn2r76 T C 7: 85,875,114 (GRCm39) N621S probably damaging Het
Wdr75 A G 1: 45,856,539 (GRCm39) T521A probably damaging Het
Wrnip1 T A 13: 32,986,739 (GRCm39) D173E probably damaging Het
Zfp317 G A 9: 19,559,100 (GRCm39) G438D probably damaging Het
Zscan10 T A 17: 23,826,164 (GRCm39) S109T possibly damaging Het
Other mutations in Naa25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02025:Naa25 APN 5 121,577,928 (GRCm39) missense probably damaging 1.00
IGL02142:Naa25 APN 5 121,564,825 (GRCm39) missense possibly damaging 0.52
IGL02541:Naa25 APN 5 121,562,594 (GRCm39) missense possibly damaging 0.92
IGL02747:Naa25 APN 5 121,552,668 (GRCm39) splice site probably benign
IGL03074:Naa25 APN 5 121,546,400 (GRCm39) critical splice donor site probably null
IGL03119:Naa25 APN 5 121,573,041 (GRCm39) missense probably null 1.00
IGL03218:Naa25 APN 5 121,564,133 (GRCm39) missense probably damaging 1.00
R0003:Naa25 UTSW 5 121,545,247 (GRCm39) intron probably benign
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0022:Naa25 UTSW 5 121,556,039 (GRCm39) missense probably damaging 1.00
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0102:Naa25 UTSW 5 121,573,632 (GRCm39) missense possibly damaging 0.69
R0399:Naa25 UTSW 5 121,573,553 (GRCm39) missense probably benign 0.00
R0973:Naa25 UTSW 5 121,576,779 (GRCm39) splice site probably benign
R1418:Naa25 UTSW 5 121,561,797 (GRCm39) missense probably damaging 1.00
R1582:Naa25 UTSW 5 121,572,892 (GRCm39) missense probably benign
R1793:Naa25 UTSW 5 121,558,656 (GRCm39) missense probably damaging 1.00
R1793:Naa25 UTSW 5 121,555,478 (GRCm39) missense possibly damaging 0.82
R1863:Naa25 UTSW 5 121,573,611 (GRCm39) missense probably benign 0.00
R3160:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3162:Naa25 UTSW 5 121,573,135 (GRCm39) splice site probably null
R3721:Naa25 UTSW 5 121,569,619 (GRCm39) missense probably benign
R3864:Naa25 UTSW 5 121,547,260 (GRCm39) missense probably damaging 0.96
R4852:Naa25 UTSW 5 121,568,755 (GRCm39) missense probably damaging 1.00
R5077:Naa25 UTSW 5 121,562,639 (GRCm39) missense probably benign 0.02
R5602:Naa25 UTSW 5 121,558,558 (GRCm39) missense probably benign 0.30
R5855:Naa25 UTSW 5 121,561,755 (GRCm39) missense possibly damaging 0.94
R6464:Naa25 UTSW 5 121,556,024 (GRCm39) missense probably damaging 1.00
R6734:Naa25 UTSW 5 121,576,888 (GRCm39) missense possibly damaging 0.65
R6767:Naa25 UTSW 5 121,577,928 (GRCm39) missense probably damaging 1.00
R6856:Naa25 UTSW 5 121,576,867 (GRCm39) missense probably damaging 1.00
R7145:Naa25 UTSW 5 121,555,552 (GRCm39) critical splice donor site probably null
R7631:Naa25 UTSW 5 121,576,791 (GRCm39) missense possibly damaging 0.92
R7701:Naa25 UTSW 5 121,564,042 (GRCm39) missense probably benign
R7800:Naa25 UTSW 5 121,562,594 (GRCm39) missense possibly damaging 0.92
R7804:Naa25 UTSW 5 121,562,652 (GRCm39) missense probably benign 0.00
R7822:Naa25 UTSW 5 121,545,276 (GRCm39) missense probably damaging 1.00
R8707:Naa25 UTSW 5 121,552,875 (GRCm39) missense probably damaging 1.00
R8944:Naa25 UTSW 5 121,552,573 (GRCm39) missense probably benign 0.34
R9486:Naa25 UTSW 5 121,577,958 (GRCm39) missense probably damaging 1.00
X0004:Naa25 UTSW 5 121,551,144 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACATCTGGCTCAGCAGTAGTG -3'
(R):5'- TTTACTAACTCATACCACACCTGTG -3'

Sequencing Primer
(F):5'- CAGTAGTGCTTCAGGGAGCAC -3'
(R):5'- TGTGACCCCGGCCTTCAG -3'
Posted On 2018-08-01