Incidental Mutation 'R6782:Zfp975'
ID 531462
Institutional Source Beutler Lab
Gene Symbol Zfp975
Ensembl Gene ENSMUSG00000069727
Gene Name zinc finger protein 975
Synonyms Gm5595
MMRRC Submission 044896-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R6782 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 42309529-42342166 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 42311454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 386 (N386K)
Ref Sequence ENSEMBL: ENSMUSP00000103626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107992]
AlphaFold Q6NVD6
Predicted Effect probably benign
Transcript: ENSMUST00000107992
AA Change: N386K

PolyPhen 2 Score 0.406 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000103626
Gene: ENSMUSG00000069727
AA Change: N386K

DomainStartEndE-ValueType
KRAB 4 66 1.53e-19 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 9.73e-4 SMART
ZnF_C2H2 187 209 1.47e-3 SMART
ZnF_C2H2 215 237 3.89e-3 SMART
ZnF_C2H2 243 265 2.57e-3 SMART
ZnF_C2H2 271 293 7.26e-3 SMART
ZnF_C2H2 299 321 1.58e-3 SMART
ZnF_C2H2 327 349 7.9e-4 SMART
ZnF_C2H2 355 377 5.9e-3 SMART
ZnF_C2H2 383 405 1.58e-3 SMART
ZnF_C2H2 411 433 6.32e-3 SMART
ZnF_C2H2 439 461 8.47e-4 SMART
ZnF_C2H2 467 489 2.57e-3 SMART
ZnF_C2H2 495 517 3.16e-3 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 C T 7: 119,847,308 (GRCm39) A724V probably damaging Het
Abcc3 A T 11: 94,249,776 (GRCm39) F1055L probably damaging Het
Akt3 A T 1: 176,877,756 (GRCm39) Y337* probably null Het
Ankrd17 T C 5: 90,402,597 (GRCm39) K1488R possibly damaging Het
Ano1 G A 7: 144,175,424 (GRCm39) T498I probably damaging Het
Arhgap42 T A 9: 9,115,721 (GRCm39) K118N probably damaging Het
Arl5b A G 2: 15,077,993 (GRCm39) E106G probably damaging Het
Atp5mc3 C T 2: 73,739,672 (GRCm39) R56Q probably benign Het
Bbx T C 16: 50,020,928 (GRCm39) R749G probably benign Het
Cacna1g A G 11: 94,350,376 (GRCm39) S490P probably damaging Het
Ccdc63 A T 5: 122,249,077 (GRCm39) Y417* probably null Het
Cep162 A T 9: 87,093,737 (GRCm39) N880K probably benign Het
Chd2 G A 7: 73,125,127 (GRCm39) Q77* probably null Het
Cntrl T G 2: 35,060,658 (GRCm39) M1397R possibly damaging Het
Dcaf7 A G 11: 105,945,581 (GRCm39) Y310C probably damaging Het
Dnah5 T A 15: 28,449,302 (GRCm39) S4235T possibly damaging Het
Dot1l C T 10: 80,625,224 (GRCm39) P1157L probably damaging Het
Esco2 T C 14: 66,057,465 (GRCm39) T577A probably benign Het
Foxp1 T C 6: 98,907,106 (GRCm39) D624G probably damaging Het
Gfi1 A T 5: 107,873,819 (GRCm39) probably null Het
Gm10985 TTCTCTCTCTCTCTCTCT TTCTCTCTCTCTCTCT 3: 53,752,626 (GRCm39) probably null Het
Gm5113 G A 7: 29,878,178 (GRCm39) V89I probably benign Het
Gtf3c2 A C 5: 31,327,180 (GRCm39) L382R probably benign Het
H3c2 T C 13: 23,936,393 (GRCm39) S11P probably benign Het
Hhip T C 8: 80,778,233 (GRCm39) N99S probably damaging Het
Htr5b T C 1: 121,438,227 (GRCm39) I335V probably benign Het
Ifi206 A G 1: 173,308,923 (GRCm39) S358P unknown Het
Loxhd1 T A 18: 77,518,873 (GRCm39) V1893D probably damaging Het
Mical2 A G 7: 111,945,968 (GRCm39) R11G probably damaging Het
Mrc1 T C 2: 14,266,148 (GRCm39) probably null Het
Npr1 T C 3: 90,363,560 (GRCm39) N821S probably benign Het
Or4g16 A G 2: 111,137,090 (GRCm39) D180G probably damaging Het
Or52a24 A G 7: 103,381,549 (GRCm39) T139A possibly damaging Het
Or5p63 T C 7: 107,811,670 (GRCm39) D22G probably benign Het
Or5p70 T G 7: 107,994,744 (GRCm39) M139R probably damaging Het
Pi4ka T A 16: 17,143,852 (GRCm39) D739V probably damaging Het
Pi4ka A G 16: 17,194,846 (GRCm39) L184P possibly damaging Het
Ptprd T C 4: 76,243,377 (GRCm39) probably null Het
Ralgapb G A 2: 158,278,486 (GRCm39) G5R probably damaging Het
Ric8b T C 10: 84,783,391 (GRCm39) V83A probably damaging Het
Sdc2 C A 15: 33,028,281 (GRCm39) T133K probably damaging Het
Slc12a7 T A 13: 73,947,088 (GRCm39) V592D probably damaging Het
Sorcs1 G T 19: 50,164,560 (GRCm39) Y990* probably null Het
Spata13 G T 14: 60,928,912 (GRCm39) G157W probably damaging Het
Tada1 A G 1: 166,217,541 (GRCm39) N226S probably benign Het
Tenm3 A G 8: 49,099,291 (GRCm39) probably null Het
Tll1 A G 8: 64,524,315 (GRCm39) V457A probably benign Het
Tmem232 T C 17: 65,807,119 (GRCm39) K25E possibly damaging Het
Tnrc18 T C 5: 142,773,063 (GRCm39) S406G unknown Het
Ush2a A G 1: 188,089,031 (GRCm39) M329V probably benign Het
Vmn2r107 T C 17: 20,577,141 (GRCm39) S380P probably damaging Het
Vmn2r73 A G 7: 85,519,563 (GRCm39) M465T probably benign Het
Wwc2 A G 8: 48,353,826 (GRCm39) Y103H possibly damaging Het
Zfp217 T C 2: 169,958,178 (GRCm39) D463G probably damaging Het
Zfp345 T C 2: 150,315,274 (GRCm39) S88G probably damaging Het
Other mutations in Zfp975
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Zfp975 APN 7 42,312,215 (GRCm39) missense probably damaging 1.00
R0194:Zfp975 UTSW 7 42,311,916 (GRCm39) missense probably benign 0.02
R0662:Zfp975 UTSW 7 42,311,950 (GRCm39) missense probably benign 0.02
R1491:Zfp975 UTSW 7 42,312,236 (GRCm39) missense probably benign 0.19
R1573:Zfp975 UTSW 7 42,311,507 (GRCm39) missense probably benign 0.03
R1738:Zfp975 UTSW 7 42,312,373 (GRCm39) missense probably benign 0.05
R1833:Zfp975 UTSW 7 42,311,263 (GRCm39) missense probably benign 0.01
R2185:Zfp975 UTSW 7 42,311,105 (GRCm39) missense possibly damaging 0.90
R4031:Zfp975 UTSW 7 42,312,377 (GRCm39) nonsense probably null
R4090:Zfp975 UTSW 7 42,312,298 (GRCm39) missense probably benign 0.10
R4356:Zfp975 UTSW 7 42,311,251 (GRCm39) missense probably damaging 1.00
R4631:Zfp975 UTSW 7 42,312,369 (GRCm39) missense probably benign 0.09
R4795:Zfp975 UTSW 7 42,314,570 (GRCm39) critical splice acceptor site probably null
R4896:Zfp975 UTSW 7 42,311,716 (GRCm39) missense probably damaging 1.00
R5266:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5267:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5580:Zfp975 UTSW 7 42,314,513 (GRCm39) nonsense probably null
R5874:Zfp975 UTSW 7 42,312,312 (GRCm39) missense probably benign 0.00
R5898:Zfp975 UTSW 7 42,311,963 (GRCm39) missense probably damaging 1.00
R6529:Zfp975 UTSW 7 42,311,325 (GRCm39) missense possibly damaging 0.79
R6937:Zfp975 UTSW 7 42,314,480 (GRCm39) missense possibly damaging 0.61
R7088:Zfp975 UTSW 7 42,312,096 (GRCm39) missense probably benign 0.02
R7233:Zfp975 UTSW 7 42,311,918 (GRCm39) missense probably benign 0.38
R7253:Zfp975 UTSW 7 42,311,036 (GRCm39) makesense probably null
R7358:Zfp975 UTSW 7 42,312,215 (GRCm39) missense probably damaging 1.00
R7659:Zfp975 UTSW 7 42,311,848 (GRCm39) missense probably benign 0.00
R7999:Zfp975 UTSW 7 42,312,356 (GRCm39) missense probably benign 0.02
R8676:Zfp975 UTSW 7 42,312,264 (GRCm39) missense probably benign 0.44
R8957:Zfp975 UTSW 7 42,311,157 (GRCm39) missense probably damaging 1.00
R9274:Zfp975 UTSW 7 42,312,299 (GRCm39) missense probably benign 0.02
R9326:Zfp975 UTSW 7 42,311,837 (GRCm39) nonsense probably null
R9536:Zfp975 UTSW 7 42,312,345 (GRCm39) missense probably benign 0.11
R9569:Zfp975 UTSW 7 42,311,413 (GRCm39) missense probably benign 0.00
R9717:Zfp975 UTSW 7 42,312,332 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- CGAAGATAGTGGGGTTGCA -3'
(R):5'- CAGGTACCTTCGAGCACATGA -3'

Sequencing Primer
(F):5'- GTTGGGTCGTAAAAAGGCTTTACCAC -3'
(R):5'- GGTACCTTCGAGCACATGAAAGAAC -3'
Posted On 2018-08-29