Incidental Mutation 'R6783:Cdcp3'
ID 531513
Institutional Source Beutler Lab
Gene Symbol Cdcp3
Ensembl Gene ENSMUSG00000006204
Gene Name CUB domain containing protein 3
Synonyms 5430419D17Rik
MMRRC Submission 044897-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6783 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 130776131-130908180 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130828493 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 316 (L316P)
Ref Sequence ENSEMBL: ENSMUSP00000061529 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050586] [ENSMUST00000124096] [ENSMUST00000208921]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000050586
AA Change: L316P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000061529
Gene: ENSMUSG00000006204
AA Change: L316P

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 85 105 N/A INTRINSIC
SR 144 244 3.3e-57 SMART
CUB 272 378 1.2e-16 SMART
SR 428 528 3.9e-56 SMART
low complexity region 533 548 N/A INTRINSIC
CUB 556 667 5.1e-38 SMART
SR 680 780 1.5e-57 SMART
Pfam:CUB 795 840 3.1e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000128522
AA Change: L189P
Predicted Effect probably benign
Transcript: ENSMUST00000208921
AA Change: L316P

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.8%
Validation Efficiency 95% (42/44)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam12 T A 7: 133,576,126 (GRCm39) Q228L probably damaging Het
Arhgap45 A G 10: 79,853,698 (GRCm39) T71A possibly damaging Het
Bag6 T A 17: 35,363,211 (GRCm39) S684T possibly damaging Het
Bcam C T 7: 19,500,806 (GRCm39) G123R probably damaging Het
Cdr2l C T 11: 115,284,495 (GRCm39) A277V possibly damaging Het
Clcn4 T A 7: 7,302,181 (GRCm39) probably benign Het
Csnk1g1 T A 9: 65,880,794 (GRCm39) I72N probably damaging Het
Cspg4b A T 13: 113,456,743 (GRCm39) K930* probably null Het
Ddx31 G A 2: 28,764,188 (GRCm39) V465I probably benign Het
Ddx54 C T 5: 120,756,779 (GRCm39) Q163* probably null Het
Dnmt3a A G 12: 3,947,406 (GRCm39) E459G probably damaging Het
Dpp8 T C 9: 64,970,844 (GRCm39) S568P possibly damaging Het
Drap1 G T 19: 5,474,219 (GRCm39) T47K probably damaging Het
Epha7 G T 4: 28,950,528 (GRCm39) R777L possibly damaging Het
Far2 T G 6: 148,052,273 (GRCm39) probably null Het
Fhdc1 T C 3: 84,352,834 (GRCm39) K797R probably benign Het
Gm10330 A T 12: 23,830,094 (GRCm39) M29K probably damaging Het
Grik3 A T 4: 125,526,093 (GRCm39) I109F probably benign Het
Il31ra T C 13: 112,688,522 (GRCm39) probably null Het
Itga1 T G 13: 115,133,513 (GRCm39) I466L probably benign Het
Itpr2 A T 6: 146,287,371 (GRCm39) probably null Het
Mical3 A C 6: 120,935,786 (GRCm39) L1580R possibly damaging Het
Or14c43 T A 7: 86,114,835 (GRCm39) V72D probably damaging Het
Or4n4 T C 14: 50,519,644 (GRCm39) D22G probably benign Het
Palb2 T A 7: 121,726,711 (GRCm39) E386D probably damaging Het
Pate8 T A 9: 36,492,631 (GRCm39) probably null Het
Polm C A 11: 5,785,534 (GRCm39) R175L probably damaging Het
Prpf40b C T 15: 99,212,784 (GRCm39) R627W probably damaging Het
Ptcd3 A T 6: 71,885,627 (GRCm39) V33D probably benign Het
Pwwp4c C T X: 73,684,021 (GRCm39) R355H probably damaging Homo
Ripk4 C A 16: 97,549,237 (GRCm39) R273L probably damaging Het
Rpap2 A G 5: 107,803,153 (GRCm39) T612A probably damaging Het
Serpinb10 A G 1: 107,474,597 (GRCm39) N253S possibly damaging Het
Sgpp1 G C 12: 75,782,243 (GRCm39) P32R probably benign Het
Sim1 T C 10: 50,784,823 (GRCm39) I156T possibly damaging Het
Ski A T 4: 155,245,289 (GRCm39) probably null Het
Spaca7b G A 8: 11,705,661 (GRCm39) Q39* probably null Het
Tent2 G A 13: 93,291,526 (GRCm39) A368V probably benign Het
Tent2 C G 13: 93,291,527 (GRCm39) A372P probably benign Het
Trdn C T 10: 33,314,811 (GRCm39) R512C probably damaging Het
Trim33 T C 3: 103,259,403 (GRCm39) Y1031H probably damaging Het
Use1 T C 8: 71,821,880 (GRCm39) L188P probably damaging Het
Usp34 G A 11: 23,362,318 (GRCm39) G1588D probably damaging Het
Vmn2r33 C A 7: 7,566,797 (GRCm39) R105L probably benign Het
Vmn2r53 G A 7: 12,335,360 (GRCm39) S100F probably damaging Het
Other mutations in Cdcp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Cdcp3 APN 7 130,839,823 (GRCm39) splice site probably null
IGL00848:Cdcp3 APN 7 130,848,453 (GRCm39) missense probably damaging 1.00
IGL00966:Cdcp3 APN 7 130,844,836 (GRCm39) nonsense probably null
IGL01286:Cdcp3 APN 7 130,848,432 (GRCm39) missense probably damaging 1.00
IGL01303:Cdcp3 APN 7 130,796,060 (GRCm39) missense possibly damaging 0.53
IGL01585:Cdcp3 APN 7 130,846,487 (GRCm39) missense probably damaging 0.97
IGL01665:Cdcp3 APN 7 130,848,386 (GRCm39) nonsense probably null
IGL01953:Cdcp3 APN 7 130,826,709 (GRCm39) missense probably benign 0.04
IGL02427:Cdcp3 APN 7 130,846,517 (GRCm39) missense probably damaging 0.99
IGL02508:Cdcp3 APN 7 130,824,559 (GRCm39) missense probably damaging 1.00
IGL02678:Cdcp3 APN 7 130,830,646 (GRCm39) missense probably damaging 1.00
IGL03092:Cdcp3 APN 7 130,803,527 (GRCm39) critical splice donor site probably null
IGL03122:Cdcp3 APN 7 130,798,243 (GRCm39) missense possibly damaging 0.68
IGL03343:Cdcp3 APN 7 130,848,420 (GRCm39) missense probably damaging 1.00
R0011:Cdcp3 UTSW 7 130,831,722 (GRCm39) missense probably damaging 0.99
R0011:Cdcp3 UTSW 7 130,831,722 (GRCm39) missense probably damaging 0.99
R0234:Cdcp3 UTSW 7 130,796,032 (GRCm39) splice site probably null
R0234:Cdcp3 UTSW 7 130,796,032 (GRCm39) splice site probably null
R0268:Cdcp3 UTSW 7 130,839,905 (GRCm39) missense probably damaging 1.00
R0383:Cdcp3 UTSW 7 130,841,268 (GRCm39) missense probably benign 0.05
R0973:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R0973:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R0974:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R1572:Cdcp3 UTSW 7 130,846,560 (GRCm39) nonsense probably null
R1911:Cdcp3 UTSW 7 130,839,818 (GRCm39) missense probably damaging 1.00
R2032:Cdcp3 UTSW 7 130,844,781 (GRCm39) missense probably damaging 1.00
R2097:Cdcp3 UTSW 7 130,783,693 (GRCm39) nonsense probably null
R2221:Cdcp3 UTSW 7 130,849,186 (GRCm39) critical splice acceptor site probably null
R2223:Cdcp3 UTSW 7 130,849,186 (GRCm39) critical splice acceptor site probably null
R2254:Cdcp3 UTSW 7 130,824,634 (GRCm39) missense probably damaging 1.00
R2913:Cdcp3 UTSW 7 130,783,753 (GRCm39) missense possibly damaging 0.90
R2991:Cdcp3 UTSW 7 130,848,429 (GRCm39) missense probably damaging 1.00
R3439:Cdcp3 UTSW 7 130,790,508 (GRCm39) critical splice donor site probably null
R4418:Cdcp3 UTSW 7 130,849,194 (GRCm39) missense possibly damaging 0.86
R4916:Cdcp3 UTSW 7 130,776,206 (GRCm39) splice site probably null
R5488:Cdcp3 UTSW 7 130,848,324 (GRCm39) missense probably damaging 1.00
R5594:Cdcp3 UTSW 7 130,841,252 (GRCm39) missense probably benign 0.12
R5897:Cdcp3 UTSW 7 130,798,280 (GRCm39) splice site probably null
R5898:Cdcp3 UTSW 7 130,843,696 (GRCm39) splice site probably null
R5940:Cdcp3 UTSW 7 130,839,992 (GRCm39) missense probably damaging 1.00
R6170:Cdcp3 UTSW 7 130,776,216 (GRCm39) splice site probably null
R6187:Cdcp3 UTSW 7 130,872,328 (GRCm39) intron probably benign
R6321:Cdcp3 UTSW 7 130,858,735 (GRCm39) critical splice donor site probably null
R6409:Cdcp3 UTSW 7 130,863,800 (GRCm39) intron probably benign
R6432:Cdcp3 UTSW 7 130,846,601 (GRCm39) critical splice donor site probably null
R6481:Cdcp3 UTSW 7 130,858,530 (GRCm39) missense probably benign 0.05
R6750:Cdcp3 UTSW 7 130,889,974 (GRCm39) intron probably benign
R6836:Cdcp3 UTSW 7 130,798,233 (GRCm39) missense possibly damaging 0.84
R6925:Cdcp3 UTSW 7 130,824,436 (GRCm39) missense possibly damaging 0.92
R6995:Cdcp3 UTSW 7 130,824,400 (GRCm39) missense probably damaging 1.00
R7199:Cdcp3 UTSW 7 130,837,641 (GRCm39) nonsense probably null
R7205:Cdcp3 UTSW 7 130,879,352 (GRCm39) critical splice donor site probably null
R7340:Cdcp3 UTSW 7 130,879,344 (GRCm39) missense unknown
R7354:Cdcp3 UTSW 7 130,873,762 (GRCm39) missense unknown
R7354:Cdcp3 UTSW 7 130,858,458 (GRCm39) missense possibly damaging 0.84
R7434:Cdcp3 UTSW 7 130,881,212 (GRCm39) missense unknown
R7485:Cdcp3 UTSW 7 130,830,562 (GRCm39) missense probably damaging 0.99
R7513:Cdcp3 UTSW 7 130,873,800 (GRCm39) missense unknown
R7562:Cdcp3 UTSW 7 130,904,426 (GRCm39) missense unknown
R7623:Cdcp3 UTSW 7 130,879,295 (GRCm39) splice site probably null
R7782:Cdcp3 UTSW 7 130,904,466 (GRCm39) splice site probably null
R7879:Cdcp3 UTSW 7 130,844,871 (GRCm39) missense probably damaging 0.98
R7935:Cdcp3 UTSW 7 130,852,205 (GRCm39) missense probably damaging 0.96
R7949:Cdcp3 UTSW 7 130,895,324 (GRCm39) splice site probably null
R7964:Cdcp3 UTSW 7 130,899,963 (GRCm39) missense unknown
R7980:Cdcp3 UTSW 7 130,836,506 (GRCm39) missense probably damaging 0.98
R8145:Cdcp3 UTSW 7 130,898,045 (GRCm39) missense unknown
R8673:Cdcp3 UTSW 7 130,844,846 (GRCm39) missense probably damaging 0.99
R8684:Cdcp3 UTSW 7 130,837,688 (GRCm39) nonsense probably null
R8721:Cdcp3 UTSW 7 130,879,335 (GRCm39) missense unknown
R8725:Cdcp3 UTSW 7 130,875,485 (GRCm39) missense unknown
R8727:Cdcp3 UTSW 7 130,875,485 (GRCm39) missense unknown
R8742:Cdcp3 UTSW 7 130,783,741 (GRCm39) missense unknown
R8807:Cdcp3 UTSW 7 130,846,507 (GRCm39) missense probably damaging 0.97
R8822:Cdcp3 UTSW 7 130,843,706 (GRCm39) critical splice acceptor site probably null
R8861:Cdcp3 UTSW 7 130,861,690 (GRCm39) nonsense probably null
R8897:Cdcp3 UTSW 7 130,867,566 (GRCm39) missense unknown
R8900:Cdcp3 UTSW 7 130,904,197 (GRCm39) intron probably benign
R9214:Cdcp3 UTSW 7 130,824,481 (GRCm39) missense possibly damaging 0.89
R9218:Cdcp3 UTSW 7 130,863,728 (GRCm39) missense unknown
R9311:Cdcp3 UTSW 7 130,859,490 (GRCm39) missense unknown
R9323:Cdcp3 UTSW 7 130,828,401 (GRCm39) missense probably damaging 0.96
R9384:Cdcp3 UTSW 7 130,904,404 (GRCm39) missense unknown
R9387:Cdcp3 UTSW 7 130,863,620 (GRCm39) missense unknown
R9417:Cdcp3 UTSW 7 130,852,218 (GRCm39) missense possibly damaging 0.60
R9502:Cdcp3 UTSW 7 130,836,815 (GRCm39) missense possibly damaging 0.61
R9603:Cdcp3 UTSW 7 130,830,643 (GRCm39) missense probably damaging 0.98
R9642:Cdcp3 UTSW 7 130,848,257 (GRCm39) missense probably benign 0.01
Z1088:Cdcp3 UTSW 7 130,848,362 (GRCm39) missense probably damaging 1.00
Z1177:Cdcp3 UTSW 7 130,867,595 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AACTGAACAATACACACTAAAGCTTT -3'
(R):5'- TGTGGAACTACACACCCCTA -3'

Sequencing Primer
(F):5'- GCCATCTTCAGCTAGAGATGG -3'
(R):5'- GATGTTCTACCACTGAGAGATGC -3'
Posted On 2018-08-29