Incidental Mutation 'R6761:Vmn1r9'
ID531699
Institutional Source Beutler Lab
Gene Symbol Vmn1r9
Ensembl Gene ENSMUSG00000091541
Gene Namevomeronasal 1 receptor 9
SynonymsV1rc30
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.123) question?
Stock #R6761 (G1)
Quality Score225.009
Status Validated
Chromosome6
Chromosomal Location57066787-57074906 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 57071306 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 122 (Y122C)
Ref Sequence ENSEMBL: ENSMUSP00000125762 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171186] [ENSMUST00000227399] [ENSMUST00000228714]
Predicted Effect probably benign
Transcript: ENSMUST00000171186
AA Change: Y122C

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000125762
Gene: ENSMUSG00000091541
AA Change: Y122C

DomainStartEndE-ValueType
Pfam:V1R 28 293 1.1e-53 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227399
AA Change: Y122C
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228714
AA Change: Y122C
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.5%
Validation Efficiency 97% (34/35)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik T C 17: 35,567,948 V61A probably benign Het
Actr3b C T 5: 25,825,139 S67F probably damaging Het
Ap3m1 T C 14: 21,038,028 M107V probably benign Het
Ccdc27 C T 4: 154,037,698 G241D unknown Het
Cit T G 5: 115,908,675 D382E probably damaging Het
Clec3b G T 9: 123,156,939 G134V probably damaging Het
Cntnap2 T A 6: 47,049,373 H44Q probably benign Het
Dst T C 1: 34,214,550 S4300P probably damaging Het
Ebna1bp2 C T 4: 118,623,361 R134* probably null Het
Efcab14 T C 4: 115,738,827 S57P probably damaging Het
Exosc2 T C 2: 31,670,863 probably null Het
Fam213a T A 14: 40,994,621 H198L probably damaging Het
Hfm1 T C 5: 106,895,279 T630A probably damaging Het
Hkdc1 A T 10: 62,408,698 I203N possibly damaging Het
Hltf T A 3: 20,083,832 probably null Het
Igkv3-2 G T 6: 70,698,517 probably benign Het
Mslnl A G 17: 25,746,073 D471G probably damaging Het
Msmo1 A G 8: 64,719,027 Y281H probably benign Het
Nid1 A G 13: 13,482,035 T584A probably benign Het
Olfr628 C T 7: 103,732,484 A186V probably damaging Het
Olfr908 A G 9: 38,516,265 T78A probably damaging Het
Otoa G A 7: 121,121,950 G396D probably damaging Het
Prss45 G T 9: 110,840,419 A197S probably damaging Het
Rpap2 T A 5: 107,620,238 I314N probably benign Het
Sash1 A G 10: 8,744,522 M458T probably damaging Het
Slc44a5 A G 3: 154,240,077 probably null Het
Sorbs2 T C 8: 45,772,614 S254P probably damaging Het
Sycp2 T C 2: 178,374,351 probably null Het
Tedc1 A G 12: 113,161,714 D252G probably damaging Het
Uty T C Y: 1,186,790 H145R probably damaging Homo
Wdfy4 T A 14: 33,095,951 N1491Y possibly damaging Het
Wdr37 T C 13: 8,849,648 T140A probably benign Het
Other mutations in Vmn1r9
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0551:Vmn1r9 UTSW 6 57071539 missense probably benign 0.16
R1295:Vmn1r9 UTSW 6 57071537 missense probably damaging 0.98
R1333:Vmn1r9 UTSW 6 57071630 missense probably damaging 1.00
R1781:Vmn1r9 UTSW 6 57071315 missense probably benign
R1840:Vmn1r9 UTSW 6 57071537 missense probably damaging 0.98
R2960:Vmn1r9 UTSW 6 57071672 missense possibly damaging 0.60
R4064:Vmn1r9 UTSW 6 57071321 missense probably damaging 0.99
R4694:Vmn1r9 UTSW 6 57071329 missense probably benign 0.01
R4884:Vmn1r9 UTSW 6 57071309 missense possibly damaging 0.67
R6023:Vmn1r9 UTSW 6 57071254 missense probably benign 0.19
R6031:Vmn1r9 UTSW 6 57071173 missense probably benign 0.00
R6031:Vmn1r9 UTSW 6 57071173 missense probably benign 0.00
R7052:Vmn1r9 UTSW 6 57071411 missense probably benign 0.44
R7129:Vmn1r9 UTSW 6 57071626 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCACTGGAGGGGATATTTTGC -3'
(R):5'- AAGAAACACATCTCTGGAGGTTG -3'

Sequencing Primer
(F):5'- CTGGAGGGGATATTTTGCTTACAGAC -3'
(R):5'- ACACATCTCTGGAGGTTGATATTG -3'
Posted On2018-08-29