Incidental Mutation 'R6324:Prl7b1'
ID 531212
Institutional Source Beutler Lab
Gene Symbol Prl7b1
Ensembl Gene ENSMUSG00000021347
Gene Name prolactin family 7, subfamily b, member 1
Synonyms PLP-N, Prlpn, 1600014J19Rik
MMRRC Submission 044478-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6324 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 27785802-27794565 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 27786878 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000079431 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080595]
AlphaFold Q8CGZ9
Predicted Effect probably null
Transcript: ENSMUST00000080595
SMART Domains Protein: ENSMUSP00000079431
Gene: ENSMUSG00000021347

DomainStartEndE-ValueType
Pfam:Hormone_1 16 241 3.1e-60 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 96% (47/49)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit enhanced fetal growth and survival following exposure of dams to low oxygen conditions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef4 G A 1: 34,762,558 (GRCm39) A605T unknown Het
Atp13a3 A G 16: 30,151,103 (GRCm39) V1069A possibly damaging Het
Atp1a2 C G 1: 172,116,903 (GRCm39) R238P probably damaging Het
Baz2b A G 2: 59,737,292 (GRCm39) S1877P probably damaging Het
Ccdc27 A T 4: 154,120,648 (GRCm39) S383T probably benign Het
Cr1l A G 1: 194,793,430 (GRCm39) V377A probably benign Het
Dazap1 A G 10: 80,113,494 (GRCm39) E130G probably benign Het
Dchs1 G T 7: 105,414,145 (GRCm39) A890E probably benign Het
Dock10 G A 1: 80,482,893 (GRCm39) T2143I probably benign Het
Eif3j1 A G 2: 121,871,659 (GRCm39) D60G probably benign Het
Enah A G 1: 181,746,136 (GRCm39) S382P probably damaging Het
Fam171b A T 2: 83,709,608 (GRCm39) K427* probably null Het
Fmn2 A T 1: 174,440,119 (GRCm39) I1179L possibly damaging Het
Focad C T 4: 88,319,305 (GRCm39) R1505* probably null Het
Frem1 T C 4: 82,901,574 (GRCm39) T985A probably benign Het
Gm3404 A T 5: 146,464,917 (GRCm39) Q219L possibly damaging Het
Gm5592 A C 7: 40,935,959 (GRCm39) S154R probably damaging Het
Gpn3 C T 5: 122,510,638 (GRCm39) probably benign Het
Gpr158 A G 2: 21,815,365 (GRCm39) E586G probably damaging Het
Gstp2 A T 19: 4,090,499 (GRCm39) I162N probably benign Het
Lin7a T A 10: 107,216,076 (GRCm39) probably null Het
Loxl4 G A 19: 42,583,817 (GRCm39) L745F probably benign Het
Ms4a19 T A 19: 11,140,811 (GRCm39) M3L probably benign Het
Mybpc1 A G 10: 88,404,481 (GRCm39) I172T possibly damaging Het
Nalcn A G 14: 123,647,161 (GRCm39) W571R possibly damaging Het
Nkx2-5 G C 17: 27,060,095 (GRCm39) P79A probably benign Het
Nufip2 A G 11: 77,582,487 (GRCm39) T134A probably benign Het
Odad1 A G 7: 45,591,134 (GRCm39) E203G probably damaging Het
Or13p4 G A 4: 118,547,728 (GRCm39) probably benign Het
Or5al1 C T 2: 85,989,800 (GRCm39) V305I probably benign Het
Or5b109 A G 19: 13,212,468 (GRCm39) M285V possibly damaging Het
Phkb A G 8: 86,745,171 (GRCm39) D616G probably benign Het
Plch1 C T 3: 63,688,811 (GRCm39) W131* probably null Het
Prop1 G A 11: 50,843,026 (GRCm39) P54S probably benign Het
Ptcd3 C T 6: 71,862,311 (GRCm39) V509I probably benign Het
Ptprg T A 14: 12,226,314 (GRCm38) D527E probably damaging Het
Rapgef2 C T 3: 78,986,439 (GRCm39) V1182I probably benign Het
Rfx7 C A 9: 72,525,696 (GRCm39) P962Q probably damaging Het
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Homo
Slc38a9 A G 13: 112,862,634 (GRCm39) I444M probably benign Het
Sorbs1 T C 19: 40,310,263 (GRCm39) T492A probably damaging Het
Synj1 A T 16: 90,735,518 (GRCm39) S1478R probably benign Het
Tnn T A 1: 159,972,774 (GRCm39) N276I probably damaging Het
Trbv19 G A 6: 41,155,692 (GRCm39) G21D probably damaging Het
Ube2o A T 11: 116,430,185 (GRCm39) D1184E probably benign Het
Vmn1r181 G A 7: 23,684,183 (GRCm39) R216Q probably benign Het
Vmn2r108 A T 17: 20,691,977 (GRCm39) L182* probably null Het
Vmn2r15 A G 5: 109,434,137 (GRCm39) *856R probably null Het
Vmn2r70 G A 7: 85,208,087 (GRCm39) H797Y probably benign Het
Zfp11 C T 5: 129,733,587 (GRCm39) A625T possibly damaging Het
Other mutations in Prl7b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00473:Prl7b1 APN 13 27,788,573 (GRCm39) missense probably damaging 0.98
IGL01350:Prl7b1 APN 13 27,786,804 (GRCm39) missense probably damaging 1.00
IGL01602:Prl7b1 APN 13 27,786,027 (GRCm39) missense possibly damaging 0.70
IGL01605:Prl7b1 APN 13 27,786,027 (GRCm39) missense possibly damaging 0.70
IGL03106:Prl7b1 APN 13 27,790,918 (GRCm39) missense probably benign 0.17
IGL03401:Prl7b1 APN 13 27,785,964 (GRCm39) missense probably benign 0.02
fleshy UTSW 13 27,786,878 (GRCm39) splice site probably null
G1Funyon:Prl7b1 UTSW 13 27,786,755 (GRCm39) missense possibly damaging 0.69
R1169:Prl7b1 UTSW 13 27,790,887 (GRCm39) missense possibly damaging 0.81
R1423:Prl7b1 UTSW 13 27,786,110 (GRCm39) missense probably damaging 0.99
R1846:Prl7b1 UTSW 13 27,786,831 (GRCm39) missense probably damaging 1.00
R2294:Prl7b1 UTSW 13 27,786,854 (GRCm39) missense possibly damaging 0.93
R6049:Prl7b1 UTSW 13 27,790,161 (GRCm39) missense probably benign 0.03
R6065:Prl7b1 UTSW 13 27,788,529 (GRCm39) missense probably benign 0.01
R6870:Prl7b1 UTSW 13 27,788,516 (GRCm39) missense probably damaging 1.00
R7473:Prl7b1 UTSW 13 27,785,996 (GRCm39) missense possibly damaging 0.70
R7742:Prl7b1 UTSW 13 27,791,031 (GRCm39) missense probably benign 0.07
R8301:Prl7b1 UTSW 13 27,786,755 (GRCm39) missense possibly damaging 0.69
R9131:Prl7b1 UTSW 13 27,790,968 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGCAATCTTCATGATGCGATC -3'
(R):5'- AAGCAACATGGTGGTTCATTAG -3'

Sequencing Primer
(F):5'- TCTTCATGATGCGATCCAGAAGG -3'
(R):5'- CAACATGGTGGTTCATTAGAAAAAG -3'
Posted On 2018-08-02