Incidental Mutation 'R6756:Or51a25'
ID 531059
Institutional Source Beutler Lab
Gene Symbol Or51a25
Ensembl Gene ENSMUSG00000066272
Gene Name olfactory receptor family 51 subfamily A member 25
Synonyms MOR11-1, Olfr559, GA_x6K02T2PBJ9-5441154-5440198
MMRRC Submission 044872-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R6756 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102372739-102373695 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102373295 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 134 (N134S)
Ref Sequence ENSEMBL: ENSMUSP00000151100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657]
AlphaFold Q8VH14
Predicted Effect probably benign
Transcript: ENSMUST00000084816
AA Change: N134S

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272
AA Change: N134S

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215657
AA Change: N134S

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C T 1: 71,298,512 (GRCm39) probably null Het
Adam7 T C 14: 68,762,728 (GRCm39) T166A probably benign Het
Ahnak G A 19: 8,984,925 (GRCm39) V2070M possibly damaging Het
Atp6v1a T A 16: 43,909,421 (GRCm39) T537S probably benign Het
Atp8b3 C T 10: 80,361,895 (GRCm39) E719K possibly damaging Het
Clba1 T C 12: 112,775,820 (GRCm39) L192P probably damaging Het
Dpy19l1 T C 9: 24,385,080 (GRCm39) T250A probably damaging Het
Fra10ac1 A C 19: 38,204,313 (GRCm39) Y88D probably damaging Het
Gm21738 C T 14: 19,418,824 (GRCm38) V35I possibly damaging Het
H2-M9 G T 17: 36,953,227 (GRCm39) H27N probably damaging Het
Hivep2 T C 10: 14,008,303 (GRCm39) C1634R probably damaging Het
Meiob A T 17: 25,058,506 (GRCm39) T470S possibly damaging Het
Ms4a7 T C 19: 11,301,889 (GRCm39) H35R possibly damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Nf1 T A 11: 79,335,413 (GRCm39) probably null Het
Npc1l1 T C 11: 6,165,153 (GRCm39) Y1053C probably damaging Het
Or4p21 T C 2: 88,277,078 (GRCm39) D68G possibly damaging Het
Pcdh10 T C 3: 45,334,541 (GRCm39) V285A possibly damaging Het
Phldb2 A T 16: 45,628,683 (GRCm39) C550S probably benign Het
Phldb3 T C 7: 24,326,756 (GRCm39) Y595H probably damaging Het
Plekha8 C T 6: 54,601,125 (GRCm39) Q288* probably null Het
Ppp1r36 G A 12: 76,474,696 (GRCm39) A64T probably benign Het
Ptprd T C 4: 75,873,536 (GRCm39) T1320A probably damaging Het
R3hdm1 GAA GAAA 1: 128,090,548 (GRCm39) probably null Het
Recql4 T C 15: 76,589,059 (GRCm39) D943G probably benign Het
Slc24a2 A G 4: 87,094,529 (GRCm39) I330T probably benign Het
Srcin1 T C 11: 97,425,836 (GRCm39) D433G probably damaging Het
Upb1 A G 10: 75,264,135 (GRCm39) T194A possibly damaging Het
Other mutations in Or51a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Or51a25 APN 7 102,372,858 (GRCm39) missense probably benign 0.01
R0505:Or51a25 UTSW 7 102,373,236 (GRCm39) missense probably damaging 0.97
R1131:Or51a25 UTSW 7 102,372,887 (GRCm39) missense probably damaging 0.99
R1449:Or51a25 UTSW 7 102,373,397 (GRCm39) missense probably damaging 1.00
R3788:Or51a25 UTSW 7 102,372,694 (GRCm39) splice site probably null
R3915:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R3980:Or51a25 UTSW 7 102,372,959 (GRCm39) missense probably damaging 0.98
R4647:Or51a25 UTSW 7 102,373,299 (GRCm39) missense probably damaging 1.00
R5242:Or51a25 UTSW 7 102,373,483 (GRCm39) missense probably benign 0.41
R5404:Or51a25 UTSW 7 102,372,807 (GRCm39) missense possibly damaging 0.95
R5464:Or51a25 UTSW 7 102,373,124 (GRCm39) missense possibly damaging 0.85
R5807:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R5965:Or51a25 UTSW 7 102,373,467 (GRCm39) missense probably benign 0.00
R6008:Or51a25 UTSW 7 102,373,574 (GRCm39) missense probably damaging 1.00
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6493:Or51a25 UTSW 7 102,373,287 (GRCm39) missense possibly damaging 0.85
R7201:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R7460:Or51a25 UTSW 7 102,373,028 (GRCm39) missense probably benign 0.09
R7695:Or51a25 UTSW 7 102,372,866 (GRCm39) missense probably benign 0.37
R8145:Or51a25 UTSW 7 102,372,937 (GRCm39) missense probably damaging 0.98
R8371:Or51a25 UTSW 7 102,372,790 (GRCm39) missense probably damaging 1.00
R8499:Or51a25 UTSW 7 102,372,932 (GRCm39) missense probably damaging 1.00
R9185:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R9230:Or51a25 UTSW 7 102,372,795 (GRCm39) missense possibly damaging 0.95
X0025:Or51a25 UTSW 7 102,373,022 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACAGTAATGTCAGCACAGGC -3'
(R):5'- TTCTGTCCATGCTAGCCCTAAG -3'

Sequencing Primer
(F):5'- CAGCTTCATGACATCAGCATGG -3'
(R):5'- GTCCATGCTAGCCCTAAGTGATG -3'
Posted On 2018-08-01