Incidental Mutation 'R6788:Map3k21'
ID 532503
Institutional Source Beutler Lab
Gene Symbol Map3k21
Ensembl Gene ENSMUSG00000031853
Gene Name mitogen-activated protein kinase kinase kinase 21
Synonyms BC021891
MMRRC Submission 044902-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # R6788 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 126637189-126674179 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 126666605 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 599 (D599V)
Ref Sequence ENSEMBL: ENSMUSP00000034316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034316]
AlphaFold Q8VDG6
Predicted Effect probably benign
Transcript: ENSMUST00000034316
AA Change: D599V

PolyPhen 2 Score 0.278 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000034316
Gene: ENSMUSG00000031853
AA Change: D599V

DomainStartEndE-ValueType
SH3 27 87 1.1e-18 SMART
TyrKc 110 382 6.04e-82 SMART
coiled coil region 402 474 N/A INTRINSIC
low complexity region 478 492 N/A INTRINSIC
low complexity region 661 677 N/A INTRINSIC
low complexity region 740 758 N/A INTRINSIC
low complexity region 766 788 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 98.9%
  • 20x: 97.4%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 A T 1: 179,580,199 (GRCm39) V2001E probably benign Het
Ahsg A G 16: 22,713,585 (GRCm39) D122G probably benign Het
Ank3 A G 10: 69,840,553 (GRCm39) Y1616C probably damaging Het
Arhgef1 A G 7: 24,619,205 (GRCm39) probably null Het
Atp7b T C 8: 22,494,391 (GRCm39) I1023V probably benign Het
Bod1l A T 5: 41,979,216 (GRCm39) Y699* probably null Het
Car12 C T 9: 66,659,244 (GRCm39) S183L probably damaging Het
Cep290 T C 10: 100,324,490 (GRCm39) S57P probably damaging Het
Cep57l1 T C 10: 41,619,145 (GRCm39) D74G probably damaging Het
Cers6 T C 2: 68,938,903 (GRCm39) Y374H possibly damaging Het
Chmp4c T A 3: 10,432,195 (GRCm39) M35K possibly damaging Het
Crkl G A 16: 17,301,645 (GRCm39) D300N probably damaging Het
Cyp3a41a A G 5: 145,642,639 (GRCm39) M240T probably benign Het
Dipk2a C T 9: 94,406,502 (GRCm39) V302I probably benign Het
Dnah12 G T 14: 26,523,470 (GRCm39) L1986F probably damaging Het
Dnah8 T C 17: 30,867,439 (GRCm39) I297T probably benign Het
Dock10 T A 1: 80,508,962 (GRCm39) I1610F probably damaging Het
Dpys T A 15: 39,720,559 (GRCm39) H67L probably damaging Het
Epc2 T G 2: 49,422,099 (GRCm39) V331G probably benign Het
Fnbp1l G A 3: 122,339,956 (GRCm39) R344* probably null Het
Gmip G T 8: 70,263,824 (GRCm39) L89F possibly damaging Het
Gmip G C 8: 70,263,826 (GRCm39) R90P probably damaging Het
Gpi1 A G 7: 33,928,415 (GRCm39) S74P probably damaging Het
Gys1 G A 7: 45,094,102 (GRCm39) E406K probably damaging Het
Hspg2 G A 4: 137,242,618 (GRCm39) G611E probably damaging Het
Klhl29 C T 12: 5,134,393 (GRCm39) V673M probably damaging Het
Lnpk T C 2: 74,360,020 (GRCm39) T332A probably benign Het
Loxl4 T C 19: 42,596,792 (GRCm39) D60G probably damaging Het
Lrr1 T C 12: 69,221,449 (GRCm39) I197T probably damaging Het
Map1lc3b A G 8: 122,320,316 (GRCm39) N43S probably benign Het
Mastl T C 2: 23,023,710 (GRCm39) N338D probably benign Het
Mepe A T 5: 104,486,074 (GRCm39) R405* probably null Het
Mrps30 T C 13: 118,516,908 (GRCm39) E437G probably benign Het
Mup15 A G 4: 61,356,465 (GRCm39) V100A possibly damaging Het
Olfml1 A T 7: 107,167,075 (GRCm39) I35F probably damaging Het
Olfml2a T A 2: 38,850,238 (GRCm39) Y651* probably null Het
Or2h1b T A 17: 37,462,713 (GRCm39) D50V probably damaging Het
Otog T C 7: 45,947,741 (GRCm39) V113A probably damaging Het
Parvg C T 15: 84,210,464 (GRCm39) L44F possibly damaging Het
Pcnx2 G T 8: 126,498,839 (GRCm39) D1553E probably damaging Het
Pcyt2 C T 11: 120,505,200 (GRCm39) G122S probably damaging Het
Pi4ka A G 16: 17,194,846 (GRCm39) L184P possibly damaging Het
Polq C T 16: 36,897,510 (GRCm39) T2134I probably damaging Het
Prkce T G 17: 86,937,489 (GRCm39) F641V probably damaging Het
Prss1 T C 6: 41,440,654 (GRCm39) I243T possibly damaging Het
Pxmp2 A G 5: 110,429,185 (GRCm39) F91L probably benign Het
Ralgapb G A 2: 158,278,486 (GRCm39) G5R probably damaging Het
Rasgef1a T G 6: 118,064,174 (GRCm39) M337R possibly damaging Het
Rassf2 A G 2: 131,844,845 (GRCm39) M199T probably damaging Het
Rtbdn A T 8: 85,679,303 (GRCm39) Y67F probably null Het
Scamp3 T C 3: 89,089,256 (GRCm39) V271A probably benign Het
Sema3a A T 5: 13,647,584 (GRCm39) R613W possibly damaging Het
Slc4a3 A T 1: 75,527,959 (GRCm39) I206F probably damaging Het
Slc9b1 A G 3: 135,063,518 (GRCm39) probably null Het
Smchd1 C A 17: 71,782,096 (GRCm39) V22F probably benign Het
Smg1 A G 7: 117,783,794 (GRCm39) probably benign Het
Spaca7b T C 8: 11,728,584 (GRCm39) E29G possibly damaging Het
Spata31e4 A C 13: 50,857,131 (GRCm39) H923P probably damaging Het
Stab1 A G 14: 30,861,117 (GRCm39) L89P probably damaging Het
Stim1 A G 7: 102,076,498 (GRCm39) E152G probably damaging Het
Tenm3 A G 8: 49,127,528 (GRCm39) F50S probably damaging Het
Tpgs2 T G 18: 25,262,927 (GRCm39) N231H probably benign Het
Trank1 T A 9: 111,219,747 (GRCm39) N2161K probably damaging Het
Trim28 A G 7: 12,759,273 (GRCm39) D129G probably benign Het
Trim66 A T 7: 109,076,961 (GRCm39) I326N probably damaging Het
Trim80 A T 11: 115,338,843 (GRCm39) T558S probably benign Het
Uggt1 T A 1: 36,269,769 (GRCm39) T83S probably benign Het
Wdr91 A G 6: 34,863,754 (GRCm39) I587T probably damaging Het
Zpld1 A T 16: 55,052,603 (GRCm39) V337D possibly damaging Het
Other mutations in Map3k21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00494:Map3k21 APN 8 126,671,412 (GRCm39) missense possibly damaging 0.52
IGL01919:Map3k21 APN 8 126,668,871 (GRCm39) missense probably damaging 0.97
IGL02065:Map3k21 APN 8 126,668,397 (GRCm39) missense probably benign 0.01
IGL02123:Map3k21 APN 8 126,652,849 (GRCm39) missense probably damaging 1.00
IGL02127:Map3k21 APN 8 126,668,886 (GRCm39) missense probably benign
IGL02863:Map3k21 APN 8 126,654,280 (GRCm39) missense probably benign 0.02
IGL03194:Map3k21 APN 8 126,650,801 (GRCm39) missense possibly damaging 0.90
PIT4142001:Map3k21 UTSW 8 126,664,047 (GRCm39) missense probably damaging 0.98
R0238:Map3k21 UTSW 8 126,671,709 (GRCm39) missense possibly damaging 0.67
R0238:Map3k21 UTSW 8 126,671,709 (GRCm39) missense possibly damaging 0.67
R0454:Map3k21 UTSW 8 126,668,858 (GRCm39) missense probably benign
R0654:Map3k21 UTSW 8 126,668,759 (GRCm39) missense probably benign 0.07
R1141:Map3k21 UTSW 8 126,668,471 (GRCm39) missense probably benign 0.32
R1177:Map3k21 UTSW 8 126,671,577 (GRCm39) missense probably benign 0.31
R1463:Map3k21 UTSW 8 126,668,876 (GRCm39) missense probably benign 0.00
R1472:Map3k21 UTSW 8 126,668,417 (GRCm39) missense probably benign
R1759:Map3k21 UTSW 8 126,671,519 (GRCm39) missense probably benign
R1988:Map3k21 UTSW 8 126,654,294 (GRCm39) missense probably benign 0.07
R2058:Map3k21 UTSW 8 126,665,461 (GRCm39) missense probably benign 0.01
R2117:Map3k21 UTSW 8 126,650,781 (GRCm39) missense probably benign 0.19
R2157:Map3k21 UTSW 8 126,664,005 (GRCm39) missense probably benign
R2436:Map3k21 UTSW 8 126,668,354 (GRCm39) nonsense probably null
R2507:Map3k21 UTSW 8 126,666,677 (GRCm39) missense possibly damaging 0.73
R3125:Map3k21 UTSW 8 126,668,593 (GRCm39) missense probably benign 0.26
R3746:Map3k21 UTSW 8 126,661,839 (GRCm39) missense probably damaging 1.00
R4016:Map3k21 UTSW 8 126,637,924 (GRCm39) missense probably damaging 1.00
R4647:Map3k21 UTSW 8 126,668,850 (GRCm39) missense probably benign
R4648:Map3k21 UTSW 8 126,668,850 (GRCm39) missense probably benign
R4864:Map3k21 UTSW 8 126,654,294 (GRCm39) missense probably benign 0.04
R5642:Map3k21 UTSW 8 126,665,563 (GRCm39) missense probably benign 0.17
R5694:Map3k21 UTSW 8 126,671,507 (GRCm39) missense probably benign 0.04
R5950:Map3k21 UTSW 8 126,668,499 (GRCm39) missense possibly damaging 0.93
R5982:Map3k21 UTSW 8 126,638,169 (GRCm39) missense probably damaging 1.00
R6440:Map3k21 UTSW 8 126,637,876 (GRCm39) missense probably damaging 1.00
R6550:Map3k21 UTSW 8 126,664,031 (GRCm39) missense probably damaging 1.00
R6664:Map3k21 UTSW 8 126,668,610 (GRCm39) missense probably benign 0.01
R6668:Map3k21 UTSW 8 126,652,852 (GRCm39) missense possibly damaging 0.60
R7369:Map3k21 UTSW 8 126,637,855 (GRCm39) missense possibly damaging 0.86
R7371:Map3k21 UTSW 8 126,661,804 (GRCm39) missense probably damaging 0.99
R7381:Map3k21 UTSW 8 126,671,717 (GRCm39) missense possibly damaging 0.83
R7388:Map3k21 UTSW 8 126,654,336 (GRCm39) missense probably damaging 1.00
R7397:Map3k21 UTSW 8 126,661,855 (GRCm39) missense probably damaging 1.00
R7497:Map3k21 UTSW 8 126,654,340 (GRCm39) missense probably damaging 0.99
R7562:Map3k21 UTSW 8 126,665,539 (GRCm39) missense probably damaging 1.00
R7564:Map3k21 UTSW 8 126,654,447 (GRCm39) critical splice donor site probably null
R7824:Map3k21 UTSW 8 126,637,702 (GRCm39) missense probably benign 0.01
R8286:Map3k21 UTSW 8 126,637,498 (GRCm39) missense probably benign 0.00
R8351:Map3k21 UTSW 8 126,671,472 (GRCm39) missense probably benign 0.00
R8451:Map3k21 UTSW 8 126,671,472 (GRCm39) missense probably benign 0.00
R8461:Map3k21 UTSW 8 126,671,361 (GRCm39) missense probably benign 0.05
R9005:Map3k21 UTSW 8 126,637,471 (GRCm39) missense
R9074:Map3k21 UTSW 8 126,664,050 (GRCm39) missense probably damaging 0.98
R9156:Map3k21 UTSW 8 126,665,463 (GRCm39) missense possibly damaging 0.81
R9217:Map3k21 UTSW 8 126,638,027 (GRCm39) missense possibly damaging 0.47
R9474:Map3k21 UTSW 8 126,650,903 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTGTGGCTCTAAGGAAGTC -3'
(R):5'- CTTTCAGCATCCTTAAGGGCCAC -3'

Sequencing Primer
(F):5'- GTGAGAGACCCTGCCTCAATATAG -3'
(R):5'- GCATCCTTAAGGGCCACATGAG -3'
Posted On 2018-08-29