Incidental Mutation 'IGL01149:Tkfc'
ID |
53306 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Tkfc
|
Ensembl Gene |
ENSMUSG00000034371 |
Gene Name |
triokinase, FMN cyclase |
Synonyms |
Dak |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
IGL01149
|
Quality Score |
|
Status
|
|
Chromosome |
19 |
Chromosomal Location |
10565155-10583018 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 10578015 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Proline
at position 38
(L38P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000044556
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025649]
[ENSMUST00000037678]
|
AlphaFold |
Q8VC30 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000025649
|
SMART Domains |
Protein: ENSMUSP00000025649 Gene: ENSMUSG00000024740
Domain | Start | End | E-Value | Type |
Pfam:MMS1_N
|
75 |
543 |
1.9e-122 |
PFAM |
low complexity region
|
755 |
775 |
N/A |
INTRINSIC |
Pfam:CPSF_A
|
788 |
1099 |
1e-92 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000037678
AA Change: L38P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000044556 Gene: ENSMUSG00000034371 AA Change: L38P
Domain | Start | End | E-Value | Type |
Pfam:Dak1
|
19 |
335 |
1.9e-112 |
PFAM |
low complexity region
|
352 |
366 |
N/A |
INTRINSIC |
Dak2
|
398 |
571 |
1.47e-58 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 30 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4632415L05Rik |
A |
G |
3: 19,949,276 (GRCm39) |
|
noncoding transcript |
Het |
Aadacl4fm4 |
T |
C |
4: 144,400,349 (GRCm39) |
D143G |
probably benign |
Het |
Adcy1 |
A |
C |
11: 7,087,385 (GRCm39) |
N420H |
probably damaging |
Het |
Avp |
T |
C |
2: 130,422,593 (GRCm39) |
|
probably benign |
Het |
B3galnt2 |
A |
T |
13: 14,155,270 (GRCm39) |
I216F |
probably benign |
Het |
Cdc42bpa |
T |
C |
1: 179,902,137 (GRCm39) |
S465P |
probably damaging |
Het |
Cdc42bpg |
T |
A |
19: 6,362,235 (GRCm39) |
|
probably benign |
Het |
Cdcp2 |
T |
C |
4: 106,964,308 (GRCm39) |
F386S |
probably benign |
Het |
Cdh4 |
A |
G |
2: 179,515,937 (GRCm39) |
T372A |
probably damaging |
Het |
Clspn |
T |
G |
4: 126,466,971 (GRCm39) |
M612R |
probably damaging |
Het |
Dll4 |
T |
C |
2: 119,161,590 (GRCm39) |
C391R |
probably damaging |
Het |
Dll4 |
T |
C |
2: 119,163,226 (GRCm39) |
Y616H |
probably damaging |
Het |
Exoc1 |
A |
G |
5: 76,690,091 (GRCm39) |
|
probably benign |
Het |
F830045P16Rik |
A |
G |
2: 129,302,232 (GRCm39) |
|
probably null |
Het |
Fhod1 |
A |
G |
8: 106,074,439 (GRCm39) |
|
probably benign |
Het |
Fign |
T |
C |
2: 63,810,104 (GRCm39) |
R389G |
possibly damaging |
Het |
Gm13941 |
T |
A |
2: 110,931,482 (GRCm39) |
E50V |
unknown |
Het |
Kit |
C |
T |
5: 75,771,536 (GRCm39) |
T231M |
probably damaging |
Het |
Neu3 |
T |
C |
7: 99,463,087 (GRCm39) |
H212R |
probably benign |
Het |
Nup214 |
G |
T |
2: 31,924,712 (GRCm39) |
S1747I |
probably damaging |
Het |
Or4f4b |
T |
C |
2: 111,314,446 (GRCm39) |
S224P |
probably damaging |
Het |
Or4q3 |
G |
T |
14: 50,583,071 (GRCm39) |
A276E |
probably damaging |
Het |
Or8b12i |
G |
T |
9: 20,082,826 (GRCm39) |
L14I |
probably damaging |
Het |
Secisbp2 |
T |
C |
13: 51,830,491 (GRCm39) |
|
probably null |
Het |
Slc26a10 |
G |
A |
10: 127,010,046 (GRCm39) |
|
probably benign |
Het |
Slc7a6 |
T |
C |
8: 106,906,232 (GRCm39) |
S155P |
probably damaging |
Het |
Slf1 |
A |
T |
13: 77,260,767 (GRCm39) |
I173N |
probably damaging |
Het |
Tedc1 |
C |
T |
12: 113,126,808 (GRCm39) |
R357* |
probably null |
Het |
Tubgcp4 |
A |
G |
2: 121,015,264 (GRCm39) |
D324G |
probably null |
Het |
Zfyve16 |
T |
C |
13: 92,644,791 (GRCm39) |
H1137R |
probably damaging |
Het |
|
Other mutations in Tkfc |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01066:Tkfc
|
APN |
19 |
10,571,892 (GRCm39) |
missense |
probably benign |
0.28 |
IGL02726:Tkfc
|
APN |
19 |
10,573,576 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL03069:Tkfc
|
APN |
19 |
10,576,518 (GRCm39) |
missense |
probably benign |
|
R1367:Tkfc
|
UTSW |
19 |
10,570,838 (GRCm39) |
missense |
probably benign |
0.19 |
R1476:Tkfc
|
UTSW |
19 |
10,572,690 (GRCm39) |
missense |
probably null |
0.55 |
R2081:Tkfc
|
UTSW |
19 |
10,574,742 (GRCm39) |
missense |
probably damaging |
1.00 |
R2130:Tkfc
|
UTSW |
19 |
10,573,405 (GRCm39) |
missense |
probably damaging |
0.97 |
R2151:Tkfc
|
UTSW |
19 |
10,576,421 (GRCm39) |
missense |
probably damaging |
1.00 |
R2443:Tkfc
|
UTSW |
19 |
10,571,902 (GRCm39) |
missense |
probably damaging |
0.97 |
R3104:Tkfc
|
UTSW |
19 |
10,574,357 (GRCm39) |
nonsense |
probably null |
|
R3105:Tkfc
|
UTSW |
19 |
10,574,357 (GRCm39) |
nonsense |
probably null |
|
R3106:Tkfc
|
UTSW |
19 |
10,574,357 (GRCm39) |
nonsense |
probably null |
|
R5027:Tkfc
|
UTSW |
19 |
10,570,023 (GRCm39) |
splice site |
probably null |
|
R5601:Tkfc
|
UTSW |
19 |
10,571,927 (GRCm39) |
missense |
probably benign |
|
R5637:Tkfc
|
UTSW |
19 |
10,571,897 (GRCm39) |
missense |
probably benign |
0.00 |
R5933:Tkfc
|
UTSW |
19 |
10,574,711 (GRCm39) |
missense |
probably benign |
0.17 |
R6792:Tkfc
|
UTSW |
19 |
10,571,888 (GRCm39) |
missense |
probably benign |
|
R6845:Tkfc
|
UTSW |
19 |
10,576,696 (GRCm39) |
missense |
probably damaging |
0.99 |
R6909:Tkfc
|
UTSW |
19 |
10,573,630 (GRCm39) |
missense |
probably benign |
0.06 |
R7007:Tkfc
|
UTSW |
19 |
10,573,727 (GRCm39) |
missense |
probably benign |
|
R7883:Tkfc
|
UTSW |
19 |
10,572,394 (GRCm39) |
splice site |
probably null |
|
R8962:Tkfc
|
UTSW |
19 |
10,570,700 (GRCm39) |
missense |
probably damaging |
1.00 |
R9039:Tkfc
|
UTSW |
19 |
10,573,612 (GRCm39) |
missense |
probably damaging |
1.00 |
R9254:Tkfc
|
UTSW |
19 |
10,574,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2013-06-21 |