Incidental Mutation 'R6825:Gas6'
ID 534108
Institutional Source Beutler Lab
Gene Symbol Gas6
Ensembl Gene ENSMUSG00000031451
Gene Name growth arrest specific 6
Synonyms growth arrest-specific, Gas-6, GAS 6
MMRRC Submission 044937-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6825 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 13515374-13544490 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13533674 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 112 (N112D)
Ref Sequence ENSEMBL: ENSMUSP00000033828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033828]
AlphaFold Q61592
Predicted Effect probably benign
Transcript: ENSMUST00000033828
AA Change: N112D

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000033828
Gene: ENSMUSG00000031451
AA Change: N112D

DomainStartEndE-ValueType
low complexity region 2 21 N/A INTRINSIC
GLA 26 90 6.66e-30 SMART
EGF 116 151 3.97e0 SMART
EGF_CA 153 193 3.1e-11 SMART
EGF_CA 194 234 1.91e-11 SMART
EGF_CA 235 275 1.25e-6 SMART
LamG 314 450 2.71e-24 SMART
LamG 502 647 1.27e-15 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
PHENOTYPE: Homozygous null mice are protected against arterial and venous thrombosis, and though platelet aggregation is impaired, spontaneous or excess trauma-induced bleeding is not observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik A T 12: 72,954,654 (GRCm39) S206T probably benign Het
Aasdh A T 5: 77,036,696 (GRCm39) probably null Het
Adam10 G T 9: 70,668,884 (GRCm39) C400F probably damaging Het
Ankle2 A T 5: 110,398,635 (GRCm39) R561S probably null Het
Arhgef5 C T 6: 43,251,895 (GRCm39) T882I probably damaging Het
Arpc1a A T 5: 145,032,936 (GRCm39) K82* probably null Het
Card11 C A 5: 140,863,837 (GRCm39) R967L probably benign Het
Ccdc82 G T 9: 13,251,601 (GRCm39) probably benign Het
Cebpz T C 17: 79,227,392 (GRCm39) D1026G probably damaging Het
Cit A T 5: 116,119,833 (GRCm39) Q1321L probably damaging Het
Clcn2 C A 16: 20,528,408 (GRCm39) probably benign Het
Csf3 G C 11: 98,593,273 (GRCm39) G130A probably damaging Het
Cul2 T A 18: 3,434,946 (GRCm39) S737T probably damaging Het
Cyp1a2 G A 9: 57,584,543 (GRCm39) H504Y probably benign Het
Cyp3a44 G A 5: 145,716,396 (GRCm39) P398L probably damaging Het
Dnah8 T C 17: 30,960,147 (GRCm39) I2206T probably damaging Het
Efr3a G A 15: 65,701,679 (GRCm39) V198I probably benign Het
Epb41l5 A T 1: 119,547,931 (GRCm39) D157E possibly damaging Het
Ercc8 T C 13: 108,295,343 (GRCm39) S6P probably damaging Het
Faxc T C 4: 21,931,672 (GRCm39) S37P probably benign Het
Fbxl19 T A 7: 127,349,187 (GRCm39) I119K probably damaging Het
Frmd4b A G 6: 97,302,437 (GRCm39) V195A possibly damaging Het
Fut9 A T 4: 25,619,925 (GRCm39) S296R probably benign Het
H2-Q1 T C 17: 35,540,028 (GRCm39) L99P probably damaging Het
Helq A T 5: 100,940,561 (GRCm39) I346N probably damaging Het
Hepacam A G 9: 37,278,976 (GRCm39) K2E possibly damaging Het
Itgae T C 11: 73,009,322 (GRCm39) M502T possibly damaging Het
Kmt2a G A 9: 44,729,704 (GRCm39) probably benign Het
Lhx9 ACC ACCC 1: 138,769,544 (GRCm39) probably null Het
Macf1 A T 4: 123,277,015 (GRCm39) probably null Het
Mgat4a T A 1: 37,503,515 (GRCm39) K220* probably null Het
Or2t43 T C 11: 58,457,476 (GRCm39) R232G possibly damaging Het
Or4c104 T C 2: 88,586,255 (GRCm39) I255V possibly damaging Het
Or5b3 G A 19: 13,388,514 (GRCm39) V194I probably benign Het
Pex5 A T 6: 124,391,340 (GRCm39) M18K probably damaging Het
Phlda3 T C 1: 135,694,562 (GRCm39) *126Q probably null Het
Plxna1 G T 6: 89,297,597 (GRCm39) D1862E probably benign Het
Pold4 A T 19: 4,282,164 (GRCm39) I7F possibly damaging Het
Prkaa1 A T 15: 5,173,432 (GRCm39) I19F possibly damaging Het
Prl7d1 T G 13: 27,894,125 (GRCm39) E148A probably benign Het
Prr14l A T 5: 32,985,892 (GRCm39) V1201E possibly damaging Het
Rab3gap1 T C 1: 127,858,158 (GRCm39) C510R probably damaging Het
Rhbdf1 C T 11: 32,159,970 (GRCm39) R802H probably damaging Het
Rpl18a A C 8: 71,348,836 (GRCm39) F47V probably damaging Het
Sema5b C A 16: 35,448,377 (GRCm39) probably null Het
Sspo G A 6: 48,442,459 (GRCm39) G1985R probably benign Het
Tcaf2 C T 6: 42,606,452 (GRCm39) A501T probably benign Het
Tcerg1 A G 18: 42,681,542 (GRCm39) D563G probably damaging Het
Tdh G A 14: 63,733,281 (GRCm39) T155M probably damaging Het
Tenm2 T C 11: 35,937,711 (GRCm39) N1654S probably benign Het
Tlr5 A T 1: 182,800,609 (GRCm39) probably benign Het
Tns1 G T 1: 74,041,482 (GRCm39) C136* probably null Het
Tomm5 A T 4: 45,106,443 (GRCm39) probably null Het
Trio A T 15: 27,889,394 (GRCm39) F512I probably damaging Het
Ttll5 A T 12: 85,930,102 (GRCm39) probably null Het
Upp1 T A 11: 9,081,707 (GRCm39) H81Q probably benign Het
Usp42 A G 5: 143,713,562 (GRCm39) S71P probably damaging Het
Vamp5 G A 6: 72,357,424 (GRCm39) probably benign Het
Zap70 A G 1: 36,817,471 (GRCm39) Y238C probably damaging Het
Zfp398 A G 6: 47,843,265 (GRCm39) D307G probably damaging Het
Other mutations in Gas6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00988:Gas6 APN 8 13,526,171 (GRCm39) missense probably damaging 0.99
IGL01100:Gas6 APN 8 13,525,118 (GRCm39) missense probably benign 0.27
IGL02014:Gas6 APN 8 13,518,359 (GRCm39) missense possibly damaging 0.59
IGL02931:Gas6 APN 8 13,527,136 (GRCm39) missense probably damaging 0.98
R0023:Gas6 UTSW 8 13,520,344 (GRCm39) missense probably damaging 1.00
R0497:Gas6 UTSW 8 13,520,387 (GRCm39) missense possibly damaging 0.86
R1126:Gas6 UTSW 8 13,533,700 (GRCm39) missense probably benign 0.02
R1597:Gas6 UTSW 8 13,543,901 (GRCm39) missense probably damaging 1.00
R1601:Gas6 UTSW 8 13,515,786 (GRCm39) missense probably damaging 1.00
R1643:Gas6 UTSW 8 13,515,902 (GRCm39) critical splice acceptor site probably null
R1914:Gas6 UTSW 8 13,527,152 (GRCm39) missense probably benign
R1967:Gas6 UTSW 8 13,520,317 (GRCm39) missense probably damaging 0.98
R2012:Gas6 UTSW 8 13,518,266 (GRCm39) missense probably damaging 1.00
R4663:Gas6 UTSW 8 13,520,254 (GRCm39) missense probably damaging 1.00
R4723:Gas6 UTSW 8 13,516,848 (GRCm39) missense probably damaging 0.99
R4750:Gas6 UTSW 8 13,526,227 (GRCm39) missense probably benign 0.29
R4869:Gas6 UTSW 8 13,525,086 (GRCm39) missense possibly damaging 0.55
R5558:Gas6 UTSW 8 13,516,764 (GRCm39) missense probably null 0.03
R5706:Gas6 UTSW 8 13,527,098 (GRCm39) missense probably damaging 0.98
R5791:Gas6 UTSW 8 13,520,217 (GRCm39) critical splice donor site probably null
R6767:Gas6 UTSW 8 13,515,784 (GRCm39) missense probably damaging 0.98
R7374:Gas6 UTSW 8 13,524,802 (GRCm39) missense probably damaging 0.99
R7419:Gas6 UTSW 8 13,521,456 (GRCm39) missense probably benign 0.19
R7588:Gas6 UTSW 8 13,516,711 (GRCm39) missense probably benign 0.03
R7810:Gas6 UTSW 8 13,516,809 (GRCm39) missense probably damaging 1.00
R8222:Gas6 UTSW 8 13,520,276 (GRCm39) missense probably benign 0.00
R8527:Gas6 UTSW 8 13,515,790 (GRCm39) missense probably damaging 1.00
R8705:Gas6 UTSW 8 13,525,156 (GRCm39) missense probably damaging 1.00
R8987:Gas6 UTSW 8 13,520,294 (GRCm39) missense probably damaging 1.00
R9553:Gas6 UTSW 8 13,525,048 (GRCm39) missense possibly damaging 0.84
R9672:Gas6 UTSW 8 13,528,273 (GRCm39) missense probably benign 0.00
X0063:Gas6 UTSW 8 13,521,538 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTGTAGTAGGGGACATACCTC -3'
(R):5'- GATTGGCATGCACTCACTGG -3'

Sequencing Primer
(F):5'- ACCCCACGGACTATTTAACTCTC -3'
(R):5'- TGGCATGCACTCACTGGAGATC -3'
Posted On 2018-09-12