Incidental Mutation 'R6752:Myh15'
ID 530855
Institutional Source Beutler Lab
Gene Symbol Myh15
Ensembl Gene ENSMUSG00000092009
Gene Name myosin, heavy chain 15
Synonyms EG667772
MMRRC Submission 044869-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R6752 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 48877849-49019467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49003290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1783 (D1783G)
Ref Sequence ENSEMBL: ENSMUSP00000127539 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168680]
AlphaFold E9Q264
Predicted Effect probably damaging
Transcript: ENSMUST00000168680
AA Change: D1783G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: D1783G

DomainStartEndE-ValueType
Pfam:Myosin_N 30 70 5.2e-12 PFAM
MYSc 76 770 N/A SMART
Pfam:Myosin_tail_1 836 1915 9.5e-118 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,086,309 (GRCm39) L45S probably benign Het
Agbl2 G A 2: 90,633,418 (GRCm39) C518Y probably damaging Het
Akt3 A T 1: 176,877,756 (GRCm39) Y337* probably null Het
Aox1 T C 1: 58,086,398 (GRCm39) I101T probably benign Het
Arhgap23 T C 11: 97,343,074 (GRCm39) F241S probably damaging Het
Asmt A G X: 169,110,096 (GRCm39) M202V probably benign Het
Atp6v0a2 A G 5: 124,779,452 (GRCm39) E189G probably damaging Het
Birc2 G A 9: 7,857,345 (GRCm39) A376V probably benign Het
Ccbe1 C T 18: 66,209,378 (GRCm39) probably null Het
Chst2 C A 9: 95,286,802 (GRCm39) E515* probably null Het
Col12a1 A T 9: 79,540,706 (GRCm39) N2426K possibly damaging Het
Dmrt2 A G 19: 25,655,706 (GRCm39) N435S probably damaging Het
Dnah14 A G 1: 181,421,017 (GRCm39) K123E probably benign Het
Dock4 T A 12: 40,870,616 (GRCm39) L1452Q probably damaging Het
Galnt7 G A 8: 58,105,985 (GRCm39) R10C probably damaging Het
Gm16506 A G 14: 43,964,876 (GRCm39) I22T unknown Het
H2-Q6 A G 17: 35,647,103 (GRCm39) T292A probably damaging Het
Ifne A G 4: 88,798,319 (GRCm39) M33T probably benign Het
Igf2r G A 17: 12,933,831 (GRCm39) R808W probably damaging Het
Igfbp5 T C 1: 72,903,068 (GRCm39) E169G probably damaging Het
Inppl1 G A 7: 101,481,749 (GRCm39) R198* probably null Het
Irgm1 T C 11: 48,757,290 (GRCm39) T174A probably damaging Het
Itih3 C T 14: 30,645,446 (GRCm39) G21S possibly damaging Het
Klra4 G T 6: 130,038,991 (GRCm39) Q134K probably benign Het
Mfsd1 T A 3: 67,503,936 (GRCm39) Y309* probably null Het
Mrps10 A G 17: 47,688,740 (GRCm39) N162S probably damaging Het
Mtmr14 T C 6: 113,217,358 (GRCm39) F90S probably damaging Het
Myo3b A G 2: 70,119,856 (GRCm39) E972G probably damaging Het
Myt1 G T 2: 181,442,875 (GRCm39) V455F probably damaging Het
Nbea A T 3: 55,944,640 (GRCm39) S575T probably benign Het
Nbea T A 3: 55,875,730 (GRCm39) T1647S probably benign Het
Ntn4 A G 10: 93,570,037 (GRCm39) N466S probably benign Het
Or10ag52 A G 2: 87,043,388 (GRCm39) M51V probably benign Het
Or5b114-ps1 T A 19: 13,352,890 (GRCm39) L188H unknown Het
Or5h27 T A 16: 59,006,694 (GRCm39) N51Y probably damaging Het
Pcdhgb4 T A 18: 37,853,704 (GRCm39) I33N probably damaging Het
Pi4ka A G 16: 17,194,846 (GRCm39) L184P possibly damaging Het
Pom121l2 T G 13: 22,165,939 (GRCm39) F70C probably damaging Het
Psmb5 T C 14: 54,854,212 (GRCm39) T89A probably benign Het
Rab11fip2 T C 19: 59,895,475 (GRCm39) D471G probably damaging Het
Rnh1 A G 7: 140,743,354 (GRCm39) V207A probably benign Het
Sh3tc2 C A 18: 62,094,108 (GRCm39) T49N probably benign Het
Skint4 T C 4: 111,977,060 (GRCm39) M158T possibly damaging Het
Skint7 T A 4: 111,837,463 (GRCm39) H80Q probably benign Het
Smg1 A G 7: 117,762,539 (GRCm39) probably benign Het
Sostdc1 T C 12: 36,364,411 (GRCm39) V40A probably benign Het
Sptlc1 C A 13: 53,489,394 (GRCm39) K437N possibly damaging Het
Stat2 T C 10: 128,119,622 (GRCm39) F503L probably damaging Het
Syt16 A T 12: 74,275,987 (GRCm39) probably null Het
Tspyl1 T C 10: 34,158,583 (GRCm39) S103P probably benign Het
Ube4a A T 9: 44,837,246 (GRCm39) S1053R probably damaging Het
Vipr1 A G 9: 121,482,959 (GRCm39) N58S probably damaging Het
Zfp184 C A 13: 22,143,578 (GRCm39) A428E probably damaging Het
Zfp292 A C 4: 34,808,593 (GRCm39) F1484V possibly damaging Het
Zfp599 G A 9: 22,160,840 (GRCm39) H442Y probably damaging Het
Zfp944 G A 17: 22,558,500 (GRCm39) T249I probably benign Het
Zkscan14 T A 5: 145,132,316 (GRCm39) H405L probably damaging Het
Other mutations in Myh15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Myh15 APN 16 48,986,176 (GRCm39) missense probably damaging 0.98
IGL01095:Myh15 APN 16 48,952,378 (GRCm39) missense probably damaging 1.00
IGL01343:Myh15 APN 16 48,976,040 (GRCm39) missense probably benign 0.09
IGL01474:Myh15 APN 16 48,952,461 (GRCm39) missense probably damaging 1.00
IGL01572:Myh15 APN 16 48,920,585 (GRCm39) missense possibly damaging 0.55
IGL01595:Myh15 APN 16 48,993,312 (GRCm39) missense probably damaging 1.00
IGL01632:Myh15 APN 16 48,881,874 (GRCm39) missense probably benign 0.00
IGL01638:Myh15 APN 16 48,889,843 (GRCm39) missense probably damaging 1.00
IGL01667:Myh15 APN 16 49,015,942 (GRCm39) missense probably benign 0.20
IGL01715:Myh15 APN 16 48,877,847 (GRCm39) unclassified probably benign
IGL01833:Myh15 APN 16 48,934,421 (GRCm39) missense probably damaging 1.00
IGL02004:Myh15 APN 16 48,930,892 (GRCm39) splice site probably benign
IGL02033:Myh15 APN 16 48,965,707 (GRCm39) missense probably benign 0.05
IGL02148:Myh15 APN 16 48,936,678 (GRCm39) missense probably damaging 1.00
IGL02225:Myh15 APN 16 48,911,526 (GRCm39) missense probably benign 0.14
IGL02249:Myh15 APN 16 48,930,847 (GRCm39) missense probably damaging 0.99
IGL02505:Myh15 APN 16 48,937,626 (GRCm39) missense possibly damaging 0.90
IGL02622:Myh15 APN 16 48,997,317 (GRCm39) missense probably benign 0.02
IGL02814:Myh15 APN 16 48,965,801 (GRCm39) splice site probably benign
IGL02869:Myh15 APN 16 48,965,767 (GRCm39) missense probably benign
IGL02879:Myh15 APN 16 48,993,422 (GRCm39) missense possibly damaging 0.68
IGL02881:Myh15 APN 16 48,937,628 (GRCm39) missense possibly damaging 0.51
IGL03077:Myh15 APN 16 48,916,901 (GRCm39) missense probably benign 0.10
IGL03354:Myh15 APN 16 48,992,373 (GRCm39) missense probably benign 0.01
IGL03411:Myh15 APN 16 48,980,330 (GRCm39) missense possibly damaging 0.58
ANU74:Myh15 UTSW 16 48,993,295 (GRCm39) missense possibly damaging 0.58
P0027:Myh15 UTSW 16 48,901,571 (GRCm39) missense possibly damaging 0.77
PIT1430001:Myh15 UTSW 16 49,017,254 (GRCm39) critical splice donor site probably null
R0017:Myh15 UTSW 16 48,983,423 (GRCm39) missense probably damaging 0.97
R0038:Myh15 UTSW 16 48,891,504 (GRCm39) splice site probably benign
R0149:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0361:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0373:Myh15 UTSW 16 49,003,322 (GRCm39) missense possibly damaging 0.86
R0433:Myh15 UTSW 16 48,965,599 (GRCm39) missense probably damaging 1.00
R0525:Myh15 UTSW 16 48,952,414 (GRCm39) missense probably benign 0.03
R0586:Myh15 UTSW 16 48,992,250 (GRCm39) splice site probably benign
R0601:Myh15 UTSW 16 48,881,944 (GRCm39) missense probably damaging 1.00
R0717:Myh15 UTSW 16 48,963,356 (GRCm39) missense probably benign 0.03
R0963:Myh15 UTSW 16 48,952,512 (GRCm39) missense probably damaging 0.97
R1075:Myh15 UTSW 16 48,940,417 (GRCm39) missense possibly damaging 0.63
R1143:Myh15 UTSW 16 48,885,449 (GRCm39) missense probably benign 0.02
R1200:Myh15 UTSW 16 48,916,882 (GRCm39) missense probably damaging 1.00
R1644:Myh15 UTSW 16 48,952,566 (GRCm39) missense probably benign 0.12
R1646:Myh15 UTSW 16 49,015,931 (GRCm39) missense probably damaging 1.00
R1720:Myh15 UTSW 16 48,913,145 (GRCm39) missense probably damaging 1.00
R1768:Myh15 UTSW 16 48,983,498 (GRCm39) missense probably benign 0.27
R1881:Myh15 UTSW 16 48,891,446 (GRCm39) missense probably damaging 0.98
R2048:Myh15 UTSW 16 48,975,928 (GRCm39) missense probably damaging 0.99
R2064:Myh15 UTSW 16 48,975,984 (GRCm39) missense possibly damaging 0.50
R2184:Myh15 UTSW 16 48,957,874 (GRCm39) missense probably damaging 0.99
R2212:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R2216:Myh15 UTSW 16 48,986,201 (GRCm39) nonsense probably null
R2321:Myh15 UTSW 16 48,933,436 (GRCm39) missense possibly damaging 0.93
R2327:Myh15 UTSW 16 48,963,313 (GRCm39) missense probably benign 0.01
R2395:Myh15 UTSW 16 48,889,877 (GRCm39) missense probably benign 0.04
R2399:Myh15 UTSW 16 48,957,952 (GRCm39) missense probably damaging 0.97
R3413:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R4234:Myh15 UTSW 16 48,983,405 (GRCm39) missense probably benign 0.04
R4382:Myh15 UTSW 16 48,963,306 (GRCm39) missense probably benign 0.03
R4421:Myh15 UTSW 16 48,929,707 (GRCm39) missense probably damaging 0.99
R4580:Myh15 UTSW 16 48,885,388 (GRCm39) missense possibly damaging 0.93
R4657:Myh15 UTSW 16 48,992,421 (GRCm39) nonsense probably null
R4780:Myh15 UTSW 16 48,940,420 (GRCm39) missense probably benign 0.13
R5004:Myh15 UTSW 16 48,952,411 (GRCm39) missense probably damaging 0.99
R5175:Myh15 UTSW 16 48,889,789 (GRCm39) missense possibly damaging 0.85
R5189:Myh15 UTSW 16 48,921,870 (GRCm39) missense probably benign 0.20
R5311:Myh15 UTSW 16 48,986,204 (GRCm39) missense possibly damaging 0.94
R5318:Myh15 UTSW 16 48,930,834 (GRCm39) missense probably damaging 0.99
R5404:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R5415:Myh15 UTSW 16 48,937,658 (GRCm39) missense probably null 1.00
R5558:Myh15 UTSW 16 48,889,900 (GRCm39) missense probably benign 0.32
R5977:Myh15 UTSW 16 48,973,866 (GRCm39) missense probably damaging 1.00
R6004:Myh15 UTSW 16 48,980,062 (GRCm39) missense probably benign 0.00
R6275:Myh15 UTSW 16 48,965,610 (GRCm39) missense probably benign 0.00
R6381:Myh15 UTSW 16 48,921,844 (GRCm39) missense probably damaging 1.00
R6448:Myh15 UTSW 16 48,992,295 (GRCm39) missense probably damaging 0.99
R6516:Myh15 UTSW 16 48,957,996 (GRCm39) missense probably benign 0.19
R6847:Myh15 UTSW 16 48,965,451 (GRCm39) missense possibly damaging 0.70
R6868:Myh15 UTSW 16 48,889,766 (GRCm39) missense probably damaging 1.00
R6889:Myh15 UTSW 16 48,973,474 (GRCm39) missense possibly damaging 0.75
R6896:Myh15 UTSW 16 48,933,434 (GRCm39) missense probably benign 0.44
R6955:Myh15 UTSW 16 48,901,598 (GRCm39) critical splice donor site probably null
R6984:Myh15 UTSW 16 48,930,775 (GRCm39) missense probably damaging 1.00
R7046:Myh15 UTSW 16 48,929,662 (GRCm39) nonsense probably null
R7095:Myh15 UTSW 16 48,992,272 (GRCm39) missense possibly damaging 0.90
R7098:Myh15 UTSW 16 48,997,420 (GRCm39) missense possibly damaging 0.53
R7134:Myh15 UTSW 16 48,901,705 (GRCm39) missense possibly damaging 0.86
R7159:Myh15 UTSW 16 48,881,937 (GRCm39) missense probably damaging 0.97
R7244:Myh15 UTSW 16 49,017,149 (GRCm39) missense probably damaging 1.00
R7278:Myh15 UTSW 16 48,911,468 (GRCm39) missense probably damaging 0.98
R7309:Myh15 UTSW 16 48,916,828 (GRCm39) missense probably benign 0.34
R7327:Myh15 UTSW 16 48,993,369 (GRCm39) missense possibly damaging 0.88
R7418:Myh15 UTSW 16 48,975,900 (GRCm39) missense possibly damaging 0.69
R7937:Myh15 UTSW 16 48,976,009 (GRCm39) missense probably benign 0.00
R8053:Myh15 UTSW 16 48,963,302 (GRCm39) missense possibly damaging 0.89
R8313:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8315:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8316:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8317:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8342:Myh15 UTSW 16 48,913,120 (GRCm39) missense probably benign
R8379:Myh15 UTSW 16 48,901,551 (GRCm39) missense probably benign
R8445:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8707:Myh15 UTSW 16 48,973,450 (GRCm39) missense probably damaging 1.00
R8729:Myh15 UTSW 16 48,881,851 (GRCm39) missense probably damaging 0.97
R8773:Myh15 UTSW 16 49,015,900 (GRCm39) missense possibly damaging 0.89
R8869:Myh15 UTSW 16 48,997,366 (GRCm39) missense probably benign
R8890:Myh15 UTSW 16 48,959,130 (GRCm39) missense probably damaging 1.00
R9026:Myh15 UTSW 16 49,007,433 (GRCm39) missense probably damaging 1.00
R9063:Myh15 UTSW 16 48,913,118 (GRCm39) missense probably benign 0.00
R9290:Myh15 UTSW 16 48,997,375 (GRCm39) missense probably damaging 1.00
R9630:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R9710:Myh15 UTSW 16 48,959,044 (GRCm39) missense probably damaging 1.00
X0012:Myh15 UTSW 16 48,963,341 (GRCm39) missense probably damaging 1.00
X0020:Myh15 UTSW 16 48,986,237 (GRCm39) missense probably damaging 1.00
Z1176:Myh15 UTSW 16 48,916,894 (GRCm39) missense probably damaging 0.98
Z1177:Myh15 UTSW 16 48,980,189 (GRCm39) missense probably benign 0.09
Z1177:Myh15 UTSW 16 48,975,981 (GRCm39) missense probably damaging 0.97
Z1177:Myh15 UTSW 16 48,901,591 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGATTAGCCAAGTCCATTTCCTTC -3'
(R):5'- TGCCATTAAACAACGTGATGAGC -3'

Sequencing Primer
(F):5'- TGCGATCCACAAGTGTCTAG -3'
(R):5'- AGCTGTGATGTTCCAGGACATTAAG -3'
Posted On 2018-08-01