Incidental Mutation 'R6763:Clec2d'
ID 531777
Institutional Source Beutler Lab
Gene Symbol Clec2d
Ensembl Gene ENSMUSG00000030157
Gene Name C-type lectin domain family 2, member d
Synonyms Clr-b, Clrb, Ocil
MMRRC Submission 044879-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6763 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 129157578-129163497 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 129161107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 68 (T68K)
Ref Sequence ENSEMBL: ENSMUSP00000032260 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032260]
AlphaFold Q91V08
Predicted Effect probably benign
Transcript: ENSMUST00000032260
AA Change: T68K

PolyPhen 2 Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000032260
Gene: ENSMUSG00000030157
AA Change: T68K

DomainStartEndE-ValueType
low complexity region 51 66 N/A INTRINSIC
CLECT 80 191 8.47e-23 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Enhanced osteoclastic activity in the bone of homozygous null mice leads to osteopenia and high serum calcium levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas C A 15: 102,248,457 (GRCm39) R286L probably null Het
Actrt2 A G 4: 154,751,836 (GRCm39) V100A probably damaging Het
Adra1b A G 11: 43,666,833 (GRCm39) L468P possibly damaging Het
Ankhd1 A G 18: 36,776,022 (GRCm39) E1457G probably benign Het
Aspm A T 1: 139,398,255 (GRCm39) M974L possibly damaging Het
Atp8a2 T A 14: 60,245,857 (GRCm39) I612F probably benign Het
Cabin1 A G 10: 75,582,564 (GRCm39) L284P probably damaging Het
Cand2 T A 6: 115,776,930 (GRCm39) M1106K probably benign Het
Ccbe1 A T 18: 66,194,459 (GRCm39) F376I possibly damaging Het
Ceacam14 A G 7: 17,549,268 (GRCm39) T220A probably benign Het
Celsr3 A G 9: 108,704,549 (GRCm39) D344G probably damaging Het
Chaf1b A G 16: 93,688,393 (GRCm39) K163E probably damaging Het
Cwc27 T C 13: 104,947,809 (GRCm39) T19A probably damaging Het
Dnah7c A T 1: 46,668,050 (GRCm39) Y1519F possibly damaging Het
E130308A19Rik A T 4: 59,752,288 (GRCm39) K467M probably damaging Het
Garnl3 T C 2: 32,944,208 (GRCm39) Y117C probably damaging Het
Gas2l3 T C 10: 89,249,231 (GRCm39) Y629C probably benign Het
Lama1 A G 17: 68,053,868 (GRCm39) N470D unknown Het
Lmtk2 T A 5: 144,110,615 (GRCm39) I445N probably damaging Het
Lrba A G 3: 86,261,570 (GRCm39) D1508G probably damaging Het
Muc5b A G 7: 141,416,021 (GRCm39) H2989R probably benign Het
Niban2 T C 2: 32,801,460 (GRCm39) probably null Het
Nln A T 13: 104,172,163 (GRCm39) W638R probably damaging Het
Nup133 T C 8: 124,671,017 (GRCm39) I127V possibly damaging Het
Nup155 C T 15: 8,165,379 (GRCm39) R672* probably null Het
Prkcb A G 7: 122,193,887 (GRCm39) Y532C probably damaging Het
Ptpro A G 6: 137,395,279 (GRCm39) probably null Het
Rab11fip5 A G 6: 85,319,152 (GRCm39) L579S probably benign Het
Rtca A G 3: 116,301,398 (GRCm39) probably null Het
Sdccag8 A G 1: 176,682,193 (GRCm39) probably null Het
Svil G T 18: 5,056,437 (GRCm39) D524Y probably damaging Het
Unc80 A G 1: 66,560,636 (GRCm39) N788S probably benign Het
Wdfy4 G T 14: 32,764,469 (GRCm39) R2140S probably damaging Het
Zfp518a A G 19: 40,902,192 (GRCm39) K707R probably damaging Het
Other mutations in Clec2d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01691:Clec2d APN 6 129,161,185 (GRCm39) missense probably damaging 1.00
IGL01984:Clec2d APN 6 129,161,192 (GRCm39) missense possibly damaging 0.89
IGL03071:Clec2d APN 6 129,160,165 (GRCm39) missense probably benign 0.30
R0626:Clec2d UTSW 6 129,160,090 (GRCm39) missense probably damaging 0.98
R0900:Clec2d UTSW 6 129,160,076 (GRCm39) missense probably benign 0.00
R2077:Clec2d UTSW 6 129,160,153 (GRCm39) missense possibly damaging 0.80
R2200:Clec2d UTSW 6 129,161,831 (GRCm39) missense possibly damaging 0.80
R2227:Clec2d UTSW 6 129,161,214 (GRCm39) missense probably benign 0.44
R4826:Clec2d UTSW 6 129,161,122 (GRCm39) missense probably benign 0.00
R5040:Clec2d UTSW 6 129,161,793 (GRCm39) missense probably damaging 1.00
R8121:Clec2d UTSW 6 129,161,847 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CTACTGACAGTGAGCACCTG -3'
(R):5'- CCTCAGGCCTCATCTGTAAC -3'

Sequencing Primer
(F):5'- CTGACAGTGAGCACCTGAGAGAG -3'
(R):5'- ATCTGTAACTCTCTATCTCAAGGC -3'
Posted On 2018-08-29