Incidental Mutation 'R6756:Meiob'
ID 531074
Institutional Source Beutler Lab
Gene Symbol Meiob
Ensembl Gene ENSMUSG00000024155
Gene Name meiosis specific with OB domains
Synonyms 4930528F23Rik
MMRRC Submission 044872-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R6756 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 25023275-25058762 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 25058506 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 470 (T470S)
Ref Sequence ENSEMBL: ENSMUSP00000024972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024972] [ENSMUST00000164251]
AlphaFold Q9D513
Predicted Effect possibly damaging
Transcript: ENSMUST00000024972
AA Change: T470S

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000024972
Gene: ENSMUSG00000024155
AA Change: T470S

DomainStartEndE-ValueType
SCOP:d1fgua2 167 271 2e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000164251
SMART Domains Protein: ENSMUSP00000129904
Gene: ENSMUSG00000024158

DomainStartEndE-ValueType
Lactamase_B 11 173 2.61e-32 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male and female infertility associated with germ cell apoptosis, reduced gonads and impaired meiosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 C T 1: 71,298,512 (GRCm39) probably null Het
Adam7 T C 14: 68,762,728 (GRCm39) T166A probably benign Het
Ahnak G A 19: 8,984,925 (GRCm39) V2070M possibly damaging Het
Atp6v1a T A 16: 43,909,421 (GRCm39) T537S probably benign Het
Atp8b3 C T 10: 80,361,895 (GRCm39) E719K possibly damaging Het
Clba1 T C 12: 112,775,820 (GRCm39) L192P probably damaging Het
Dpy19l1 T C 9: 24,385,080 (GRCm39) T250A probably damaging Het
Fra10ac1 A C 19: 38,204,313 (GRCm39) Y88D probably damaging Het
Gm21738 C T 14: 19,418,824 (GRCm38) V35I possibly damaging Het
H2-M9 G T 17: 36,953,227 (GRCm39) H27N probably damaging Het
Hivep2 T C 10: 14,008,303 (GRCm39) C1634R probably damaging Het
Ms4a7 T C 19: 11,301,889 (GRCm39) H35R possibly damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Nf1 T A 11: 79,335,413 (GRCm39) probably null Het
Npc1l1 T C 11: 6,165,153 (GRCm39) Y1053C probably damaging Het
Or4p21 T C 2: 88,277,078 (GRCm39) D68G possibly damaging Het
Or51a25 T C 7: 102,373,295 (GRCm39) N134S probably benign Het
Pcdh10 T C 3: 45,334,541 (GRCm39) V285A possibly damaging Het
Phldb2 A T 16: 45,628,683 (GRCm39) C550S probably benign Het
Phldb3 T C 7: 24,326,756 (GRCm39) Y595H probably damaging Het
Plekha8 C T 6: 54,601,125 (GRCm39) Q288* probably null Het
Ppp1r36 G A 12: 76,474,696 (GRCm39) A64T probably benign Het
Ptprd T C 4: 75,873,536 (GRCm39) T1320A probably damaging Het
R3hdm1 GAA GAAA 1: 128,090,548 (GRCm39) probably null Het
Recql4 T C 15: 76,589,059 (GRCm39) D943G probably benign Het
Slc24a2 A G 4: 87,094,529 (GRCm39) I330T probably benign Het
Srcin1 T C 11: 97,425,836 (GRCm39) D433G probably damaging Het
Upb1 A G 10: 75,264,135 (GRCm39) T194A possibly damaging Het
Other mutations in Meiob
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Meiob APN 17 25,042,603 (GRCm39) missense probably benign 0.00
IGL01830:Meiob APN 17 25,054,105 (GRCm39) missense probably benign 0.45
IGL01838:Meiob APN 17 25,042,643 (GRCm39) missense possibly damaging 0.68
R0165:Meiob UTSW 17 25,054,135 (GRCm39) missense probably benign 0.00
R0605:Meiob UTSW 17 25,037,236 (GRCm39) splice site probably benign
R1170:Meiob UTSW 17 25,055,458 (GRCm39) missense probably damaging 1.00
R1496:Meiob UTSW 17 25,032,026 (GRCm39) missense possibly damaging 0.93
R1721:Meiob UTSW 17 25,053,021 (GRCm39) missense probably damaging 1.00
R1857:Meiob UTSW 17 25,042,544 (GRCm39) missense probably damaging 1.00
R1858:Meiob UTSW 17 25,042,544 (GRCm39) missense probably damaging 1.00
R1937:Meiob UTSW 17 25,037,305 (GRCm39) missense probably benign 0.34
R2066:Meiob UTSW 17 25,037,290 (GRCm39) missense probably damaging 1.00
R2510:Meiob UTSW 17 25,035,571 (GRCm39) splice site probably benign
R3433:Meiob UTSW 17 25,035,571 (GRCm39) splice site probably benign
R3906:Meiob UTSW 17 25,046,922 (GRCm39) missense probably benign 0.00
R4967:Meiob UTSW 17 25,037,353 (GRCm39) missense probably damaging 1.00
R5707:Meiob UTSW 17 25,054,025 (GRCm39) missense probably benign
R6109:Meiob UTSW 17 25,031,993 (GRCm39) missense probably benign
R6524:Meiob UTSW 17 25,051,491 (GRCm39) missense probably benign
R7167:Meiob UTSW 17 25,055,419 (GRCm39) missense probably damaging 1.00
R8382:Meiob UTSW 17 25,046,913 (GRCm39) missense possibly damaging 0.79
R8440:Meiob UTSW 17 25,037,302 (GRCm39) missense probably benign
R8751:Meiob UTSW 17 25,047,008 (GRCm39) critical splice donor site probably null
R9000:Meiob UTSW 17 25,047,916 (GRCm39) splice site probably benign
R9799:Meiob UTSW 17 25,042,574 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTTCCTTTGTGGTCACTGGT -3'
(R):5'- ATTTCCCCATGTGAGAGTAGACA -3'

Sequencing Primer
(F):5'- CTTCCTTTGTGGTCACTGGTTTTCAG -3'
(R):5'- CCCATGTGAGAGTAGACAGGGTAAG -3'
Posted On 2018-08-01