Incidental Mutation 'R6828:Olfm4'
ID 534277
Institutional Source Beutler Lab
Gene Symbol Olfm4
Ensembl Gene ENSMUSG00000022026
Gene Name olfactomedin 4
Synonyms GC1, OlfD, pPD4, LOC380924, LOC239192, GW112
MMRRC Submission 045020-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R6828 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 80237742-80260581 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80258973 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 374 (D374G)
Ref Sequence ENSEMBL: ENSMUSP00000154285 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088735] [ENSMUST00000228749]
AlphaFold Q3UZZ4
Predicted Effect probably damaging
Transcript: ENSMUST00000088735
AA Change: D407G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000086112
Gene: ENSMUSG00000022026
AA Change: D407G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 32 43 N/A INTRINSIC
low complexity region 225 243 N/A INTRINSIC
OLF 274 532 8.53e-72 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000228749
AA Change: D374G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced colonization of the gastric mucosa by Helicobacter pylori but increased inflammatory response to H. pylori infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A T 17: 24,545,389 (GRCm39) M349K possibly damaging Het
Akap12 A G 10: 4,304,606 (GRCm39) E472G probably damaging Het
Ap2s1 T C 7: 16,482,626 (GRCm39) Y94H probably damaging Het
Apeh A G 9: 107,964,237 (GRCm39) F530L probably damaging Het
Aplnr G A 2: 84,970,103 (GRCm39) probably benign Het
Arid3b A G 9: 57,717,446 (GRCm39) probably null Het
Ash1l A C 3: 88,983,420 (GRCm39) D2874A probably benign Het
Aurka T A 2: 172,199,172 (GRCm39) R277S probably damaging Het
Calhm4 A G 10: 33,919,953 (GRCm39) F105L possibly damaging Het
Ccar1 C A 10: 62,600,209 (GRCm39) W574L probably damaging Het
Cd8b1 T C 6: 71,311,100 (GRCm39) F207L probably benign Het
Clec14a T C 12: 58,315,290 (GRCm39) R111G probably damaging Het
Clk3 G A 9: 57,668,132 (GRCm39) T263I possibly damaging Het
Col11a2 A G 17: 34,272,607 (GRCm39) probably null Het
Col5a3 C T 9: 20,709,748 (GRCm39) G604D unknown Het
Cracdl T C 1: 37,663,898 (GRCm39) T667A possibly damaging Het
Crb2 ACTGCTGCTGCTGCTGCTGCTGC ACTGCTGCTGCTGCTGCTGC 2: 37,666,421 (GRCm39) probably benign Het
Ctps1 A T 4: 120,405,335 (GRCm39) V369D probably damaging Het
Dennd5b A G 6: 148,895,244 (GRCm39) I1262T probably damaging Het
Dmxl1 C T 18: 50,054,091 (GRCm39) P2566S probably damaging Het
Fam170b A G 14: 32,557,915 (GRCm39) D250G probably damaging Het
Foxs1 G A 2: 152,775,048 (GRCm39) Q2* probably null Het
Frmpd1 T C 4: 45,275,383 (GRCm39) V512A probably damaging Het
Fry G A 5: 150,389,911 (GRCm39) probably null Het
Gria1 A G 11: 57,180,288 (GRCm39) Y677C probably damaging Het
Igdcc4 T C 9: 65,029,979 (GRCm39) I343T probably benign Het
Igkv1-132 T C 6: 67,736,697 (GRCm39) V5A probably benign Het
Ikzf5 A T 7: 130,993,401 (GRCm39) C256S probably damaging Het
Itk G A 11: 46,232,045 (GRCm39) H297Y probably damaging Het
Lamb3 A G 1: 193,017,756 (GRCm39) E879G probably benign Het
Lpin2 T C 17: 71,529,123 (GRCm39) V127A probably damaging Het
Man2b1 C A 8: 85,813,548 (GRCm39) P247T possibly damaging Het
Meak7 G A 8: 120,499,306 (GRCm39) T62I possibly damaging Het
Mxd3 T C 13: 55,473,967 (GRCm39) K122E probably benign Het
Npr1 C A 3: 90,372,120 (GRCm39) V231L probably benign Het
Nsd2 C T 5: 34,050,912 (GRCm39) A1263V probably damaging Het
Optc A T 1: 133,825,605 (GRCm39) I307N probably damaging Het
Or5p80 A C 7: 108,229,500 (GRCm39) Q100H possibly damaging Het
Or6c3b A T 10: 129,527,863 (GRCm39) S16T probably damaging Het
Pecr C A 1: 72,306,616 (GRCm39) E222* probably null Het
Pibf1 A G 14: 99,423,987 (GRCm39) N520S probably benign Het
Rhoj A G 12: 75,355,653 (GRCm39) N19S probably benign Het
Rock2 G A 12: 16,992,960 (GRCm39) probably null Het
Rpa1 G A 11: 75,205,697 (GRCm39) T220I probably damaging Het
Sdf2l1 C G 16: 16,950,158 (GRCm39) R6P probably benign Het
Sipa1l3 G A 7: 29,038,457 (GRCm39) H397Y probably benign Het
Snrk T C 9: 121,966,632 (GRCm39) I185T probably damaging Het
Srrt A T 5: 137,295,230 (GRCm39) V300E probably damaging Het
Taok2 A T 7: 126,471,047 (GRCm39) probably null Het
Tmem131 T C 1: 36,843,724 (GRCm39) K1379R possibly damaging Het
Usp15 T C 10: 122,963,894 (GRCm39) I543V probably damaging Het
Zfp553 A G 7: 126,835,447 (GRCm39) E334G probably damaging Het
Zim1 T C 7: 6,680,688 (GRCm39) Y325C probably damaging Het
Other mutations in Olfm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00532:Olfm4 APN 14 80,258,583 (GRCm39) missense probably benign 0.12
IGL01108:Olfm4 APN 14 80,259,339 (GRCm39) missense probably benign 0.15
IGL01599:Olfm4 APN 14 80,258,750 (GRCm39) missense probably damaging 1.00
IGL01872:Olfm4 APN 14 80,259,368 (GRCm39) makesense probably null
IGL01928:Olfm4 APN 14 80,249,392 (GRCm39) missense possibly damaging 0.71
IGL02333:Olfm4 APN 14 80,259,210 (GRCm39) missense probably damaging 1.00
IGL02336:Olfm4 APN 14 80,243,761 (GRCm39) missense probably damaging 1.00
IGL02811:Olfm4 APN 14 80,259,113 (GRCm39) missense probably damaging 1.00
PIT4651001:Olfm4 UTSW 14 80,258,925 (GRCm39) missense probably benign 0.00
R1428:Olfm4 UTSW 14 80,258,843 (GRCm39) missense probably damaging 1.00
R1649:Olfm4 UTSW 14 80,249,422 (GRCm39) missense probably damaging 0.98
R2139:Olfm4 UTSW 14 80,251,755 (GRCm39) missense probably benign 0.00
R2270:Olfm4 UTSW 14 80,249,315 (GRCm39) missense probably damaging 0.96
R2401:Olfm4 UTSW 14 80,259,192 (GRCm39) missense probably damaging 1.00
R4527:Olfm4 UTSW 14 80,258,664 (GRCm39) missense probably benign 0.13
R4649:Olfm4 UTSW 14 80,258,747 (GRCm39) missense probably benign 0.00
R5232:Olfm4 UTSW 14 80,259,122 (GRCm39) missense probably damaging 1.00
R5512:Olfm4 UTSW 14 80,258,787 (GRCm39) missense probably benign 0.32
R6198:Olfm4 UTSW 14 80,237,813 (GRCm39) missense probably benign 0.18
R6642:Olfm4 UTSW 14 80,259,107 (GRCm39) missense probably damaging 1.00
R6916:Olfm4 UTSW 14 80,251,638 (GRCm39) missense probably damaging 0.97
R6960:Olfm4 UTSW 14 80,258,754 (GRCm39) missense probably damaging 0.97
R7329:Olfm4 UTSW 14 80,249,369 (GRCm39) missense possibly damaging 0.79
R7971:Olfm4 UTSW 14 80,259,240 (GRCm39) missense probably damaging 0.98
R8872:Olfm4 UTSW 14 80,258,943 (GRCm39) missense probably damaging 1.00
R9008:Olfm4 UTSW 14 80,255,607 (GRCm39) missense unknown
R9398:Olfm4 UTSW 14 80,249,249 (GRCm39) missense probably benign 0.12
R9599:Olfm4 UTSW 14 80,243,747 (GRCm39) missense probably damaging 1.00
R9600:Olfm4 UTSW 14 80,243,747 (GRCm39) missense probably damaging 1.00
R9784:Olfm4 UTSW 14 80,249,348 (GRCm39) missense probably damaging 0.99
Z1176:Olfm4 UTSW 14 80,258,659 (GRCm39) missense probably benign 0.39
Z1177:Olfm4 UTSW 14 80,237,892 (GRCm39) missense probably benign 0.40
Predicted Primers PCR Primer
(F):5'- ACAGACTTTACGACTCATTGGAC -3'
(R):5'- CCACATACCATGAAGGCATTCG -3'

Sequencing Primer
(F):5'- ACTATCGGATTCGCTATGGCCAAG -3'
(R):5'- TCGAAACAGATGGCTTGTACTGC -3'
Posted On 2018-09-12