Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01014:Lrrc55'

53446

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc55

Ensembl Gene

ENSMUSG00000075224

Gene Name

leucine rich repeat containing 55

Synonyms

LOC241528, A330097E02Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01014

Quality Score

Status

Chromosome

Chromosomal Location

85018411-85029110 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85026559 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 155 (I155T)

Ref Sequence

ENSEMBL: ENSMUSP00000107228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099930] [ENSMUST00000111601]

AlphaFold

Q3UY51

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099930
AA Change: I155T

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000097514
Gene: ENSMUSG00000075224
AA Change: I155T

Domain	Start	End	E-Value	Type
signal peptide	1	47	N/A	INTRINSIC
LRRNT	50	82	2.57e-7	SMART
LRR	103	124	3.29e-1	SMART
LRR	126	148	4.7e0	SMART
LRR	150	173	2.47e2	SMART
LRR	174	197	2.4e1	SMART
LRRCT	209	263	6.85e-9	SMART
transmembrane domain	272	294	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000111601
AA Change: I155T

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000107228
Gene: ENSMUSG00000075224
AA Change: I155T

Domain	Start	End	E-Value	Type
signal peptide	1	47	N/A	INTRINSIC
LRRNT	50	82	2.57e-7	SMART
LRR	103	124	3.29e-1	SMART
LRR	126	148	4.7e0	SMART
LRR	150	173	2.47e2	SMART
LRR	174	197	2.4e1	SMART
LRRCT	209	263	6.85e-9	SMART
transmembrane domain	272	294	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126401

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139377

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra1	G	A	7: 139,455,576 (GRCm39)	M401I	probably benign	Het
Adgra1	C	T	7: 139,455,577 (GRCm39)	H402Y	probably damaging	Het
Akap13	T	C	7: 75,400,381 (GRCm39)		probably benign	Het
Akap9	A	G	5: 4,018,683 (GRCm39)	E1088G	probably benign	Het
Aox1	T	C	1: 58,361,960 (GRCm39)	F722S	possibly damaging	Het
Arhgef39	G	A	4: 43,499,502 (GRCm39)	R36C	probably damaging	Het
Art2a	C	A	7: 101,204,115 (GRCm39)	C141F	probably damaging	Het
Brwd1	A	G	16: 95,817,373 (GRCm39)	F1380L	probably benign	Het
Cadps2	A	T	6: 23,496,873 (GRCm39)	N102K	possibly damaging	Het
Ccdc30	C	A	4: 119,250,776 (GRCm39)	R22L	possibly damaging	Het
Ccdc74a	A	T	16: 17,467,661 (GRCm39)	T200S	possibly damaging	Het
Cd200	G	A	16: 45,215,063 (GRCm39)	T196I	probably benign	Het
Cd244a	A	G	1: 171,401,856 (GRCm39)	Y194C	probably damaging	Het
Cdh23	T	C	10: 60,143,301 (GRCm39)	T3009A	probably damaging	Het
Clec12b	T	A	6: 129,362,393 (GRCm39)	N21Y	probably damaging	Het
Cntln	A	G	4: 84,968,145 (GRCm39)	E788G	probably benign	Het
Col11a1	C	T	3: 113,917,458 (GRCm39)		probably benign	Het
Cttnbp2	T	A	6: 18,423,894 (GRCm39)	N810I	probably damaging	Het
Dhx15	A	T	5: 52,309,266 (GRCm39)	V719D	probably damaging	Het
Dnah6	A	G	6: 73,051,764 (GRCm39)		probably benign	Het
Dnajc13	A	G	9: 104,080,417 (GRCm39)	I888T	probably damaging	Het
Fasn	T	C	11: 120,708,055 (GRCm39)	K666E	probably damaging	Het
Gnas	C	T	2: 174,139,767 (GRCm39)		probably benign	Het
Lmntd2	T	C	7: 140,793,952 (GRCm39)	Q7R	probably damaging	Het
Lmo7	G	A	14: 102,157,993 (GRCm39)		probably benign	Het
Meis3	C	T	7: 15,912,872 (GRCm39)		probably benign	Het
Mib2	C	T	4: 155,742,187 (GRCm39)	V334M	probably damaging	Het
Myo3a	A	G	2: 22,337,284 (GRCm39)	I386V	probably benign	Het
Neb	C	A	2: 52,177,170 (GRCm39)	M1390I	probably benign	Het
Nmd3	G	A	3: 69,633,719 (GRCm39)	V69I	probably benign	Het
Nsmce3	G	T	7: 64,522,382 (GRCm39)	D95E	possibly damaging	Het
Or4c12	T	C	2: 89,773,604 (GRCm39)	Y285C	probably damaging	Het
Or4f58	A	G	2: 111,851,477 (GRCm39)	S241P	probably damaging	Het
Or5w16	T	C	2: 87,577,469 (GRCm39)	F310L	probably benign	Het
Pde4d	T	C	13: 110,086,036 (GRCm39)	V538A	probably damaging	Het
Pgap6	T	A	17: 26,335,983 (GRCm39)		probably benign	Het
Plxnb1	A	T	9: 108,935,102 (GRCm39)	H982L	probably benign	Het
Pold2	G	T	11: 5,822,293 (GRCm39)	Q459K	probably benign	Het
Ptpn14	G	A	1: 189,554,830 (GRCm39)	R130Q	probably damaging	Het
Rnf10	A	T	5: 115,395,042 (GRCm39)	L182Q	probably damaging	Het
Syne2	G	A	12: 75,952,051 (GRCm39)	D440N	probably damaging	Het
Tlcd1	G	A	11: 78,070,283 (GRCm39)		probably null	Het
Tpte	A	T	8: 22,810,898 (GRCm39)	Y185F	probably benign	Het

Other mutations in Lrrc55

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01646:Lrrc55	APN	2	85,022,333 (GRCm39)	missense	probably damaging	0.99
malice	UTSW	2	85,026,615 (GRCm39)	missense	probably damaging	1.00
spite	UTSW	2	85,026,727 (GRCm39)	missense	probably benign	0.34
R0149:Lrrc55	UTSW	2	85,026,589 (GRCm39)	missense	probably damaging	0.98
R0361:Lrrc55	UTSW	2	85,026,589 (GRCm39)	missense	probably damaging	0.98
R0491:Lrrc55	UTSW	2	85,022,264 (GRCm39)	missense	probably damaging	1.00
R4223:Lrrc55	UTSW	2	85,026,460 (GRCm39)	missense	possibly damaging	0.82
R4654:Lrrc55	UTSW	2	85,026,880 (GRCm39)	missense	possibly damaging	0.82
R4746:Lrrc55	UTSW	2	85,026,514 (GRCm39)	missense	probably damaging	1.00
R5756:Lrrc55	UTSW	2	85,026,727 (GRCm39)	missense	probably benign	0.34
R6329:Lrrc55	UTSW	2	85,026,653 (GRCm39)	missense	probably benign	0.28
R6705:Lrrc55	UTSW	2	85,026,699 (GRCm39)	missense	probably benign	0.33
R6985:Lrrc55	UTSW	2	85,022,274 (GRCm39)	missense	probably benign	0.27
R7229:Lrrc55	UTSW	2	85,026,784 (GRCm39)	missense	probably damaging	1.00
R8132:Lrrc55	UTSW	2	85,022,259 (GRCm39)	missense	probably benign	0.00
R8483:Lrrc55	UTSW	2	85,022,295 (GRCm39)	missense	probably benign	0.22
R8932:Lrrc55	UTSW	2	85,026,615 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-28