Incidental Mutation 'IGL01125:Vmn2r121'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r121
Ensembl Gene ENSMUSG00000072049
Gene Namevomeronasal 2, receptor 121
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #IGL01125
Quality Score
Chromosomal Location124127339-124135910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 124132807 bp
Amino Acid Change Isoleucine to Phenylalanine at position 218 (I218F)
Ref Sequence ENSEMBL: ENSMUSP00000092067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094491]
Predicted Effect probably damaging
Transcript: ENSMUST00000094491
AA Change: I218F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: I218F

signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 448 3.2e-26 PFAM
Pfam:NCD3G 506 560 2.1e-19 PFAM
Pfam:7tm_3 593 828 3.8e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg2 C T X: 160,492,708 T931I probably damaging Het
Atp5g3 A G 2: 73,910,949 probably benign Het
Btd T A 14: 31,667,776 F485I probably benign Het
Camk2d A G 3: 126,798,285 probably benign Het
Cd300lg A T 11: 102,054,221 probably benign Het
Col9a1 A G 1: 24,224,645 probably null Het
Cybb T A X: 9,446,744 N367I possibly damaging Het
Dcaf17 T C 2: 71,089,805 V479A probably benign Het
Dscaml1 G T 9: 45,749,632 probably null Het
Espl1 T C 15: 102,322,938 F51S probably damaging Het
Gm8979 A T 7: 106,082,814 N411K unknown Het
Gsdmc3 T A 15: 63,861,457 D258V probably benign Het
Ifngr1 C T 10: 19,597,413 probably benign Het
Kcnip1 A T 11: 33,633,202 D194E probably damaging Het
Lrrtm1 C T 6: 77,244,453 R298C probably damaging Het
Map3k4 G A 17: 12,271,962 S194L probably damaging Het
Mfsd7a A G 5: 108,444,592 probably benign Het
Mmp16 A G 4: 18,112,066 K481E possibly damaging Het
Myh1 A T 11: 67,220,660 M1642L probably benign Het
Nol9 G T 4: 152,046,609 C363F probably damaging Het
Nsd1 T C 13: 55,245,617 S344P probably damaging Het
Olfr678 A T 7: 105,069,601 I45F probably benign Het
Phf20 G A 2: 156,303,184 probably null Het
Ppp3cc G T 14: 70,218,252 H467Q probably damaging Het
Rab28 A G 5: 41,635,894 M136T probably benign Het
Rag1 A G 2: 101,642,001 I932T probably damaging Het
Sez6 T C 11: 77,977,289 probably benign Het
Sorcs1 T C 19: 50,228,201 T647A probably damaging Het
Sspo T A 6: 48,492,888 C4507S probably damaging Het
Traf3ip3 T C 1: 193,184,464 probably null Het
Vmn2r61 A G 7: 42,260,126 Y25C probably damaging Het
Other mutations in Vmn2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r121 APN X 124127802 missense probably benign 0.04
IGL00990:Vmn2r121 APN X 124127783 missense possibly damaging 0.95
IGL00990:Vmn2r121 APN X 124133716 missense probably benign 0.00
IGL01450:Vmn2r121 APN X 124131191 missense possibly damaging 0.57
IGL01619:Vmn2r121 APN X 124132300 missense probably benign
IGL01797:Vmn2r121 APN X 124131351 splice site probably benign
IGL02227:Vmn2r121 APN X 124132681 missense probably benign 0.44
IGL02971:Vmn2r121 APN X 124127894 missense probably damaging 1.00
IGL03058:Vmn2r121 APN X 124132921 missense probably benign 0.00
IGL03142:Vmn2r121 APN X 124132938 missense possibly damaging 0.94
IGL03183:Vmn2r121 APN X 124132326 missense probably benign 0.03
E0370:Vmn2r121 UTSW X 124127920 missense probably benign 0.01
R0196:Vmn2r121 UTSW X 124132182 missense probably benign 0.03
R1381:Vmn2r121 UTSW X 124128140 missense probably damaging 1.00
R1399:Vmn2r121 UTSW X 124129848 missense possibly damaging 0.94
R1423:Vmn2r121 UTSW X 124129905 missense possibly damaging 0.52
R1687:Vmn2r121 UTSW X 124132791 missense probably benign 0.39
R2121:Vmn2r121 UTSW X 124133742 splice site probably null
R2124:Vmn2r121 UTSW X 124133742 splice site probably null
R3151:Vmn2r121 UTSW X 124131152 missense probably benign 0.20
R4460:Vmn2r121 UTSW X 124128584 missense probably benign 0.01
R4735:Vmn2r121 UTSW X 124128638 missense probably benign
R5332:Vmn2r121 UTSW X 124133575 missense probably benign
R6102:Vmn2r121 UTSW X 124133575 missense probably benign
X0023:Vmn2r121 UTSW X 124135657 missense possibly damaging 0.64
Posted On2013-06-21