Incidental Mutation 'R6836:Vmn2r74'
| ID |
534567 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
R6836 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85606630 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 239
(I239F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166355
AA Change: I239F
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: I239F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.9%
|
| Validation Efficiency |
100% (62/62) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl2 |
T |
C |
2: 26,971,718 (GRCm39) |
M1T |
probably null |
Het |
| Aim2 |
C |
G |
1: 173,291,546 (GRCm39) |
T317R |
probably damaging |
Het |
| Alox8 |
T |
C |
11: 69,077,331 (GRCm39) |
Y473C |
probably damaging |
Het |
| Alox8 |
T |
C |
11: 69,080,715 (GRCm39) |
R209G |
possibly damaging |
Het |
| Asb5 |
A |
G |
8: 55,038,106 (GRCm39) |
M210V |
probably benign |
Het |
| Atp2c2 |
T |
A |
8: 120,461,154 (GRCm39) |
L249Q |
probably damaging |
Het |
| AU018091 |
T |
G |
7: 3,213,986 (GRCm39) |
D77A |
probably damaging |
Het |
| Bahcc1 |
A |
T |
11: 120,162,583 (GRCm39) |
K294* |
probably null |
Het |
| Baz2b |
C |
T |
2: 59,747,769 (GRCm39) |
R1298Q |
probably damaging |
Het |
| Bivm |
T |
A |
1: 44,182,296 (GRCm39) |
N501K |
possibly damaging |
Het |
| Bpifb5 |
T |
A |
2: 154,069,985 (GRCm39) |
I145N |
probably benign |
Het |
| Casq2 |
A |
T |
3: 101,994,076 (GRCm39) |
N41I |
probably damaging |
Het |
| Ccdc18 |
T |
C |
5: 108,345,833 (GRCm39) |
L993P |
probably damaging |
Het |
| Cdcp3 |
A |
T |
7: 130,798,233 (GRCm39) |
I81F |
possibly damaging |
Het |
| Cfap44 |
A |
G |
16: 44,224,442 (GRCm39) |
D50G |
probably damaging |
Het |
| Clca3a2 |
T |
A |
3: 144,512,144 (GRCm39) |
I91F |
probably damaging |
Het |
| Crebbp |
T |
A |
16: 3,997,886 (GRCm39) |
H66L |
possibly damaging |
Het |
| Cyfip2 |
T |
C |
11: 46,163,467 (GRCm39) |
T321A |
probably benign |
Het |
| Dido1 |
A |
G |
2: 180,304,100 (GRCm39) |
V1268A |
probably benign |
Het |
| E030030I06Rik |
A |
C |
10: 22,024,391 (GRCm39) |
V174G |
probably damaging |
Het |
| Gm20730 |
G |
T |
6: 43,058,767 (GRCm39) |
|
probably null |
Het |
| Gm36176 |
T |
C |
10: 77,682,976 (GRCm39) |
|
probably benign |
Het |
| Gper1 |
T |
A |
5: 139,412,435 (GRCm39) |
M260K |
probably damaging |
Het |
| Igfbp2 |
T |
C |
1: 72,888,817 (GRCm39) |
L89P |
probably damaging |
Het |
| Katnal1 |
T |
C |
5: 148,830,974 (GRCm39) |
N200S |
probably damaging |
Het |
| Kcnk13 |
G |
T |
12: 100,027,948 (GRCm39) |
R341L |
probably damaging |
Het |
| Klhl20 |
T |
A |
1: 160,932,976 (GRCm39) |
E277D |
probably benign |
Het |
| Lingo1 |
T |
C |
9: 56,527,056 (GRCm39) |
Y517C |
probably damaging |
Het |
| Lrrk1 |
C |
T |
7: 65,992,527 (GRCm39) |
E82K |
probably benign |
Het |
| Mtor |
T |
A |
4: 148,573,955 (GRCm39) |
V1275D |
possibly damaging |
Het |
| Ncan |
C |
T |
8: 70,552,965 (GRCm39) |
S1089N |
possibly damaging |
Het |
| Notch4 |
C |
T |
17: 34,805,074 (GRCm39) |
T1643I |
probably damaging |
Het |
| Or13a25 |
A |
C |
7: 140,248,093 (GRCm39) |
I298L |
possibly damaging |
Het |
| Or1i2 |
A |
G |
10: 78,448,424 (GRCm39) |
L17P |
probably damaging |
Het |
| Or2y15 |
A |
T |
11: 49,350,904 (GRCm39) |
T133S |
possibly damaging |
Het |
| Or4c10 |
T |
C |
2: 89,760,683 (GRCm39) |
C177R |
probably damaging |
Het |
| Pcdhgb6 |
T |
C |
18: 37,876,015 (GRCm39) |
V241A |
probably benign |
Het |
| Phf11b |
T |
A |
14: 59,565,572 (GRCm39) |
T102S |
possibly damaging |
Het |
| Pkd1 |
T |
A |
17: 24,800,233 (GRCm39) |
V2998E |
probably damaging |
Het |
| Ppp1r13b |
T |
C |
12: 111,801,629 (GRCm39) |
S352G |
probably benign |
Het |
| Ptprh |
C |
T |
7: 4,554,134 (GRCm39) |
V778M |
probably damaging |
Het |
| Ptprz1 |
C |
T |
6: 23,030,664 (GRCm39) |
Q1008* |
probably null |
Het |
| Ralgapa1 |
A |
T |
12: 55,651,058 (GRCm39) |
|
probably null |
Het |
| Rbm20 |
G |
A |
19: 53,802,500 (GRCm39) |
G336E |
probably damaging |
Het |
| Sdsl |
T |
C |
5: 120,600,167 (GRCm39) |
I77V |
probably benign |
Het |
| Serpina3b |
G |
A |
12: 104,100,341 (GRCm39) |
E308K |
probably benign |
Het |
| Sfrp5 |
G |
A |
19: 42,190,149 (GRCm39) |
T101I |
probably damaging |
Het |
| Slc2a13 |
C |
T |
15: 91,205,835 (GRCm39) |
V451I |
probably benign |
Het |
| Slc6a9 |
C |
T |
4: 117,725,083 (GRCm39) |
A559V |
possibly damaging |
Het |
| Spg11 |
C |
T |
2: 121,890,016 (GRCm39) |
A2109T |
probably damaging |
Het |
| Stard9 |
C |
T |
2: 120,530,324 (GRCm39) |
R2194C |
probably benign |
Het |
| Tfeb |
T |
C |
17: 48,097,123 (GRCm39) |
|
probably null |
Het |
| Tiam2 |
T |
A |
17: 3,464,655 (GRCm39) |
I128N |
probably benign |
Het |
| Tmem161b |
C |
A |
13: 84,370,537 (GRCm39) |
|
probably benign |
Het |
| Tpr |
T |
G |
1: 150,312,424 (GRCm39) |
|
probably null |
Het |
| Traf3ip1 |
T |
C |
1: 91,448,722 (GRCm39) |
I456T |
probably benign |
Het |
| Ttll4 |
T |
A |
1: 74,728,572 (GRCm39) |
D892E |
probably damaging |
Het |
| Ubr1 |
T |
A |
2: 120,727,156 (GRCm39) |
|
probably null |
Het |
| Wdfy3 |
C |
T |
5: 102,100,865 (GRCm39) |
V251M |
probably damaging |
Het |
| Xylb |
T |
A |
9: 119,220,820 (GRCm39) |
L531H |
probably damaging |
Het |
| Zfp960 |
T |
A |
17: 17,308,434 (GRCm39) |
C383S |
probably damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGGACGCATATAGCAAGAAATCTC -3'
(R):5'- TCACCAGATATCTCGCAAGGAC -3'
Sequencing Primer
(F):5'- AGTTGTGATACGCTAACCCAG -3'
(R):5'- GATATCTCGCAAGGACACATTTC -3'
|
| Posted On |
2018-09-12 |
Incidental Mutation