Incidental Mutation 'R6809:Mapk1'
ID 533727
Institutional Source Beutler Lab
Gene Symbol Mapk1
Ensembl Gene ENSMUSG00000063358
Gene Name mitogen-activated protein kinase 1
Synonyms Erk2, 9030612K14Rik, Prkm1, p42mapk, MAPK2
MMRRC Submission 044922-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6809 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 16801246-16865317 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 16853326 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 49 (M49L)
Ref Sequence ENSEMBL: ENSMUSP00000156214 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069107] [ENSMUST00000115731] [ENSMUST00000232067] [ENSMUST00000232611]
AlphaFold P63085
Predicted Effect probably benign
Transcript: ENSMUST00000069107
AA Change: M291L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000065983
Gene: ENSMUSG00000063358
AA Change: M291L

DomainStartEndE-ValueType
S_TKc 23 311 1.06e-95 SMART
low complexity region 330 344 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115731
AA Change: M291L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000111396
Gene: ENSMUSG00000063358
AA Change: M291L

DomainStartEndE-ValueType
S_TKc 23 311 1.06e-95 SMART
low complexity region 330 344 N/A INTRINSIC
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000232067
AA Change: M49L

PolyPhen 2 Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000232611
AA Change: M291L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Meta Mutation Damage Score 0.0900 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
PHENOTYPE: Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A130010J15Rik T A 1: 192,857,089 (GRCm39) V147E possibly damaging Het
Abtb3 A G 10: 85,467,240 (GRCm39) T732A probably benign Het
Adgrv1 A T 13: 81,621,072 (GRCm39) M3893K probably benign Het
Aox3 T C 1: 58,157,840 (GRCm39) S66P probably damaging Het
Apeh G A 9: 107,969,878 (GRCm39) H186Y probably damaging Het
Bloc1s5 A G 13: 38,787,961 (GRCm39) V141A probably benign Het
Bltp1 A G 3: 36,928,431 (GRCm39) N61S probably damaging Het
Col28a1 T C 6: 7,999,468 (GRCm39) Y1083C probably damaging Het
Crb1 A G 1: 139,170,864 (GRCm39) V842A probably benign Het
Dapk1 A G 13: 60,899,103 (GRCm39) S858G probably benign Het
Dlgap2 G T 8: 14,229,619 (GRCm39) probably benign Het
Dpysl4 A G 7: 138,673,576 (GRCm39) D199G probably benign Het
Eml6 C T 11: 29,753,161 (GRCm39) V917I probably benign Het
Fut9 T A 4: 25,620,647 (GRCm39) T56S probably benign Het
Gtdc1 G C 2: 44,465,563 (GRCm39) S214* probably null Het
Gtdc1 A G 2: 44,715,396 (GRCm39) F49S probably damaging Het
Hoxd9 A G 2: 74,529,590 (GRCm39) Y282C probably damaging Het
Hrc A G 7: 44,985,803 (GRCm39) E318G probably benign Het
Ikzf2 T C 1: 69,609,661 (GRCm39) T195A probably damaging Het
Krt36 A T 11: 99,996,335 (GRCm39) S30T probably benign Het
Lrp1 A G 10: 127,390,925 (GRCm39) F2991L probably benign Het
Lrrc34 T A 3: 30,688,749 (GRCm39) Q184L possibly damaging Het
Mroh2a G T 1: 88,162,938 (GRCm39) Q360H probably benign Het
Mrpl48 A G 7: 100,195,574 (GRCm39) probably benign Het
Ncln A G 10: 81,323,512 (GRCm39) probably null Het
Nol4 T A 18: 23,053,882 (GRCm39) Q96L probably damaging Het
Or2y1e G T 11: 49,218,687 (GRCm39) V150L probably benign Het
Or5g25 G A 2: 85,478,317 (GRCm39) A116V probably damaging Het
Padi2 A G 4: 140,674,077 (GRCm39) probably null Het
Pak5 T G 2: 135,939,501 (GRCm39) I545L possibly damaging Het
Paqr5 T A 9: 61,876,064 (GRCm39) R157W probably null Het
Pard3b G A 1: 62,200,340 (GRCm39) R293H probably damaging Het
Phf11d C A 14: 59,593,844 (GRCm39) C110F probably damaging Het
Pkn2 G A 3: 142,504,765 (GRCm39) P804S probably damaging Het
Pnpla6 G A 8: 3,584,611 (GRCm39) C743Y possibly damaging Het
Pramel14 A G 4: 143,719,651 (GRCm39) V238A probably benign Het
Pramel58 C A 5: 94,831,277 (GRCm39) Q95K probably benign Het
Psip1 A G 4: 83,386,879 (GRCm39) M164T probably benign Het
Rgs22 C G 15: 36,048,910 (GRCm39) S914T probably damaging Het
Rufy4 G A 1: 74,172,206 (GRCm39) V310I probably benign Het
Ryr2 G A 13: 11,741,816 (GRCm39) L2122F probably damaging Het
Sgcb T G 5: 73,798,036 (GRCm39) N142T probably benign Het
Slc27a6 A G 18: 58,738,126 (GRCm39) E394G probably benign Het
Slc29a2 T C 19: 5,079,271 (GRCm39) V298A probably damaging Het
Slf2 C A 19: 44,931,907 (GRCm39) T654N probably damaging Het
Spata4 A C 8: 55,055,368 (GRCm39) K123Q possibly damaging Het
Taar7b T C 10: 23,876,756 (GRCm39) V307A probably benign Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Ttn T C 2: 76,693,983 (GRCm39) E295G possibly damaging Het
Ubqln4 A T 3: 88,462,679 (GRCm39) Q48L possibly damaging Het
Ugt1a10 T A 1: 87,983,647 (GRCm39) D148E probably damaging Het
Vmn2r85 T A 10: 130,261,795 (GRCm39) N181Y probably benign Het
Wdfy3 C T 5: 102,071,813 (GRCm39) V1026I possibly damaging Het
Other mutations in Mapk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Mapk1 APN 16 16,853,322 (GRCm39) missense probably benign 0.00
IGL01486:Mapk1 APN 16 16,836,144 (GRCm39) splice site probably benign
IGL01764:Mapk1 APN 16 16,801,597 (GRCm39) missense possibly damaging 0.50
IGL02138:Mapk1 APN 16 16,841,316 (GRCm39) missense probably benign 0.18
IGL02701:Mapk1 APN 16 16,833,770 (GRCm39) missense probably benign 0.00
R0517:Mapk1 UTSW 16 16,833,910 (GRCm39) missense probably benign 0.02
R1609:Mapk1 UTSW 16 16,856,170 (GRCm39) splice site probably benign
R1862:Mapk1 UTSW 16 16,844,293 (GRCm39) missense probably benign 0.36
R2885:Mapk1 UTSW 16 16,844,309 (GRCm39) missense probably benign
R4205:Mapk1 UTSW 16 16,856,321 (GRCm39) intron probably benign
R4959:Mapk1 UTSW 16 16,836,170 (GRCm39) missense probably damaging 1.00
R5694:Mapk1 UTSW 16 16,836,333 (GRCm39) missense probably benign 0.02
R6630:Mapk1 UTSW 16 16,844,249 (GRCm39) missense probably damaging 1.00
R8230:Mapk1 UTSW 16 16,843,930 (GRCm39) missense noncoding transcript
R9132:Mapk1 UTSW 16 16,856,300 (GRCm39) critical splice donor site probably null
R9214:Mapk1 UTSW 16 16,853,549 (GRCm39) missense probably benign 0.02
R9373:Mapk1 UTSW 16 16,836,154 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- ACAGTTCCAAAGGATTTACAGGT -3'
(R):5'- AAATCTTGACAAGGACACGGCT -3'

Sequencing Primer
(F):5'- TGTGTAAAGATGCCAGATCCCCTG -3'
(R):5'- ACACGGCTAGGGCTTCTGTTC -3'
Posted On 2018-09-12