Incidental Mutation 'R6829:Vmn1r14'
ID 534295
Institutional Source Beutler Lab
Gene Symbol Vmn1r14
Ensembl Gene ENSMUSG00000114982
Gene Name vomeronasal 1 receptor 14
Synonyms V1rc7
MMRRC Submission 044939-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R6829 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 57203140-57211335 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57210536 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 38 (L38P)
Ref Sequence ENSEMBL: ENSMUSP00000154520 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177435] [ENSMUST00000227209] [ENSMUST00000227574] [ENSMUST00000227768] [ENSMUST00000227884]
AlphaFold H3BJ46
Predicted Effect probably benign
Transcript: ENSMUST00000177435
AA Change: L38P

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000135207
Gene: ENSMUSG00000114982
AA Change: L38P

DomainStartEndE-ValueType
Pfam:V1R 28 293 3.9e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227209
Predicted Effect probably benign
Transcript: ENSMUST00000227574
Predicted Effect probably benign
Transcript: ENSMUST00000227768
AA Change: L38P

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000227884
AA Change: L38P

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 98% (40/41)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 A T 14: 66,265,446 (GRCm39) probably null Het
Adamts5 A T 16: 85,666,959 (GRCm39) M511K possibly damaging Het
Adcy9 A G 16: 4,125,018 (GRCm39) probably null Het
Cast T C 13: 74,876,463 (GRCm39) E113G possibly damaging Het
Ccdc198 A G 14: 49,464,025 (GRCm39) *295Q probably null Het
Dcaf1 T A 9: 106,715,803 (GRCm39) S307T probably damaging Het
Dmxl1 C T 18: 50,054,091 (GRCm39) P2566S probably damaging Het
Elac2 A G 11: 64,880,190 (GRCm39) E111G probably benign Het
Fbxw4 A G 19: 45,624,813 (GRCm39) F57S possibly damaging Het
Gm17655 T G 5: 110,194,792 (GRCm39) H330P probably damaging Het
Gm2a T C 11: 54,994,576 (GRCm39) probably null Het
Gon4l T A 3: 88,787,413 (GRCm39) D600E possibly damaging Het
Gsg1l2 T C 11: 67,665,684 (GRCm39) I84T possibly damaging Het
Igsf9 A G 1: 172,323,241 (GRCm39) R652G probably benign Het
Il17rd C T 14: 26,809,379 (GRCm39) R112* probably null Het
Jph1 C A 1: 17,074,647 (GRCm39) R457L probably damaging Het
Khdrbs3 T C 15: 68,964,810 (GRCm39) V249A possibly damaging Het
Mocs2 A G 13: 114,955,980 (GRCm39) S43G probably benign Het
Myom2 T A 8: 15,172,643 (GRCm39) L1190* probably null Het
Or2w1 T A 13: 21,317,023 (GRCm39) I26N possibly damaging Het
Or4f62 G C 2: 111,986,139 (GRCm39) probably benign Het
Or5ac16 A G 16: 59,021,898 (GRCm39) V297A probably damaging Het
Or8k33 A T 2: 86,383,613 (GRCm39) L285* probably null Het
Pgc A T 17: 48,043,706 (GRCm39) probably null Het
Plch1 T G 3: 63,604,939 (GRCm39) D1655A probably damaging Het
Pnliprp2 G A 19: 58,748,305 (GRCm39) G29R probably benign Het
Polg A G 7: 79,109,857 (GRCm39) V382A probably benign Het
Rb1cc1 T C 1: 6,319,488 (GRCm39) I969T probably benign Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Het
Sdf2l1 C G 16: 16,950,158 (GRCm39) R6P probably benign Het
Sema7a A G 9: 57,868,181 (GRCm39) E538G probably benign Het
Slc2a2 C T 3: 28,781,590 (GRCm39) Q513* probably null Het
Slc4a8 A G 15: 100,698,419 (GRCm39) Y636C probably damaging Het
Tasor A G 14: 27,164,438 (GRCm39) D248G possibly damaging Het
Trpm5 A G 7: 142,623,166 (GRCm39) probably benign Het
Washc4 T C 10: 83,396,380 (GRCm39) S397P probably damaging Het
Wfdc3 C T 2: 164,576,178 (GRCm39) G38R possibly damaging Het
Zan A G 5: 137,414,540 (GRCm39) probably benign Het
Zfhx3 C T 8: 109,676,915 (GRCm39) T2655M probably damaging Het
Other mutations in Vmn1r14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1083:Vmn1r14 UTSW 6 57,211,184 (GRCm39) missense probably damaging 1.00
R1533:Vmn1r14 UTSW 6 57,211,286 (GRCm39) missense probably damaging 1.00
R1759:Vmn1r14 UTSW 6 57,211,297 (GRCm39) missense probably benign 0.00
R3945:Vmn1r14 UTSW 6 57,211,254 (GRCm39) missense probably benign 0.13
R4034:Vmn1r14 UTSW 6 57,211,310 (GRCm39) missense possibly damaging 0.63
R4273:Vmn1r14 UTSW 6 57,211,133 (GRCm39) missense probably damaging 1.00
R4342:Vmn1r14 UTSW 6 57,210,808 (GRCm39) missense probably benign 0.09
R4451:Vmn1r14 UTSW 6 57,211,213 (GRCm39) missense possibly damaging 0.86
R5978:Vmn1r14 UTSW 6 57,210,929 (GRCm39) missense probably benign 0.06
R6378:Vmn1r14 UTSW 6 57,210,587 (GRCm39) missense probably benign 0.09
R7153:Vmn1r14 UTSW 6 57,210,851 (GRCm39) missense probably benign 0.10
R8015:Vmn1r14 UTSW 6 57,211,015 (GRCm39) missense probably damaging 0.96
R8105:Vmn1r14 UTSW 6 57,211,245 (GRCm39) missense probably benign 0.00
R8830:Vmn1r14 UTSW 6 57,211,017 (GRCm39) missense probably damaging 0.98
R8831:Vmn1r14 UTSW 6 57,210,505 (GRCm39) missense probably benign 0.05
Z1177:Vmn1r14 UTSW 6 57,211,126 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GAATCACAAGTTTCATGTGTGCTC -3'
(R):5'- ATCATGACAGCCTGGAACAC -3'

Sequencing Primer
(F):5'- CCACCATTCTCTTAGGATGA -3'
(R):5'- GCCTGGAACACACTCAGGAG -3'
Posted On 2018-09-12