Incidental Mutation 'R6829:Or5ac16'
ID 534318
Institutional Source Beutler Lab
Gene Symbol Or5ac16
Ensembl Gene ENSMUSG00000052537
Gene Name olfactory receptor family 5 subfamily AC member 16
Synonyms MOR182-8, GA_x54KRFPKG5P-55416332-55415412, Olfr198
MMRRC Submission 044939-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R6829 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 59021867-59022787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59021898 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 297 (V297A)
Ref Sequence ENSEMBL: ENSMUSP00000146813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064452] [ENSMUST00000208244]
AlphaFold Q7TS40
Predicted Effect probably damaging
Transcript: ENSMUST00000064452
AA Change: V297A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065535
Gene: ENSMUSG00000052537
AA Change: V297A

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.9e-45 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208244
AA Change: V297A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 A T 14: 66,265,446 (GRCm39) probably null Het
Adamts5 A T 16: 85,666,959 (GRCm39) M511K possibly damaging Het
Adcy9 A G 16: 4,125,018 (GRCm39) probably null Het
Cast T C 13: 74,876,463 (GRCm39) E113G possibly damaging Het
Ccdc198 A G 14: 49,464,025 (GRCm39) *295Q probably null Het
Dcaf1 T A 9: 106,715,803 (GRCm39) S307T probably damaging Het
Dmxl1 C T 18: 50,054,091 (GRCm39) P2566S probably damaging Het
Elac2 A G 11: 64,880,190 (GRCm39) E111G probably benign Het
Fbxw4 A G 19: 45,624,813 (GRCm39) F57S possibly damaging Het
Gm17655 T G 5: 110,194,792 (GRCm39) H330P probably damaging Het
Gm2a T C 11: 54,994,576 (GRCm39) probably null Het
Gon4l T A 3: 88,787,413 (GRCm39) D600E possibly damaging Het
Gsg1l2 T C 11: 67,665,684 (GRCm39) I84T possibly damaging Het
Igsf9 A G 1: 172,323,241 (GRCm39) R652G probably benign Het
Il17rd C T 14: 26,809,379 (GRCm39) R112* probably null Het
Jph1 C A 1: 17,074,647 (GRCm39) R457L probably damaging Het
Khdrbs3 T C 15: 68,964,810 (GRCm39) V249A possibly damaging Het
Mocs2 A G 13: 114,955,980 (GRCm39) S43G probably benign Het
Myom2 T A 8: 15,172,643 (GRCm39) L1190* probably null Het
Or2w1 T A 13: 21,317,023 (GRCm39) I26N possibly damaging Het
Or4f62 G C 2: 111,986,139 (GRCm39) probably benign Het
Or8k33 A T 2: 86,383,613 (GRCm39) L285* probably null Het
Pgc A T 17: 48,043,706 (GRCm39) probably null Het
Plch1 T G 3: 63,604,939 (GRCm39) D1655A probably damaging Het
Pnliprp2 G A 19: 58,748,305 (GRCm39) G29R probably benign Het
Polg A G 7: 79,109,857 (GRCm39) V382A probably benign Het
Rb1cc1 T C 1: 6,319,488 (GRCm39) I969T probably benign Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Het
Sdf2l1 C G 16: 16,950,158 (GRCm39) R6P probably benign Het
Sema7a A G 9: 57,868,181 (GRCm39) E538G probably benign Het
Slc2a2 C T 3: 28,781,590 (GRCm39) Q513* probably null Het
Slc4a8 A G 15: 100,698,419 (GRCm39) Y636C probably damaging Het
Tasor A G 14: 27,164,438 (GRCm39) D248G possibly damaging Het
Trpm5 A G 7: 142,623,166 (GRCm39) probably benign Het
Vmn1r14 T C 6: 57,210,536 (GRCm39) L38P probably benign Het
Washc4 T C 10: 83,396,380 (GRCm39) S397P probably damaging Het
Wfdc3 C T 2: 164,576,178 (GRCm39) G38R possibly damaging Het
Zan A G 5: 137,414,540 (GRCm39) probably benign Het
Zfhx3 C T 8: 109,676,915 (GRCm39) T2655M probably damaging Het
Other mutations in Or5ac16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Or5ac16 APN 16 59,022,460 (GRCm39) missense possibly damaging 0.94
IGL03053:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
IGL03168:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
R1355:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1370:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1510:Or5ac16 UTSW 16 59,022,546 (GRCm39) missense probably damaging 0.99
R1777:Or5ac16 UTSW 16 59,022,379 (GRCm39) missense probably benign 0.35
R1962:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R1964:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R5409:Or5ac16 UTSW 16 59,021,920 (GRCm39) missense probably damaging 1.00
R5642:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R5704:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R6323:Or5ac16 UTSW 16 59,022,645 (GRCm39) missense probably damaging 1.00
R7315:Or5ac16 UTSW 16 59,022,496 (GRCm39) missense probably benign 0.00
R7738:Or5ac16 UTSW 16 59,022,318 (GRCm39) missense probably benign 0.00
R8540:Or5ac16 UTSW 16 59,022,323 (GRCm39) missense possibly damaging 0.56
R8815:Or5ac16 UTSW 16 59,022,264 (GRCm39) missense possibly damaging 0.78
R8844:Or5ac16 UTSW 16 59,021,929 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGACGAGATGCTCACTGC -3'
(R):5'- CCTTCTTGCCATCCTGAAAACAAAG -3'

Sequencing Primer
(F):5'- GAGATGCTCACTGCCTTCAACAG -3'
(R):5'- TTGCCATCCTGAAAACAAAGTCTGAG -3'
Posted On 2018-09-12