Incidental Mutation 'R6801:Dchs2'
ID 533328
Institutional Source Beutler Lab
Gene Symbol Dchs2
Ensembl Gene ENSMUSG00000102692
Gene Name dachsous cadherin related 2
Synonyms LOC229459
MMRRC Submission 044914-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.384) question?
Stock # R6801 (G1)
Quality Score 129.008
Status Validated
Chromosome 3
Chromosomal Location 83035255-83264516 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 83035841 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 196 (M196K)
Ref Sequence ENSEMBL: ENSMUSP00000141425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000191829]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000191829
AA Change: M196K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000141425
Gene: ENSMUSG00000102692
AA Change: M196K

DomainStartEndE-ValueType
low complexity region 11 30 N/A INTRINSIC
CA 70 149 1.6e-8 SMART
CA 173 278 1.9e-9 SMART
CA 302 395 2e-33 SMART
CA 423 522 3.2e-7 SMART
CA 546 642 1.1e-29 SMART
CA 666 750 5.6e-22 SMART
CA 774 855 1.5e-8 SMART
CA 876 958 4.2e-19 SMART
CA 982 1060 3e-8 SMART
CA 1067 1168 9.3e-7 SMART
CA 1192 1271 1.1e-28 SMART
CA 1299 1379 4e-16 SMART
CA 1403 1486 6.1e-16 SMART
CA 1510 1596 3.5e-18 SMART
CA 1619 1700 4.4e-27 SMART
CA 1724 1805 6.4e-27 SMART
CA 1828 1909 4.3e-29 SMART
CA 1933 2014 3.4e-27 SMART
CA 2038 2116 4.2e-7 SMART
CA 2139 2218 2.5e-15 SMART
CA 2242 2323 2.1e-34 SMART
CA 2346 2423 3e-24 SMART
CA 2447 2525 2e-17 SMART
CA 2549 2641 9.8e-16 SMART
CA 2665 2745 2.3e-24 SMART
CA 2769 2856 5.9e-19 SMART
CA 2880 2959 1e-3 SMART
transmembrane domain 2973 2995 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.8%
Validation Efficiency 100% (49/49)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 T A 8: 25,174,680 (GRCm39) Y695F possibly damaging Het
Arhgap20 A G 9: 51,759,892 (GRCm39) D545G probably damaging Het
Arhgef11 A G 3: 87,643,159 (GRCm39) E1457G possibly damaging Het
Atp2b4 T A 1: 133,655,524 (GRCm39) I747F probably damaging Het
Bche T A 3: 73,609,133 (GRCm39) I98L probably benign Het
C2cd6 TC T 1: 59,133,742 (GRCm39) probably null Het
Ccdc90b A G 7: 92,216,943 (GRCm39) T72A probably benign Het
Chrd A G 16: 20,554,497 (GRCm39) E352G possibly damaging Het
Csmd2 A G 4: 128,277,743 (GRCm39) E953G probably benign Het
Ddx10 G A 9: 53,159,207 (GRCm39) Q33* probably null Het
Dennd4b T A 3: 90,176,086 (GRCm39) V201E probably damaging Het
Fbn2 T A 18: 58,246,420 (GRCm39) H494L probably benign Het
Fbxw13 G A 9: 109,023,795 (GRCm39) A83V probably null Het
Fxr1 A G 3: 34,108,452 (GRCm39) D321G possibly damaging Het
Galm A G 17: 80,489,053 (GRCm39) H233R probably benign Het
Gm7298 A G 6: 121,752,768 (GRCm39) T837A probably benign Het
Gmppa C G 1: 75,418,391 (GRCm39) S258C possibly damaging Het
Hk1 T G 10: 62,116,910 (GRCm39) E645A probably damaging Het
Igkv1-132 A G 6: 67,737,324 (GRCm39) T97A probably damaging Het
Kcnc1 T C 7: 46,084,716 (GRCm39) F547L probably damaging Het
Lama5 G A 2: 179,833,455 (GRCm39) P1519L probably damaging Het
Lingo2 T A 4: 35,709,566 (GRCm39) E138V probably damaging Het
Myb T C 10: 21,020,865 (GRCm39) probably null Het
Mybl1 A G 1: 9,753,353 (GRCm39) V243A probably benign Het
Mylk4 C T 13: 32,912,393 (GRCm39) S189N probably benign Het
Or13c7 T A 4: 43,855,206 (GRCm39) L299* probably null Het
Or2y16 A G 11: 49,335,169 (GRCm39) M164V probably benign Het
Or4k77 A T 2: 111,199,394 (GRCm39) Q139L probably benign Het
Or4x12-ps1 A T 2: 89,915,953 (GRCm39) I284N probably damaging Het
Or5w1b A G 2: 87,475,667 (GRCm39) Y267H probably benign Het
Or8g19 A T 9: 39,055,506 (GRCm39) I37F probably benign Het
Oxld1 A T 11: 120,347,650 (GRCm39) D182E probably damaging Het
Phf13 A T 4: 152,076,017 (GRCm39) L295Q probably damaging Het
Prrc2c TTGCTGCTGCTGCTGCTGCTGCTGCTGC TTGCTGCTGCTGCTGCTGCTGCTGC 1: 162,536,630 (GRCm39) probably benign Het
Prss33 A G 17: 24,053,813 (GRCm39) L88P possibly damaging Het
Ralgds A G 2: 28,438,448 (GRCm39) Y596C probably damaging Het
Rftn2 A G 1: 55,233,418 (GRCm39) I379T possibly damaging Het
Rnf214 C T 9: 45,807,403 (GRCm39) E267K probably damaging Het
Rpp14 T C 14: 8,083,717 (GRCm38) probably benign Het
Rpusd2 A G 2: 118,865,876 (GRCm39) Y191C probably damaging Het
Serpinb9c T A 13: 33,341,807 (GRCm39) M1L probably benign Het
Shroom3 A G 5: 93,088,795 (GRCm39) D434G probably damaging Het
Smc5 G A 19: 23,192,010 (GRCm39) S888L probably benign Het
Suv39h2 C T 2: 3,465,458 (GRCm39) R299K probably benign Het
Trappc4 A T 9: 44,315,685 (GRCm39) I176N probably damaging Het
Trim12c A T 7: 103,997,337 (GRCm39) V73E probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Other mutations in Dchs2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1707:Dchs2 UTSW 3 83,034,912 (GRCm39) unclassified probably benign
R5857:Dchs2 UTSW 3 83,177,620 (GRCm39) missense possibly damaging 0.79
R5897:Dchs2 UTSW 3 83,192,717 (GRCm39) missense possibly damaging 0.95
R5959:Dchs2 UTSW 3 83,232,725 (GRCm39) missense probably benign 0.01
R6007:Dchs2 UTSW 3 83,253,534 (GRCm39) missense probably damaging 0.99
R6054:Dchs2 UTSW 3 83,253,543 (GRCm39) missense probably benign 0.00
R6059:Dchs2 UTSW 3 83,263,043 (GRCm39) missense probably benign 0.06
R6075:Dchs2 UTSW 3 83,262,368 (GRCm39) missense possibly damaging 0.68
R6379:Dchs2 UTSW 3 83,262,453 (GRCm39) missense probably damaging 1.00
R6393:Dchs2 UTSW 3 83,037,218 (GRCm39) missense probably damaging 1.00
R6405:Dchs2 UTSW 3 83,261,570 (GRCm39) missense probably benign 0.01
R6432:Dchs2 UTSW 3 83,178,425 (GRCm39) missense possibly damaging 0.96
R6434:Dchs2 UTSW 3 83,176,577 (GRCm39) missense probably damaging 1.00
R6561:Dchs2 UTSW 3 83,036,476 (GRCm39) missense probably benign 0.04
R6798:Dchs2 UTSW 3 83,255,593 (GRCm39) missense probably damaging 1.00
R6855:Dchs2 UTSW 3 83,255,501 (GRCm39) missense probably benign 0.08
R6956:Dchs2 UTSW 3 83,261,233 (GRCm39) missense probably benign 0.00
R7090:Dchs2 UTSW 3 83,255,581 (GRCm39) missense probably benign 0.03
R7249:Dchs2 UTSW 3 83,035,336 (GRCm39) nonsense probably null
R7252:Dchs2 UTSW 3 83,232,610 (GRCm39) missense probably benign 0.04
R7462:Dchs2 UTSW 3 83,253,462 (GRCm39) splice site probably null
R7482:Dchs2 UTSW 3 83,156,032 (GRCm39) missense possibly damaging 0.68
R7487:Dchs2 UTSW 3 83,263,613 (GRCm39) missense probably damaging 0.99
R7529:Dchs2 UTSW 3 83,261,705 (GRCm39) missense possibly damaging 0.89
R7542:Dchs2 UTSW 3 83,176,591 (GRCm39) missense probably benign 0.16
R7544:Dchs2 UTSW 3 83,262,434 (GRCm39) missense probably damaging 1.00
R7547:Dchs2 UTSW 3 83,263,434 (GRCm39) missense probably damaging 0.96
R7587:Dchs2 UTSW 3 83,211,822 (GRCm39) missense probably benign
R7632:Dchs2 UTSW 3 83,255,357 (GRCm39) missense probably benign 0.00
R7694:Dchs2 UTSW 3 83,036,789 (GRCm39) missense probably damaging 1.00
R7701:Dchs2 UTSW 3 83,253,513 (GRCm39) missense possibly damaging 0.83
R7746:Dchs2 UTSW 3 83,035,364 (GRCm39) missense possibly damaging 0.94
R7838:Dchs2 UTSW 3 83,211,834 (GRCm39) missense probably benign 0.01
R7886:Dchs2 UTSW 3 83,212,392 (GRCm39) missense probably damaging 1.00
R8055:Dchs2 UTSW 3 83,037,032 (GRCm39) missense probably benign 0.00
R8068:Dchs2 UTSW 3 83,207,745 (GRCm39) missense probably benign 0.12
R8094:Dchs2 UTSW 3 83,262,929 (GRCm39) missense probably benign 0.02
R8160:Dchs2 UTSW 3 83,178,112 (GRCm39) missense probably benign 0.19
R8166:Dchs2 UTSW 3 83,261,640 (GRCm39) missense probably benign 0.28
R8278:Dchs2 UTSW 3 83,178,310 (GRCm39) missense probably damaging 1.00
R8422:Dchs2 UTSW 3 83,232,570 (GRCm39) missense probably benign 0.30
R8506:Dchs2 UTSW 3 83,208,481 (GRCm39) missense probably benign 0.17
R8517:Dchs2 UTSW 3 83,178,419 (GRCm39) missense probably damaging 0.96
R8528:Dchs2 UTSW 3 83,261,918 (GRCm39) missense probably damaging 0.96
R8693:Dchs2 UTSW 3 83,192,631 (GRCm39) missense probably damaging 1.00
R8708:Dchs2 UTSW 3 83,036,049 (GRCm39) missense probably benign 0.00
R8757:Dchs2 UTSW 3 83,261,567 (GRCm39) missense possibly damaging 0.96
R8768:Dchs2 UTSW 3 83,253,592 (GRCm39) missense probably benign 0.12
R8776:Dchs2 UTSW 3 83,263,701 (GRCm39) missense possibly damaging 0.46
R8776-TAIL:Dchs2 UTSW 3 83,263,701 (GRCm39) missense possibly damaging 0.46
R8802:Dchs2 UTSW 3 83,253,544 (GRCm39) missense probably benign 0.01
R8821:Dchs2 UTSW 3 83,192,670 (GRCm39) missense probably benign 0.00
R8831:Dchs2 UTSW 3 83,192,670 (GRCm39) missense probably benign 0.00
R8897:Dchs2 UTSW 3 83,036,720 (GRCm39) missense probably damaging 1.00
R8957:Dchs2 UTSW 3 83,189,573 (GRCm39) missense
R8973:Dchs2 UTSW 3 83,261,763 (GRCm39) missense possibly damaging 0.86
R8991:Dchs2 UTSW 3 83,036,143 (GRCm39) missense probably benign 0.00
R9015:Dchs2 UTSW 3 83,188,751 (GRCm39) missense possibly damaging 0.86
R9051:Dchs2 UTSW 3 83,261,493 (GRCm39) missense probably benign 0.02
R9117:Dchs2 UTSW 3 83,176,662 (GRCm39) missense probably benign 0.31
R9120:Dchs2 UTSW 3 83,187,535 (GRCm39) missense probably damaging 0.99
R9189:Dchs2 UTSW 3 83,255,561 (GRCm39) missense probably damaging 1.00
R9264:Dchs2 UTSW 3 83,177,784 (GRCm39) missense probably damaging 1.00
R9280:Dchs2 UTSW 3 83,189,255 (GRCm39) missense possibly damaging 0.88
R9293:Dchs2 UTSW 3 83,189,361 (GRCm39) missense possibly damaging 0.90
R9322:Dchs2 UTSW 3 83,189,001 (GRCm39) missense possibly damaging 0.73
R9345:Dchs2 UTSW 3 83,036,101 (GRCm39) missense probably benign 0.00
R9408:Dchs2 UTSW 3 83,192,573 (GRCm39) missense probably benign 0.02
R9432:Dchs2 UTSW 3 83,036,032 (GRCm39) missense possibly damaging 0.65
R9445:Dchs2 UTSW 3 83,146,284 (GRCm39) missense probably damaging 0.99
R9466:Dchs2 UTSW 3 83,176,564 (GRCm39) missense probably damaging 1.00
R9612:Dchs2 UTSW 3 83,178,193 (GRCm39) missense probably damaging 0.97
R9622:Dchs2 UTSW 3 83,263,766 (GRCm39) nonsense probably null
R9679:Dchs2 UTSW 3 83,261,697 (GRCm39) missense probably damaging 0.99
R9722:Dchs2 UTSW 3 83,261,301 (GRCm39) missense probably benign 0.01
R9767:Dchs2 UTSW 3 83,212,206 (GRCm39) missense probably benign 0.01
RF012:Dchs2 UTSW 3 83,262,375 (GRCm39) missense probably benign 0.03
Z1177:Dchs2 UTSW 3 83,178,447 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- CAGGACCACTATAGCTTCGTG -3'
(R):5'- CAAGCTTCAATGTGCAGCTC -3'

Sequencing Primer
(F):5'- ACTATAGCTTCGTGGCCGC -3'
(R):5'- CCAAGTCTAAGGGTTCCA -3'
Posted On 2018-09-12