Incidental Mutation 'R6761:Clec3b'
ID 531708
Institutional Source Beutler Lab
Gene Symbol Clec3b
Ensembl Gene ENSMUSG00000025784
Gene Name C-type lectin domain family 3, member b
Synonyms Tna
MMRRC Submission 044877-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6761 (G1)
Quality Score 202.009
Status Validated
Chromosome 9
Chromosomal Location 122980011-122986497 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 122986004 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Valine at position 134 (G134V)
Ref Sequence ENSEMBL: ENSMUSP00000026890 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026890]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000026890
AA Change: G134V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000026890
Gene: ENSMUSG00000025784
AA Change: G134V

DomainStartEndE-ValueType
low complexity region 27 36 N/A INTRINSIC
CLECT 71 198 1.02e-25 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.5%
Validation Efficiency 97% (34/35)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele develop pronounced cervical lordosis and thoracic kyphosis associated with wedge-shaped deformities of the vertebrae, growth plate irregularities, and an asymmetric development of the intervertebral disks. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik T C 17: 35,878,845 (GRCm39) V61A probably benign Het
Actr3b C T 5: 26,030,137 (GRCm39) S67F probably damaging Het
Ap3m1 T C 14: 21,088,096 (GRCm39) M107V probably benign Het
Ccdc27 C T 4: 154,122,155 (GRCm39) G241D unknown Het
Cit T G 5: 116,046,734 (GRCm39) D382E probably damaging Het
Cntnap2 T A 6: 47,026,307 (GRCm39) H44Q probably benign Het
Dst T C 1: 34,253,631 (GRCm39) S4300P probably damaging Het
Ebna1bp2 C T 4: 118,480,558 (GRCm39) R134* probably null Het
Efcab14 T C 4: 115,596,024 (GRCm39) S57P probably damaging Het
Exosc2 T C 2: 31,560,875 (GRCm39) probably null Het
Hfm1 T C 5: 107,043,145 (GRCm39) T630A probably damaging Het
Hkdc1 A T 10: 62,244,477 (GRCm39) I203N possibly damaging Het
Hltf T A 3: 20,137,996 (GRCm39) probably null Het
Igkv3-2 G T 6: 70,675,501 (GRCm39) probably benign Het
Mslnl A G 17: 25,965,047 (GRCm39) D471G probably damaging Het
Msmo1 A G 8: 65,172,061 (GRCm39) Y281H probably benign Het
Nid1 A G 13: 13,656,620 (GRCm39) T584A probably benign Het
Olfr908 A G 9: 38,427,561 (GRCm39) T78A probably damaging Het
Or52a24 C T 7: 103,381,691 (GRCm39) A186V probably damaging Het
Otoa G A 7: 120,721,173 (GRCm39) G396D probably damaging Het
Prss45 G T 9: 110,669,487 (GRCm39) A197S probably damaging Het
Prxl2a T A 14: 40,716,578 (GRCm39) H198L probably damaging Het
Rpap2 T A 5: 107,768,104 (GRCm39) I314N probably benign Het
Sash1 A G 10: 8,620,286 (GRCm39) M458T probably damaging Het
Slc44a5 A G 3: 153,945,714 (GRCm39) probably null Het
Sorbs2 T C 8: 46,225,651 (GRCm39) S254P probably damaging Het
Sycp2 T C 2: 178,016,144 (GRCm39) probably null Het
Tedc1 A G 12: 113,125,334 (GRCm39) D252G probably damaging Het
Uty T C Y: 1,186,790 (GRCm39) H145R probably damaging Homo
Vmn1r9 A G 6: 57,048,291 (GRCm39) Y122C probably benign Het
Wdfy4 T A 14: 32,817,908 (GRCm39) N1491Y possibly damaging Het
Wdr37 T C 13: 8,899,684 (GRCm39) T140A probably benign Het
Other mutations in Clec3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02441:Clec3b APN 9 122,980,178 (GRCm39) missense possibly damaging 0.61
IGL02884:Clec3b APN 9 122,985,827 (GRCm39) missense probably benign 0.00
IGL03092:Clec3b APN 9 122,980,100 (GRCm39) start gained probably benign
R0025:Clec3b UTSW 9 122,986,090 (GRCm39) missense probably benign
R9785:Clec3b UTSW 9 122,985,997 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCTTCTGTGACAGCCATC -3'
(R):5'- TGGCAGATGTAGGGCAACTG -3'

Sequencing Primer
(F):5'- GACAGCCATCTCTCCCTTCAGTG -3'
(R):5'- TGTAGGGCAACTGATCGC -3'
Posted On 2018-08-29