Incidental Mutation 'IGL01014:Or5w16'
ID 53445
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w16
Ensembl Gene ENSMUSG00000068817
Gene Name olfactory receptor family 5 subfamily W member 16
Synonyms Olfr1140, GA_x6K02T2Q125-49250025-49250960, MOR177-6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.205) question?
Stock # IGL01014
Quality Score
Status
Chromosome 2
Chromosomal Location 87576505-87577524 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87577469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 310 (F310L)
Ref Sequence ENSEMBL: ENSMUSP00000149645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111568] [ENSMUST00000214723] [ENSMUST00000217572]
AlphaFold Q7TR39
Predicted Effect probably benign
Transcript: ENSMUST00000111568
AA Change: F310L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: F310L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-44 PFAM
Pfam:7tm_1 41 290 2.8e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214723
AA Change: F310L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217102
Predicted Effect probably benign
Transcript: ENSMUST00000217572
AA Change: F310L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217634
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra1 G A 7: 139,455,576 (GRCm39) M401I probably benign Het
Adgra1 C T 7: 139,455,577 (GRCm39) H402Y probably damaging Het
Akap13 T C 7: 75,400,381 (GRCm39) probably benign Het
Akap9 A G 5: 4,018,683 (GRCm39) E1088G probably benign Het
Aox1 T C 1: 58,361,960 (GRCm39) F722S possibly damaging Het
Arhgef39 G A 4: 43,499,502 (GRCm39) R36C probably damaging Het
Art2a C A 7: 101,204,115 (GRCm39) C141F probably damaging Het
Brwd1 A G 16: 95,817,373 (GRCm39) F1380L probably benign Het
Cadps2 A T 6: 23,496,873 (GRCm39) N102K possibly damaging Het
Ccdc30 C A 4: 119,250,776 (GRCm39) R22L possibly damaging Het
Ccdc74a A T 16: 17,467,661 (GRCm39) T200S possibly damaging Het
Cd200 G A 16: 45,215,063 (GRCm39) T196I probably benign Het
Cd244a A G 1: 171,401,856 (GRCm39) Y194C probably damaging Het
Cdh23 T C 10: 60,143,301 (GRCm39) T3009A probably damaging Het
Clec12b T A 6: 129,362,393 (GRCm39) N21Y probably damaging Het
Cntln A G 4: 84,968,145 (GRCm39) E788G probably benign Het
Col11a1 C T 3: 113,917,458 (GRCm39) probably benign Het
Cttnbp2 T A 6: 18,423,894 (GRCm39) N810I probably damaging Het
Dhx15 A T 5: 52,309,266 (GRCm39) V719D probably damaging Het
Dnah6 A G 6: 73,051,764 (GRCm39) probably benign Het
Dnajc13 A G 9: 104,080,417 (GRCm39) I888T probably damaging Het
Fasn T C 11: 120,708,055 (GRCm39) K666E probably damaging Het
Gnas C T 2: 174,139,767 (GRCm39) probably benign Het
Lmntd2 T C 7: 140,793,952 (GRCm39) Q7R probably damaging Het
Lmo7 G A 14: 102,157,993 (GRCm39) probably benign Het
Lrrc55 A G 2: 85,026,559 (GRCm39) I155T possibly damaging Het
Meis3 C T 7: 15,912,872 (GRCm39) probably benign Het
Mib2 C T 4: 155,742,187 (GRCm39) V334M probably damaging Het
Myo3a A G 2: 22,337,284 (GRCm39) I386V probably benign Het
Neb C A 2: 52,177,170 (GRCm39) M1390I probably benign Het
Nmd3 G A 3: 69,633,719 (GRCm39) V69I probably benign Het
Nsmce3 G T 7: 64,522,382 (GRCm39) D95E possibly damaging Het
Or4c12 T C 2: 89,773,604 (GRCm39) Y285C probably damaging Het
Or4f58 A G 2: 111,851,477 (GRCm39) S241P probably damaging Het
Pde4d T C 13: 110,086,036 (GRCm39) V538A probably damaging Het
Pgap6 T A 17: 26,335,983 (GRCm39) probably benign Het
Plxnb1 A T 9: 108,935,102 (GRCm39) H982L probably benign Het
Pold2 G T 11: 5,822,293 (GRCm39) Q459K probably benign Het
Ptpn14 G A 1: 189,554,830 (GRCm39) R130Q probably damaging Het
Rnf10 A T 5: 115,395,042 (GRCm39) L182Q probably damaging Het
Syne2 G A 12: 75,952,051 (GRCm39) D440N probably damaging Het
Tlcd1 G A 11: 78,070,283 (GRCm39) probably null Het
Tpte A T 8: 22,810,898 (GRCm39) Y185F probably benign Het
Other mutations in Or5w16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01538:Or5w16 APN 2 87,576,942 (GRCm39) missense probably benign 0.10
IGL01735:Or5w16 APN 2 87,576,650 (GRCm39) missense probably benign 0.00
IGL02224:Or5w16 APN 2 87,576,757 (GRCm39) nonsense probably null
IGL03047:Or5w16 UTSW 2 87,577,338 (GRCm39) missense possibly damaging 0.63
R0537:Or5w16 UTSW 2 87,577,017 (GRCm39) missense probably benign 0.06
R1701:Or5w16 UTSW 2 87,576,894 (GRCm39) missense probably damaging 0.99
R1998:Or5w16 UTSW 2 87,577,316 (GRCm39) missense probably damaging 1.00
R2430:Or5w16 UTSW 2 87,576,999 (GRCm39) missense possibly damaging 0.52
R4750:Or5w16 UTSW 2 87,576,852 (GRCm39) missense probably benign
R5048:Or5w16 UTSW 2 87,576,663 (GRCm39) missense probably benign 0.01
R5494:Or5w16 UTSW 2 87,576,950 (GRCm39) missense probably damaging 1.00
R5521:Or5w16 UTSW 2 87,577,406 (GRCm39) missense probably benign 0.24
R7786:Or5w16 UTSW 2 87,576,645 (GRCm39) missense probably damaging 1.00
R8017:Or5w16 UTSW 2 87,577,392 (GRCm39) missense probably damaging 0.98
R8019:Or5w16 UTSW 2 87,577,392 (GRCm39) missense probably damaging 0.98
R8463:Or5w16 UTSW 2 87,577,437 (GRCm39) missense probably benign 0.01
R8827:Or5w16 UTSW 2 87,576,777 (GRCm39) missense possibly damaging 0.63
R9038:Or5w16 UTSW 2 87,577,125 (GRCm39) missense probably damaging 1.00
X0019:Or5w16 UTSW 2 87,576,764 (GRCm39) missense possibly damaging 0.96
Z1088:Or5w16 UTSW 2 87,576,833 (GRCm39) missense probably damaging 0.99
Z1177:Or5w16 UTSW 2 87,576,968 (GRCm39) missense possibly damaging 0.48
Posted On 2013-06-28