Incidental Mutation 'R6757:Fpr-rs4'
| ID |
531098 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fpr-rs4
|
| Ensembl Gene |
ENSMUSG00000048062 |
| Gene Name |
formyl peptide receptor, related sequence 4 |
| Synonyms |
|
| MMRRC Submission |
044873-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.084)
|
| Stock # |
R6757 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
18241995-18242966 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 18242394 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 134
(Q134*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093311
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095651]
|
| AlphaFold |
A4FUQ5 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000095651
AA Change: Q134*
|
| SMART Domains |
Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062
AA Change: Q134*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
43 |
297 |
4.9e-35 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.4%
- 20x: 95.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
A |
T |
1: 11,666,558 (GRCm39) |
*288Y |
probably null |
Het |
| Art2a |
G |
T |
7: 101,204,221 (GRCm39) |
L106I |
probably benign |
Het |
| Bmi1 |
C |
T |
2: 18,688,840 (GRCm39) |
T203M |
probably damaging |
Het |
| Cpm |
A |
G |
10: 117,507,543 (GRCm39) |
D220G |
probably damaging |
Het |
| Cyp2a22 |
A |
C |
7: 26,638,629 (GRCm39) |
D52E |
probably benign |
Het |
| Dag1 |
A |
C |
9: 108,095,216 (GRCm39) |
I92S |
probably damaging |
Het |
| Dntt |
A |
T |
19: 41,025,601 (GRCm39) |
H73L |
probably damaging |
Het |
| Epha5 |
A |
C |
5: 84,253,737 (GRCm39) |
I716S |
probably damaging |
Het |
| Fzd8 |
T |
A |
18: 9,213,238 (GRCm39) |
C107S |
possibly damaging |
Het |
| Garre1 |
G |
A |
7: 33,938,502 (GRCm39) |
A799V |
possibly damaging |
Het |
| Gnptab |
T |
C |
10: 88,273,364 (GRCm39) |
L1047P |
probably damaging |
Het |
| Gstt1 |
A |
T |
10: 75,634,217 (GRCm39) |
|
probably null |
Het |
| Kdm2a |
T |
C |
19: 4,369,271 (GRCm39) |
R1115G |
probably damaging |
Het |
| Myl10 |
G |
C |
5: 136,726,825 (GRCm39) |
V70L |
probably benign |
Het |
| Myo1b |
C |
T |
1: 51,852,207 (GRCm39) |
E179K |
probably damaging |
Het |
| Nrp1 |
T |
A |
8: 129,152,349 (GRCm39) |
I186N |
probably damaging |
Het |
| Or10g3 |
A |
G |
14: 52,610,172 (GRCm39) |
C113R |
probably damaging |
Het |
| Pole |
T |
C |
5: 110,451,476 (GRCm39) |
V835A |
probably damaging |
Het |
| Shprh |
A |
G |
10: 11,057,252 (GRCm39) |
|
probably null |
Het |
| Slc39a14 |
A |
T |
14: 70,548,333 (GRCm39) |
L238Q |
probably damaging |
Het |
| Spata31e5 |
A |
C |
1: 28,819,191 (GRCm39) |
I30S |
probably damaging |
Het |
| Usp40 |
A |
T |
1: 87,907,759 (GRCm39) |
I619N |
probably damaging |
Het |
|
| Other mutations in Fpr-rs4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Fpr-rs4
|
APN |
17 |
18,242,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01064:Fpr-rs4
|
APN |
17 |
18,242,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Fpr-rs4
|
APN |
17 |
18,242,493 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02544:Fpr-rs4
|
APN |
17 |
18,242,473 (GRCm39) |
missense |
probably benign |
|
|
IGL02837:Fpr-rs4
|
UTSW |
17 |
18,242,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0179:Fpr-rs4
|
UTSW |
17 |
18,242,289 (GRCm39) |
nonsense |
probably null |
|
|
R0383:Fpr-rs4
|
UTSW |
17 |
18,242,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0686:Fpr-rs4
|
UTSW |
17 |
18,242,613 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1551:Fpr-rs4
|
UTSW |
17 |
18,242,589 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1956:Fpr-rs4
|
UTSW |
17 |
18,242,518 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2040:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2041:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2043:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2045:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2048:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2092:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2093:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R2136:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R3624:Fpr-rs4
|
UTSW |
17 |
18,242,596 (GRCm39) |
frame shift |
probably null |
|
|
R4684:Fpr-rs4
|
UTSW |
17 |
18,242,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6076:Fpr-rs4
|
UTSW |
17 |
18,242,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Fpr-rs4
|
UTSW |
17 |
18,242,748 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6639:Fpr-rs4
|
UTSW |
17 |
18,242,394 (GRCm39) |
nonsense |
probably null |
|
|
R8703:Fpr-rs4
|
UTSW |
17 |
18,242,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9007:Fpr-rs4
|
UTSW |
17 |
18,242,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9318:Fpr-rs4
|
UTSW |
17 |
18,242,217 (GRCm39) |
missense |
probably benign |
|
|
R9357:Fpr-rs4
|
UTSW |
17 |
18,242,211 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9435:Fpr-rs4
|
UTSW |
17 |
18,242,391 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Fpr-rs4
|
UTSW |
17 |
18,242,956 (GRCm39) |
missense |
probably benign |
0.16 |
|
Z1088:Fpr-rs4
|
UTSW |
17 |
18,242,181 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACACTGTGACCACTGTCTC -3'
(R):5'- CTGCTCTTCAGAGGTTGCAACC -3'
Sequencing Primer
(F):5'- GACCACTGTCTCTTATCTGAACTTGG -3'
(R):5'- GGTTGCAACCCAGGATTCAAATTTAG -3'
|
| Posted On |
2018-08-01 |
Incidental Mutation