Mutagenetix > Incidental Mutation

Incidental Mutation 'R6794:Vmn2r118'

531683

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

Vmn2r119, EG668547, EG383258

MMRRC Submission

044907-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.128) question?

Stock #

R6794 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

55899341-55931672 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 55899348 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 852 (H852L)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168440
AA Change: H852L

PolyPhen 2 Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: H852L

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.7%
20x: 96.4%

Validation Efficiency

100% (37/37)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agxt	T	C	1: 93,063,104 (GRCm39)	V30A	possibly damaging	Het
Atf7	T	C	15: 102,465,900 (GRCm39)	K87E	probably benign	Het
Bltp3b	T	C	10: 89,641,624 (GRCm39)	S932P	probably benign	Het
Btg4	A	C	9: 51,030,651 (GRCm39)	K250N	possibly damaging	Het
Cracdl	A	G	1: 37,676,936 (GRCm39)		probably null	Het
Cyc1	A	G	15: 76,228,850 (GRCm39)	Y132C	probably damaging	Het
Dcaf5	A	T	12: 80,445,667 (GRCm39)	D137E	possibly damaging	Het
Ddr2	C	A	1: 169,809,667 (GRCm39)	W770L	probably damaging	Het
Disc1	T	C	8: 125,814,514 (GRCm39)	V126A	probably benign	Het
Dock8	A	G	19: 25,099,805 (GRCm39)	N643D	probably benign	Het
Gabrg1	C	T	5: 70,973,314 (GRCm39)	R75H	probably damaging	Het
Gm14418	A	T	2: 177,079,631 (GRCm39)	H121Q	probably damaging	Het
H2-Ob	T	A	17: 34,460,162 (GRCm39)	L20Q	possibly damaging	Het
Herpud1	T	A	8: 95,121,398 (GRCm39)		probably null	Het
Ica1	T	C	6: 8,653,659 (GRCm39)	D326G	probably benign	Het
Jph3	T	C	8: 122,512,124 (GRCm39)	L704P	probably benign	Het
Kmt2e	TGCCGCCGCCGCCGCCACCGCCGCCGCCGC	TGCCGCCGCCGCCGCCGCCACCGCCGCCGCCGC	5: 23,704,474 (GRCm39)		probably benign	Het
Lnpep	T	G	17: 17,751,421 (GRCm39)	N948T	probably damaging	Het
Mdn1	T	A	4: 32,741,893 (GRCm39)	V3888D	probably damaging	Het
Muc5ac	T	C	7: 141,363,289 (GRCm39)		probably benign	Het
Nfkb2	T	C	19: 46,296,159 (GRCm39)		probably null	Het
Pik3r2	T	C	8: 71,223,361 (GRCm39)	H380R	probably benign	Het
Prim1	T	C	10: 127,854,018 (GRCm39)	S124P	probably damaging	Het
Prokr1	T	C	6: 87,565,675 (GRCm39)	T57A	possibly damaging	Het
Ptpn4	T	C	1: 119,671,120 (GRCm39)	T213A	probably damaging	Het
Sapcd2	A	G	2: 25,266,379 (GRCm39)	S389G	probably damaging	Het
Scn5a	T	C	9: 119,364,955 (GRCm39)	Q421R	probably damaging	Het
Serac1	A	G	17: 6,101,985 (GRCm39)	Y430H	probably damaging	Het
Shf	A	G	2: 122,184,321 (GRCm39)	L234P	probably damaging	Het
Slc22a29	G	T	19: 8,138,887 (GRCm39)	S525Y	probably benign	Het
Thbs1	A	G	2: 117,950,519 (GRCm39)		probably null	Het
Tln2	T	C	9: 67,193,840 (GRCm39)	D666G	probably benign	Het
Ubqlnl	C	T	7: 103,797,992 (GRCm39)	E502K	probably benign	Het
Vmn2r72	A	G	7: 85,387,204 (GRCm39)	F787L	probably damaging	Het
Xpc	G	A	6: 91,483,839 (GRCm39)	A169V	probably benign	Het
Ylpm1	A	G	12: 85,043,655 (GRCm39)	H131R	unknown	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55,899,708 (GRCm39)	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55,900,204 (GRCm39)	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55,900,000 (GRCm39)	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55,915,585 (GRCm39)	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55,899,990 (GRCm39)	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55,899,619 (GRCm39)	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55,917,517 (GRCm39)	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55,931,598 (GRCm39)	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55,917,870 (GRCm39)	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55,899,655 (GRCm39)	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55,914,996 (GRCm39)	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55,915,616 (GRCm39)	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55,917,717 (GRCm39)	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55,917,717 (GRCm39)	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55,915,643 (GRCm39)	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55,918,021 (GRCm39)	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55,917,970 (GRCm39)	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55,917,772 (GRCm39)	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55,915,466 (GRCm39)	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55,915,620 (GRCm39)	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55,900,237 (GRCm39)	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55,917,935 (GRCm39)	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55,917,935 (GRCm39)	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55,915,496 (GRCm39)	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55,917,643 (GRCm39)	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55,915,083 (GRCm39)	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55,918,530 (GRCm39)	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55,899,456 (GRCm39)	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55,917,406 (GRCm39)	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55,918,556 (GRCm39)	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55,899,882 (GRCm39)	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55,899,925 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55,931,650 (GRCm39)	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55,915,421 (GRCm39)	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55,917,347 (GRCm39)	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55,917,665 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55,917,860 (GRCm39)	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55,899,581 (GRCm39)	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55,899,894 (GRCm39)	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55,918,565 (GRCm39)	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55,918,565 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55,899,765 (GRCm39)	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55,900,103 (GRCm39)	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55,931,494 (GRCm39)	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55,899,871 (GRCm39)	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55,915,093 (GRCm39)	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55,899,996 (GRCm39)	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55,899,714 (GRCm39)	missense	possibly damaging	0.92
R6929:Vmn2r118	UTSW	17	55,917,440 (GRCm39)	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55,915,496 (GRCm39)	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55,899,853 (GRCm39)	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55,900,242 (GRCm39)	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55,915,484 (GRCm39)	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55,917,936 (GRCm39)	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55,917,423 (GRCm39)	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55,915,057 (GRCm39)	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55,915,642 (GRCm39)	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55,917,216 (GRCm39)	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55,917,835 (GRCm39)	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55,918,649 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55,917,207 (GRCm39)	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55,899,837 (GRCm39)	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55,918,009 (GRCm39)	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55,915,415 (GRCm39)	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55,900,218 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55,917,655 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CTTAGGATCTACCCAGAAGCAAATC -3'
(R):5'- AGTGTTTGGGTCACCTTCC -3'

Sequencing Primer
(F):5'- TTAACATAAAATGTGGG -3'
(R):5'- GGGTCACCTTCCTCCCTG -3'

Posted On

2018-08-29